LOCUS       NM_018201               3855 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens TBC1 domain family member 13 (TBC1D13), transcript
            variant 1, mRNA.
ACCESSION   NM_018201
VERSION     NM_018201.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3855)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3855)
  AUTHORS   Shin,S.Y., Fauman,E.B., Petersen,A.K., Krumsiek,J., Santos,R.,
            Huang,J., Arnold,M., Erte,I., Forgetta,V., Yang,T.P., Walter,K.,
            Menni,C., Chen,L., Vasquez,L., Valdes,A.M., Hyde,C.L., Wang,V.,
            Ziemek,D., Roberts,P., Xi,L., Grundberg,E., Waldenberger,M.,
            Richards,J.B., Mohney,R.P., Milburn,M.V., John,S.L., Trimmer,J.,
            Theis,F.J., Overington,J.P., Suhre,K., Brosnan,M.J., Gieger,C.,
            Kastenmuller,G., Spector,T.D. and Soranzo,N.
  CONSRTM   Multiple Tissue Human Expression Resource (MuTHER) Consortium
  TITLE     An atlas of genetic influences on human blood metabolites
  JOURNAL   Nat Genet 46 (6), 543-550 (2014)
   PUBMED   24816252
REFERENCE   3  (bases 1 to 3855)
  AUTHORS   Davey,J.R., Humphrey,S.J., Junutula,J.R., Mishra,A.K.,
            Lambright,D.G., James,D.E. and Stockli,J.
  TITLE     TBC1D13 is a RAB35 specific GAP that plays an important role in
            GLUT4 trafficking in adipocytes
  JOURNAL   Traffic 13 (10), 1429-1441 (2012)
   PUBMED   22762500
REFERENCE   4  (bases 1 to 3855)
  AUTHORS   Ishibashi,K., Kanno,E., Itoh,T. and Fukuda,M.
  TITLE     Identification and characterization of a novel Tre-2/Bub2/Cdc16
            (TBC) protein that possesses Rab3A-GAP activity
  JOURNAL   Genes Cells 14 (1), 41-52 (2009)
   PUBMED   19077034
REFERENCE   5  (bases 1 to 3855)
  AUTHORS   Yoshimura,S., Egerer,J., Fuchs,E., Haas,A.K. and Barr,F.A.
  TITLE     Functional dissection of Rab GTPases involved in primary cilium
            formation
  JOURNAL   J Cell Biol 178 (3), 363-369 (2007)
   PUBMED   17646400
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL441992.17.
            
            On Nov 23, 2018 this sequence version replaced NM_018201.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.149220.1,
                                           SRR1660807.66384.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372648.10/ ENSP00000361731.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-124               AL441992.17        87839-87962
            125-198             AL441992.17        88920-88993
            199-239             AL441992.17        91321-91361
            240-301             AL441992.17        91966-92027
            302-401             AL441992.17        92180-92279
            402-484             AL441992.17        93078-93160
            485-644             AL441992.17        97641-97800
            645-855             AL441992.17        103836-104046
            856-1019            AL441992.17        104542-104705
            1020-1180           AL441992.17        106445-106605
            1181-1238           AL441992.17        106840-106897
            1239-3855           AL441992.17        108400-111016
FEATURES             Location/Qualifiers
     source          1..3855
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.11"
     gene            1..3855
                     /gene="TBC1D13"
                     /note="TBC1 domain family member 13"
                     /db_xref="GeneID:54662"
                     /db_xref="HGNC:HGNC:25571"
                     /db_xref="MIM:616218"
     exon            1..124
                     /gene="TBC1D13"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..1304
                     /gene="TBC1D13"
                     /note="isoform a is encoded by transcript variant 1;
