LOCUS       NM_019020              10960 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens TBC1 domain family member 16 (TBC1D16), transcript
            variant 1, mRNA.
ACCESSION   NM_019020
VERSION     NM_019020.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10960)
  AUTHORS   Yan,J., Zheng,Y., Yuan,P., Wang,S., Han,S., Yin,J., Peng,B., Li,Z.,
            Sun,Y., He,X. and Liu,W.
  TITLE     Novel Host Protein TBC1D16, a GTPase Activating Protein of Rab5C,
            Inhibits Prototype Foamy Virus Replication
  JOURNAL   Front Immunol 12, 658660 (2021)
   PUBMED   34367131
  REMARK    GeneRIF: Novel Host Protein TBC1D16, a GTPase Activating Protein of
            Rab5C, Inhibits Prototype Foamy Virus Replication.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10960)
  AUTHORS   Liu,H., Chen,P., Yang,Y.L., Zhu,K.W., Wang,T., Tang,L., Liu,Y.L.,
            Cao,S., Zhou,G., Zeng,H., Zhao,X.L., Zhang,W. and Chen,X.P.
  TITLE     TBC1D16 predicts chemosensitivity and prognosis in adult acute
            myeloid leukemia (AML) patients
  JOURNAL   Eur J Pharmacol 895, 173894 (2021)
   PUBMED   33476656
  REMARK    GeneRIF: TBC1D16 predicts chemosensitivity and prognosis in adult
            acute myeloid leukemia (AML) patients.
REFERENCE   3  (bases 1 to 10960)
  AUTHORS   Rodger,E.J., Chatterjee,A., Stockwell,P.A. and Eccles,M.R.
  TITLE     Characterisation of DNA methylation changes in EBF3 and TBC1D16
            associated with tumour progression and metastasis in multiple
            cancer types
  JOURNAL   Clin Epigenetics 11 (1), 114 (2019)
   PUBMED   31383000
  REMARK    GeneRIF: Findings suggest characteristic DNA methylation changes in
            TBC1D16 is relatively common tumor-associated epigenetic events in
            multiple tumor types, which is consistent with a potential role as
            more general drivers of tumor progression.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 10960)
  AUTHORS   Yang,Z., Shen,H., He,W., Ouyang,L., Guo,Y., Qian,F., Xu,B., Xie,D.
            and Yang,G.
  TITLE     Expression of TBC1D16 Is Associated with Favorable Prognosis of
            Epithelial Ovarian Cancer
  JOURNAL   Tohoku J Exp Med 245 (3), 141-148 (2018)
   PUBMED   29962380
  REMARK    GeneRIF: TBC1D16 is a predictive marker for favorable prognosis of
            Epithelial ovarian cancer.
REFERENCE   5  (bases 1 to 10960)
  AUTHORS   Jeremian,R., Chen,Y.A., De Luca,V., Vincent,J.B., Kennedy,J.L.,
            Zai,C.C. and Strauss,J.
  TITLE     Investigation of correlations between DNA methylation, suicidal
            behavior and aging
  JOURNAL   Bipolar Disord 19 (1), 32-40 (2017)
   PUBMED   28276657
  REMARK    GeneRIF: Bipolar disorder participants with a history of Suicidal
            behavior showed less overall methylation in the intron 3 of
            TRE2/BUB2/CDC16 domain family member 16 (TBC1D16).
REFERENCE   6  (bases 1 to 10960)
  AUTHORS   Vizoso,M., Ferreira,H.J., Lopez-Serra,P., Carmona,F.J.,
            Martinez-Cardus,A., Girotti,M.R., Villanueva,A., Guil,S.,
            Moutinho,C., Liz,J., Portela,A., Heyn,H., Moran,S., Vidal,A.,
            Martinez-Iniesta,M., Manzano,J.L., Fernandez-Figueras,M.T.,
            Elez,E., Munoz-Couselo,E., Botella-Estrada,R., Berrocal,A.,
            Ponten,F., Oord,Jv., Gallagher,W.M., Frederick,D.T., Flaherty,K.T.,
            McDermott,U., Lorigan,P., Marais,R. and Esteller,M.
