LOCUS       NM_018317               2967 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens TBC1 domain family member 19 (TBC1D19), transcript
            variant 1, mRNA.
ACCESSION   NM_018317
VERSION     NM_018317.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2967)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2967)
  AUTHORS   Popovic,D., Akutsu,M., Novak,I., Harper,J.W., Behrends,C. and
            Dikic,I.
  TITLE     Rab GTPase-activating proteins in autophagy: regulation of
            endocytic and autophagy pathways by direct binding to human ATG8
            modifiers
  JOURNAL   Mol Cell Biol 32 (9), 1733-1744 (2012)
   PUBMED   22354992
REFERENCE   3  (bases 1 to 2967)
  AUTHORS   Ishibashi,K., Kanno,E., Itoh,T. and Fukuda,M.
  TITLE     Identification and characterization of a novel Tre-2/Bub2/Cdc16
            (TBC) protein that possesses Rab3A-GAP activity
  JOURNAL   Genes Cells 14 (1), 41-52 (2009)
   PUBMED   19077034
REFERENCE   4  (bases 1 to 2967)
  AUTHORS   Yoshimura,S., Egerer,J., Fuchs,E., Haas,A.K. and Barr,F.A.
  TITLE     Functional dissection of Rab GTPases involved in primary cilium
            formation
  JOURNAL   J Cell Biol 178 (3), 363-369 (2007)
   PUBMED   17646400
REFERENCE   5  (bases 1 to 2967)
  AUTHORS   Rush,J., Moritz,A., Lee,K.A., Guo,A., Goss,V.L., Spek,E.J.,
            Zhang,H., Zha,X.M., Polakiewicz,R.D. and Comb,M.J.
  TITLE     Immunoaffinity profiling of tyrosine phosphorylation in cancer
            cells
  JOURNAL   Nat Biotechnol 23 (1), 94-101 (2005)
   PUBMED   15592455
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC093807.3 and AC107390.4.
            
            On Nov 23, 2018 this sequence version replaced NM_018317.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.206149.1,
                                           SRR1660809.169987.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264866.9/ ENSP00000264866.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-209               AC093807.3         85026-85234
            210-282             AC093807.3         114111-114183
            283-328             AC093807.3         115350-115395
            329-404             AC093807.3         121555-121630
            405-479             AC093807.3         138153-138227
            480-543             AC093807.3         139713-139776
            544-590             AC093807.3         141083-141129
            591-701             AC093807.3         160539-160649
            702-774             AC093807.3         167275-167347
            775-813             AC107390.4         3676-3714
            814-926             AC107390.4         5303-5415
            927-1001            AC107390.4         15202-15276
            1002-1064           AC107390.4         19872-19934
            1065-1149           AC107390.4         49460-49544
            1150-1194           AC107390.4         51608-51652
            1195-1227           AC107390.4         66982-67014
            1228-1337           AC107390.4         71391-71500
            1338-1429           AC107390.4         74035-74126
            1430-1545           AC107390.4         79938-80053
            1546-1616           AC107390.4         85347-85417
            1617-2967           AC107390.4         86400-87750
FEATURES             Location/Qualifiers
     source          1..2967
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p15.2"
     gene            1..2967
                     /gene="TBC1D19"
                     /note="TBC1 domain family member 19"
                     /db_xref="GeneID:55296"
                     /db_xref="HGNC:HGNC:25624"
     exon            1..209
                     /gene="TBC1D19"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..1691
                     /gene="TBC1D19"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="TBC1 domain family member 19 isoform 1"
