LOCUS       NM_001396959            5985 bp    mRNA    linear   PRI 11-SEP-2024
DEFINITION  Homo sapiens TBC1 domain family member 1 (TBC1D1), transcript
            variant 6, mRNA.
ACCESSION   NM_001396959 XM_005262647
VERSION     NM_001396959.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5985)
  AUTHORS   Wang,Q., Rong,P., Zhang,W., Yang,X., Chen,L., Cao,Y., Liu,M.,
            Feng,W., Ouyang,Q., Chen,Q., Li,H., Liang,H., Meng,F., Wang,H.Y.
            and Chen,S.
  TITLE     TBC1D1 is an energy-responsive polarization regulator of
            macrophages via governing ROS production in obesity
  JOURNAL   Sci China Life Sci 67 (9), 1899-1914 (2024)
   PUBMED   38902450
  REMARK    GeneRIF: TBC1D1 is an energy-responsive polarization regulator of
            macrophages via governing ROS production in obesity.
REFERENCE   2  (bases 1 to 5985)
  AUTHORS   Song,D., Yang,Q., Li,L., Wei,Y., Zhang,C., Du,H., Ren,G. and Li,H.
  TITLE     Novel prognostic biomarker TBC1D1 is associated with immunotherapy
            resistance in gliomas
  JOURNAL   Front Immunol 15, 1372113 (2024)
   PUBMED   38529286
  REMARK    GeneRIF: Novel prognostic biomarker TBC1D1 is associated with
            immunotherapy resistance in gliomas.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5985)
  AUTHORS   Cai,J., Jiang,Y., Chen,P., Liang,J., Zhang,Y., Yuan,R., Fan,H.,
            Zhong,Y., Cai,J., Cheng,S. and Zhang,Y.
  TITLE     TBC1D1 represses glioma progression by altering the integrity of
            the cytoskeleton
  JOURNAL   Aging (Albany NY) 16 (1), 431-444 (2024)
   PUBMED   38189823
  REMARK    GeneRIF: TBC1D1 represses glioma progression by altering the
            integrity of the cytoskeleton.
REFERENCE   4  (bases 1 to 5985)
  AUTHORS   Miklosz,A., Lukaszuk,B., Supruniuk,E., Grubczak,K., Moniuszko,M.,
            Choromanska,B., Mysliwiec,P. and Chabowski,A.
  TITLE     Does TBC1D4 (AS160) or TBC1D1 Deficiency Affect the Expression of
            Fatty Acid Handling Proteins in the Adipocytes Differentiated from
            Human Adipose-Derived Mesenchymal Stem Cells (ADMSCs) Obtained from
            Subcutaneous and Visceral Fat Depots?
  JOURNAL   Cells 10 (6), 1515 (2021)
   PUBMED   34208471
  REMARK    GeneRIF: Does TBC1D4 (AS160) or TBC1D1 Deficiency Affect the
            Expression of Fatty Acid Handling Proteins in the Adipocytes
            Differentiated from Human Adipose-Derived Mesenchymal Stem Cells
            (ADMSCs) Obtained from Subcutaneous and Visceral Fat Depots?
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5985)
  AUTHORS   Hook,S.C., Chadt,A., Heesom,K.J., Kishida,S., Al-Hasani,H.,
            Tavare,J.M. and Thomas,E.C.
  TITLE     TBC1D1 interacting proteins, VPS13A and VPS13C, regulate GLUT4
            homeostasis in C2C12 myotubes
  JOURNAL   Sci Rep 10 (1), 17953 (2020)
   PUBMED   33087848
  REMARK    GeneRIF: TBC1D1 interacting proteins, VPS13A and VPS13C, regulate
            GLUT4 homeostasis in C2C12 myotubes.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5985)
  AUTHORS   Yoshimura,S., Egerer,J., Fuchs,E., Haas,A.K. and Barr,F.A.
  TITLE     Functional dissection of Rab GTPases involved in primary cilium
            formation
  JOURNAL   J Cell Biol 178 (3), 363-369 (2007)
   PUBMED   17646400
REFERENCE   7  (bases 1 to 5985)
  AUTHORS   Roach,W.G., Chavez,J.A., Miinea,C.P. and Lienhard,G.E.