  TITLE     Epigenetic activation of a cryptic TBC1D16 transcript enhances
            melanoma progression by targeting EGFR
  JOURNAL   Nat Med 21 (7), 741-750 (2015)
   PUBMED   26030178
  REMARK    GeneRIF: RAB5C is identified as a new TBC1D16 target and showed
            that it regulates EGFR in melanoma cells.
REFERENCE   7  (bases 1 to 10960)
  AUTHORS   Goueli,B.S., Powell,M.B., Finger,E.C. and Pfeffer,S.R.
  TITLE     TBC1D16 is a Rab4A GTPase activating protein that regulates
            receptor recycling and EGF receptor signaling
  JOURNAL   Proc Natl Acad Sci U S A 109 (39), 15787-15792 (2012)
   PUBMED   23019362
  REMARK    GeneRIF: TBC1D16 is a GTPase activating protein for Rab4A that
            regulates transferrin receptor recycling and EGFR trafficking and
            signaling.
REFERENCE   8  (bases 1 to 10960)
  AUTHORS   Popovic,D., Akutsu,M., Novak,I., Harper,J.W., Behrends,C. and
            Dikic,I.
  TITLE     Rab GTPase-activating proteins in autophagy: regulation of
            endocytic and autophagy pathways by direct binding to human ATG8
            modifiers
  JOURNAL   Mol Cell Biol 32 (9), 1733-1744 (2012)
   PUBMED   22354992
REFERENCE   9  (bases 1 to 10960)
  AUTHORS   Akavia,U.D., Litvin,O., Kim,J., Sanchez-Garcia,F., Kotliar,D.,
            Causton,H.C., Pochanard,P., Mozes,E., Garraway,L.A. and Pe'er,D.
  TITLE     An integrated approach to uncover drivers of cancer
  JOURNAL   Cell 143 (6), 1005-1017 (2010)
   PUBMED   21129771
  REMARK    GeneRIF: TBC1D16 and RAB27A, were identified known drivers of
            melanoma both are involved in the regulation of vesicular
            trafficking, which highlights this process as important for
            proliferation in melanoma.
REFERENCE   10 (bases 1 to 10960)
  AUTHORS   Yoshimura,S., Egerer,J., Fuchs,E., Haas,A.K. and Barr,F.A.
  TITLE     Functional dissection of Rab GTPases involved in primary cilium
            formation
  JOURNAL   J Cell Biol 178 (3), 363-369 (2007)
   PUBMED   17646400
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC116025.21, CN361974.1, BC028290.1, AC100791.15 and BC062601.1.
            
            On Nov 22, 2018 this sequence version replaced NM_019020.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC028290.1, SRR3476690.49392.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000310924.7/ ENSP00000309794.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                AC116025.21        173780-173793       c
            15-24               CN361974.1         14-23
            25-2540             BC028290.1         1-2516
            2541-8710           AC100791.15        172817-178986       c
            8711-10960          BC062601.1         1-2250
FEATURES             Location/Qualifiers
     source          1..10960
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.3"
     gene            1..10960
                     /gene="TBC1D16"
