LOCUS       NM_001369496            1796 bp    mRNA    linear   PRI 04-OCT-2024
DEFINITION  Homo sapiens TBC1 domain family member 10C (TBC1D10C), transcript
            variant 7, mRNA.
ACCESSION   NM_001369496
VERSION     NM_001369496.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1796)
  AUTHORS   Qiao,H., Lv,R., Pang,Y., Yao,Z., Zhou,X., Zhu,W. and Zhou,W.
  TITLE     Weighted Gene Coexpression Network Analysis Identifies TBC1D10C as
            a New Prognostic Biomarker for Breast Cancer
  JOURNAL   Anal Cell Pathol (Amst) 2022, 5259187 (2022)
   PUBMED   35425695
  REMARK    GeneRIF: Weighted Gene Coexpression Network Analysis Identifies
            TBC1D10C as a New Prognostic Biomarker for Breast Cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1796)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1796)
  AUTHORS   Jiang,W., Zhou,X., Li,Z., Liu,K., Wang,W., Tan,R., Cong,X.,
            Shan,J., Zhan,Y., Cui,Z., Jiang,L., Li,Q., Shen,S., Bai,M.,
            Cheng,Y., Li,B., Tan,M., Ma,D.K., Liu,J.O. and Dang,Y.
  TITLE     Prolyl 4-hydroxylase 2 promotes B-cell lymphoma progression via
            hydroxylation of Carabin
  JOURNAL   Blood 131 (12), 1325-1336 (2018)
   PUBMED   29437589
  REMARK    GeneRIF: identify prolyl 4-hydroxylase 2 (P4HA2) as a specific
            proline hydroxylase of Carabin. Carabin hydroxylation leads to its
            proteasomal degradation, thereby activating the Ras/extracellular
            signal-regulated kinase pathway and increasing B-cell lymphoma
            proliferation.
REFERENCE   4  (bases 1 to 1796)
  AUTHORS   Schickel,J.N., Pasquali,J.L., Soley,A., Knapp,A.M., Decossas,M.,
            Kern,A., Fauny,J.D., Marcellin,L., Korganow,A.S., Martin,T. and
            Soulas-Sprauel,P.
  TITLE     Carabin deficiency in B cells increases BCR-TLR9
            costimulation-induced autoimmunity
  JOURNAL   EMBO Mol Med 4 (12), 1261-1275 (2012)
   PUBMED   23109291
  REMARK    GeneRIF: Carabin as a new negative regulator of B-cell function,
            whose deficiency in B cells speeds up early B-cell responses
REFERENCE   5  (bases 1 to 1796)
  AUTHORS   Hsu,C., Morohashi,Y., Yoshimura,S., Manrique-Hoyos,N., Jung,S.,
            Lauterbach,M.A., Bakhti,M., Gronborg,M., Mobius,W., Rhee,J.,
            Barr,F.A. and Simons,M.
  TITLE     Regulation of exosome secretion by Rab35 and its GTPase-activating
            proteins TBC1D10A-C
  JOURNAL   J Cell Biol 189 (2), 223-232 (2010)
   PUBMED   20404108
REFERENCE   6  (bases 1 to 1796)
  AUTHORS   Datta,D., Contreras,A.G., Basu,A., Dormond,O., Flynn,E.,
            Briscoe,D.M. and Pal,S.
  TITLE     Calcineurin inhibitors activate the proto-oncogene Ras and promote
            protumorigenic signals in renal cancer cells
  JOURNAL   Cancer Res 69 (23), 8902-8909 (2009)
   PUBMED   19903851
REFERENCE   7  (bases 1 to 1796)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 1796)
  AUTHORS   Yoshimura,S., Egerer,J., Fuchs,E., Haas,A.K. and Barr,F.A.
  TITLE     Functional dissection of Rab GTPases involved in primary cilium
            formation
  JOURNAL   J Cell Biol 178 (3), 363-369 (2007)
   PUBMED   17646400
REFERENCE   9  (bases 1 to 1796)
  AUTHORS   Fuchs,E., Haas,A.K., Spooner,R.A., Yoshimura,S., Lord,J.M. and
            Barr,F.A.
  TITLE     Specific Rab GTPase-activating proteins define the Shiga toxin and
            epidermal growth factor uptake pathways
  JOURNAL   J Cell Biol 177 (6), 1133-1143 (2007)
   PUBMED   17562788
REFERENCE   10 (bases 1 to 1796)
  AUTHORS   Pan,F., Sun,L., Kardian,D.B., Whartenby,K.A., Pardoll,D.M. and
            Liu,J.O.
