LOCUS       NM_024682               2095 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens TBC1 domain family member 17 (TBC1D17), transcript
            variant 1, mRNA.
ACCESSION   NM_024682
VERSION     NM_024682.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2095)
  AUTHORS   Rao,X.S., Cong,X.X., Gao,X.K., Shi,Y.P., Shi,L.J., Wang,J.F.,
            Ni,C.Y., He,M.J., Xu,Y., Yi,C., Meng,Z.X., Liu,J., Lin,P.,
            Zheng,L.L. and Zhou,Y.T.
  TITLE     AMPK-mediated phosphorylation enhances the auto-inhibition of
            TBC1D17 to promote Rab5-dependent glucose uptake
  JOURNAL   Cell Death Differ 28 (12), 3214-3234 (2021)
   PUBMED   34045668
  REMARK    GeneRIF: AMPK-mediated phosphorylation enhances the auto-inhibition
            of TBC1D17 to promote Rab5-dependent glucose uptake.
REFERENCE   2  (bases 1 to 2095)
  AUTHORS   Yamano,K., Fogel,A.I., Wang,C., van der Bliek,A.M. and Youle,R.J.
  TITLE     Mitochondrial Rab GAPs govern autophagosome biogenesis during
            mitophagy
  JOURNAL   Elife 3, e01612 (2014)
   PUBMED   24569479
  REMARK    GeneRIF: Demonstrate that TBC1D15 and TBC1D17 mediate proper
            autophagic encapsulation of mitochondria by regulating Rab7
            activity at the interface between mitochondria and isolation
            membranes.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2095)
  AUTHORS   Vaibhava,V., Nagabhushana,A., Chalasani,M.L., Sudhakar,C.,
            Kumari,A. and Swarup,G.
  TITLE     Optineurin mediates a negative regulation of Rab8 by the
            GTPase-activating protein TBC1D17
  JOURNAL   J Cell Sci 125 (Pt 21), 5026-5039 (2012)
   PUBMED   22854040
  REMARK    GeneRIF: Optineurin acts as an adaptor to bring together Rab8 and
            its GTPase-activating protein TBC1D17.
REFERENCE   4  (bases 1 to 2095)
  AUTHORS   Popovic,D., Akutsu,M., Novak,I., Harper,J.W., Behrends,C. and
            Dikic,I.
  TITLE     Rab GTPase-activating proteins in autophagy: regulation of
            endocytic and autophagy pathways by direct binding to human ATG8
            modifiers
  JOURNAL   Mol Cell Biol 32 (9), 1733-1744 (2012)
   PUBMED   22354992
REFERENCE   5  (bases 1 to 2095)
  AUTHORS   Ishibashi,K., Kanno,E., Itoh,T. and Fukuda,M.
  TITLE     Identification and characterization of a novel Tre-2/Bub2/Cdc16
            (TBC) protein that possesses Rab3A-GAP activity
  JOURNAL   Genes Cells 14 (1), 41-52 (2009)
   PUBMED   19077034
REFERENCE   6  (bases 1 to 2095)
  AUTHORS   Yoshimura,S., Egerer,J., Fuchs,E., Haas,A.K. and Barr,F.A.
  TITLE     Functional dissection of Rab GTPases involved in primary cilium
            formation
  JOURNAL   J Cell Biol 178 (3), 363-369 (2007)
   PUBMED   17646400
REFERENCE   7  (bases 1 to 2095)
  AUTHORS   Fuchs,E., Haas,A.K., Spooner,R.A., Yoshimura,S., Lord,J.M. and
            Barr,F.A.
  TITLE     Specific Rab GTPase-activating proteins define the Shiga toxin and
            epidermal growth factor uptake pathways
  JOURNAL   J Cell Biol 177 (6), 1133-1143 (2007)
   PUBMED   17562788
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC003516.1, KC877742.1 and AI927008.1.