                     /note="TBC1 domain family member 16"
                     /db_xref="GeneID:125058"
                     /db_xref="HGNC:HGNC:28356"
                     /db_xref="MIM:616637"
     exon            1..78
                     /gene="TBC1D16"
                     /inference="alignment:Splign:2.1.0"
     exon            79..321
                     /gene="TBC1D16"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..2444
                     /gene="TBC1D16"
                     /note="isoform a is encoded by transcript variant 1;
                     CTD-2529O21.1"
                     /codon_start=1
                     /product="TBC1 domain family member 16 isoform a"
                     /protein_id="NP_061893.2"
                     /db_xref="CCDS:CCDS11766.1"
                     /db_xref="GeneID:125058"
                     /db_xref="HGNC:HGNC:28356"
                     /db_xref="MIM:616637"
                     /translation="MSLGRLLRRASSKASDLLTLTPGGSGSGSPSVLDGEIIYSKNNV
                     CVHPPEGLQGLGEHHPGYLCLYMEKDEMLGATLILAWVPNSRIQRQDEEALRYITPES
                     SPVRKAPRPRGRRTRSSGASHQPSPTELRPTLTPKDEDILVVAQSVPDRMLASPAPED
                     EEKLAQGLGVDGAQPASQPACSPSGILSTVSPQDVTEEGREPRPEAGEEDGSLELSAE
                     GVSRDSSFDSDSDTFSSPFCLSPISAALAESRGSVFLESDSSPPSSSDAGLRFPDSNG
                     LLQTPRWDEPQRVCALEQICGVFRVDLGHMRSLRLFFSDEACTSGQLVVASRESQYKV
                     FHFHHGGLDKLSDVFQQWKYCTEMQLKDQQVAPDKTCMQFSIRRPKLPSSETHPEESM
                     YKRLGVSAWLNHLNELGQVEEEYKLRKAIFFGGIDVSIRGEVWPFLLRYYSHESTSEE
                     REALRLQKRKEYSEIQQKRLSMTPEEHRAFWRNVQFTVDKDVVRTDRNNQFFRGEDNP
                     NVESMRRILLNYAVYNPAVGYSQGMSDLVAPILAEVLDESDTFWCFVGLMQNTIFVSS
                     PRDEDMEKQLLYLRELLRLTHVRFYQHLVSLGEDGLQMLFCHRWLLLCFKREFPEAEA
                     LRIWEACWAHYQTDYFHLFICVAIVAIYGDDVIEQQLATDQMLLHFGNLAMHMNGELV
                     LRKARSLLYQFRLLPRIPCSLHDLCKLCGSGMWDSGSMPAVECTGHHPGSESCPYGGT
                     VEMPSPKSLREGKKGPKTPQDGFGFRR"
     exon            322..919
                     /gene="TBC1D16"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1081
                     /gene="TBC1D16"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1229
                     /gene="TBC1D16"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1397
                     /gene="TBC1D16"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..1546
                     /gene="TBC1D16"
                     /inference="alignment:Splign:2.1.0"
     exon            1547..1681
                     /gene="TBC1D16"
                     /inference="alignment:Splign:2.1.0"
     exon            1682..1868
                     /gene="TBC1D16"
                     /inference="alignment:Splign:2.1.0"
     exon            1869..2048
                     /gene="TBC1D16"
                     /inference="alignment:Splign:2.1.0"
     exon            2049..2195
                     /gene="TBC1D16"