                     /protein_id="NP_060787.2"
                     /db_xref="CCDS:CCDS3439.1"
                     /db_xref="GeneID:55296"
                     /db_xref="HGNC:HGNC:25624"
                     /translation="MLQEESDLSLIIAQIVQKLKGSNLYSQLERQAWASLQRPEIKLE
                     SLKEDIKEFFKISGWEKKLQNAVYSELSVFPLPSHPAAPPEHLKEPLVYMRKAQGSWE
                     KRILKSLNSMCTELSIPLARKRPVGEQKELLNKWNEMGTDEPDLSLFRPVYAPKDFLE
                     VLINLRNPNYENGDSLSFRTHLGLIQVPLKVKDIPELKECFVELGLNIGQLGIDDSTQ
                     VPPELFENEHVRIGQKVLAEQDSAAAQQYIRQGSPTALRAELWALILNISSQPEDVLY
                     YEQLKTNVIQHDLLVDSLIYKDVKLTASNDDYYFVFEDYLYQVLLCFSRDTSVLSHFA
                     FNSASPPKSYIRGKLGLEEYAVFYPPNGVIPFHGFSMYVAPLCFLYHEPSKLYQIFRE
                     MYVRFFFRLHSISSHPSGIVSLCLLFETLLQTYLPQLFYHLREIGAQPLRISFKWMVR
                     AFSGYLATDQLLLLWDRILGYNSLEILAVLAAAVFAFRAVNLMEVTSLAAAEAVLADL
                     STLKVMPLLQIFLFATVT"
     exon            210..282
                     /gene="TBC1D19"
                     /inference="alignment:Splign:2.1.0"
     exon            283..328
                     /gene="TBC1D19"
                     /inference="alignment:Splign:2.1.0"
     exon            329..404
                     /gene="TBC1D19"
                     /inference="alignment:Splign:2.1.0"
     exon            405..479
                     /gene="TBC1D19"
                     /inference="alignment:Splign:2.1.0"
     exon            480..543
                     /gene="TBC1D19"
                     /inference="alignment:Splign:2.1.0"
     exon            544..590
                     /gene="TBC1D19"
                     /inference="alignment:Splign:2.1.0"
     exon            591..701
                     /gene="TBC1D19"
                     /inference="alignment:Splign:2.1.0"
     exon            702..774
                     /gene="TBC1D19"
                     /inference="alignment:Splign:2.1.0"
     exon            775..813
                     /gene="TBC1D19"
                     /inference="alignment:Splign:2.1.0"
     exon            814..926
                     /gene="TBC1D19"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1001
                     /gene="TBC1D19"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1064
                     /gene="TBC1D19"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1149
                     /gene="TBC1D19"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..1194
                     /gene="TBC1D19"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1227
                     /gene="TBC1D19"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1337
                     /gene="TBC1D19"
                     /inference="alignment:Splign:2.1.0"
     exon            1338..1429
                     /gene="TBC1D19"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..1545
                     /gene="TBC1D19"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1616
                     /gene="TBC1D19"
                     /inference="alignment:Splign:2.1.0"
     exon            1617..2967
                     /gene="TBC1D19"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1795..1800
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TBC1D19"
                     /note="hexamer: AATAAA"
     polyA_site      1824
                     /gene="TBC1D19"
                     /note="major polyA site"
     regulatory      2021..2026
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TBC1D19"
                     /note="hexamer: AATAAA"
     polyA_site      2043
                     /gene="TBC1D19"
     regulatory      2073..2078
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TBC1D19"
                     /note="hexamer: TATAAA"
     polyA_site      2093
                     /gene="TBC1D19"
     regulatory      2936..2941
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TBC1D19"