            
            On Nov 23, 2018 this sequence version replaced NM_024682.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.925937.1, AK022230.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000221543.10/ ENSP00000221543.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-317               BC003516.1         131-447
            318-318             KC877742.1         281-281
            319-2089            BC003516.1         449-2219
            2090-2095           AI927008.1         19-24               c
FEATURES             Location/Qualifiers
     source          1..2095
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.33"
     gene            1..2095
                     /gene="TBC1D17"
                     /note="TBC1 domain family member 17"
                     /db_xref="GeneID:79735"
                     /db_xref="HGNC:HGNC:25699"
                     /db_xref="MIM:616659"
     exon            1..43
                     /gene="TBC1D17"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..1969
                     /gene="TBC1D17"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="TBC1 domain family member 17 isoform 1"
                     /protein_id="NP_078958.2"
                     /db_xref="CCDS:CCDS12785.1"
                     /db_xref="GeneID:79735"
                     /db_xref="HGNC:HGNC:25699"
                     /db_xref="MIM:616659"
                     /translation="MEGAGYRVVFEKGGVYLHTSAKKYQDRDSLIAGVIRVVEKDNDV
                     LLHWAPVEEAGDSTQILFSKKDSSGGDSCASEEEPTFDPGYEPDWAVISTVRPQLCHS
                     EPTRGAEPSCPQGSWAFSVSLGELKSIRRSKPGLSWAYLVLVTQAGGSLPALHFHRGG
                     TRALLRVLSRYLLLASSPQDSRLYLVFPHDSSALSNSFHHLQLFDQDSSNVVSRFLQD
                     PYSTTFSSFSRVTNFFRGALQPQPEGAASDLPPPPDDEPEPGFEVISCVELGPRPTVE
                     RGPPVTEEEWARHVGPEGRLQQVPELKNRIFSGGLSPSLRREAWKFLLGYLSWEGTAE
                     EHKAHIRKKTDEYFRMKLQWKSVSPEQERRNSLLHGYRSLIERDVSRTDRTNKFYEGP
                     ENPGLGLLNDILLTYCMYHFDLGYVQGMSDLLSPILYVIQNEVDAFWCFCGFMELVQG
                     NFEESQETMKRQLGRLLLLLRVLDPLLCDFLDSQDSGSLCFCFRWLLIWFKREFPFPD
                     VLRLWEVLWTGLPGPNLHLLVACAILDMERDTLMLSGFGSNEILKHINELTMKLSVED
                     VLTRAEALHRQLTACPELPHNVQEILGLAPPAEPHSPSPTASPLPLSPTRAPPTPPPS
                     TDTAPQPDSSLEILPEEEDEGADS"
     exon            44..142
                     /gene="TBC1D17"
                     /inference="alignment:Splign:2.1.0"
     exon            143..217
                     /gene="TBC1D17"
                     /inference="alignment:Splign:2.1.0"
     exon            218..341
                     /gene="TBC1D17"
                     /inference="alignment:Splign:2.1.0"
     exon            342..549
                     /gene="TBC1D17"
                     /inference="alignment:Splign:2.1.0"
     exon            550..661
                     /gene="TBC1D17"
                     /inference="alignment:Splign:2.1.0"
     exon            662..820
                     /gene="TBC1D17"
                     /inference="alignment:Splign:2.1.0"
     exon            821..949
                     /gene="TBC1D17"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1053
                     /gene="TBC1D17"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1148
                     /gene="TBC1D17"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1265
                     /gene="TBC1D17"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1366
                     /gene="TBC1D17"
                     /inference="alignment:Splign:2.1.0"
