LOCUS       NM_001199107            6611 bp    mRNA    linear   PRI 12-DEC-2024
DEFINITION  Homo sapiens TBC1 domain family member 24 (TBC1D24), transcript
            variant 1, mRNA.
ACCESSION   NM_001199107
VERSION     NM_001199107.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6611)
  AUTHORS   Lei,P., Zhu,Q. and Dong,W.
  TITLE     Investigation of a novel TBC1D24 variation causing autosomal
            dominant non-syndromic hearing loss
  JOURNAL   Sci Rep 14 (1), 4734 (2024)
   PUBMED   38413761
  REMARK    GeneRIF: Investigation of a novel TBC1D24 variation causing
            autosomal dominant non-syndromic hearing loss.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6611)
  AUTHORS   Shao,Q., Shi,X., Ma,B., Zeng,J., Zheng,A. and Xie,W.
  TITLE     TBC1D24-related familial infantile multifocal myoclonus:
            Description of a new Chinese pedigree with a 20 year follow up
  JOURNAL   Epilepsy Res 182, 106923 (2022)
   PUBMED   35413638
  REMARK    GeneRIF: TBC1D24-related familial infantile multifocal myoclonus:
            Description of a new Chinese pedigree with a 20 year follow up.
REFERENCE   3  (bases 1 to 6611)
  AUTHORS   Ozieblo,D., Leja,M.L., Lazniewski,M., Sarosiak,A., Tacikowska,G.,
            Kochanek,K., Plewczynski,D., Skarzynski,H. and Oldak,M.
  TITLE     TBC1D24 emerges as an important contributor to progressive
            postlingual dominant hearing loss
  JOURNAL   Sci Rep 11 (1), 10300 (2021)
   PUBMED   33986365
  REMARK    GeneRIF: TBC1D24 emerges as an important contributor to progressive
            postlingual dominant hearing loss.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6611)
  AUTHORS   Zhang,N., Hou,M., Ma,S., Liu,Y., Wei,W. and Chen,Z.
  TITLE     Novel variants in TBC1D24 associated with epilepsy and deafness:
            Report of two cases
  JOURNAL   Int J Dev Neurosci 81 (1), 98-105 (2021)
   PUBMED   33063868
  REMARK    GeneRIF: Novel variants in TBC1D24 associated with epilepsy and
            deafness: Report of two cases.
REFERENCE   5  (bases 1 to 6611)
  AUTHORS   Tona,R., Lopez,I.A., Fenollar-Ferrer,C., Faridi,R., Anselmi,C.,
            Khan,A.A., Shahzad,M., Morell,R.J., Gu,S., Hoa,M., Dong,L.,
            Ishiyama,A., Belyantseva,I.A., Riazuddin,S. and Friedman,T.B.
  TITLE     Mouse Models of Human Pathogenic Variants of TBC1D24 Associated
            with Non-Syndromic Deafness DFNB86 and DFNA65 and Syndromes
            Involving Deafness
  JOURNAL   Genes (Basel) 11 (10), 1122 (2020)
   PUBMED   32987832
  REMARK    GeneRIF: Mouse Models of Human Pathogenic Variants of TBC1D24
            Associated with Non-Syndromic Deafness DFNB86 and DFNA65 and
            Syndromes Involving Deafness.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6611)
  AUTHORS   Ishibashi,K., Kanno,E., Itoh,T. and Fukuda,M.
  TITLE     Identification and characterization of a novel Tre-2/Bub2/Cdc16
            (TBC) protein that possesses Rab3A-GAP activity
  JOURNAL   Genes Cells 14 (1), 41-52 (2009)
   PUBMED   19077034
REFERENCE   7  (bases 1 to 6611)
  AUTHORS   Yoshimura,S., Egerer,J., Fuchs,E., Haas,A.K. and Barr,F.A.