                     epididymis secretory sperm binding protein"
                     /codon_start=1
                     /product="TBC1 domain family member 13 isoform a"
                     /protein_id="NP_060671.3"
                     /db_xref="CCDS:CCDS6911.1"
                     /db_xref="GeneID:54662"
                     /db_xref="HGNC:HGNC:25571"
                     /db_xref="MIM:616218"
                     /translation="MSSLHKSRIADFQDVLKEPSIALEKLRELSFSGIPCEGGLRCLC
                     WKILLNYLPLERASWTSILAKQRELYAQFLREMIIQPGIAKANMGVSREDVTFEDHPL
                     NPNPDSRWNTYFKDNEVLLQIDKDVRRLCPDISFFQRATDYPCLLILDPQNEFETLRK
                     RVEQTTLKSQTVARNRSGVTNMSSPHKNSVPSSLNEYEVLPNGCEAHWEVVERILFIY
                     AKLNPGIAYVQGMNEIVGPLYYTFATDPNSEWKEHAEADTFFCFTNLMAEIRDNFIKS
                     LDDSQCGITYKMEKVYSTLKDKDVELYLKLQEQNIKPQFFAFRWLTLLLSQEFLLPDV
                     IRIWDSLFADDNRFDFLLLVCCAMLMLIREQLLEGDFTVNMRLLQDYPITDVCQILQK
                     AKELQDSK"
     exon            125..198
                     /gene="TBC1D13"
                     /inference="alignment:Splign:2.1.0"
     exon            199..239
                     /gene="TBC1D13"
                     /inference="alignment:Splign:2.1.0"
     exon            240..301
                     /gene="TBC1D13"
                     /inference="alignment:Splign:2.1.0"
     exon            302..401
                     /gene="TBC1D13"
                     /inference="alignment:Splign:2.1.0"
     exon            402..484
                     /gene="TBC1D13"
                     /inference="alignment:Splign:2.1.0"
     exon            485..644
                     /gene="TBC1D13"
                     /inference="alignment:Splign:2.1.0"
     exon            645..855
                     /gene="TBC1D13"
                     /inference="alignment:Splign:2.1.0"
     exon            856..1019
                     /gene="TBC1D13"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1180
                     /gene="TBC1D13"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1238
                     /gene="TBC1D13"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..3855
                     /gene="TBC1D13"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3829..3834
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TBC1D13"
                     /note="hexamer: AATAAA"
     polyA_site      3855
                     /gene="TBC1D13"
                     /note="major polyA site"
ORIGIN      
        1 gcgcagagcc ccgcgtccct ggggggcggc ggcggcggcg gcagcgcagg cggcagaggc
       61 gcaggcggcg gaggcggctg gggggtccgg aagtcaacac catgtcaagt ctgcacaaga
      121 gccgaattgc agatttccag gatgtcctga aggagccctc aattgcattg gaaaagctgc
      181 gggaactcag ctttagtggc atcccctgtg agggcggact gcggtgcctc tgctggaaga
      241 ttctcttgaa ctaccttccc ttggagagag cctcatggac ctccatcctg gccaagcaga
      301 gggagctgta tgcccagttc ctgagggaaa tgatcatcca gcctggcatt gccaaggcca
      361 acatgggtgt gtccagggag gatgtgactt ttgaggacca tccactcaac cccaaccctg
      421 acagccggtg gaacacgtac ttcaaggaca acgaggtgct gctgcagatc gacaaagatg
      481 tccggaggtt gtgcccagac atttccttct tccagagggc cactgactac ccttgcctcc
      541 tcatcctgga cccccagaat gagtttgaaa cccttcgtaa gagagtggaa cagacaacac
      601 tgaaatctca gacggtggcc cggaaccgga gtggggtcac aaatatgagc tccccacaca
      661 agaactctgt gccatcatcc ctaaatgagt atgaggtgct gcccaatggc tgtgaggccc
      721 actgggaggt ggtggagcgg atcctgttca tctacgccaa gctcaaccct ggcatcgctt
      781 atgtgcaagg catgaatgaa atcgtggggc ccctctacta cacctttgcc accgacccca
      841 atagtgagtg gaaagagcac gccgaggcag acaccttttt ctgcttcacc aacctcatgg
      901 ccgagatccg ggacaacttt atcaagagcc tggatgactc gcagtgtggc atcacctaca