  TITLE     Substrate specificity and effect on GLUT4 translocation of the Rab
            GTPase-activating protein Tbc1d1
  JOURNAL   Biochem J 403 (2), 353-358 (2007)
   PUBMED   17274760
  REMARK    GeneRIF: form of Tbc1d1 also inhibited GLUT4 translocation and that
            this effect also required a functional GAP domain
REFERENCE   8  (bases 1 to 5985)
  AUTHORS   Stone,S., Abkevich,V., Russell,D.L., Riley,R., Timms,K., Tran,T.,
            Trem,D., Frank,D., Jammulapati,S., Neff,C.D., Iliev,D., Gress,R.,
            He,G., Frech,G.C., Adams,T.D., Skolnick,M.H., Lanchbury,J.S.,
            Gutin,A., Hunt,S.C. and Shattuck,D.
  TITLE     TBC1D1 is a candidate for a severe obesity gene and evidence for a
            gene/gene interaction in obesity predisposition
  JOURNAL   Hum Mol Genet 15 (18), 2709-2720 (2006)
   PUBMED   16893906
  REMARK    GeneRIF: coding variant R125W affects obesity susceptibility,
            delimits the location of an obesity gene at 4q34-35 and identifies
            a gene/gene interaction that influences the risk for obesity
            predisposition
REFERENCE   9  (bases 1 to 5985)
  AUTHORS   Rush,J., Moritz,A., Lee,K.A., Guo,A., Goss,V.L., Spek,E.J.,
            Zhang,H., Zha,X.M., Polakiewicz,R.D. and Comb,M.J.
  TITLE     Immunoaffinity profiling of tyrosine phosphorylation in cancer
            cells
  JOURNAL   Nat Biotechnol 23 (1), 94-101 (2005)
   PUBMED   15592455
REFERENCE   10 (bases 1 to 5985)
  AUTHORS   White,R.A., Pasztor,L.M., Richardson,P.M. and Zon,L.I.
  TITLE     The gene encoding TBC1D1 with homology to the tre-2/USP6 oncogene,
            BUB2, and cdc16 maps to mouse chromosome 5 and human chromosome 4
  JOURNAL   Cytogenet Cell Genet 89 (3-4), 272-275 (2000)
   PUBMED   10965142
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC021106.6, AC108933.3 and AC098680.3.
            
            On Oct 28, 2021 this sequence version replaced XM_005262647.3.
            
            Summary: TBC1D1 is the founding member of a family of proteins
            sharing a 180- to 200-amino acid TBC domain presumed to have a role
            in regulating cell growth and differentiation. These proteins share
            significant homology with TRE2 (USP6; MIM 604334), yeast Bub2, and
            CDC16 (MIM 603461) (White et al., 2000 [PubMed 10965142]).[supplied
            by OMIM, Mar 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074969.1491271.1,
                                           SRR14038197.2158816.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000698857.1/ ENSP00000513987.1
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-265               AC021106.6         57336-57600
            266-775             AC021106.6         68255-68764
            776-1240            AC021106.6         180761-181225
            1241-1330           AC021106.6         184606-184695
            1331-1435           AC021106.6         186843-186947
            1436-1568           AC021106.6         187838-187970
            1569-1660           AC108933.3         932-1023
            1661-1771           AC108933.3         8732-8842
            1772-1900           AC108933.3         17506-17634
            1901-1987           AC108933.3         18961-19047
            1988-2268           AC108933.3         22762-23042
