LOCUS       NM_031937               1972 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens TBC1 domain family member 10A (TBC1D10A), transcript
            variant 2, mRNA.
ACCESSION   NM_031937
VERSION     NM_031937.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1972)
  AUTHORS   Miller,M.R., McDermitt,D.J., Sauvanet,C., Lombardo,A.T., Zaman,R.
            and Bretscher,A.
  TITLE     The RabGAPs EPI64A and EPI64B regulate the apical structure of
            epithelial cells dagger
  JOURNAL   Mol Biol Cell 33 (1), ar8 (2022)
   PUBMED   34757852
  REMARK    GeneRIF: The RabGAPs EPI64A and EPI64B regulate the apical
            structure of epithelial cells (dagger).
REFERENCE   2  (bases 1 to 1972)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1972)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1972)
  AUTHORS   Xie,Y., Mansouri,M., Rizk,A. and Berger,P.
  TITLE     Regulation of VEGFR2 trafficking and signaling by Rab
            GTPase-activating proteins
  JOURNAL   Sci Rep 9 (1), 13342 (2019)
   PUBMED   31527750
  REMARK    GeneRIF: Regulation of VEGFR2 trafficking and signaling by Rab
            GTPase-activating proteins.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1972)
  AUTHORS   Biesemann,A., Gorontzi,A., Barr,F. and Gerke,V.
  TITLE     Rab35 protein regulates evoked exocytosis of endothelial
            Weibel-Palade bodies
  JOURNAL   J Biol Chem 292 (28), 11631-11640 (2017)
   PUBMED   28566286
  REMARK    GeneRIF: Data suggest that Rab35, interacting with TBC1D10A,
            functions in vascular endothelial cells as a negative regulator of
            histamine-evoked, Ca2+-dependent Weibel-Palade body exocytosis,
            most likely acting through the downstream effectors ACAP2 and Arf6.
            (Rab35 = rab GTP-binding protein 53; TBC1D10A = TBC1 domain family
            member 10A; ACAP2 = centaurin beta2; Arf6 = ADP-ribosylation factor
            6)
REFERENCE   6  (bases 1 to 1972)
  AUTHORS   Kapranov,P., Drenkow,J., Cheng,J., Long,J., Helt,G., Dike,S. and
            Gingeras,T.R.
  TITLE     Examples of the complex architecture of the human transcriptome
            revealed by RACE and high-density tiling arrays
  JOURNAL   Genome Res 15 (7), 987-997 (2005)
   PUBMED   15998911
REFERENCE   7  (bases 1 to 1972)
  AUTHORS   Cheng,J., Kapranov,P., Drenkow,J., Dike,S., Brubaker,S., Patel,S.,
            Long,J., Stern,D., Tammana,H., Helt,G., Sementchenko,V.,
            Piccolboni,A., Bekiranov,S., Bailey,D.K., Ganesh,M., Ghosh,S.,
            Bell,I., Gerhard,D.S. and Gingeras,T.R.
  TITLE     Transcriptional maps of 10 human chromosomes at 5-nucleotide
            resolution
  JOURNAL   Science 308 (5725), 1149-1154 (2005)
   PUBMED   15790807
REFERENCE   8  (bases 1 to 1972)
  AUTHORS   Collins,J.E., Wright,C.L., Edwards,C.A., Davis,M.P., Grinham,J.A.,
            Cole,C.G., Goward,M.E., Aguado,B., Mallya,M., Mokrab,Y.,
            Huckle,E.J., Beare,D.M. and Dunham,I.
  TITLE     A genome annotation-driven approach to cloning the human ORFeome
  JOURNAL   Genome Biol 5 (10), R84 (2004)
   PUBMED   15461802
REFERENCE   9  (bases 1 to 1972)
  AUTHORS   Reczek,D. and Bretscher,A.
  TITLE     Identification of EPI64, a TBC/rabGAP domain-containing microvillar
            protein that binds to the first PDZ domain of EBP50 and E3KARP
  JOURNAL   J Cell Biol 153 (1), 191-206 (2001)
   PUBMED   11285285
REFERENCE   10 (bases 1 to 1972)
  AUTHORS   Dunham,I., Shimizu,N., Roe,B.A., Chissoe,S., Hunt,A.R.,
            Collins,J.E., Bruskiewich,R., Beare,D.M., Clamp,M., Smink,L.J.,
            Ainscough,R., Almeida,J.P., Babbage,A., Bagguley,C., Bailey,J.,
            Barlow,K., Bates,K.N., Beasley,O., Bird,C.P., Blakey,S.,
            Bridgeman,A.M., Buck,D., Burgess,J., Burrill,W.D., O'Brien,K.P. et
            al.