      961 agatggagaa ggtttactcc accttgaaag ataaggatgt ggagctctac ctgaaactgc
     1021 aagagcagaa catcaagcct cagttctttg ccttccgctg gctgacactg ctgctgtccc
     1081 aggagttctt gctgcctgac gtcatccgca tctgggactc cctcttcgcc gatgacaacc
     1141 gctttgactt cctcctcctc gtctgctgcg ccatgctcat gctgatccgg gagcagttgc
     1201 tggaagggga cttcactgtg aatatgcggc tgctgcagga ctaccccatc acagatgtct
     1261 gccagatcct gcagaaagcc aaggagctcc aagactcaaa gtagcccggc ggcaagaggc
     1321 ccatgttccg gagagaagcc tcccgaccct gtgccctggc tcccgggaca catagaaacc
     1381 tgtaggaacc cagcctgagg ggaagccaca ggatcggccc gagacccagg ccatgcccac
     1441 tggggacaca ctgtgccgtg ctccttctgc cgccacgccc agctccccac ctgccctgca
     1501 ctctgccctc tttgcccagg atactgagga gggctggagc tcgggaagtt gtccttcctg
     1561 ggccagggcc gtttctggca ctgggaggct ggcaggggcc cctccctgcc tcggctctgc
     1621 cgccccagcc tcagttcctg cttctggtct tctcctgggc tccactcagg ggaggtgctt
     1681 ggccaatggg ccagaaaccg cttctgagcg gggcacttcg gctgctccac agggaaggcg
     1741 acactgaaag ctgagtcctg ccgtctgtct cacccacaga tgtctgtagt cggtcggtgt
     1801 gaatgtgggc ccaagtcccc aggcatcttc tccgtgtgtg tgtgtgtgtg tgtgtgtgtg
     1861 tgtgtgtgtg tgtgtgtgtg ttagggagtg agggtctctc aggcctccag gtctcccagc
     1921 ccctccttct ctgtctctac ctctctgcct gtctccttcc acctccttcc cagagtggga
     1981 ctgtgtcttg cttcatgatt cctctctcca ttactctccc tgcccttctc tgttggggtg
     2041 ccttatcctg agccacctcc tctccccgct tgcctctgct cccctgaacc tgggagacag
     2101 atgaggagac tggctcagca aggcccctgg aggtcaagct tggcctttgc ctcctgttcc
     2161 catcccccag ccctggctcc taggtcctcc caactgggag ggagtcctcc gtgcctcact
     2221 tagagggttc tgaacccgtt ccctacacag aaatcttgga aaccaaatgc tgctgagtaa
     2281 ggatgaagct ttgagcctcc tgcccctgct ttctgcccag ggagggagaa ggaagagggg
     2341 gagctggttt ttctggaggt tcccccagag gccctcctgt ccgaaaagaa aaggaccttg
     2401 attctgagcc cagggtcgga acccattgct tcagaagagt tgtcattccc tcggcttcca
     2461 ggtcccaacc cagggttggg ttgagtgagt cccacaaagg gcaagtgggg cccgaggaag
     2521 cctctctggg gccaggggta gctgagctta aaggccctgg gtcctgccag ttccaggagg
     2581 gccatgtctg tgcctctgtg tacccctcca cccgctgcgg gctgagggag gtgcagggcc
     2641 ttctctgacc cctgcctgag ctgttcccag ggctggagca ggtgtaccct gagcaggggc
     2701 agctggccac tcccagttct caccaagtca cctccctcct tgtacaaggt ttgcgtccgg
     2761 aagccgggtg ccatagtgag gaccctcgtc ctccagactg gctggcagga gtcaggcccc
     2821 agcagccctc ctgcccccaa agctttccga gtctggtggg caggacttct cgctgccctt
     2881 ccaagcccgg ctttgggcca ggaaaggctt ccccaggtgg ctcttctacc aggcttttcc
     2941 tttgatgccg cctggatttc cgcacctgcc tgtctcctct cccagagcac agtatttggg
     3001 agactttgac tatttattca gactcctggc tatgtattgc acattggcaa gtgctctggg
     3061 gatgaggcat gggtatagga agggagaaag gagttggaga caagatcctc ttcattttcc
     3121 aagatcaaag tcagcctctt ctccccatgc ttctaggaac tgcctggttt tcgagcaggt
     3181 cctggctgag cgggctctga gttctgtact ggaattgagt gtaaagatgg gaagagaact
     3241 gggctgactc caggacctcc aggatgaggc agaggcatga tgcttcctgc tcacctgggc
     3301 caccctctct ccaggacttg tcagctggtg gttcagcccc ttctccaacc ccttcataag
     3361 cttgggccac tgcctgggac ccagcagaca ctgcccagga ctctttagtg cactcactct
     3421 tgtctgcccc ctaccttccc tcctggaacc acactacttg aatcaccatt actttgcctc
     3481 gctggcagag ttgggtcaag tgccctctcc ttgaccttga gatgaaggtc aagagcacag
     3541 ggaccaggcc ttggttaggc tgagctccca gcaggacacc gcctgcagaa aggacctgcc
     3601 ctgataatgt cccttcccca gattctcaag cagatgccca agggaggtcc ccacagagcc
     3661 agagtgcctg aggcttcctg cttgagaacc tgccccctgg atcttggaca cttacagatt
     3721 gagctgtatg aattcagcgg gtctcactcc agagggtcag aacgtttgct ttagtttttt
     3781 catctgtttt gttccttgag tcagtgctgt tgatgacgag ttgtcttgaa taaatcatgt
     3841 gttctttgca atggg
//