            2269-2430           AC108933.3         25043-25204
            2431-2550           AC108933.3         26250-26369
            2551-2690           AC108933.3         27343-27482
            2691-2876           AC108933.3         63076-63261
            2877-3038           AC108933.3         69073-69234
            3039-3197           AC108933.3         76143-76301
            3198-3442           AC098680.3         3529-3773
            3443-3602           AC098680.3         5852-6011
            3603-3772           AC098680.3         12781-12950
            3773-3946           AC098680.3         20903-21076
            3947-5985           AC098680.3         24954-26992
FEATURES             Location/Qualifiers
     source          1..5985
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p14"
     gene            1..5985
                     /gene="TBC1D1"
                     /gene_synonym="TBC; TBC1"
                     /note="TBC1 domain family member 1"
                     /db_xref="GeneID:23216"
                     /db_xref="HGNC:HGNC:11578"
                     /db_xref="MIM:609850"
     exon            1..265
                     /gene="TBC1D1"
                     /gene_synonym="TBC; TBC1"
                     /inference="alignment:Splign:2.1.0"
     exon            266..775
                     /gene="TBC1D1"
                     /gene_synonym="TBC; TBC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             359..4147
                     /gene="TBC1D1"
                     /gene_synonym="TBC; TBC1"
                     /note="isoform 5 is encoded by transcript variant 6; TBC1
                     (tre-2/USP6, BUB2, cdc16) domain family, member 1"
                     /codon_start=1
                     /product="TBC1 domain family member 1 isoform 5"
                     /protein_id="NP_001383888.1"
                     /db_xref="CCDS:CCDS93491.1"
                     /db_xref="GeneID:23216"
                     /db_xref="HGNC:HGNC:11578"
                     /db_xref="MIM:609850"
                     /translation="MEPITFTARKHLLSNEVSVDFGLQLVGSLPVHSLTTMPMLPWVV
                     AEVRRLSRQSTRKEPVTKQVRLCVSPSGLRCEPEPGRSQQWDPLIYSSIFECKPQRVH
                     KLIHNSHDPSYFACLIKEDAVHRQSICYVFKADDQTKVPEIISSIRQAGKIARQEELH
                     CPSEFDDTFSKKFEVLFCGRVTVAHKKAPPALIDECIEKFNHVSGSRGSESPRPNPPH
                     AAPTGSQEPVRRPMRKSFSQPGLRSLAFRKELQDGGLRSSGFFSSFEESDIENHLISG
                     HNIVQPTDIEENRTMLFTIGQSEVYLISPDTKKIALEKNFKEISFCSQGIRHVDHFGF
                     ICRESSGGGGFHFVCYVFQCTNEALVDEIMMTLKQAFTVAAVQQTAKAPAQLCEGCPL
                     QSLHKLCERIEGMNSSKTKLELQKHLTTLTNQEQATIFEEVQKLRPRNEQRENELIIS
                     FLRCLYEEKQKEHIHIGEMKQTSQMAAENIGSELPPSATRFRLDMLKNKAKRSLTESL
                     ESILSRGNKARGLQEHSISVDLDSSLSSTLSNTSKEPSVCEKEALPISESSFKLLGSS
                     EDLSSDSESHLPEEPAPLSPQQAFRRRANTLSHFPIECQEPPQPARGSPGVSQRKLMR
                     YHSVSTETPHERNVDPSPVGESKHRPGQSSAPAPPPRLNPSASSPNFFKYLKHNSSGE
                     QSGNAVPKSISYRNALRKKLHSSSSVPNFLKFLAPVDENNTSDFMNTKRDFESKANHL
                     GDSGGTPVKTRRHSWRQQIFLRVATPQKACDSSSRYEDYSELGELPPRSPLEPVCEDG
                     PFGPPPEEKKRTSRELRELWQKAILQQILLLRMEKENQKLQASENDLLNKRLKLDYEE
                     ITPCLKEVTTVWEKMLSTPGRSKIKFDMEKMHSAVGQGVPRHHRGEIWKFLAEQFHLK
                     HQFPSKQQPKDVPYKELLKQLTSQQHAILIDLGRTFPTHPYFSAQLGAGQLSLYNILK
