LOCUS       NM_002536               3785 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens TBC1 domain family member 25 (TBC1D25), transcript
            variant 3, mRNA.
ACCESSION   NM_002536
VERSION     NM_002536.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3785)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 3785)
  AUTHORS   Roy,M., Stephens,E., Bouhour,S. and Roux,S.
  TITLE     RabGAP TBC1D25 is involved in human osteoclast activity
  JOURNAL   Eur J Cell Biol 100 (3), 151145 (2021)
   PUBMED   33353759
  REMARK    GeneRIF: RabGAP TBC1D25 is involved in human osteoclast activity.
REFERENCE   3  (bases 1 to 3785)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3785)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 3785)
  AUTHORS   Panarella,A., Bexiga,M.G., Galea,G., O' Neill,E.D., Salvati,A.,
            Dawson,K.A. and Simpson,J.C.
  TITLE     A systematic High-Content Screening microscopy approach reveals key
            roles for Rab33b, OATL1 and Myo6 in nanoparticle trafficking in
            HeLa cells
  JOURNAL   Sci Rep 6, 28865 (2016)
   PUBMED   27374232
  REMARK    GeneRIF: Rab33b, OATL1 and Myo6 have roles in nanoparticle
            trafficking in HeLa cells
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3785)
  AUTHORS   Ishibashi,K., Kanno,E., Itoh,T. and Fukuda,M.
  TITLE     Identification and characterization of a novel Tre-2/Bub2/Cdc16
            (TBC) protein that possesses Rab3A-GAP activity
  JOURNAL   Genes Cells 14 (1), 41-52 (2009)
   PUBMED   19077034
REFERENCE   7  (bases 1 to 3785)
  AUTHORS   Tian,H., Liu,X., Zhang,B., Sun,Q. and Sun,D.
  TITLE     Adenovirus-mediated expression of both antisense ornithine
            decarboxylase and S-adenosylmethionine decarboxylase inhibits lung
            cancer cell growth
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 39 (6), 423-430 (2007)
   PUBMED   17558447
  REMARK    GeneRIF: Our study showed that adenovirus-mediated antisense ODC
            and expression inhibits tumor cell growth through blocking the
            polyamine synthesis pathway.
REFERENCE   8  (bases 1 to 3785)
  AUTHORS   Bernards,A.
  TITLE     GAPs galore! A survey of putative Ras superfamily GTPase activating
            proteins in man and Drosophila
  JOURNAL   Biochim Biophys Acta 1603 (2), 47-82 (2003)
   PUBMED   12618308
  REMARK    Review article
REFERENCE   9  (bases 1 to 3785)
  AUTHORS   Chang,L.S., Lin,S.Y., Lieu,A.S. and Wu,T.L.
  TITLE     Differential expression of human 5S snoRNA genes
  JOURNAL   Biochem Biophys Res Commun 299 (2), 196-200 (2002)
   PUBMED   12437969
REFERENCE   10 (bases 1 to 3785)
  AUTHORS   Geraghty,M.T., Brody,L.C., Martin,L.S., Marble,M., Kearns,W.,
            Pearson,P., Monaco,A.P., Lehrach,H. and Valle,D.
  TITLE     The isolation of cDNAs from OATL1 at Xp 11.2 using a 480-kb YAC
  JOURNAL   Genomics 16 (2), 440-446 (1993)
   PUBMED   8314581
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY154299.1, BC101817.1,
            AF196969.3, AC115618.3 and BU630180.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_002536.3.
            
            Summary: This gene encodes a protein with a TBC domain and
            functions as a Rab GTPase activating protein. The encoded protein
            is involved in the fusion of autophagosomes with endosomes and
            lysosomes. This gene was previously known as ornithine
            aminotransferase-like 1, but has no similarity to ornithine
            aminotransferase. [provided by RefSeq, Jan 2017].