  TITLE     The DNA sequence of human chromosome 22
  JOURNAL   Nature 402 (6761), 489-495 (1999)
   PUBMED   10591208
  REMARK    Erratum:[Nature 2000 Apr 20;404(6780):904]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA944522.1, BC171775.1 and BC150187.1.
            
            On Jun 2, 2019 this sequence version replaced NM_031937.2.
            
            Transcript Variant: This variant (2) used an alternate in-frame
            splice site in the 5_ coding region, compared to variant 1. The
            encoded protein (isoform 2) is shorter, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF331038.1, BC150187.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000215790.12/ ENSP00000215790.8
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                DA944522.1         29-47
            20-1438             BC171775.1         1-1419
            1439-1972           BC150187.1         1384-1917
FEATURES             Location/Qualifiers
     source          1..1972
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q12.2"
     gene            1..1972
                     /gene="TBC1D10A"
                     /gene_synonym="dJ130H16.1; dJ130H16.2; EPI64; TBC1D10"
                     /note="TBC1 domain family member 10A"
                     /db_xref="GeneID:83874"
                     /db_xref="HGNC:HGNC:23609"
                     /db_xref="MIM:610020"
     exon            1..269
                     /gene="TBC1D10A"
                     /gene_synonym="dJ130H16.1; dJ130H16.2; EPI64; TBC1D10"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..1587
                     /gene="TBC1D10A"
                     /gene_synonym="dJ130H16.1; dJ130H16.2; EPI64; TBC1D10"
                     /note="isoform 2 is encoded by transcript variant 2;
                     EBP50-PDZ interactor of 64 kD; EBP50-PDX interactor of 64
                     kDa; rab27A-GAP-alpha"
                     /codon_start=1
                     /product="TBC1 domain family member 10A isoform 2"
                     /protein_id="NP_114143.1"
                     /db_xref="CCDS:CCDS13874.1"
                     /db_xref="GeneID:83874"
                     /db_xref="HGNC:HGNC:23609"
                     /db_xref="MIM:610020"
                     /translation="MAKSNGENGPRAPAAGESLSGTRESLAQGPDAATTDELSSLGSD
                     SEANGFAERRIDKFGFIVGSQGAEGALEEVPLEVLRQRESKWLDMLNNWDKWMAKKHK
                     KIRLRCQKGIPPSLRGRAWQYLSGGKVKLQQNPGKFDELDMSPGDPKWLDVIERDLHR
                     QFPFHEMFVSRGGHGQQDLFRVLKAYTLYRPEEGYCQAQAPIAAVLLMHMPAEQAFWC
                     LVQICEKYLPGYYSEKLEAIQLDGEILFSLLQKVSPVAHKHLSRQKIDPLLYMTEWFM
                     CAFSRTLPWSSVLRVWDMFFCEGVKIIFRVGLVLLKHALGSPEKVKACQGQYETIERL
                     RSLSPKIMQEAFLVQEVVELPVTERQIEREHLIQLRRWQETRGELQCRSPPRLHGAKA
                     ILDAEPGPRPALQPSPSIRLPLDAPLPGSKAKPKPPKQAQKEQRKQMKGRGQLEKPPA
                     PNQAMVVAAAGDACPPQHVPPKDSAPKDSAPQDLAPQVSAHHRSQESLTSQESEDTYL
                     "
     exon            270..369
                     /gene="TBC1D10A"
                     /gene_synonym="dJ130H16.1; dJ130H16.2; EPI64; TBC1D10"
                     /inference="alignment:Splign:2.1.0"
     exon            370..477
                     /gene="TBC1D10A"
                     /gene_synonym="dJ130H16.1; dJ130H16.2; EPI64; TBC1D10"
                     /inference="alignment:Splign:2.1.0"
     exon            478..584
                     /gene="TBC1D10A"
                     /gene_synonym="dJ130H16.1; dJ130H16.2; EPI64; TBC1D10"
                     /inference="alignment:Splign:2.1.0"
     exon            585..699
                     /gene="TBC1D10A"
                     /gene_synonym="dJ130H16.1; dJ130H16.2; EPI64; TBC1D10"