                     /inference="alignment:Splign:2.1.0"
     exon            2196..10960
                     /gene="TBC1D16"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3258..3263
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TBC1D16"
                     /note="hexamer: AATACA"
     polyA_site      3283
                     /gene="TBC1D16"
                     /note="major polyA site"
     regulatory      7653..7658
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TBC1D16"
                     /note="hexamer: AATAAA"
     polyA_site      7675
                     /gene="TBC1D16"
                     /note="major polyA site"
     regulatory      10933..10938
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TBC1D16"
                     /note="hexamer: AATAAA"
     polyA_site      10960
                     /gene="TBC1D16"
ORIGIN      
        1 actggcggcg gcagcggcgg aggcgacggt ggcggctctc ggagccggcg cgaatccggc
       61 ccccgcagcg ggacccgggc aggtcttgac gagccctgcc cgggccgacg catgcggagg
      121 atggaaacac ttgcccggca atgtctctgg gccgcctcct tcgcagggcc tcctccaaag
      181 cctcggacct cctgaccctc acccccggtg gcagcggcag cgggtccccc tctgtcctgg
      241 atggagagat catctactcc aagaacaatg tctgcgtgca cccgccggag gggctgcagg
      301 ggctggggga gcaccaccca ggttacctgt gcttgtacat ggagaaggat gagatgctgg
      361 gagccaccct catcctggca tgggtcccca actctcgcat ccagaggcag gacgaggagg
      421 ccctgcgcta catcacaccc gagagctccc ccgttcgcaa ggcaccccgc cctcggggcc
      481 ggcgcacccg gagctcagga gcctcccacc agccctcccc gacggagctg cggcctaccc
      541 tgacccccaa agatgaggac atcctggtgg tggcccagag tgttccagac cgcatgctcg
      601 ccagccctgc gccagaggat gaggagaagc tggcgcaggg cttgggggtg gatggtgccc
      661 agccagcctc gcagcctgct tgcagcccct ccgggatctt gtcgacggtc agtccgcagg
      721 atgtcaccga ggaggggcgg gagccgcggc ccgaggccgg ggaggaggat ggctctttgg
      781 aactgtcagc cgagggcgtg agcagagaca gctcctttga ctcagactca gacaccttct
      841 cctcgccctt ctgcctctcg cccatcagcg cggcgctggc cgagagccgc ggctccgtgt
      901 ttctggaaag tgacagcagc cccccgtcca gctccgacgc cggcctgcgg ttcccggaca
      961 gcaacggcct cctgcagacc ccacgctggg acgagccgca gcgggtgtgc gccctggagc
     1021 agatttgcgg cgtgttccgc gtggacctgg gccacatgcg ctccctccgc cttttcttca
     1081 gcgacgaggc ctgcaccagc ggccagctgg tcgttgccag ccgagagagc cagtacaagg
     1141 ttttccactt ccaccacggc ggcctggaca agctgtctga cgtgttccag cagtggaaat
     1201 actgcaccga gatgcagctc aaagaccagc aggtcgcccc cgataagaca tgcatgcagt
     1261 tctccatccg ccgccccaag ctgccgtcct ccgagacgca ccccgaggag agcatgtaca
     1321 agaggctcgg cgtctccgcc tggctcaacc acctgaatga gctgggccag gtggaggagg
     1381 agtacaagct gcggaaggcc attttctttg gcggtattga tgtgtcaatc cgcggggagg
     1441 tctggccctt cctgctgcgc tattacagcc acgagtccac gtcggaggag cgggaggcgc
     1501 tgcggctgca gaagcgaaag gagtactctg agatccagca gaaaaggctc tccatgactc
     1561 ccgaggagca cagagcgttc tggcgtaatg tgcagttcac tgtggacaaa gacgtggtcc
