LOCUS       NM_014346               3758 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens TBC1 domain family member 22A (TBC1D22A), transcript
            variant 1, mRNA.
ACCESSION   NM_014346
VERSION     NM_014346.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3758)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 3758)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 3758)
  AUTHORS   Liu,A.Y., Gu,D., Hixson,J.E., Rao,D.C., Shimmin,L.C., Jaquish,C.E.,
            Liu,D.P., He,J. and Kelly,T.N.
  TITLE     Genome-wide linkage and regional association study of
            obesity-related phenotypes: the GenSalt study
  JOURNAL   Obesity (Silver Spring) 22 (2), 545-556 (2014)
   PUBMED   23526746
  REMARK    GeneRIF: genetic association studies in population in Han Chinese:
            Data suggest that SNPs in TBC1D22A (rs7755450 and rs11758293) are
            associated with body mass index in obese females; other SNPs in
            TBC1D22A are associated with body mass index in obese males.
REFERENCE   4  (bases 1 to 3758)
  AUTHORS   Greninger,A.L., Knudsen,G.M., Betegon,M., Burlingame,A.L. and
            DeRisi,J.L.
  TITLE     ACBD3 interaction with TBC1 domain 22 protein is differentially
            affected by enteroviral and kobuviral 3A protein binding
  JOURNAL   mBio 4 (2), e00098-e00013 (2013)
   PUBMED   23572552
  REMARK    GeneRIF: Using affinity purification-mass spectrometry, we
            identified the putative Rab33 GTPase-activating proteins TBC1D22A
            and TBC1D22B as ACBD3-interacting factors.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3758)
  AUTHORS   Yashin,A.I., Wu,D., Arbeev,K.G. and Ukraintseva,S.V.
  TITLE     Joint influence of small-effect genetic variants on human longevity
  JOURNAL   Aging (Albany NY) 2 (9), 612-620 (2010)
   PUBMED   20834067
REFERENCE   6  (bases 1 to 3758)
  AUTHORS   Ishibashi,K., Kanno,E., Itoh,T. and Fukuda,M.
  TITLE     Identification and characterization of a novel Tre-2/Bub2/Cdc16
            (TBC) protein that possesses Rab3A-GAP activity
  JOURNAL   Genes Cells 14 (1), 41-52 (2009)
   PUBMED   19077034
REFERENCE   7  (bases 1 to 3758)
  AUTHORS   Tempel,W., Tong,Y., Dimov,S., Bochkarev,A. and Park,H.
  TITLE     First crystallographic models of human TBC domains in the context
            of a family-wide structural analysis
  JOURNAL   Proteins 71 (1), 497-502 (2008)
   PUBMED   18186464
  REMARK    GeneRIF: crystal structures of the first two mammalian TBCs, human
            TBC1 family members 22A (TBC1D22A) and 14 (TBC1D14)
REFERENCE   8  (bases 1 to 3758)
  AUTHORS   Yoshimura,S., Egerer,J., Fuchs,E., Haas,A.K. and Barr,F.A.
  TITLE     Functional dissection of Rab GTPases involved in primary cilium
            formation
  JOURNAL   J Cell Biol 178 (3), 363-369 (2007)
   PUBMED   17646400
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL118516.10, Z82187.1, U51561.1, Z80896.2, Z79999.2, AL023733.1 and
            FP325331.1.