                     /inference="alignment:Splign:2.1.0"
     exon            700..765
                     /gene="TBC1D10A"
                     /gene_synonym="dJ130H16.1; dJ130H16.2; EPI64; TBC1D10"
                     /inference="alignment:Splign:2.1.0"
     exon            766..955
                     /gene="TBC1D10A"
                     /gene_synonym="dJ130H16.1; dJ130H16.2; EPI64; TBC1D10"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1110
                     /gene="TBC1D10A"
                     /gene_synonym="dJ130H16.1; dJ130H16.2; EPI64; TBC1D10"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1972
                     /gene="TBC1D10A"
                     /gene_synonym="dJ130H16.1; dJ130H16.2; EPI64; TBC1D10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1951..1956
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TBC1D10A"
                     /gene_synonym="dJ130H16.1; dJ130H16.2; EPI64; TBC1D10"
                     /note="hexamer: AATAAA"
     polyA_site      1972
                     /gene="TBC1D10A"
                     /gene_synonym="dJ130H16.1; dJ130H16.2; EPI64; TBC1D10"
                     /note="major polyA site"
ORIGIN      
        1 gtcggcggca gcagggcggc tgaggtggcc gctggagctc aggcggcggg cgcggctggg
       61 atggcgaaga gcaacggaga gaatgggccg cgcgcgcccg cggccgggga aagcctgtcg
      121 ggaacccggg agagcctggc ccagggcccc gacgccgcaa ccaccgacga actcagctct
      181 ctcgggtctg actcggaggc caacggcttc gccgagcgcc gcatcgacaa gttcggcttc
      241 atcgtgggct cgcagggcgc cgagggcgcg ctggaggaag tacccctgga ggtgctgagg
      301 cagagggagt ccaagtggct ggacatgctc aacaactggg acaaatggat ggccaagaag
      361 cacaaaaaga ttcgtctgcg gtgccaaaag ggcatcccgc cttctctgcg gggccgtgct
      421 tggcagtacc tgtcaggagg caaggtgaag ttacagcaga accctggaaa gtttgacgag
      481 ctggacatgt cccctgggga ccccaagtgg ctggacgtga ttgagcgtga cctgcaccgg
      541 cagttcccat tccatgagat gtttgtgtcc cgggggggcc acggccagca ggacctattc
      601 cgtgtgctga aggcctacac gctgtaccgg cccgaggagg gctactgcca ggcccaggcg
      661 cccattgccg ctgtcttgct catgcatatg cctgctgagc aagccttctg gtgcctggta
      721 cagatctgtg agaagtacct gcccggctac tacagcgaga aactggaggc gatccagctg
      781 gacggggaga tccttttctc gctgttgcag aaggtgtcgc cggtggccca caagcacctc
      841 agccgtcaga agatcgaccc gctcctctat atgacagaat ggttcatgtg cgccttctcc
      901 cgaaccttgc cctggagctc tgtgctgcgt gtctgggaca tgttcttctg tgaaggggtc
      961 aagatcatct tccgggtggg gctggtgctg ctgaagcacg cgctgggctc ccctgagaag
     1021 gtcaaagcct gccagggcca gtacgagacc atcgagcgac tgcggagcct cagccccaag
     1081 atcatgcagg aggcctttct ggtccaggag gtggtggagt tgcccgtgac agagcgccag
     1141 attgagcgcg aacacctcat tcagctgcgg cgctggcagg agacccgggg tgagctgcag
     1201 tgccgctccc cgcccaggct gcatggtgcc aaggctatct tggatgcaga acctggtccc
     1261 cggcctgccc tacaaccttc accatccatc cgcctgcccc tagatgcccc cctccctggc
     1321 tccaaagcca agcccaagcc acccaagcag gcccagaagg agcagcggaa acagatgaag
     1381 gggagagggc agctggagaa gcccccagcc ccaaatcaag ccatggtggt ggccgctgca
     1441 ggagatgcat gtcccccaca gcatgtgccc ccgaaggact cagcccccaa ggactcagcc
     1501 cctcaggatt tggctcccca ggtctcagcc caccaccgct cccaggagag cttgacgtcc
     1561 caagagagtg aggacaccta cttgtaaccc tggcagctaa ggcctccagg gcggggtctc
     1621 catataacta cacggttcat gaactgacat tccacatcct gcccaccctc tgagggccaa
     1681 gctgcctggc cactgggctg ggctggagtc tggctggtcc aacacagatt ctgcctggtc
     1741 caacacagat tctgcctgag cctccttatt tattttcttt acagtggcac tcaggctggc
     1801 ccagccaggg caggcagaag ctagggcctg gggggtgggg cctccttcag ccccctcctc
     1861 ctgggggatg ctccccaggg ttagggtgct ggtgtgaggg gaaagggtgg ggtgttcttt
     1921 gtgtaaaata gaaacatggt tttgtacaga aataaacagc cttgtataga ga
//
