LOCUS       NM_015527               3580 bp    mRNA    linear   PRI 28-AUG-2024
DEFINITION  Homo sapiens TBC1 domain family member 10B (TBC1D10B), mRNA.
ACCESSION   NM_015527
VERSION     NM_015527.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3580)
  AUTHORS   Chi,X.J., Song,Y.B., Zhang,H., Wei,L.Q., Gao,Y., Miao,X.J.,
            Yang,S.T., Lin,C.Y., Lan,D. and Zhang,X.
  TITLE     TBC1D10B promotes tumor progression in colon cancer via
            PAK4-mediated promotion of the PI3K/AKT/mTOR pathway
  JOURNAL   Apoptosis 29 (7-8), 1185-1197 (2024)
   PUBMED   38824479
  REMARK    GeneRIF: TBC1D10B promotes tumor progression in colon cancer via
            PAK4-mediated promotion of the PI3K/AKT/mTOR pathway.
REFERENCE   2  (bases 1 to 3580)
  AUTHORS   Miller,M.R., McDermitt,D.J., Sauvanet,C., Lombardo,A.T., Zaman,R.
            and Bretscher,A.
  TITLE     The RabGAPs EPI64A and EPI64B regulate the apical structure of
            epithelial cells dagger
  JOURNAL   Mol Biol Cell 33 (1), ar8 (2022)
   PUBMED   34757852
  REMARK    GeneRIF: The RabGAPs EPI64A and EPI64B regulate the apical
            structure of epithelial cells (dagger).
REFERENCE   3  (bases 1 to 3580)
  AUTHORS   Liu,Y., Li,J., Wang,S., Song,H. and Yu,T.
  TITLE     STAT4-mediated down-regulation of miR-3619-5p facilitates stomach
            adenocarcinoma by modulating TBC1D10B
  JOURNAL   Cancer Biol Ther 21 (7), 656-664 (2020)
   PUBMED   32397798
  REMARK    GeneRIF: STAT4-mediated down-regulation of miR-3619-5p facilitates
            stomach adenocarcinoma by modulating TBC1D10B.
REFERENCE   4  (bases 1 to 3580)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 3580)
  AUTHORS   Xie,Y., Mansouri,M., Rizk,A. and Berger,P.
  TITLE     Regulation of VEGFR2 trafficking and signaling by Rab
            GTPase-activating proteins
  JOURNAL   Sci Rep 9 (1), 13342 (2019)
   PUBMED   31527750
  REMARK    GeneRIF: Regulation of VEGFR2 trafficking and signaling by Rab
            GTPase-activating proteins.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3580)
  AUTHORS   Ishibashi,K., Kanno,E., Itoh,T. and Fukuda,M.
  TITLE     Identification and characterization of a novel Tre-2/Bub2/Cdc16
            (TBC) protein that possesses Rab3A-GAP activity
  JOURNAL   Genes Cells 14 (1), 41-52 (2009)
   PUBMED   19077034
REFERENCE   7  (bases 1 to 3580)
  AUTHORS   Yoshimura,S., Egerer,J., Fuchs,E., Haas,A.K. and Barr,F.A.
  TITLE     Functional dissection of Rab GTPases involved in primary cilium
            formation
  JOURNAL   J Cell Biol 178 (3), 363-369 (2007)
   PUBMED   17646400
REFERENCE   8  (bases 1 to 3580)
  AUTHORS   Fuchs,E., Haas,A.K., Spooner,R.A., Yoshimura,S., Lord,J.M. and
            Barr,F.A.
  TITLE     Specific Rab GTPase-activating proteins define the Shiga toxin and
            epidermal growth factor uptake pathways
  JOURNAL   J Cell Biol 177 (6), 1133-1143 (2007)
   PUBMED   17562788
REFERENCE   9  (bases 1 to 3580)
  AUTHORS   Choy,K.W., Wang,C.C., Ogura,A., Lau,T.K., Rogers,M.S., Ikeo,K.,
            Gojobori,T., Lam,D.S. and Pang,C.P.