            
            Transcript Variant: This variant (3) uses an alternate in-frame
            splice junction compared to variant 1. The resulting isoform (c)
            has the same N- and C-termini but is shorter compared to isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.156985.1,
                                           SRR1803615.174231.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000376771.9/ ENSP00000365962.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                HY154299.1         180-226
            48-1446             BC101817.1         1-1399
            1447-1447           AF196969.3         38645-38645
            1448-2237           BC101817.1         1401-2190
            2238-3205           AF196969.3         39436-40403
            3206-3248           AC115618.3         32-74
            3249-3785           BU630180.1         19-555              c
FEATURES             Location/Qualifiers
     source          1..3785
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.23"
     gene            1..3785
                     /gene="TBC1D25"
                     /gene_synonym="MG81; OATL1"
                     /note="TBC1 domain family member 25"
                     /db_xref="GeneID:4943"
                     /db_xref="HGNC:HGNC:8092"
                     /db_xref="MIM:311240"
     exon            1..207
                     /gene="TBC1D25"
                     /gene_synonym="MG81; OATL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..2151
                     /gene="TBC1D25"
                     /gene_synonym="MG81; OATL1"
                     /note="isoform c is encoded by transcript variant 3;
                     ornithine aminotransferase-like 1; 5SN3 snoRNA"
                     /codon_start=1
                     /product="TBC1 domain family member 25 isoform c"
                     /protein_id="NP_002527.1"
                     /db_xref="CCDS:CCDS35242.1"
                     /db_xref="GeneID:4943"
                     /db_xref="HGNC:HGNC:8092"
                     /db_xref="MIM:311240"
                     /translation="MATASGASDLSGSGAPPPGVGAQAAAAAEEEEREVVRVRVKKCE
                     SFLPPEFRSFAVDPQITSLDVLQHILIRAFDLSGKKNFGISYLGRDRLGQEVYLSLLS
                     DWDLSTAFATASKPYLQLRVDIRPSEDSPLLEDWDIISPKDVIGSDVLLAEKRSSLTT
                     AALPFTQSILTQVGRTLSKVQQVLSWSYGEDVKPFKPPLSDAEFHTYLNHEGQLSRPE
                     ELRLRIYHGGVEPSLRKVVWRYLLNVYPDGLTGRERMDYMKRKSREYEQLKSEWAQRA
                     NPEDLEFIRSTVLKDVLRTDRAHPYYAGPEDGPHLRALHDLLTTYAVTHPQVSYCQGM
                     SDLASPILAVMDHEGHAFVCFCGIMKRLAANFHPDGRAMATKFAHLKLLLRHADPDFY
                     QYLQEAGADDLFFCYRWLLLELKREFAFDDALRMLEVTWSSLPPDPPEHEVELVGPPS
                     QVADAGFGGHRGWPVRQRHMLRPAGGGGSTFEDAVDHLATASQGPGGGGRLLRQASLD
                     GLQQLRDNMGSRRDPLVQLPHPAALISSKSLSEPLLNSPDPLLSSFSHPDSPSSSSPP
                     STQEASPTGDMAVGSPLMQEVGSPKDPGKSLPPVPPMGLPPPQEFGRGNPFMLFLCLA
                     ILLEHRDHIMRNGLDYNELAMHFDRLVRKHHLGRVLRRARALFADYLQSEVWDSEEGA
                     EATAAS"