  TITLE     Feedback inhibition of calcineurin and Ras by a dual inhibitory
            protein Carabin
  JOURNAL   Nature 445 (7126), 433-436 (2007)
   PUBMED   17230191
  REMARK    GeneRIF: Carabin is a negative feedback inhibitor of the
            calcineurin signalling pathway that also mediates crosstalk between
            calcineurin and Ras
            GeneRIF: Carabin inhibits calcineurin and Ras and was identified by
            a yeast-two-hybrid screen with calcineurin
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP003419.3.
            
            Summary: The protein encoded by this gene has an N-terminal
            Rab-GTPase domain and a binding site at the C-terminus for
            calcineurin, and is an inhibitor of both the Ras signaling pathway
            and calcineurin, a phosphatase regulated by calcium and calmodulin.
            Genes encoding similar proteins are located on chromosomes 16 and
            22. Multiple transcript variants encoding different isoforms have
            been found for this gene. [provided by RefSeq, Jan 2013].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC036873.1, SRR1163655.476889.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000542590.2/ ENSP00000443654.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-272               AP003419.3         84548-84819
            273-372             AP003419.3         85550-85649
            373-480             AP003419.3         85864-85971
            481-587             AP003419.3         86060-86166
            588-702             AP003419.3         86368-86482
            703-768             AP003419.3         87092-87157
            769-958             AP003419.3         87292-87481
            959-1113            AP003419.3         89444-89598
            1114-1796           AP003419.3         89872-90554
FEATURES             Location/Qualifiers
     source          1..1796
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.2"
     gene            1..1796
                     /gene="TBC1D10C"
                     /gene_synonym="CARABIN; EPI64C"
                     /note="TBC1 domain family member 10C"
                     /db_xref="GeneID:374403"
                     /db_xref="HGNC:HGNC:24702"
                     /db_xref="MIM:610831"
     exon            1..272
                     /gene="TBC1D10C"
                     /gene_synonym="CARABIN; EPI64C"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..1461
                     /gene="TBC1D10C"
                     /gene_synonym="CARABIN; EPI64C"
                     /note="isoform 1 is encoded by transcript variant 7"
                     /codon_start=1
                     /product="carabin isoform 1"
                     /protein_id="NP_001356425.1"
                     /db_xref="CCDS:CCDS8162.1"
                     /db_xref="GeneID:374403"
                     /db_xref="HGNC:HGNC:24702"
                     /db_xref="MIM:610831"
                     /translation="MAQALGEDLVQPPELQDDSSSLGSDSELSGPGPYRQADRYGFIG
                     GSSAEPGPGHPPADLIRQREMKWVEMTSHWEKTMSRRYKKVKMQCRKGIPSALRARCW
                     PLLCGAHVCQKNSPGTYQELAEAPGDPQWMETIGRDLHRQFPLHEMFVSPQGHGQQGL
                     LQVLKAYTLYRPEQGYCQAQGPVAAVLLMHLPPEEAFWCLVQICEVYLPGYYGPHMEA
                     VRLDAEVFMALLRRLLPHVHKHLQQVGVGPLLYLPEWFLCLFARSLPFPTVLRVWDAF
                     LSEGARVLFRVGLTLVRLALGTAEQRGACPGLLETLGALRAIPPAQLQEEAFMSQVHS
                     VVLSERDLQREIKAQLAQLPDSAPGPPPRPQVRLAGAQAIFEAQQLAGVRRGAKPEVP
                     RIVVQPPEEPRPPRRKPQTRGKTFHGLLTRARGPPIEGPPRPQRGSTSFLDTRF"
     exon            273..372
                     /gene="TBC1D10C"
                     /gene_synonym="CARABIN; EPI64C"
                     /inference="alignment:Splign:2.1.0"