            
            On Aug 31, 2019 this sequence version replaced NM_014346.4.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038192.717298.1,
                                           SRR14038194.1321521.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000337137.9/ ENSP00000336724.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-199               AL118516.10        43732-43930
            200-256             AL118516.10        73602-73658
            257-597             AL118516.10        74583-74923
            598-774             AL118516.10        78526-78702
            775-845             Z82187.1           22101-22171
            846-974             U51561.1           7072-7200
            975-1037            U51561.1           10590-10652
            1038-1152           U51561.1           27880-27994
            1153-1262           Z80896.2           37682-37791
            1263-1338           Z79999.2           4217-4292
            1339-1466           AL023733.1         978-1105
            1467-1562           FP325331.1         32910-33005
            1563-3758           FP325331.1         94900-97095
FEATURES             Location/Qualifiers
     source          1..3758
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.31"
     gene            1..3758
                     /gene="TBC1D22A"
                     /gene_synonym="C22orf4; HSC79E021"
                     /note="TBC1 domain family member 22A"
                     /db_xref="GeneID:25771"
                     /db_xref="HGNC:HGNC:1309"
                     /db_xref="MIM:616879"
     exon            1..199
                     /gene="TBC1D22A"
                     /gene_synonym="C22orf4; HSC79E021"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..1691
                     /gene="TBC1D22A"
                     /gene_synonym="C22orf4; HSC79E021"
                     /note="isoform a is encoded by transcript variant 1;
                     putative GTPase activator"
                     /codon_start=1
                     /product="TBC1 domain family member 22A isoform a"
                     /protein_id="NP_055161.1"
                     /db_xref="CCDS:CCDS14078.1"
                     /db_xref="GeneID:25771"
                     /db_xref="HGNC:HGNC:1309"
                     /db_xref="MIM:616879"
                     /translation="MASDGARKQFWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRS
                     TAKMPTTPVKAKRVSTFQEFESNTSDAWDAGEDDDELLAMAAESLNSEVVMETANRVL
                     RNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAA
                     PLQRSQSLPHSATVTLGGTSDPSTLSSSALSEREASRLDKFKQLLAGPNTDLEELRRL
                     SWSGIPKPVRPMTWKLLSGYLPANVDRRPATLQRKQKEYFAFIEHYYDSRNDEVHQDT
                     YRQIHIDIPRMSPEALILQPKVTEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFI
                     CEYIEAEEVDTVDVSGVPAEVLCNIEADTYWCMSKLLDGIQDNYTFAQPGIQMKVKML
                     EELVSRIDEQVHRHLDQHEVRYLQFAFRWMNNLLMREVPLRCTIRLWDTYQSEPDGFS
                     HFHLYVCAAFLVRWRKEILEEKDFQELLLFLQNLPTAHWDDEDISLLLAEAYRLKFAF
                     ADAPNHYKK"
     exon            200..256
                     /gene="TBC1D22A"
                     /gene_synonym="C22orf4; HSC79E021"
                     /inference="alignment:Splign:2.1.0"
     exon            257..597
                     /gene="TBC1D22A"
                     /gene_synonym="C22orf4; HSC79E021"
                     /inference="alignment:Splign:2.1.0"
     exon            598..774
                     /gene="TBC1D22A"