     exon            208..317
                     /gene="TBC1D25"
                     /gene_synonym="MG81; OATL1"
                     /inference="alignment:Splign:2.1.0"
     exon            318..472
                     /gene="TBC1D25"
                     /gene_synonym="MG81; OATL1"
                     /inference="alignment:Splign:2.1.0"
     exon            473..600
                     /gene="TBC1D25"
                     /gene_synonym="MG81; OATL1"
                     /inference="alignment:Splign:2.1.0"
     exon            601..789
                     /gene="TBC1D25"
                     /gene_synonym="MG81; OATL1"
                     /inference="alignment:Splign:2.1.0"
     exon            790..3785
                     /gene="TBC1D25"
                     /gene_synonym="MG81; OATL1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2390
                     /gene="TBC1D25"
                     /gene_synonym="MG81; OATL1"
                     /note="major polyA site"
     regulatory      3766..3771
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TBC1D25"
                     /gene_synonym="MG81; OATL1"
                     /note="hexamer: AGTAAA"
     polyA_site      3785
                     /gene="TBC1D25"
                     /gene_synonym="MG81; OATL1"
ORIGIN      
        1 ggggcggcgg gcgtcagtac agtagagtgt gcgccggggt ggggggcaac ggtcagccgt
       61 caccctgaga cgggcggcgg cgggatggca acagcctccg gggcctcgga cttgtctggc
      121 tccggagcgc ccccgcccgg tgtgggagct caggcggcgg cggccgctga ggaggaggag
      181 cgagaggtgg tgcgggtccg agtcaagaaa tgtgagagct tcttgccgcc agagttccgc
      241 tcttttgctg tagatcccca gatcacctcg ctcgacgtgt tgcagcacat cctcatccga
      301 gcctttgatt tgagtgggaa gaagaacttt ggcatcagct acctgggccg ggaccggcta
      361 ggacaggaag tttacctctc acttctatct gactgggacc tcagcacagc ctttgccact
      421 gcctccaaac cttacctgca attgcgtgta gatattcggc cctcggagga cagcccattg
      481 ctagaagact gggacataat cagccccaaa gatgtcattg gctccgacgt gttgctggct
      541 gagaaacggt catcactgac gactgccgcc ctgcccttta cacagtccat cctcactcag
      601 gtgggccgta ccttgtctaa ggtccaacaa gtgctgagct ggtcgtatgg ggaagatgtc
      661 aagcccttca agccacccct gagcgatgct gagtttcaca cgtacctgaa ccacgagggc
      721 cagctctccc gacccgagga gttgcgcctg cggatctatc atggcggtgt ggagccctcg
      781 ctgcgaaagg tggtgtggcg gtacctgctg aacgtgtatc cagatggact gacaggccga
      841 gagcggatgg actacatgaa acgcaagagc cgcgagtatg agcagctcaa gagcgagtgg
      901 gcccagcgag cgaaccctga ggacctggaa ttcatccgca gcacggtcct caaggatgta
      961 ctgcgcactg accgggccca cccctactat gcggggcctg aggatggccc acatctacgg
     1021 gcgctgcacg acctgctcac cacctatgcc gttacccacc cacaggtgtc ctactgccag
     1081 ggcatgagtg accttgcctc acccatcctc gctgtcatgg accatgaggg ccatgccttt
     1141 gtttgctttt gtggcatcat gaaacgcctg gccgccaact tccaccctga cggccgcgcc
     1201 atggccacca agtttgcaca cttgaagctg ttgctgcgac acgctgaccc tgacttttat
     1261 caatacctgc aagaggcagg cgctgatgac ctcttcttct gttaccgctg gctgctgctg
     1321 gaactcaagc gtgagttcgc cttcgacgat gccctccgca tgcttgaggt cacttggagt