  TITLE     Functional dissection of Rab GTPases involved in primary cilium
            formation
  JOURNAL   J Cell Biol 178 (3), 363-369 (2007)
   PUBMED   17646400
REFERENCE   8  (bases 1 to 6611)
  AUTHORS   Zara,F., Gennaro,E., Stabile,M., Carbone,I., Malacarne,M.,
            Majello,L., Santangelo,R., de Falco,F.A. and Bricarelli,F.D.
  TITLE     Mapping of a locus for a familial autosomal recessive idiopathic
            myoclonic epilepsy of infancy to chromosome 16p13
  JOURNAL   Am J Hum Genet 66 (5), 1552-1557 (2000)
   PUBMED   10741954
REFERENCE   9  (bases 1 to 6611)
  AUTHORS   Guerrini,R., Bonanni,P., Nardocci,N., Parmeggiani,L.,
            Piccirilli,M., De Fusco,M., Aridon,P., Ballabio,A., Carrozzo,R. and
            Casari,G.
  TITLE     Autosomal recessive rolandic epilepsy with paroxysmal
            exercise-induced dystonia and writer's cramp: delineation of the
            syndrome and gene mapping to chromosome 16p12-11.2
  JOURNAL   Ann Neurol 45 (3), 344-352 (1999)
   PUBMED   10072049
REFERENCE   10 (bases 1 to 6611)
  AUTHORS   Balestrini,S., Campeau,P.M., Mei,D., Guerrini,R. and Sisodiya,S.
  TITLE     TBC1D24-Related Disorders
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   25719194
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC106820.4, BC112389.1,
            AB032997.1 and AC093525.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001199107.1.
            
            Summary: This gene encodes a protein with a conserved domain,
            referred to as the TBC domain, characteristic of proteins which
            interact with GTPases. TBC domain proteins may serve as
            GTPase-activating proteins for a particular group of GTPases, the
            Rab (Ras-related proteins in brain) small GTPases which are
            involved in the regulation of membrane trafficking. Mutations in
            this gene are associated with familial infantile myoclonic
            epilepsy. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Feb 2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB032997.1, SRR14038197.1328042.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA2142670
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000646147.1/ ENSP00000494678.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                AC106820.4         28822-28840         c
            20-1044             BC112389.1         1-1025
            1045-4366           AB032997.1         1019-4340
            4367-4847           AC106820.4         1-481               c
            4848-6611           AC093525.3         87510-89273         c
FEATURES             Location/Qualifiers
     source          1..6611
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..6611
                     /gene="TBC1D24"
                     /gene_synonym="DEE16; DFNA65; DFNB86; DOORS; EIEE16; EIM;
                     EPRPDC; FIME; TLDC6"
                     /note="TBC1 domain family member 24"
                     /db_xref="GeneID:57465"
                     /db_xref="HGNC:HGNC:29203"