     1621 ggacagatcg gaacaaccag ttcttccggg gggaagacaa tcccaatgtg gagagcatga
     1681 ggaggatcct gctgaactac gccgtgtaca accctgccgt cggctattcc caagggatgt
     1741 cggacctggt ggcgcccatc ttggccgagg tcctggatga gtcagacacc ttctggtgct
     1801 ttgtgggttt gatgcagaac acgatcttcg tcagctcacc ccgggacgag gacatggaga
     1861 aacaactgct gtacctgcgc gagctgctgc ggctgacgca cgtgcgcttc taccagcacc
     1921 tggtctcgct gggcgaggac ggcctgcaga tgctcttctg ccaccgctgg ctccttctgt
     1981 gcttcaagcg ggagttcccc gaggccgaag cgctgcggat ctgggaggcc tgctgggccc
     2041 actaccagac ggactacttc caccttttca tctgcgtggc catcgtggcc atctacgggg
     2101 atgacgtcat cgagcagcag ctggccacgg accagatgct cctgcacttc ggaaacctgg
     2161 ccatgcacat gaacggggag ctcgttctcc ggaaggcgag gagtttgctg taccagttcc
     2221 gcctcctgcc ccggatcccc tgcagcctgc acgatctgtg taagctgtgc gggtcaggca
     2281 tgtgggacag cggctccatg cccgcggtgg agtgcaccgg ccaccatccc ggctcggaga
     2341 gctgtcccta cgggggcacg gtggagatgc cttcccccaa gtccctgagg gaaggcaaga
     2401 agggcccaaa gacgccgcag gacggcttcg gcttccgcag ataggtcggg cccccgacac
     2461 cggacagggg ttgaggggac ctcctcagag gccctgggca cgggaggggg tggggctggg
     2521 cgtgaagggg acaggggacg gtagaaacct aaggaaaatg cttttgggca acatgagagg
     2581 aaccttttca tattaatgac aaaattagag tctggaagtg acagaagtca gatctacagc
     2641 cacccagagg aaagtcagct cctgaaacgc tgcagtggaa cgcgcagcca ccgcacctga
     2701 gacgcaggct ggctgggctc tcctgctggc tgccctggag gatttcaaca tgtcccagga
     2761 tttgctccac cctcgagggc agccagacag cgtcgccagg caatgaggaa agcagagaca
     2821 ggagaggaag gcctcactca cccactgcgt cgagggctgc agaacacagc ggggtcctgt
     2881 ccaggcccag ggacatcttt gcaagccaga cacacttcct cttgagacct cgttctctcg
     2941 gagtgagcca aacacacttc ccaaaacgtc cccagccaca gctgggatgc cgatggaaag
     3001 gcatctgcca taaaagaaaa gcaaaagata aaaagcccaa ccgatgtggg gatagagagg
     3061 cggaagagca gtcaggcttg aggagctggc gcttgtaatg tttatccgtt taaacatttc
     3121 gtcctcctgg tacacgaagg gaactgtctg cccaggagcc tgagcctcag gctgttggag
     3181 aagcatctga tgcctttttc tttgctgggg gtcttctacg tgaggttcct tggcgttgtt
     3241 taaggtcaac tccaccaaat acagcaacca gctggggctt gaatgggtcg atgtgtgcgt
     3301 gtgtccctgc gtgcatgcat gcatgcacac gtgcgtgcgt gtttgtgttt gcaagatcct
     3361 ctgacaatga tctgctttgt cccagggacg tggtagtgta ttagctgacc aaccaagaca
     3421 aggacacctg gaaatagtta gactcttcca cttcccttca ggacctgtga actcagatat
     3481 gtaagtcagc ttctcaggtg gtcggacgtg agagcgacca cagtgaagga gccagcactc
     3541 agggctctct gccttctatg tgggaatgag gtcttcccaa cagactctcc ctcttccaaa
     3601 agattgtgta tcagttgctc cttctgggat ttagagatgg acagaaaagg gtgtgcgatc
     3661 tatgctgtga gaactcccag ccagcttaga agtgtcgagc catttgcaca gaaagccact
     3721 ccttgagcga ggagaccaaa tccctcctga aatcctccat cgcgtccttc tggggagaaa
     3781 aacccttgat gtgctgagaa ccatcatggg gaccaggata gaaggcttct tcccactcaa
     3841 agcttttctc cctggagggt gggcactgct gggccatgcc acttcaaagc agtgttcctc
     3901 agcaggaaag cggaggtcac cacttaccgg cctcctccac cttctcggct tctcttttct
