LOCUS       NM_015188               5637 bp    mRNA    linear   PRI 10-FEB-2024
DEFINITION  Homo sapiens TBC1 domain family member 12 (TBC1D12), mRNA.
ACCESSION   NM_015188 XM_051081 XM_937729
VERSION     NM_015188.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5637)
  AUTHORS   Ishibashi,K., Kanno,E., Itoh,T. and Fukuda,M.
  TITLE     Identification and characterization of a novel Tre-2/Bub2/Cdc16
            (TBC) protein that possesses Rab3A-GAP activity
  JOURNAL   Genes Cells 14 (1), 41-52 (2009)
   PUBMED   19077034
REFERENCE   2  (bases 1 to 5637)
  AUTHORS   Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
            French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
            Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
            Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
            Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
            Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
            Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
            Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
            Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
            Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
            Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
            Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
            Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
            Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
            Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
            Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
            Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
            Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
            Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
            Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
            Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
            Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
            Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
            Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
            Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA808973.1, AB011180.1 and AL138759.20.
            
            On May 17, 2019 this sequence version replaced NM_015188.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB011180.1, AB449898.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000225235.5/ ENSP00000225235.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-450               DA808973.1         113-562
            451-2535            AB011180.1         379-2463
            2536-5637           AL138759.20        54101-57202
FEATURES             Location/Qualifiers
     source          1..5637
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q23.33"
     gene            1..5637
                     /gene="TBC1D12"
                     /note="TBC1 domain family member 12"
                     /db_xref="GeneID:23232"
                     /db_xref="HGNC:HGNC:29082"
                     /db_xref="MIM:620003"
     exon            1..1044
                     /gene="TBC1D12"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..2401
                     /gene="TBC1D12"
                     /codon_start=1
                     /product="TBC1 domain family member 12"
                     /protein_id="NP_056003.1"