                     /db_xref="MIM:613577"
     exon            1..44
                     /gene="TBC1D24"
                     /gene_synonym="DEE16; DFNA65; DFNB86; DOORS; EIEE16; EIM;
                     EPRPDC; FIME; TLDC6"
                     /inference="alignment:Splign:2.1.0"
     exon            45..1124
                     /gene="TBC1D24"
                     /gene_synonym="DEE16; DFNA65; DFNB86; DOORS; EIEE16; EIM;
                     EPRPDC; FIME; TLDC6"
                     /inference="alignment:Splign:2.1.0"
     CDS             160..1839
                     /gene="TBC1D24"
                     /gene_synonym="DEE16; DFNA65; DFNB86; DOORS; EIEE16; EIM;
                     EPRPDC; FIME; TLDC6"
                     /note="isoform 1 is encoded by transcript variant 1;
                     TBC/LysM-associated domain containing 6; skywalker
                     homolog; deafness, autosomal dominant 65; Infantile
                     myoclonic epilepsy"
                     /codon_start=1
                     /product="TBC1 domain family member 24 isoform 1"
                     /protein_id="NP_001186036.1"
                     /db_xref="CCDS:CCDS55980.1"
                     /db_xref="GeneID:57465"
                     /db_xref="HGNC:HGNC:29203"
                     /db_xref="MIM:613577"
                     /translation="MDSPGYNCFVDKDKMDAAIQDLGPKELSCTELQELKQLARQGYW
                     AQSHALRGKVYQRLIRDIPCRTVTPDASVYSDIVGKIVGKHSSSCLPLPEFVDNTQVP
                     SYCLNARGEGAVRKILLCLANQFPDISFCPALPAVVALLLHYSIDEAECFEKACRILA
                     CNDPGRRLIDQSFLAFESSCMTFGDLVNKYCQAAHKLMVAVSEDVLQVYADWQRWLFG
                     ELPLCYFARVFDVFLVEGYKVLYRVALAILKFFHKVRAGQPLESDSVKQDIRTFVRDI
                     AKTVSPEKLLEKAFAIRLFSRKEIQLLQMANEKALKQKGITVKQKSVSLSKRQFVHLA
                     VHAENFRSEIVSVREMRDIWSWVPERFALCQPLLLFSSLQHGYSLARFYFQCEGHEPT
                     LLLIKTTQKEVCGAYLSTDWSERNKFGGKLGFFGTGECFVFRLQPEVQRYEWVVIKHP
                     ELTKPPPLMAAEPTAPLSHSASSDPADRLSPFLAARHFNLPSKTESMFMAGGSDCLIV
                     GGGGGQALYIDGDLNRGRTSHCDTFNNQPLCSENFLIAAVEAWGFQDPDTQ"
     exon            1125..1142
                     /gene="TBC1D24"
                     /gene_synonym="DEE16; DFNA65; DFNB86; DOORS; EIEE16; EIM;
                     EPRPDC; FIME; TLDC6"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1301
                     /gene="TBC1D24"
                     /gene_synonym="DEE16; DFNA65; DFNB86; DOORS; EIEE16; EIM;
                     EPRPDC; FIME; TLDC6"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1365
                     /gene="TBC1D24"
                     /gene_synonym="DEE16; DFNA65; DFNB86; DOORS; EIEE16; EIM;
                     EPRPDC; FIME; TLDC6"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..1461
                     /gene="TBC1D24"
                     /gene_synonym="DEE16; DFNA65; DFNB86; DOORS; EIEE16; EIM;
                     EPRPDC; FIME; TLDC6"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..1684
                     /gene="TBC1D24"
                     /gene_synonym="DEE16; DFNA65; DFNB86; DOORS; EIEE16; EIM;