     3961 ccatgaaccc aggtcgtcca gcaggtactt ccaagttccc aggtctgtct gcctaagagc
     4021 cttttgagga gaccgtcctg gagccccatc agtgcccaga tcctggggta ccgaccattg
     4081 ctgtctagca gtgggggatc ctgtggtggg aatggggtgg gcttctcatc catgttgctt
     4141 ctgggaagag agggttgcct ttctgggcta gggaggtggc tggagcttct gccctgaccc
     4201 tccgctagaa accagttata tccattgcca cagcaatact gtgtaacaaa tccgccaaca
     4261 ctcggtggcc tgcaacagtc agcactgatc tagggcagga gtcagcagtc tgggcagggt
     4321 gattcttctg gtctaggctg ggcttgtttg tttagggcca gtgggttgtt aagtcccagg
     4381 ggatgctcat ggtgcagagg tcggacctgg ccctgctctg tggtctcttg catccctcct
     4441 gcaggccagc catggcacag ccaaaggcac ggagggagag acagcaagtg cctttccaag
     4501 ccttggtgga caccacacct gcagctctcc ccttggccac agcaagtcac gtggctgggc
     4561 tcagcattaa ggggtggggg acaggcctgc cactttattg tccgctctgc acagtcgggt
     4621 ggcagtaggc tgagaatttg gagggctaaa caactgggac tctggagagt ctgtgtccta
     4681 ataatgcctg ctttggagca ctccttcccc acccgcctgc tccaggggaa tagcgtccct
     4741 ggtcctagca tttcactaga tacctcgtgc ctttgaaccg ctgtgtttgg gagggaggaa
     4801 gaggatagac aggtccaggg ctcccctcac ttgggaaggt cctagtagaa ggcattcctt
     4861 ctgagtctcc tggccctaca gcttctcacc cctgctgctc cccaagacct gacccggacc
     4921 aatcagctgc atctctgcac caagtgccac ccccaccgtg cactgctcgc acctcacgct
     4981 ccccatgggc tggcccggac cccagtgagg tctgcacctc tcggaccagc caggacctcg
     5041 gaagccatga gctgggtgtt cagggcttgg cggaggagac gctgctccgc gggggatgga
     5101 gaagccccgc ccctccacaa ctcccttaat ctggatgcaa ttagaggaaa ccagccaaaa
     5161 accccgcggc agctgttgcc ccgggattat tcccagccag cgagaggcat tagggcgata
     5221 attcagtcat tagacttcta gccttcccac cgccagaacg tgcaaatagg ggataatcag
     5281 ccctgcacgg ccatcctcag caatgctgct tatttaaccc attttttaaa atgacactta
     5341 atgttattgg ctggcgtacg tgtgtgcgca tacttaaaag ttgatgcgtg gtgcagctct
     5401 gctgctaatg tctgctgaca gcgtcgcccg atgttgctca gggcctctgg gaagagggga
     5461 cacctttgat gtgggcgtgc tggcacccaa gaggcaacgt ggtcaggctc gatgcttgcc
     5521 agccctggaa ggtcccgcca gggttggggg gtcgggtgag cactcagaga tctggggagg
     5581 aagcgaggag cctggtgtcc tcaccaggtg cagaggggaa atgcgtactg ctccagaagg
     5641 ttctgactca agtctcggcc ctgaggactc agaactcaca agtcatggat caagtacaga
     5701 gggagggagg gccccagccc acccctgcgg gggaggagga gggtctgaag gtgggagggc
     5761 agctccatga gcagccactg ttcctgacca gccgaagtgc caggcagggg gaggtttcca
     5821 tgtccaggag ggagaggacc tccaccctct gacctttcag ttttccatag cagcccagtg
     5881 tgaagctcgg cgggggtggg cagggcatca ggacaagatg aagatgctgg ctctggaatg
     5941 aggactcccc ttgggctaag gggtagtggc tggcagaggt tgcccagctc ttttggaggc
     6001 cacagggaat agaggtgggg tggtgcttcc gttcctgtga ggcccgcccc cctgagcccc
     6061 ctcgtctgct tcttgtttgg cagaaataga tgtggggcac agcccctaga tgatgggaat
     6121 ctgcccaagc tgtgccctct ggggaatgaa atcttgctcc tcgtgcagct tcccctttcc
     6181 cttgcggggt gggggctggg ggtgccaagg ctccaccctt ggagggggtt gctgggggtg
     6241 ccaaggctcc accctttgct cgctgggcag agggaaggaa gcacctccct gtatgctctg