  TITLE     Genomic annotation of 15,809 ESTs identified from pooled early
            gestation human eyes
  JOURNAL   Physiol Genomics 25 (1), 9-15 (2006)
   PUBMED   16368877
REFERENCE   10 (bases 1 to 3580)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC106782.5, AI672923.1, BY795947.2 and BC072453.1.
            
            On Nov 23, 2018 this sequence version replaced NM_015527.3.
            
            Summary: Small G proteins of the RAB family (see MIM 179508)
            function in intracellular vesicle trafficking by switching from the
            GTP-bound state to the GDP-bound state with the assistance of
            guanine nucleotide exchange factors (GEFs; see MIM 609700) and
            GTPase-activating proteins (GAPs). TBC1D10B functions as a GAP for
            several proteins of the Rab family (Ishibashi et al., 2009 [PubMed
            19077034]).[supplied by OMIM, Nov 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK023192.1, BC072453.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000409939.8/ ENSP00000386538.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-293               AC106782.5         179244-179536       c
            294-316             AI672923.1         64-86
            317-981             BY795947.2         1-665
            982-3580            BC072453.1         1-2599
FEATURES             Location/Qualifiers
     source          1..3580
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p11.2"
     gene            1..3580
                     /gene="TBC1D10B"
                     /gene_synonym="EPI64B; FP2461"
                     /note="TBC1 domain family member 10B"
                     /db_xref="GeneID:26000"
                     /db_xref="HGNC:HGNC:24510"
                     /db_xref="MIM:613620"
     exon            1..1267
                     /gene="TBC1D10B"
                     /gene_synonym="EPI64B; FP2461"
                     /inference="alignment:Splign:2.1.0"
     CDS             312..2738
                     /gene="TBC1D10B"
                     /gene_synonym="EPI64B; FP2461"
                     /note="rab27A-GAP-beta; Rab27A-GAPbeta"
                     /codon_start=1
                     /product="TBC1 domain family member 10B"
                     /protein_id="NP_056342.3"
                     /db_xref="CCDS:CCDS10676.2"
                     /db_xref="GeneID:26000"
                     /db_xref="HGNC:HGNC:24510"
                     /db_xref="MIM:613620"
                     /translation="METGTAPLVAPPRRHGAPAAPSPPPRGSRAGPVVVVAPGPPVTT
                     ATSAPVTLVAPGEARPAWVPGSAETSAPAPAPAPAPAPAVTGSTVVVLTLEASPEAPK
                     PQLPSGPESPEPAAVAGVETSRALAAGADSPKTEEARPSPAPGPGTPTGTPTRTPSRT
                     APGALTAKPPLAPKPGTTVASGVTARSASGQVTGGHGAAAATSASAGQAPEDPSGPGT
                     GPSGTCEAPVAVVTVTPAPEPAENSQDLGSTSSLGPGISGPRGQAPDTLSYLDSVSLM
                     SGTLESLADDVSSMGSDSEINGLALRKTDKYGFLGGSQYSGSLESSIPVDVARQRELK
                     WLDMFSNWDKWLSRRFQKVKLRCRKGIPSSLRAKAWQYLSNSKELLEQNPGKFEELER
                     APGDPKWLDVIEKDLHRQFPFHEMFAARGGHGQQDLYRILKAYTIYRPDEGYCQAQAP
                     VAAVLLMHMPAEQAFWCLVQICDKYLPGYYSAGLEAIQLDGEIFFALLRRASPLAHRH