                     EPRPDC; FIME; TLDC6"
                     /inference="alignment:Splign:2.1.0"
     exon            1685..6611
                     /gene="TBC1D24"
                     /gene_synonym="DEE16; DFNA65; DFNB86; DOORS; EIEE16; EIM;
                     EPRPDC; FIME; TLDC6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6589..6594
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TBC1D24"
                     /gene_synonym="DEE16; DFNA65; DFNB86; DOORS; EIEE16; EIM;
                     EPRPDC; FIME; TLDC6"
                     /note="hexamer: AATAAA"
     polyA_site      6611
                     /gene="TBC1D24"
                     /gene_synonym="DEE16; DFNA65; DFNB86; DOORS; EIEE16; EIM;
                     EPRPDC; FIME; TLDC6"
                     /note="major polyA site"
ORIGIN      
        1 agaaaggccg gcgcggcagg ctgaggagaa agcggcgcgc ggagggtgtg agatggcaga
       61 caggtttgca ggaaaccctc agaaaggggg ctggaggatt tagccactct gtcctcccct
      121 tccggcagtc cagggcctcc tcccgagcac agcggcgcta tggactctcc aggatacaac
      181 tgcttcgtgg acaaagacaa gatggacgct gccatccagg acctggggcc caaggagctg
      241 agctgcactg aactgcagga actgaagcag ctggcgcgcc agggctactg ggcccaaagc
      301 cacgccctgc ggggaaaggt gtaccagcgc ctgatccggg acattccctg ccgcacggtc
      361 acgcctgacg ccagcgtgta cagcgacatc gtgggcaaga tcgtgggcaa gcacagcagc
      421 agctgcctgc cgctgcccga gttcgtggac aacacgcagg tgcccagcta ctgcctgaat
      481 gcacgcggcg agggggccgt gcgcaagatc ctcctgtgcc tggccaacca gttccccgac
      541 atctccttct gccccgccct gccggccgtg gtggccctgc tgctgcacta cagcatcgac
      601 gaggccgagt gcttcgagaa ggcctgccgc atcctggcct gcaatgaccc cggcaggagg
      661 ctgatcgacc agagcttcct ggcctttgag tcgtcctgca tgacgtttgg ggacctggtg
      721 aacaagtact gccaggcggc ccacaagctg atggtggccg tgtcggagga tgtcctgcag
      781 gtctatgcgg actggcagcg ctggctgttt ggggagctgc ccctctgcta cttcgcccgg
      841 gtctttgacg tcttcctggt ggagggctac aaggtgctgt accgcgtggc gctggccatc
      901 ctcaagttct tccacaaggt gagggccggg cagccgctgg agtcggacag cgtgaagcag
      961 gacatccgca cgttcgtcag agacatcgcg aagacggtgt cccctgagaa gctgctggag
     1021 aaagcgttcg ccatccgcct cttctcccgc aaggagatcc agctcctgca gatggccaat
     1081 gagaaagccc tgaagcagaa gggcatcacc gtgaagcaga agagtgtgtc actttctaaa
     1141 aggcagtttg tacacttggc cgtccatgca gagaacttcc gctcggagat cgtcagcgtg
     1201 agggagatga gagacatctg gtcctgggtc cccgagcgct ttgccctgtg ccagcccctt
     1261 ctgctgttct cctccctgca gcacgggtac agcctggcca ggttctactt ccagtgtgaa
     1321 ggacatgagc ctaccctctt gctcatcaag accacgcaga aggaggtgtg tggtgcttac
     1381 ctgtccacag actggagtga gagaaataag tttggaggca aactgggctt ctttgggacc
     1441 ggagaatgct ttgtgtttag gctgcagcct gaggtgcagc gctacgagtg ggtggtgatc
     1501 aagcaccccg agctgaccaa gcccccaccc ttgatggctg ccgagcccac cgccccactc
     1561 agccactccg cctcctcaga ccccgctgac cgcctctcgc ccttcctggc cgctcgccac
     1621 ttcaacctgc cctccaagac cgagtccatg ttcatggcgg ggggcagcga ctgcctcatc
     1681 gtcgggggag gaggcggcca ggcgctctac atcgatgggg acctgaaccg gggccgcaca