                     /gene_synonym="C22orf4; HSC79E021"
                     /inference="alignment:Splign:2.1.0"
     exon            775..845
                     /gene="TBC1D22A"
                     /gene_synonym="C22orf4; HSC79E021"
                     /inference="alignment:Splign:2.1.0"
     exon            846..974
                     /gene="TBC1D22A"
                     /gene_synonym="C22orf4; HSC79E021"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1037
                     /gene="TBC1D22A"
                     /gene_synonym="C22orf4; HSC79E021"
                     /inference="alignment:Splign:2.1.0"
     exon            1038..1152
                     /gene="TBC1D22A"
                     /gene_synonym="C22orf4; HSC79E021"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1262
                     /gene="TBC1D22A"
                     /gene_synonym="C22orf4; HSC79E021"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..1338
                     /gene="TBC1D22A"
                     /gene_synonym="C22orf4; HSC79E021"
                     /inference="alignment:Splign:2.1.0"
     exon            1339..1466
                     /gene="TBC1D22A"
                     /gene_synonym="C22orf4; HSC79E021"
                     /inference="alignment:Splign:2.1.0"
     exon            1467..1562
                     /gene="TBC1D22A"
                     /gene_synonym="C22orf4; HSC79E021"
                     /inference="alignment:Splign:2.1.0"
     exon            1563..3758
                     /gene="TBC1D22A"
                     /gene_synonym="C22orf4; HSC79E021"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2131..2136
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TBC1D22A"
                     /gene_synonym="C22orf4; HSC79E021"
                     /note="hexamer: AATAAA"
     polyA_site      2152
                     /gene="TBC1D22A"
                     /gene_synonym="C22orf4; HSC79E021"
     regulatory      3740..3745
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TBC1D22A"
                     /gene_synonym="C22orf4; HSC79E021"
                     /note="hexamer: AATAAA"
     polyA_site      3758
                     /gene="TBC1D22A"
                     /gene_synonym="C22orf4; HSC79E021"
                     /note="major polyA site"
ORIGIN      
        1 ggaagagctt ctcggctcta ggctctggag tcccgggagc agtgaggggc cacccggggc
       61 acaggaaagg gccgctaggg gagggccggg tgcactcggg gtgtctgggc cgcgggtctg
      121 agggatgagg aggggccatg gccagcgacg gggccaggaa gcaattctgg aagcgcagca
      181 acagcaagct cccgggcagc atccagcacg tgtatggtgc ccagcacccc ccctttgatc
      241 cactgttaca tggcactttg ctcaggtcca cggccaagat gccgaccaca ccagtgaagg
      301 ccaagagggt cagcaccttc caggagtttg agagcaatac cagcgatgcc tgggacgctg
      361 gggaggacga cgatgagctc ctggccatgg cggcggagag cctgaactcc gaggtggtca
      421 tggagacggc caaccgtgtg ctgcgtaacc acagccagcg gcaggggcgg cccacgctgc
      481 aggaggggcc agggcttcag cagaagccca ggcccgaggc agagccgccc tcacccccca
      541 gcggcgacct ccggctggtg aagtcggtca gtgagagcca cacgtcctgt cctgcagaaa
      601 gtgccagcga tgccgcccct ctgcagaggt cccagtctct cccacactcg gccaccgtca
      661 cgctgggtgg cacatctgac cccagcactc tcagcagctc agcgctgagc gaaagagagg
      721 cctcccggct cgacaagttc aagcagctgc ttgccggccc caacacggac cttgaggaat
      781 tacggaggtt gagctggtcc ggaatcccta agccagtgcg tccaatgacg tggaagctcc
      841 tctcaggtta ccttcccgcc aatgtagacc ggagaccagc cactctccag agaaaacaaa
      901 aagaatattt tgcatttatt gagcactatt acgattctag gaacgacgaa gttcaccagg