                     AYSLLDQEVGYCQGLSFVAGILLLHMSEEEAFKMLKFLMFDMGLRKQYRPDMIILQIQ
                     MYQLSRLLHDYHRDLYNHLEEHEIGPSLYAAPWFLTMFASQFPLGFVARVFDMIFLQG
                     TEVIFKVALSLLGSHKPLILQHENLETIVDFIKSTLPNLGLVQMEKTINQVFEMDIAK
                     QLQAYEVEYHVLQEELIDSSPLSDNQRMDKLEKTNSSLRKQNLDLLEQLQVANGRIQS
                     LEATIEKLLSSESKLKQAMLTLELERSALLQTVEELRRRSAEPSDREPECTQPEPTGD
                     "
     exon            776..1240
                     /gene="TBC1D1"
                     /gene_synonym="TBC; TBC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..1330
                     /gene="TBC1D1"
                     /gene_synonym="TBC; TBC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1435
                     /gene="TBC1D1"
                     /gene_synonym="TBC; TBC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..1568
                     /gene="TBC1D1"
                     /gene_synonym="TBC; TBC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1569..1660
                     /gene="TBC1D1"
                     /gene_synonym="TBC; TBC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..1771
                     /gene="TBC1D1"
                     /gene_synonym="TBC; TBC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1772..1900
                     /gene="TBC1D1"
                     /gene_synonym="TBC; TBC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1901..1987
                     /gene="TBC1D1"
                     /gene_synonym="TBC; TBC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1988..2268
                     /gene="TBC1D1"
                     /gene_synonym="TBC; TBC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2269..2430
                     /gene="TBC1D1"
                     /gene_synonym="TBC; TBC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2431..2550
                     /gene="TBC1D1"
                     /gene_synonym="TBC; TBC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2551..2690
                     /gene="TBC1D1"
                     /gene_synonym="TBC; TBC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2691..2876
                     /gene="TBC1D1"
                     /gene_synonym="TBC; TBC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2877..3038
                     /gene="TBC1D1"
                     /gene_synonym="TBC; TBC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3039..3197
                     /gene="TBC1D1"
                     /gene_synonym="TBC; TBC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3198..3442
                     /gene="TBC1D1"
                     /gene_synonym="TBC; TBC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3443..3602
                     /gene="TBC1D1"
                     /gene_synonym="TBC; TBC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3603..3772
                     /gene="TBC1D1"
                     /gene_synonym="TBC; TBC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3773..3946
                     /gene="TBC1D1"
                     /gene_synonym="TBC; TBC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3947..5985
                     /gene="TBC1D1"
                     /gene_synonym="TBC; TBC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4411..4416
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TBC1D1"