                     LRRQRIDPVLYMTEWFMCIFARTLPWASVLRVWDMFFCEGVKIIFRVALVLLRHTLGS
                     VEKLRSCQGMYETMEQLRNLPQQCMQEDFLVHEVTNLPVTEALIERENAAQLKKWRET
                     RGELQYRPSRRLHGSRAIHEERRRQQPPLGPSSSLLSLPGLKSRGSRAAGGAPSPPPP
                     VRRASAGPAPGPVVTAEGLHPSLPSPTGNSTPLGSSKETRKQEKERQKQEKERQKQEK
                     EREKERQKQEKEREKQEKEREKQEKERQKQEKKAQGRKLSLRRKADGPPGPHDGGDRP
                     SAEARQDAYF"
     exon            1268..1367
                     /gene="TBC1D10B"
                     /gene_synonym="EPI64B; FP2461"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1475
                     /gene="TBC1D10B"
                     /gene_synonym="EPI64B; FP2461"
                     /inference="alignment:Splign:2.1.0"
     exon            1476..1582
                     /gene="TBC1D10B"
                     /gene_synonym="EPI64B; FP2461"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..1697
                     /gene="TBC1D10B"
                     /gene_synonym="EPI64B; FP2461"
                     /inference="alignment:Splign:2.1.0"
     exon            1698..1763
                     /gene="TBC1D10B"
                     /gene_synonym="EPI64B; FP2461"
                     /inference="alignment:Splign:2.1.0"
     exon            1764..1953
                     /gene="TBC1D10B"
                     /gene_synonym="EPI64B; FP2461"
                     /inference="alignment:Splign:2.1.0"
     exon            1954..2108
                     /gene="TBC1D10B"
                     /gene_synonym="EPI64B; FP2461"
                     /inference="alignment:Splign:2.1.0"
     exon            2109..3580
                     /gene="TBC1D10B"
                     /gene_synonym="EPI64B; FP2461"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3580
                     /gene="TBC1D10B"
                     /gene_synonym="EPI64B; FP2461"
                     /note="major polyA site"
ORIGIN      
        1 gagacgctgg cgcggagccg gctctgcggc gtgtgcgcag gcgcgaggtc ggcggctcgc
       61 ccccaagcag gagggagggg gcggtggcga gagcgcgcga gggggtgaga gggctcgaga
      121 gagaccccgg cgcgcggcgc cccccgaccc ctgccccgcc tctgcgcgcc cagcggccgc
      181 tccgcccccg gcgcgcgccg agccgcgccc ttcgccctct cccctttctc ggctggcctc
      241 gccgggaggc ccgaggggcg gcgccttctg cggcctcccc ggcgggggga tgtgaggggc
      301 ggcccgcggc catggagacg ggcacggcgc ccctggtggc cccgccgcgc cgtcatggcg
      361 cccccgcggc cccctcgccg ccgccccggg gttcccgggc cgggcccgtc gtggtggtgg
      421 ctccgggacc tccagtgact acggccactt cggcccccgt caccctggtg gcccccgggg
      481 aggcgcggcc cgcctgggtc ccggggtcgg ccgagacctc tgctccggcc ccggccccag
      541 ccccggcccc agccccggct gtcacgggca gcacggtggt ggtgctgacc ctggaggcct
      601 cgcccgaagc cccaaagccg cagctcccct ccggcccgga atccccagag cccgcggcag
      661 tggctggagt tgagacatcg agggctctgg ccgcaggggc agactcgccg aagacagagg
      721 aggctcgacc ctcacccgcc ccaggaccag ggacccccac cgggacccct accaggaccc
      781 cttccagaac ggctcctggt gccctgaccg ccaaaccccc gcttgccccc aagccgggaa
      841 ccacagtggc ctcaggagtg actgcacgga gtgcatcagg acaagtgaca ggtgggcatg
      901 gagctgccgc agcaacatca gcatcagcag gacaggctcc tgaggacccc tcaggccctg
      961 gcacaggccc ctctgggact tgtgaggctc cggtagctgt cgtgaccgtg accccagctc