                     /db_xref="CCDS:CCDS41553.1"
                     /db_xref="GeneID:23232"
                     /db_xref="HGNC:HGNC:29082"
                     /db_xref="MIM:620003"
                     /translation="MVGPEDAGACSGRNPKLLPVPAPDPVGQDRKVIRATGGFGGGVG
                     AVEPPEEADEEEEADEEEETPPRQLLQRYLAAAGEQLEPGLCYCPLPAGQAGAPPPSA
                     APRSDACLLGSGSKHRGAEVADGRAPRHEGMTNGDSGFLPGRDCRDLEEARGLARAGG
                     RESRRRRPYGRLRLEGPGDEDADGAGSPSDWASPLEDPLRSCCLVAADAQEPEGAGSD
                     SGDSPASSCSSSEDSEQRGVGAGGPEEGAPPATSAERTNGGAEPRLGFSDIHFNSRNT
                     FQVSRGQSARDHLPPAGPPVPLPAAEQGPAGASARARRSGGFADFFTRNLFPKRTKEL
                     KSVVHSAPGWKLFGKVPPRENLQKTSKIIQQEYEARTGRTCKPPPQSSRRKNFEFEPL
                     STTALILEDRPSNLPAKSVEEALRHRQEYDEMVAEAKKREIKEAHKRKRIMKERFKQE
                     ENIASAMVIWINEILPNWEVMRSTRRVRELWWQGLPPSVRGKVWSLAVGNELNITPEL
                     YEIFLSRAKERWKSFSETSSENDTEGVSVADREASLELIKLDISRTFPSLYIFQKGGP
                     YHDVLHSILGAYTCYRPDVGYVQGMSFIAAVLILNLEEADAFIAFANLLNKPCQLAFF
                     RVDHSMMLKYFATFEVFFEENLSKLFLHFKSYSLTPDIYLIDWIFTLYSKSLPLDLAC
                     RVWDVFCRDGEEFLFRTGLGILRLYEDILLQMDFIHIAQFLTKLPEDITSEKLFSCIA
                     AIQMQNSTKKWTQVFASVMKDIKEGDKNSSPALKS"
     exon            1045..1168
                     /gene="TBC1D12"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1284
                     /gene="TBC1D12"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1367
                     /gene="TBC1D12"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1485
                     /gene="TBC1D12"
                     /inference="alignment:Splign:2.1.0"
     exon            1486..1592
                     /gene="TBC1D12"
                     /inference="alignment:Splign:2.1.0"
     exon            1593..1673
                     /gene="TBC1D12"
                     /inference="alignment:Splign:2.1.0"
     exon            1674..1762
                     /gene="TBC1D12"
                     /inference="alignment:Splign:2.1.0"
     exon            1763..1834
                     /gene="TBC1D12"
                     /inference="alignment:Splign:2.1.0"
     exon            1835..1963
                     /gene="TBC1D12"
                     /inference="alignment:Splign:2.1.0"
     exon            1964..2073
                     /gene="TBC1D12"
                     /inference="alignment:Splign:2.1.0"
     exon            2074..2332
                     /gene="TBC1D12"
                     /inference="alignment:Splign:2.1.0"
     exon            2333..5637
                     /gene="TBC1D12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5213..5218
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TBC1D12"
                     /note="hexamer: AATAAA"
     polyA_site      5235
                     /gene="TBC1D12"
                     /note="major polyA site"
     regulatory      5501..5506
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TBC1D12"
                     /note="hexamer: ATTAAA"
     polyA_site      5533
                     /gene="TBC1D12"
ORIGIN      
        1 agagctgttc tctggccaag cctgcgcctg tagtccttct ttgcctcctg gggcggccgc
       61 cacccacccc cagatggtgg gtccggagga tgccggagcc tgctcgggaa gaaaccccaa
      121 gttgctcccg gtgcctgcgc cggaccccgt gggccaggac aggaaggtaa tccgggccac
      181 gggcggcttt ggcggaggcg tcggcgctgt ggagccgccg gaggaggctg acgaggagga