     1381 tcgctgcccc ctgatcctcc tgaacatgag gtagagctgg ttggaccccc cagccaagtg
     1441 gcagacgctg gttttggtgg ccacaggggg tggcccgtgc gacagaggca catgctgagg
     1501 cctgctggtg gaggaggtag tacctttgaa gatgctgttg accacctggc cacagccagt
     1561 caggggcctg gtggtggggg gcgtctcctg agacaggcca gcttggatgg cctccagcaa
     1621 ctcagggata acatgggctc caggagggac cctctggtcc agctgcccca cccagctgcc
     1681 cttatcagct ccaagtccct ctctgagcct ttattgaact ccccagaccc actgctctcc
     1741 tccttttccc accctgattc cccatcttcc tcatctccac catccaccca ggaggcctct
     1801 cccactggtg atatggctgt aggatccccc ttgatgcaag aggtaggctc cccgaaagac
     1861 cctggaaagt ccctgccacc tgtaccacca atgggcctgc ccccacccca ggagtttggc
     1921 cgggggaacc cattcatgct gttcctctgc ctggccatcc tgctggagca ccgcgaccac
     1981 atcatgcgca atgggctgga ttataatgag ctggccatgc actttgaccg ccttgtgcga
     2041 aaacaccacc tggggcgcgt cctgcgccgg gctagggctc tctttgctga ttacctgcag
     2101 tcagaggtgt gggactcaga ggagggggct gaggccacag ccgcatcttg atcaggcttt
     2161 ctcaagccct ccatcggccc caccagatct ccattctttg ccatgagggc caacacatga
     2221 gaccccacct ccctccctgc ctgccagccc tagacttgtt ggagcataga gcccttcctc
     2281 cccaggccta agtatgtgga gctctgcttt ggcactgccc cgcagaggcc acgcctattt
     2341 attctgtttc tgttgttttg tttttaacaa ctatactttg cacacatgaa ggtcactgtg
     2401 gtttgtgtgt ttctctgcct cctccctggg ttttgctgta gatggagtcc tcaggggccc
     2461 tttacctgat ggaggggaaa tacttcactt ggtggagaga ggctccagct tcccccttgt
     2521 gatggggaga gtggatgctg acaatcagtt cccaaaggtg agcccaggtg gagcactgct
     2581 tgaggaaggc ctgagtctgt ttttttggta catccatcgg cctgtaaggg tctgtattat
     2641 ggctgtgaat atatgttttc aggacagccc cctggatgag agataagaga gttcctggct
     2701 caaaaaagga caagattctt tactgagatt gggaagtatg ggctacttag aaacgttgga
     2761 gcagccaccc ctggcattcc acatgtcacc atttctagga tcttggcctc tctgtgaggt
     2821 ttatgcacca atgctggcag ccctgggcag gggcctcggc ctcctttttg ttttccactt
     2881 cagacaggta ccgtgcagat gttaacaagg tttgagcgag gtgcatctca cacaagtgtg
     2941 aaagcccaat catcacattg ttgaattaca aaaggatcta gggctcctat tcttgtcact
     3001 tgctttggag ccagtttgaa agactggcct agcccatgcc tagcggccct aaactgggat
     3061 tccagctcac agcacctgtc ttaaccattt cagcagtaga aaccacttat ttaccttctc
     3121 catctcacta atatggacaa acaacaagca ctgataaaac gcaggcccta atagaattca
     3181 cttcgttatt tggaggataa tgatcaaaaa aaggtccttt ttcccactga catgctcaga
     3241 gggtgggatt ctctcacagg ccaggtgctg tcatccacaa aggatgggtg aaataactgg
     3301 ggtcctcagg tcacggtcta gccacaccag cttctcccaa gtactaacca ggcttgaccc
     3361 tgcttagctt cagaggtcag acaagatctg gcatgttcag gatggtatgg ctgtagacca
     3421 ggctgggttc tggccagagc tgttgcacta ggcaatgctg ccagagatga ggaggcatca
     3481 gggcagtcat cccttctgct gtttgcccca agaatgccat acaaacctgg ggatgaccct
     3541 taaaagtctc ccgtcacccc cagtattggg gggaagctga ctattcctca gatgatagcc
     3601 cagtcacttg aagaacagga caagactatt ctgtgtctag ggggctcaag cactgtgtgt
     3661 gggtctaacg aatgcatttt gtggaaatgg gctcagactc cccaaagggc catccaacct
     3721 atgggagtgt ctggccttct gaggtcctga aatgtctctt ttgtcagtaa acagctaata
     3781 ccctc
//