      961 acacatacag gcagatccac atagacatcc ctcgcatgag ccctgaagcg ttgatcctgc
     1021 agcccaaggt gacggagatt tttgaaagga tcttgttcat atgggcgatc cgccacccag
     1081 ccagtggata cgttcagggt ataaatgatc tcgtcactcc tttctttgtg gtcttcattt
     1141 gtgaatacat agaggcagag gaggtggaca cggtggacgt ctccggcgtg cccgcagagg
     1201 tgctgtgcaa catcgaggcc gacacctact ggtgcatgag caagctgctg gatggcattc
     1261 aggacaacta cacctttgcc caacctggga ttcaaatgaa agtgaaaatg ttagaagaac
     1321 tcgtgagccg gattgatgag caagtgcacc ggcacctgga ccaacacgaa gtgagatacc
     1381 tgcagtttgc cttccgctgg atgaacaacc tgctgatgag ggaggtgccc ctgcgttgta
     1441 ccatccgcct gtgggacacc taccagtctg aaccggacgg cttttctcat ttccacttgt
     1501 acgtgtgcgc tgcttttctc gtgagatgga ggaaggaaat actagaagaa aaagattttc
     1561 aagagctgct gctcttcctc cagaacctgc ccacagccca ctgggatgat gaggacatca
     1621 gcctgttgct ggccgaggcc taccgcctca agtttgcttt tgccgacgcc cccaatcact
     1681 acaagaaatg agcccaggcc cacccgcagc tggcctcact gtcccgggtg gcgcgcccca
     1741 cctgcctggc tggtggtagg cccctgtgag ctggtcccgg gctgctaaaa ggccttgtga
     1801 ggtggcccca ccctccaggg gagctggtga agatgggcca cagacctggt ctagggctga
     1861 caaagacagg gacagccttt gttttctgag ataccaaaga gagccagggg agggccccgg
     1921 gttcggcggc cagaggcagg tcaggggtcc cctctccctc tccctgcaat gtccttgcca
     1981 aatgactgcc tcgtgctgcc cctagtccgg ggcagcctag gaggccgacc ctctttggag
     2041 tcctgctgtc tgggtgccag ggccggaacg aggtagtggc catctcatac ctactctgaa
     2101 atgcaaaact tctattctgt tgagtgaaag aataaaatgt agacaaaatc tagaccgaga
     2161 cgttgcgctg acccggggtc tctgtgccgc gaggtcccct cacagctgta tttcactgct
     2221 gctggccctt tccctccgtg tgttttcctg cttgcttggt ttaaacgtgg ctgggaagct
     2281 gaaggctgga gtccaagccg tgagcccgcc gagtgcctgg gaggccgtgg gaccaaaggc
     2341 tgggagcaga gggaggcctc gccatcgcct tactttccac cttgaacctc ttttacaaga
     2401 gagaaacccc cacctccctg aggtccaggg ccaagtggcc ccgccacgca ggtaggcgcc
     2461 ggcctcagcc agagcccctg gaggcccacc caggctgtcg ggccatgttg ggctggcaga
     2521 cgggcagggg gtcgcgtccc tgtcatcaaa gccctgaacc acagtgctct tctcaccgca
     2581 gcctggaagc ggaatgagct tttggagact tcctgggact tgctgtcctt gtccaggtct
     2641 gccaggtgta ggggaggtgt gactggttcc atcatggacc ggttcctcca tggaccggtt
     2701 cctccgtgga ccggttccgc catggaccgg ttccgccatg gaccactcct gccctggacc
     2761 actcctgccc tggaccggtt ctgccgtgga ctggttcccg ccgtggacca gttcccgctg
     2821 tatactggtt ctgccctgga ctggttcccg ctgtggactg gttccttggg gctctaagtg
     2881 cggaagggcc cagagctggt ccctgcccag cgccctgcta gggctgtgtc cttggctcca
     2941 ggggccttgg gactggcttc ccagcgttcc ctcggtgtgt cacaggctgc atgacccctg
     3001 gaatgcgggc agggccacag ccacagtctg tctgatccct gagcccagga caggctcacg
     3061 tcctcagcga cccactggtg actgacttcc cagactctcc tctgtccctc aggagcagcc
     3121 gtgtcctctc ccaggcccta ggacactgcc agagactgtg ggacatacag gcataagtga
     3181 tgtgtgtgtt tctgcttctg ttttaaaaat ccagggtcat tacacacagc atggaaatta
     3241 gcacaaaatg ctgtgcaaac gtcagatgct cccaaaccag caaagggatg ggcttgcttc
     3301 acatcagatg cgggcacgcc ttacccctgc cttccgtgtc cccaccccag ggtcaagggt
     3361 tcctcagacc agccatgcct cctcctcctg ccgcctcctt ttctagatgg ggaggggatt
     3421 ccgtcacaag aagagccgcc cctcggccgt gtgcaggaag ccccatgtcg ctttgccgag
     3481 atcagccctg ggaggatccc cttctccagc tcagatcatg ccgtgtggcc agaaggctgc
     3541 ggacacaact gacctgcttc tcgaggtggt tgatgtttta aacaggaagc tccacggagt
     3601 tcagccctgt gtgcatttcc tcatgtatgt aaacgccaag actgaatgtg agaggtgttg
     3661 gccgcgggcc ttaagtctga gcagatccat ctggaatgtt cggggtgtgc tgtctggatg
     3721 tggtgcgcta aaaacacgga ataaagatca gtgacaaa
//