                     /gene_synonym="TBC; TBC1"
                     /note="hexamer: AATAAA"
     polyA_site      4431
                     /gene="TBC1D1"
                     /gene_synonym="TBC; TBC1"
                     /note="major polyA site"
     regulatory      5957..5962
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TBC1D1"
                     /gene_synonym="TBC; TBC1"
                     /note="hexamer: AATAAA"
     polyA_site      5985
                     /gene="TBC1D1"
                     /gene_synonym="TBC; TBC1"
ORIGIN      
        1 ctcctcttcg gctgctgctc ctggtgccgc caccgtccgc cggtgcctgt tgctgccgcc
       61 gccgcgggac ctgctgtgtc ctcagctggg tggagaagag gcgggcgccg agccgagggg
      121 agccccctcc ccgtcccccc gcggcgggaa gagcgcagcc agccgggtgc gatggactcc
      181 ccgcccgccc aggccgtccc caggatgccc ccaagcacct gcgcgtcccg gcccggcccc
      241 gggctctgag cgcgccgcgg cacaggtttc tgcatatgaa gtgtgtaaaa tagattgctt
      301 gatccaaaac agaaaaacag tgataactgt tttgctgagt tcccagaccc ttcccaagat
      361 ggaaccaata acattcacag caaggaaaca tctgctttct aacgaggtct cggtggattt
      421 tggcctgcag ctggtgggct ccctgcctgt gcattccctg accaccatgc ccatgctgcc
      481 ctgggttgtg gctgaggtgc gaagactcag caggcagtcc accagaaagg aacctgtaac
      541 caagcaagtc cggctttgcg tttcaccctc tggactgaga tgtgaacctg agccagggag
      601 aagtcaacag tgggatcccc tgatctattc cagcatcttt gagtgcaagc ctcagcgtgt
      661 tcacaaactg attcacaaca gtcatgaccc aagttacttt gcttgtctga ttaaggaaga
      721 cgctgtccac cggcagagta tctgctatgt gttcaaagcc gatgatcaaa caaaagtgcc
      781 tgagatcatc agctccatcc gtcaggcggg gaagatcgcc cggcaggagg agctgcactg
      841 cccgtccgag ttcgacgaca cgttttccaa gaagttcgag gtgctcttct gcggccgcgt
      901 gacggtggcg cacaagaagg ctccgccggc cctgatcgac gagtgcatcg agaagttcaa
      961 tcacgtcagc ggcagccggg ggtccgagag cccccgcccc aacccgcccc atgccgcgcc
     1021 cacagggagc caggagcctg tgcgcaggcc catgcgcaag tccttctccc agcccggcct
     1081 gcgctcgctg gcctttagga aggagctgca ggatgggggc ctccgaagca gcggcttctt
     1141 cagctccttc gaggagagcg acattgagaa ccacctcatt agcggacaca atattgtgca
     1201 gcccacagat atcgaggaaa atcgaactat gctcttcacg attggccagt ctgaagttta
     1261 cctcatcagt cctgacacca aaaaaatagc attggagaaa aattttaagg agatatcctt
     1321 ttgctctcag ggcatcagac acgtggacca ctttgggttt atctgtcggg agtcttccgg
     1381 aggtggcggc tttcattttg tctgttacgt gtttcagtgc acaaatgagg ctctggttga
     1441 tgaaattatg atgaccctga aacaggcctt cacggtggcc gcagtgcagc agacagctaa
     1501 ggcgccagcc cagctgtgtg agggctgccc cctgcaaagc ctgcacaagc tctgtgagag
     1561 gatagaggga atgaattctt ccaaaacaaa actagaactg caaaagcacc tgacgacatt
     1621 aaccaatcag gagcaggcga ctatttttga agaggttcag aaattgagac cgagaaatga
     1681 gcagcgagag aatgaattga ttatttcttt tctgagatgt ttatatgaag agaaacagaa
     1741 agaacacatc catattgggg agatgaagca gacatcgcag atggcagcag agaatattgg
     1801 aagtgaatta ccacccagtg ccactcgatt taggctagat atgctgaaaa acaaagcaaa
     1861 gagatcttta acagagtctt tagaaagtat tttgtcccgg ggtaataaag ccagaggcct
     1921 gcaggaacac tccatcagtg tggatctgga tagctccctg tctagtacat taagtaacac
     1981 cagcaaagag ccatctgtgt gtgaaaagga ggccttgccc atctctgaga gctcctttaa
     2041 gctcctcggc tcctcggagg acctgtccag tgactcggag agtcatctcc cagaagagcc
     2101 agctccgctg tcgccccagc aggccttcag gaggcgagca aacaccctga gtcacttccc
     2161 catcgaatgc caggaacctc cacaacctgc ccgggggtcc ccgggggttt cgcaaaggaa