     6301 caggggcccc tgcaggccac tttgcctcag aggaaggagg agaggtcccc tgggaaaatg
     6361 cgcacacaca cacacacaca cacacacaca cacgcacatg cacacacgca cgcatgcaca
     6421 cacacacaca catatgtgca ggggtgcagc ctaagtcagt ggagccagga ctggctgcgc
     6481 agctgggcct gccccattct tggagtcccc agggaatgag cctcaggatc cacttcgtcc
     6541 cttgtttcta agccaggctg cacggccgtt cctgggtgtg aaagcattct gtcctgtctc
     6601 cagtcagagg gaaccgcccc caaactagaa agctaatttc ccccgaaggt tcatgaagcc
     6661 agaggcatgc ccttgggggt tggtcgggag aagggtgaga ggcagtgctg tggaaggggc
     6721 ctggcccctg ctgcctgcga ttctccccgg gtatgtggcc ttctgcctcc ttcagcctca
     6781 gtttcctcac ctgtaacatg agaataatga tgcctgcctg cccaggccac ctcctgggag
     6841 tgcattgggg actctaagtg taaaactgtc atgaggatgg tttatgaagt cccagggacc
     6901 acacctgcca ctcagggaag agaccgctga cctcagccat cagccgtgtg catcgtgagg
     6961 ggcagcgagc tcaggacgga gagctctccc ttggttcgga gtcagcacac ctgcactccc
     7021 acacgcccac ccagctgtgt gtcctccgcc gagggcgagc ctctctgtga ctcttctgta
     7081 aaatgcaccc cattctgccc actcctgcca cgagacccat cctctgcgat cccgccaggc
     7141 atgtgtgtgt gaatgcatgt gcaaagctct ccatcagaag ggtggtgtgg gccctgcagg
     7201 tcctacccct cggccttgaa gctccctcgg gctgcggact ctgcctcctg ggtctgagca
     7261 ttagaaccag gagaggggtg tccctgggca gagccagggg tgcaaacagc ctgcagccat
     7321 ctggcctttt aagtatagtg tgtcgcattt ccgggtagga aggtagcatt tcaagttcaa
     7381 agagaggtca agtcatgcaa ccatctttcc tccagcactt ttggggtaag gaggacagtt
     7441 tttgttatgg tttaggggaa attttcatga aatttccacc attaccaata gattactgat
     7501 gtccatggca agtgatctgt tcttggtatt ttgttttgtt ttgttttggt ttttaaatgt
     7561 aatcacccat tggtcaggcc caggactggt caccatgagc tctgctagcc acggccccaa
     7621 cgatgcttcc ggctctcatg gattccacag caaataaaac tgtactgaca acagatgcac
     7681 gctgtacagt gcctctggaa ggtgcggtgg gacttgctgg gtcaaagcac ggcaggctct
     7741 gtgctgggca aacagggccc cgtggcagcc caagggcagc ctgcagacgc cagtgtgccc
     7801 ggcttctccc atgttctgag atgggggagg ggaaggtgta aaagagagct ggatgggggc
     7861 tgtggggact gagggtcctg ggaggctggc caggggctca gcaagcgccc actttgggag
     7921 gccttgccct ctgggctgtg gttggacagc actaggcctg caggctgggc tgccaggagg
     7981 aagagcagct ccggacctca ggccccccca gcaggcggcg atggagggtg atgggagaat
     8041 tgacgagtgc tcgcggggtc tcactcggga aagggccggt taactctgag caactgggag
     8101 cctcgctccc accccagtgc ctggaaacac aaacagtatt ttattgagcc ttggctgccg
     8161 gggctctggt ttcaggaaaa gcctcagtcc tgcatttgtg aatttttaag gaggcaaaca
     8221 aggtgaattt gaccttccta ggagtgggag ttagggaaaa ttcaggctgc cctaccaagc
     8281 ccttggaacc gtgcagcagg ggtcagggga gggatgggca aaggcggttt ggcccatgga
     8341 gcaggtctcc tggtcctccc ggagcacggg gggcggggag ctccagctct tcatcaagcg
     8401 ccctttgggg tttccaactg ttttctgttg ttctctgtgt gtcttttccc cttttgcctg
     8461 ggggcggggg ctggagggga acatacctct tatctacatc actcgggtct catgtctgaa
     8521 gggcctgtct cacctgccac ctacctggcc ttggcctcga catctgagcg cctcatcacc
     8581 tcctctccac atgcccaggg gtgcccctcc caaggctggc tgggcaggtc ccacggacta