      241 ggaggctgac gaggaggagg agacgccgcc tcggcagctc cttcagcgtt acctcgcggc
      301 ggccggggag cagctggagc cggggctctg ctactgtccg ctccccgctg gccaggccgg
      361 cgccccgccg ccctcggcag ccccacgatc ggacgcctgc ctgctgggct cgggctccaa
      421 acaccgcggc gcggaggtgg ctgatggccg cgcgccgcgg cacgaaggca tgaccaacgg
      481 cgactcgggt tttctgccgg gccgggactg tcgcgatctg gaagaggctc gcgggctggc
      541 gcgcgccggc ggccgggagt cgcgccgccg ccgcccctac ggccgccttc gcctggaggg
      601 gcctggcgac gaggacgcgg acggcgcggg aagcccgtcc gattgggcct ctccgcttga
      661 ggacccgctg cggagctgct gcctggtggc cgcggacgcc caggagcccg agggcgcggg
      721 cagcgactcg ggggacagcc ccgccagcag ctgcagcagt agcgaggact cagagcagcg
      781 gggagtcggc gccgggggtc ccgaggaggg cgcgccccct gccacctcgg ccgagaggac
      841 taatgggggt gcggagccgc gcctgggctt ttctgacatt cacttcaact ctcgcaacac
      901 gttccaggtg agccgcggtc agagcgcccg cgatcacctg cccccggcgg ggccgccggt
      961 gcccttgccc gccgcggagc agggtcctgc gggggcttcg gcccgggctc gacggagtgg
     1021 cggcttcgcg gacttcttca ccagaaacct ttttccaaaa aggacaaagg aactcaaatc
     1081 agttgtccat agtgctcctg gttggaaatt atttggtaaa gtccctccta gagagaatct
     1141 tcagaaaaca tccaaaatca ttcagcagga atatgaagca cgaacgggga ggacctgtaa
     1201 accaccacct cagtcttcaa gacgcaagaa ttttgaattt gagccgcttt ctaccactgc
     1261 cttgattctt gaggatcgac catcaaatct tcctgccaaa tctgtggaag aagctttacg
     1321 tcaccgacaa gaatacgatg agatggtggc tgaggctaaa aaacgagaaa ttaaggaagc
     1381 acataaaaga aaaagaatca tgaaagaacg atttaagcag gaagaaaata ttgcaagtgc
     1441 aatggtaatt tggatcaatg aaatactgcc caattgggaa gtaatgcgta gtacaagaag
     1501 agttcgagaa ttgtggtggc agggattgcc ccctagtgtc cgtgggaaag tttggagtct
     1561 agctgtagga aatgaactaa atatcactcc tgaactttat gaaatcttcc tctcaagagc
     1621 aaaagaacgg tggaaaagtt tcagtgaaac aagttcagag aatgatacag aaggtgtatc
     1681 tgttgctgat cgagaggcca gtctggaatt aattaagttg gacatatccc gtacatttcc
     1741 atctctctac atctttcaga agggtggtcc atatcatgat gtcttgcata gtattttagg
     1801 ggcatacaca tgctacaggc ctgatgttgg ttatgtccaa gggatgtcct tcattgcagc
     1861 agtactcatt ctcaatttgg aagaggcaga tgcctttatc gcatttgcca atctcctgaa
     1921 taagccatgc cagttggcct tttttcgtgt ggatcacagc atgatgttga aatattttgc
     1981 aacatttgaa gtattctttg aagaaaatct ttccaaatta tttcttcact tcaaatctta
     2041 cagtcttaca ccagatatat acttgataga ctggatcttc acactatata gcaaatcact
     2101 accacttgat ctggcctgtc gagtctggga tgtattttgc agagatgggg aagaattttt
     2161 atttaggact ggattaggaa tcctccgatt atatgaagat attctcctgc agatggactt
     2221 tattcatata gcacagtttc taactaaatt gccagaagat atcacatcgg aaaagctgtt
     2281 cagttgtatt gcagccattc agatgcagaa tagcaccaaa aaatggactc aggtctttgc
     2341 atctgtaatg aaggatatta aagaaggaga caagaacagt agtcctgctt tgaaaagcta
     2401 gtcttcaaaa ttgacagact aactgacata gaaaaagtgg tttttggata aaggtttttt
     2461 gtttcctatg taaaaggcgt ggaagaaaat gttggagata cctaaaagaa tcaagaggtg
     2521 gaaaactgct gattttacat tttatggctg aagtaaatga aataagtaac ttattgacag
     2581 tattaataaa ctattatttt gtaggtagag tcatttttca aaggaaaaag tttaagtggt
     2641 gagtttatat tccacaattt ggagtaaaca aaatgcaata aatttttaaa atagctttga
     2701 agatacttca aatttttaca tcttttcttt tgtaacagtt accacaaaga tattctggag
     2761 gctagagtag gattgttaaa tactactgtt aacctccaaa gtactatagt acagacattg
     2821 tttccagttc tgaccttttg aagatattat agaccagtaa tgaacagatt tggttgtaaa
     2881 ttatttaagt cactgaagat gtcatttatc ttcattcaca agttggggca aattcgagtt