                     /note="hexamer: AATAAA"
     polyA_site      2967
                     /gene="TBC1D19"
ORIGIN      
        1 agtgtaataa ggtcccggag aagtgtcact ggccctgagt gggacccggt agcccgttcg
       61 ctccgcgccg gcggcctgtc cccgcggctt ggcgggctag ggcaggggaa atgttgcagg
      121 aggagtcgga cctctctctc attattgccc agatagtcca aaagctcaag ggctccaatt
      181 tgtactctca gctggaacgg caggcctggg ccagtcttca gagacctgag attaaacttg
      241 aatcactgaa agaagatatt aaggaattct ttaaaatatc aggttgggag aagaaacttc
      301 agaatgctgt ttatagtgaa ctgagtgtgt ttcctttacc tagtcatcct gctgcacctc
      361 ctgaacatct taaagaacct ttggtataca tgaggaaagc acagggaagt tgggaaaaaa
      421 gaattttgaa gagtttaaat agtatgtgca ctgaactgag tatcccactg gcacgaaaga
      481 ggccagttgg agaacagaaa gaacttctta ataaatggaa tgaaatggga actgatgaac
      541 cagatttaag ccttttcaga cctgtttatg cacctaagga ttttcttgag gtattaatta
      601 atcttcgcaa cccaaattat gaaaacggtg attctcttag tttcaggact catttgggtt
      661 taattcaagt tccactgaaa gtaaaagaca tccctgaatt gaaagaatgc tttgtggaac
      721 ttggcttaaa tataggacaa ctgggtatag atgattctac acaagtgcct cctgaacttt
      781 ttgaaaatga acatgtacgt attgggcaaa aagttctagc agaacaagat agtgctgctg
      841 ctcaacagta catcagacaa ggaagtccca cggcactgag agctgaattg tgggctctca
      901 ttttgaatat ttccagccaa cctgaggatg tcttgtatta tgagcagctt aagaccaatg
      961 tgatacaaca tgaccttttg gtggacagtc taatctataa agatgtgaag ttgacagcaa
     1021 gcaatgatga ttattatttt gtatttgaag attatttata tcaggtatta ctttgttttt
     1081 cccgggatac atctgtgttg agtcactttg cattcaacag tgcctcgcca ccaaaatcat
     1141 acataagagg aaaactagga ctggaagaat atgctgtctt ttacccacca aatggtgtta
     1201 tcccttttca tggattttca atgtatgttg caccactttg ttttctatac catgaacctt
     1261 ccaaattgta tcagatattc cgtgagatgt atgtgcgttt tttcttcaga ctccattcca
     1321 tctcttctca tccttctggt attgtgtcac tctgtctgct gtttgaaact cttcttcaaa
     1381 cttatcttcc ccaactcttt tatcatctac gagaaattgg ggctcaacca cttcgcatat
     1441 catttaagtg gatggttcga gctttctctg gatacttagc tacagatcag ctcttgcttt
     1501 tatgggatag aatcctagga tacaactctc tggaaattct tgctgtgctg gcagctgccg
     1561 tgtttgcttt ccgagcagtg aacctgatgg aggtgacatc actggctgca gctgaagcag
     1621 ttcttgctga cctttctact ttaaaagtta tgcctcttct tcagattttt ctgtttgcta
     1681 ctgtcacctg atcttcttca cagtcactgg caacacatct agtttttcat tagaaacaaa
     1741 tcatgaacta tgcaaactct gcataaaacc aaaatgaaac tttgcatata agccaataaa
     1801 gatcatgttc cctcttcagt taaacctaag tagtttctca ctttttgaaa caataactct
     1861 gcaccaaata ttgcatcgca tgctgctgat tttcaagaga gaagcaataa acacaacttc
     1921 tgctaaattg agcattatat atataatatt ataatatata tataatcctg acttgtcaat
     1981 ggcatgtaat aatatatgca ataagaacta aagatactgt aataaacttc aagaggtaat
     2041 gtagcttctt ggataattct tttatgtcag tttataaatt tatctctaga taatgtattg
     2101 ttttgtctca taaattgctc ctcactaaga gccaggggtg gggtagggtg tgagaacact
     2161 tgaaaaagat aatgttttta agtaggaatt caaaagttgc ttaaatggtg ttttaagcaa
     2221 ctttttacac cccagggatt ttctacattt ctctccattt tatttctctc tttaaacatc
     2281 tctactgggg aaggtcgaat acaattgtct ccatttgaca atattttatg cttgactctc
     2341 tgaaagtcag aaaattatag gtgatccctt ttcacttctc aaccttcctt ctcttgctta
     2401 gaagacttga cattgccgat gcttgttgcc agcttctgtt actttgtaac tatacaagga
     2461 agacacccaa gagaatgagg agtcaaaacc ccattcactt ttgctgaagc ttggtttaac
     2521 aagatttact tctagggcag agcagctgag agagattaaa agtaggtagt aggcattcat
     2581 tctaaactgc agacattatg caaggcatca gccttatttt gggctttatt ataagtgaag
     2641 ggtcttattt tgtattactt cctaaagacc taccatttct gtaatatgga ataatagtat
     2701 gtggggtaaa aagtccaaaa actattgtcc tttgatttta gtttcaaatt taagatgctg
     2761 atcacttcac taaaactgta aatcagtaga ttgatacgct tattgattgc ctagaatttt
     2821 attcagtttt acccaaatgt attttatgag tcttttattt tggcagtatg tattaggaaa
     2881 aatgcttgtt gatttactaa gagctgaata ataatttatt ccatgattga ttcttaataa
     2941 accccatttt attgcttttg aaggtga
//