     8641 ggccccagga ggagcagtgg gcttccccca ggaaagagca gagccagcac tgcctgccta
     8701 gggagggcac ccactaccag gcatggctgg tggctccgtt taaagaaatc tttgtccatg
     8761 tgggagtggg aggtgcttcc ccatcctgcc tggaagccac gtcctggctc ttaccgtgga
     8821 ctctgcaaca gccgtggtgg ccacatgaag atggaggaac ctggtggctc aggggcccct
     8881 gatgtcaccg cctccaaggc aacgggactg ggcagggcag ctcctcagga aggatgatcc
     8941 cacctgcacg ggtcagccct gcagggggac aaggcccacc acaaccccac ctcaggccac
     9001 caactggacc tgtcctgcca agaaggtccc ttccaatttg tccggcagct ggttccctgg
     9061 atacagccca gacgcagcat catcctcatg ttcacctctg ctgtgcccta cttcccccgt
     9121 aaatgacaac tgtgtagtca cccacgccgg gcaagagaac ataggtgcca cctggcgggc
     9181 cacacttttc aggggccgtg cctcgggcag gcccggctct ctgttgtccc gcagccctca
     9241 gggctggcgg tggctgctca gtgcctaggg agtgcccttg ccacacagct gggcagcgag
     9301 catgactcag cgtttacact caaccagccg cacaggctcc agaggggaag ttctctgggg
     9361 tccttctatg agagagcatc ctgtctgcag ccctgttctg gctccttcca catcattcat
     9421 gcattcatcc cacgaggact atggtaccgt gggctcgctc tagggaagca aggcaggagc
     9481 gcactggggc tacttggatt cccggggcag acacatatgt accctgcaca ccctcaaatg
     9541 agcaaagcca ccccactggc ccctgggtga ggccatgtgg acccccacac ctttggggcc
     9601 ggctgggcaa accttgaacc cccaatttct gcgtggcctt tggctgccct ccttctccaa
     9661 ggcgtgactc ttactccaga gactcaggcg agcacgtgtc ccttacctta ttttctctca
     9721 atcaaactga aacccattgt gatcccccat agtccagtgc ggtctctgtt attattacgg
     9781 gtgtctccct tcctccccgt gcccaggaca ggccatgagc cagagataca aggggcccca
     9841 ggcaagatgc agggctctct gctcctggct ctttatcgtc gtcgggacac cctttgtcca
     9901 aactcaagga atcccgggag gtctggcttt gccgctttgg ctgggactca ggtacctggg
     9961 catacctgca tctgtgcccc ctcttcgtcc cagtgagacg gaccctcagt atccccccca
    10021 acatagaaca ggaaggtctc aagccagccc cctcctccag ttcaatcacc ctccctcaca
    10081 tccacccaga gaagtccaga cctgtggcca cttccatgcc ctctccagac caggagacac
    10141 ctgctgctga cctcgtggaa aacttagatt ttgacattct gatgcttcgg aagtggtggc
    10201 tcctcctcct tcacccctcc gccacctgtg ggcctcctct ctgcatctca agagaacaac
    10261 cagatctttg ggctcctggg gtgtgtgcca tgcaatttag acgaagtgct ttgaaaatat
    10321 gccattcagt ctctgactag gaaaataagt ctgacctgat aggtccgatg tcatcagctc
    10381 ttcaacatga gacaaaagag gggattttat gttttgagtc attagaatga tataataatt
    10441 ttctgaattg acatctggat gttgaaatta ggatggtgca aaaggggtcc agggcctcag
    10501 gctgggcgca gcagccagct cccaatgacg cagaagctgc ttcaaaaccc cctcaacaaa
    10561 gaggggcaca tgcaagtcac caaagtggga agccttcacc aaggccacac ccaaagtcta
    10621 ctgattgtct gtccaaagtt cgttgattcc tggccatgaa caagcacaat agaaaaagac
    10681 acagggtcct agtggctaca agtcaatgtg aattggcaca tggtctagca gttttaaaat
    10741 ctgacagtag agtatggcaa tgggcaaggg ccaagaagtc ctgagatggg aggtcagcgc
    10801 tctaactggg ctcagtggag gtctgtgacc agtgtctgga cactagctac aggggaccgg
    10861 gcagaggatt ctgggcagaa ggaaaatgtc taaaagtact ttgggagggt aaaggacagg
    10921 ggccttattt aaaataaaga ctgaaggata ataagtgtca
//