     exon            1367..1466
                     /gene="TBC1D17"
                     /inference="alignment:Splign:2.1.0"
     exon            1467..1564
                     /gene="TBC1D17"
                     /inference="alignment:Splign:2.1.0"
     exon            1565..1681
                     /gene="TBC1D17"
                     /inference="alignment:Splign:2.1.0"
     exon            1682..1768
                     /gene="TBC1D17"
                     /inference="alignment:Splign:2.1.0"
     exon            1769..2095
                     /gene="TBC1D17"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2071..2076
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TBC1D17"
                     /note="hexamer: ATTAAA"
     polyA_site      2095
                     /gene="TBC1D17"
                     /note="major polyA site"
ORIGIN      
        1 agtggggcct tcggcggcga ctatggaagg agccggctac agggtggtgt ttgagaaggg
       61 cggagtgtac ctgcacacca gcgctaagaa gtatcaggac cgagactctc tcatcgctgg
      121 tgtcatccgt gtcgtggaaa aggacaatga cgtcctcctg cactgggctc ctgtagagga
      181 ggctggagat tccacccaaa tcctcttctc caagaaggac tccagtgggg gtgactcatg
      241 tgcttctgag gaggaaccaa cctttgaccc cggctatgaa cctgactggg ctgtcatcag
      301 cactgtgcgg ccacagctct gccactcaga gcccacgaga ggtgcagagc ccagctgccc
      361 ccagggctcc tgggccttct cagtgagtct gggggagcta aagtccatcc gccgctccaa
      421 gccaggcctc agctgggcct acctggttct ggtgacccag gctggaggtt ccctgcccgc
      481 actgcacttc caccgcgggg gcacccgcgc cctgctccgc gtcctcagcc gctacctgct
      541 gttggccagc tccccgcagg actcccgcct ctaccttgtc ttcccccacg actcctctgc
      601 tctctccaac tccttccacc acctgcagct ctttgaccag gacagctcca atgtggtgtc
      661 acgcttcctc caggatccct actccaccac cttcagcagc ttctcccgag tgaccaactt
      721 cttccggggt gccctgcagc cacagcctga gggagccgcc tccgaccttc ccccgccacc
      781 cgacgatgag cccgagcctg gattcgaggt catttcctgt gtggagctgg ggcctcggcc
      841 aaccgtggag cggggccctc cagttacaga ggaggagtgg gcacgccacg tgggccctga
      901 aggtcgcctg cagcaggtcc ctgagctgaa gaaccggatc ttctcggggg gtctgagccc
      961 cagcctgcgg cgcgaggcct ggaagttcct cctagggtac ctcagctggg aaggcacagc
     1021 tgaggagcac aaggcccaca tacgcaagaa aacggatgag tatttccgca tgaagctgca
     1081 gtggaaatct gtgagccctg agcaggagcg gagaaactca cttctgcatg gataccgcag
     1141 cctcatcgaa agggatgtga gccgcactga caggaccaac aagttctacg agggtcccga
     1201 gaacccgggg ctgggcctgc tgaacgatat cctcctcacc tactgcatgt atcacttcga
     1261 cctcggctac gtccagggca tgagtgatct tctctccccg atcctctacg tcattcagaa
     1321 cgaggtggat gctttctggt gtttctgtgg cttcatggag ctcgtgcaag ggaactttga
     1381 agagagccag gagaccatga agcggcaact cgggcgactg ctgctgctcc tgagggtgct
     1441 ggaccccctg ctctgcgact tcctggattc ccaggactcc ggctctctct gcttctgttt
     1501 ccggtggctg ctcatctggt tcaagaggga attccccttc ccggatgtcc ttcggctgtg
     1561 ggaggtgctg tggacagggc tccctggccc caatctgcac ctgctggtgg cctgcgccat
     1621 cctggacatg gagagggaca ccctcatgct gtccggcttc ggctccaatg agatcctcaa
     1681 gcacatcaac gagctgacta tgaagctgag cgtggaggac gtgctgaccc gcgccgaggc
     1741 cctgcaccgc cagctaaccg cctgccccga gctgccccac aacgtgcagg agatcctggg
     1801 gctggccccg cccgcagagc cccacagccc ctcgcccacc gcctccccgc tgcctctgtc
     1861 gcccacccgg gccccgccca ccccgccgcc ctccacggac acagccccgc agcccgacag
     1921 cagcctggag atcctgcccg aggaggagga cgagggcgcc gactcctaac cccgccaggc
     1981 agcctcgttc tgcacaggca ctttagcccg agccaggcac acctgcgagg gggcaggtgt
     2041 gctccgccgc cctgctgata agctggcttc attaaactga cacttctcat gtgca
//