     1741 agccactgcg acaccttcaa caaccagccc ctctgctccg agaacttcct cattgctgcc
     1801 gtggaggcct ggggcttcca ggaccctgac acccagtgac ggcctgtgcc acggtgactg
     1861 agccgtggtg gggcggtggg ccgaggctgg gctgccgcct cgggcagcag agagcagatg
     1921 aaacccccat gtggtaggca gggttggggg acggcaggac cccatggcca agcctggcgt
     1981 tgcctggacc tgctgctgcc tctacctggg gtttgggctg ggcttcccca gtccacctgc
     2041 atctgggtca gagctggagg gcctgctgtg cccccagccc cacccagagc tggcatagga
     2101 agtaccttcc tcctccgtgg aggcttccat agcccaaggc cttgggagtg tctgggtctt
     2161 gctgcccctg agcctctcta ggcagcctga gcccctgggg tgggagtaca acggcagtgg
     2221 gaacgtgcag ctaagggtgg gcctgtggtg ccccctgctg gtgccgcata gcatcgcgcc
     2281 ctcctgagca gggccctgca gcctggctgg ctggcgactg aatcccagcg tagatcccga
     2341 gaacagactg gcacccttgg gcctgccccc tggcggaccc caccccctgt cctgggcgtt
     2401 tgccccagtt ccctccccag gcctcctggg ccacctctca cattaaccct tcttggctgc
     2461 ctctgaggct cccctgggct gcgtttggga gctgctgggt gggaggagga gggtgggatt
     2521 tgtgctgggc tccaccccca gggagggtgg gagctggagg gggatgtcac atgtccttgt
     2581 gtttctgcag agcctgaagc ttttgctggg cctccctgcg tgttcccatc tgaagaggta
     2641 gccccgggag aggccctcag ggaccgaccc agaccagcaa gctccatttc caggggtctg
     2701 cccagagaag cctggaccca gggggcttct cagctcccct cccttccagc ccaggcctcc
     2761 ttgagctcct gtagcctctg cagctgccca tttcacctct ttgtcattgc aatgacctgg
     2821 ggcccagggt cacgcccaag cccctctttg tggcatgctc atctcagtgc agccccaact
     2881 gcttctctgc accaggcccc gtgccctccc ctggccctgg ccacacagca cctccttggc
     2941 caccttgcat ggatgcatgt cctccctctg tccctcttgt ggtgctgtgg ctggccacgt
     3001 gtcagggttt tctgtgagcc tctcacctta cagcctttgg gcccctgggc ccctgccctg
     3061 cctgagccct gcgctggcca gacgcaggta ggtgccaggg gaggccttgc ctctgggcac
     3121 tatagggggc agccccctgc cttgtgacct ccctccatgc cccatgacct ccttcaactc
     3181 gtcttgaggg tctggtcacc acggagggga gaagggagac acagaggccc aagtggctgt
     3241 tctgggacca tggaagcctg ggtcacagag gcaggtacca gcagtcctgc ccccaccccc
     3301 gtccctgctg gcctccagcc agtgccactt ggagtcccct gcaccgtgcc actttccatc
     3361 cccacaccat tgcctgctcc tcccatgggg ctttagcctc ccctgaccat ctgctcatgt
     3421 agcctctgac tgggcgcaca gtggtgcagg aggaaggacc gggaaccctg tgtggctttg
     3481 ggcaagctga caaacccgtc tggaactcag tttccccagc tgtgaaatgg ggccagtccc
     3541 catgccctgc tgtcctcctc acaggactgt tgagaggctc gcagggggat ggggtgaatc
     3601 cctctcacgg ggagaggtat gggagggaag tcgccactca tctcagccca ccgcagccct
     3661 ccaggccccc gcctgagccc ctgaggccct catctgtacc gccagctttg gtgttcatta
     3721 aacatggtct tgctgcatca actccagggc tccaagctga gtctgatctc ttcagccaga
     3781 ggggcctccg ggggcttcct gggcctacag ccaagcaggt gtgggaggct gcccgctgta
     3841 gtgctcaccc acattctatg actggaatgc tgcaagcctc ttccagaggg agccctccag
     3901 gagcagggaa gtcatatccg tggaccattt gtaggtttcc ctctgcaaac ttcctgaact
     3961 gggtggtgat ttttctggcg agttaagtcc agcaggttct gcgtggctgc ccccaggggg
     4021 ccccacccgg gccttccagt gatctggacc aggaagacgg attgctgctg ggtcatgatt
     4081 tccacatcat gagcgaagtt ctttgttttt tgtgtgcatg caaaatattg tttctttaaa
     4141 tttaatatct tttcctaact tttctactaa cctagaaggt atgtgtgatt attatctttt