     exon            373..480
                     /gene="TBC1D10C"
                     /gene_synonym="CARABIN; EPI64C"
                     /inference="alignment:Splign:2.1.0"
     exon            481..587
                     /gene="TBC1D10C"
                     /gene_synonym="CARABIN; EPI64C"
                     /inference="alignment:Splign:2.1.0"
     exon            588..702
                     /gene="TBC1D10C"
                     /gene_synonym="CARABIN; EPI64C"
                     /inference="alignment:Splign:2.1.0"
     exon            703..768
                     /gene="TBC1D10C"
                     /gene_synonym="CARABIN; EPI64C"
                     /inference="alignment:Splign:2.1.0"
     exon            769..958
                     /gene="TBC1D10C"
                     /gene_synonym="CARABIN; EPI64C"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1113
                     /gene="TBC1D10C"
                     /gene_synonym="CARABIN; EPI64C"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1796
                     /gene="TBC1D10C"
                     /gene_synonym="CARABIN; EPI64C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1776..1781
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TBC1D10C"
                     /gene_synonym="CARABIN; EPI64C"
                     /note="hexamer: AATAAA"
     polyA_site      1796
                     /gene="TBC1D10C"
                     /gene_synonym="CARABIN; EPI64C"
                     /note="major polyA site"
ORIGIN      
        1 gagataccct gaaacctccc ccctctgacc ccgcagccag gccccaggct ggccgggagt
       61 ggcccctcac actggttctc cccactttct ctgcctgtgg catcgaaggc cccgggcacc
      121 atggcccagg ccctggggga ggacctggtg cagcctcccg agctgcagga tgactccagc
      181 tccttggggt ccgactcaga gctcagcggg cctggcccat atcgccaggc cgaccgctat
      241 ggattcattg ggggcagctc agcagagcca gggccgggcc acccacctgc agacctcatc
      301 cgccaacggg agatgaagtg ggtggagatg acctcgcact gggagaaaac catgtcccgg
      361 cggtacaaga aggtaaagat gcagtgccgg aaaggcatcc cgtctgccct gcgcgcccga
      421 tgctggcccc tgttgtgtgg ggcccatgtg tgccagaaga acagccctgg cacctatcag
      481 gagctggcag aggcccctgg agacccacag tggatggaga ccattggcag ggacctgcac
      541 cgtcaattcc ctctgcacga gatgtttgtg tcgcctcagg gccacgggca gcaggggctc
      601 ctgcaggtgc tcaaggccta caccctgtat cgaccggagc agggctactg ccaggcccag
      661 gggcccgtgg ctgctgtgct gctcatgcac ctgcccccag aggaggcctt ctggtgcctg
      721 gtgcagatct gtgaggtcta cctccctggg tactacgggc cccacatgga ggctgtgcgg
      781 ctggacgccg aggtgttcat ggccctgctg cggcggctgc ttccgcacgt gcacaagcac
      841 ctgcagcagg tgggcgtcgg acccctgctg tacctgcccg agtggttcct gtgcctcttc
      901 gcccgctccc tgcccttccc cacagtgctg cgtgtctggg atgccttcct cagtgagggt
      961 gccagagtac tgttccgtgt ggggctgaca ctggtgcgcc tggcgctggg cactgcagag
     1021 cagcgagggg cctgccctgg cctcctggag acactgggag cccttcgagc catccccccc
     1081 gcgcagctgc aggaggaggc cttcatgtca caggtgcaca gcgtggtgct gtcagagcgg
     1141 gacctgcagc gggagatcaa ggcccagctg gcccagctgc ccgattccgc gccgggaccc
     1201 ccgccccggc cacaggtccg cctcgccggg gcccaagcca tctttgaggc ccagcagctg
     1261 gcaggagtgc gacgaggcgc caagcctgag gtgcctcgga ttgtggtgca gcccccggag
     1321 gagcccagac caccgcggcg gaaaccccag acccgcggca agactttcca tgggctcctg
     1381 actcgggccc ggggcccccc catcgagggg ccccccaggc cccaacgagg ctccacctcc
     1441 ttcctggaca cccgcttctg agaggaccat ggacttagtg tcccccagtc tcaattgcct
     1501 gatggctgat gccggcccgg caaataggca ccgcacttta ctcttgggac tcggggactt
     1561 ggcttccttc ctggcaagga ccaggcagtg gggaaggagg aggtcctccg tggtacatac
     1621 tgggtcaggc actagcatgg aggagggtca cagagtgggg cacgtgagga cccatggaac
     1681 cgtcctggtg cccaggccct cacaagtacc aaagccagca ccaaaggagt cagggaaggg
     1741 gttggctgag tcaagggacc ccagagggca ccaggaataa aatcttcttg aacaga
//