     2941 acctaggaac tggaaatgtt ggtgggagat tgtttattgt ttgtttagat gtttttccat
     3001 agtatggtgt ccatttgttt tttaagggaa attttttgtc ttccttaagg aattcctatc
     3061 actcagagaa ttttagccat tctggttcta gtctaacaaa ttattcatct aataatttga
     3121 cattaagaaa actataaata actggtagaa ggaaagtgct ttgcacttca gtggattgaa
     3181 gacttgactt tgagagtaag tccaaaaaca tatatgatgt ttctcagtga taagagtaaa
     3241 aagtaatgaa tcctgagagt tcttaaacag catgctactt ggcaagactt catatttttt
     3301 agttacaatt cttccactgt ttaactccag tttgaaattt gaaatctaat atgtagctaa
     3361 atctgtgact tgtaaaactc tatgcataat ttttcctaat cagtggaaat aagaataaaa
     3421 gaaaaaggta aagttaattt tttttctaag tctacatcct atctcttgat tcagttgcct
     3481 gaagaagctg ggtaaggaga ttagtcttgt tattgattct tttatgtgtc agtgccatct
     3541 taatctcttc acatggtaca ctaaatgctg cctataaccc atcctcatct tctttactca
     3601 tcattgcttt cttcaaggaa ggtcttgata ctgccctcgt ctacctcact atccgctagt
     3661 ctagatagtg actctttgga aaattggtag cctctgaatg agttatccaa cttctgcttc
     3721 ctcacattgg ccactttgca taggttcggg aacttagcag gttttaaatc atcatgccca
     3781 tggaggtgaa atactttgag gaatgggaac atctcttcac tgtgtttttg gatcagcctt
     3841 ctctcaaccg ccaagaaatg catgatttcc ctgccaactc taggaagtag tgctgcatga
     3901 ttgaatcatt atttgatgaa ttctttcatt gtaacatagg gagtcatttt caaaaaggta
     3961 gatatgaact taaattaaat tgacttatga atgctttgcc tgtgggccca acagtgtcat
     4021 gaccctccaa ttgaaacata gcatgaatta tttttatgtc gagttcttga actgctaatc
     4081 aggtgtgtgt ttccttgaag tccagagcag gatccaggtc agatgaagga ggtggtatgc
     4141 ctggcttaac tgctgaaaat agagcattga aactcttcac aatgtgctgc attgggtttc
     4201 tgcttggctt tctcactgaa aagtaaattg gggaaaatgc tgcttttact attttgcatt
     4261 ttatagcaac attaacagtc ttttcccagt caggtgctgt ccagggaaca tgtttccctt
     4321 gggaggtctg aacagagtga cctggcttga tgtatttcct gagctctagt accatatcat
     4381 agaattagtt aaatgtagtc aacagcaatg tcagaacaat tgacattgtc tttccaagag
     4441 tgaatgcatt ggctttcgga actgctacta gagacataca tgaggcagcg aacacatctt
     4501 taggtggggg caaggctata tctgattgac agagatctct gatctctaat gacatattgc
     4561 tattgtccta ttatgtttaa atttgaacct aaatcacttg agtgttatga gtgatggcta
     4621 tataacatgc tgtttggtta gatttacagt gtgtttttat gttgcagttt agtttgaaac
     4681 aacacttaag cacactattt ctgttagtgt atatagtttt caaactaaca agcctgcgat
     4741 ccttgttagt gtagtgactg cctctttagg agtatggggc cctagggtgt ccatatattt
     4801 ttaccccatg ggtcattcta gtctaaggac tactagtaga accctcaaaa ggtaattgct
     4861 attataggga cttacttatt ggagactggt aatataataa aatattgaag gagtggccat
     4921 ggtcttagca ggttttagaa tgacctttta actccagtaa ctacttcctt ggtattggta
     4981 tccttgatag agggaatata acatctggca gtaatctcat tcaggttata ctacctgact
     5041 aaatttaatc atactttcat gtatttgttt cctcagttgg acctaagtta ctgtatttgt
     5101 ttttcttatt tttttattat tgtacagttt ctttaccttt caagtataaa tgtgtatata
     5161 aaatgtaaat acaaagaatt cactaaaaac cactcataac aattactgtg taaataaaac
     5221 tggtaagcag agtaattact tgaaatgagt cttcattact ttggggatat ctgttttatt
     5281 taactgcatc tcaaggaaac aaaggaaata atctttgttt ttgtttgcca aatttgtctt
     5341 ccaaggaatg cactaagcct tcagtctttt tagactgaca gtactggcag ctaaaatatt
     5401 gtactgtatc ttctcttgag cccagtatgt aggaaatatg tgataattca catggtcagt
     5461 atatggcagt ttttgttgtt gttgttacag tatattttca attaaaaaaa aacttttcct
     5521 aaaatactca aaataatgtg aaatttaata tggtgtttca tttgtttgtc tactcaatat
     5581 atatatttct tacttaatgt tcctttagtc caggtctaca atgccttatt taaatgc
//