     4201 ttattcttat cactgtactt gttagtatct gatattaggt attcccaaat agaacataat
     4261 ttattttgtt aatgttctct atttcttctt gattatttat tagctttgga tgttaaaaat
     4321 tagccaaaag tggctgctct gcctatgaag tagccattct ttgtttaaaa aaaaaaaaag
     4381 ccaacatttg ttgaaactgc ataataaatt atcatttgtt tttagaaaca ttcaaagaat
     4441 tattttttga tttttttttt ttttgggaca gagtcaccca ggctggagtg cagtggcatg
     4501 atcttggctc actgcaacct ccgcctcctg ggttcaagcg attctcctgc ctcagcctcc
     4561 tgagtagctg ggattacagg catacgccac cacgcccagc taaatttttt ttgtattttt
     4621 agtagaggca gggtttcact gtgttggtca ggctggtctt gaactcctga cctcgtgatc
     4681 cacccccccc tcagcctccc aaagtgctgg gattacaggc gtgagccacc gcgcctagcc
     4741 tattttttaa tttttttgaa tagaccactt tgtgctgaat aaatgtttaa catttatttt
     4801 taaaacaaca attgcaccta atttaaaata gtttattaaa tgaattcatt aaagcagatt
     4861 atatgccttt ggggcttcag aaaatcagtt taagcaaaag aacttatgag agtaagtcat
     4921 ttgtacttga attttttcag agttttaatg aactaaagta ttttaatttt tctatttttg
     4981 taagccgcat acttcatttt ttgagttttt cagtggaatt tgttttaaaa cgttttgaag
     5041 atttcagagg ccttcatatt tctcttatcc actttctgaa cccataaagc ctttgcagtc
     5101 tccttgagta gtttatattt agtaatttag ttgtgtacct ttttattttg aagtaatttt
     5161 tgatttgcag aagagttgca gagacggtac agggtttcca tgtaccctca ccttccccca
     5221 agtcaatatc aaaacaaaga aataagcatt gttgcattgc tgttaactaa accacaggcc
     5281 tattgagatt gtcccttttt tttttttttt tttttttgag acagagtctc gctctgtcgc
     5341 ccaggctgga gtgcagtggc gcgatctcgg ctcaccgcaa gccccgcctc ccggattcac
     5401 gccattctcc tgcctcagcc tcctgagtag ctgggactac aggcacctgc taccacaccc
     5461 ggctaatttt tttatatttt tagtagagat ggggtttcac cgtgttagcc aggatggtct
     5521 tgatctcctg acctcgtgat ctgccctcct cggcctccca aagtgctggg attacaggcg
     5581 tgagcaaccg cgcccagccg agattgcccc gtttttttcc cactgtccag gaatcgattt
     5641 aatttttaca gttgtttact ttctcacatt tttactaagt ccagaatatc atcaaactca
     5701 caaaaccact ggtcaaaaaa acccaaatgg ccactaatta ggcaatacag cacctgcctc
     5761 aaatttgggt tcatatagat ttttttcctc cctttttgtg gagaacatag tcttgctgtg
     5821 ttgcccaggc tagtcttgaa ctcctggact caagcaatcc tcccgcctct gcctccctaa
     5881 attctgggat tacaggcgtg agctgctgtg cccagctcat ccagattctt gctggttctc
     5941 tttctcagcc taaatgtctt gtttgcgtgg agaaattatc aaatgaagca ggagtgccaa
     6001 acaagcctca taggctcttc accctacaac atctatgtta ggtagaaaag tatgtggatt
     6061 tttaaaaatc atctggtata aagagttttt aagaactatc ttcatcatct tagtatcaga
     6121 ttgtgcttga gaagttaggt acaatgtaat gtgattcatt gctaaaaaca aaatgcctcc
     6181 cacaattgca gactcactca ttttaccaaa ctatggaatt tgtcaacacc ttttcttggg
     6241 accaaggaag caaagtcagt ggataccgtg tcctgtagac atgtcacttg tgataaggca
     6301 cggacaacat gaactggcaa aaacattggc atttggtcaa atgcttatga gctaaggata
     6361 gaagggaaaa aatagttgtg tgaatgattt tacctcttag ttcttacgaa ggatggttat
     6421 cgggctggaa aaatgtttat tggactgatg ctttggagcc tctcaatgaa tgtaataaaa
     6481 aaaatgtgta gtgagcacaa atgtatggat ttgcagcaca atccaacttt gaaaatgtga
     6541 aaataagtga gttagtgata tgtttggttg gtgttaattt gagtcctaaa taaaatcgag
     6601 aactggtaaa a
//