     1021 cggagcctgc tgaaaactct caagacctgg gctccacgtc cagcctggga cctggcatct
     1081 ctgggcctcg agggcaggcc ccggacacgc tgagttactt ggactccgtg agcctcatgt
     1141 ctgggacctt ggagtccttg gcggatgatg tgagctccat gggctcagat tcagagataa
     1201 acgggctggc cctgcgcaag acggacaagt atggcttcct tgggggcagc cagtactcgg
     1261 gcagcctaga gagctccatt cccgtggacg tggctcggca gcgggagctc aaatggctgg
     1321 acatgttcag taactgggat aagtggctgt cacggcgatt ccagaaggtg aagctgcgct
     1381 gccggaaggg gatcccctcc tctctcagag ccaaagcctg gcagtacctg tctaatagca
     1441 aggaacttct ggagcagaac ccaggaaagt ttgaggagct ggaacgggct cctggggacc
     1501 ccaagtggct ggatgtgatt gagaaggacc tgcaccgcca gttccctttc cacgagatgt
     1561 ttgctgctcg aggggggcat gggcaacagg acctgtaccg aatcctgaag gcctacacca
     1621 tctaccggcc tgacgagggt tactgccagg cccaggcccc cgtggctgcg gtcctgctca
     1681 tgcacatgcc tgcggagcaa gccttttggt gcctggtgca gatctgcgac aagtacctcc
     1741 caggttacta cagtgcaggg ctggaggcca ttcagctgga cggggagatc ttttttgcac
     1801 tcctgcgccg ggcctccccg ctggcgcatc gccacctgcg gcggcagcgc attgaccctg
     1861 tgctctacat gacggagtgg ttcatgtgca tcttcgcccg caccctgccc tgggcgtcgg
     1921 tgctgcgtgt ctgggacatg tttttctgtg aaggcgttaa gatcatcttc cgggtggccc
     1981 tggtcctgct gcgccacacg ctgggctcag tggagaagct gcgctcctgc caaggcatgt
     2041 atgagaccat ggagcagctg cgtaacctgc cccagcagtg catgcaggaa gacttcctgg
     2101 tgcatgaggt gaccaatctg ccggtgacag aagcactgat tgagcgggag aatgcagccc
     2161 agctcaagaa gtggcgggaa acgcgggggg agctgcagta tcggccctca cggcgactgc
     2221 atgggtcccg ggccatccac gaggagcgcc ggcggcaaca gccacccctg ggcccctcct
     2281 ccagcctcct cagcctccct ggcctcaaga gccgaggctc ccgggcagct ggaggggccc
     2341 cgtccccgcc gccccccgtc cgcagagcca gtgctgggcc tgccccaggg cctgtggtca
     2401 ctgctgaggg actgcatcca tcccttccct cacccactgg caatagcacc cccttgggtt
     2461 ccagcaagga gacccggaag caggagaagg agcggcagaa acaggagaag gagcggcaga
     2521 aacaggagaa ggagcgggag aaggagcggc agaagcagga gaaagagcga gagaagcagg
     2581 aaaaggagcg agagaagcag gagaaggagc ggcagaagca ggagaagaag gctcaaggcc
     2641 ggaagctttc gctgcgtcga aaggcagatg ggcccccagg cccccatgat ggtggggaca
     2701 ggccctcagc cgaggcccgg caggacgctt acttctgacc tctgccctgg ggctggactg
     2761 catggccccc ctctttccct cagccaagaa caggcctggc ccaaggtgcc accccctagc
     2821 accttgtcag gctgtccctt gctggggaaa gtggcttggt tccccatctc ctcgccagct
     2881 gctgatccct acacgggcag gacagatggg cagctgcaaa tgagtctgga gcctctcatc
     2941 tcccatgagg ctcagctggg gtctctgtcg ctcctgcccc agttccctct gggtcccctc
     3001 ctaggtgctg tcctgaatgg cccgttgtca tcccaggggt gactcctggt gatgggagtc
     3061 agcagtttca gattcttaca ctccatagct ccccttacca tgaggtggag ctggcttcct
     3121 tttccctgtc ttcagccctc cctgtctccc ccacttcctg gccagggctc tcattctgga
     3181 cctgtgttgt aattgtgtac agaggatggc gttggcctgg ggtgggggtg ctcgctttgt
     3241 cttctgtcct ttggttctcc ttccataatg ctcctgtacc cagtttattt aaggggacat
     3301 gcactggaat aggaaatgtc ccccatctcc cttcctgcac cctgctgtgc tccctccaaa
     3361 cccaccttgc tctgtgttct caggcccccc tgcttttgtc tcaccaggac ccataccttt
     3421 caccttgttc ccttccaccc ctccagttag tccctatctg ggtaagggtc ttcccttgag
     3481 ctccaggggg tggaacccaa tgtttacatt ctcttctgtc tctgccccca ccccatgcag
     3541 cgctttgagg aattggaaaa gaacctgctg ttgtacctgg
//