     2221 acttatgagg tatcactcag tgagcacaga gacgcctcat gaacgaaatg tggatccttc
     2281 acctgtgggt gagtctaagc accgcccagg tcagtcttca gctcctgctc ctccacctcg
     2341 tcttaacccc tccgcctcct cgccaaactt ttttaagtac ctaaaacata attccagtgg
     2401 agaacaaagt gggaatgctg tgccaaagag catctcctac cgtaatgccc tgcggaaaaa
     2461 acttcattct tcttcctctg tgccaaattt tctaaaattt ctggctcctg tagatgaaaa
     2521 taacacctct gattttatga acacaaaaag ggactttgaa tccaaagcaa accatcttgg
     2581 tgattctggt gggactcctg tgaagacccg gaggcattcc tggaggcagc agatattcct
     2641 ccgagtagcc accccgcaga aggcgtgcga ttcttccagc agatatgaag attattcaga
     2701 gctgggagag cttcccccac gatctccttt agaaccagtt tgtgaagatg ggccctttgg
     2761 ccccccacca gaggaaaaga aaaggacatc tcgtgagctc cgagagctgt ggcaaaaggc
     2821 tattcttcaa cagatactgc tgcttagaat ggagaaggaa aatcagaagc tccaagcctc
     2881 tgaaaatgat ttgctgaaca agcgcctgaa gctcgattat gaagaaatta ctccctgtct
     2941 taaagaagta actacagtgt gggaaaagat gcttagcact ccaggaagat caaaaattaa
     3001 gtttgacatg gaaaaaatgc actcggctgt tgggcaaggt gtgccacgtc atcaccgagg
     3061 tgaaatctgg aaatttctag ctgagcaatt ccaccttaaa caccagtttc ccagcaaaca
     3121 gcagccaaag gatgtgccat acaaagaact cttaaagcag ctgacttccc agcagcatgc
     3181 gattcttatt gaccttgggc gaacctttcc tacacaccca tacttctctg cccagcttgg
     3241 agcaggacag ctatcgcttt acaacatttt gaaggcctac tcacttctag accaggaagt
     3301 gggatattgc caaggtctca gctttgtagc aggcattttg cttcttcata tgagtgagga
     3361 agaggcgttt aaaatgctca agtttctgat gtttgacatg gggctgcgga aacagtatcg
     3421 gccagacatg attattttac agatccagat gtaccagctc tcgaggttgc ttcatgatta
     3481 ccacagagac ctctacaatc acctggagga gcacgagatc ggccccagcc tctacgctgc
     3541 cccctggttc ctcaccatgt ttgcctcaca gttcccgctg ggattcgtag ccagagtctt
     3601 tgatatgatt tttcttcagg gaacagaggt catatttaaa gtggctttaa gtctgttggg
     3661 aagccataag cccttgattc tgcagcatga aaacctagaa accatagttg actttataaa
     3721 aagcacgcta cccaaccttg gcttggtaca gatggaaaag accatcaatc aggtatttga
     3781 aatggacatc gctaaacagt tacaagctta tgaagttgag taccacgtcc ttcaagaaga
     3841 acttatcgat tcctctcctc tcagtgacaa ccaaagaatg gataaattag agaaaaccaa
     3901 cagcagctta cgcaaacaga accttgacct ccttgaacag ttgcaggtgg caaatggtag
     3961 gatccaaagc cttgaggcca ccattgagaa gctcctgagc agtgagagca agctgaagca
     4021 ggccatgctt accttagaac tggagcggtc ggccctgctg cagacggtgg aggagctgcg
     4081 gcggcggagc gcagagccca gcgaccggga gcctgagtgc acgcagcccg agcccacggg
     4141 cgactgacag ctctgcagga gagattgcaa caccatccca cactgtccag gccttaactg
     4201 agagggacag aagacgctgg aaggagagaa ggaagcggga agtgtgcttc tcagggagga
     4261 aaccggcttg ccagcaagta gattcttacg aactccaact tgcaattcag ggggcatgtc
     4321 ccagtgtttt ttttgttgtt tttagatact aaatcgtccc ttctccagtc ctgattactg
     4381 tacacagtag ctttagatgg cgtggacgtg aataaatgca acttatgttt tcttgttggt
     4441 tcctttttga gtgtcactgt gtttgtaaag agcattcaca atacggtgga atttcaaaag
     4501 ctggaagagc tcgagatcat gcctcaggca aaggcgtggg tccatcgttc ttccgagagg
     4561 gtttgtgtgg cgactacacc ctcagcgtcc ctggcaaggt gcagttggct ctcgcccatt
     4621 cttgttatgg aaacctaaga tgatcattgg gaagatcagt gatcttgggt cattgatccc
     4681 tggctcagag gatagcggtt tccatcataa accaagatga tgagttcagc ctttatccct
     4741 cgtggttcca ctagatgtaa cttaaaggag ttaacatttg aggactttgt tctacatcag
     4801 attttactat ttgaatgttt aagatcactt tattgaattt gaagatcatc aaattaaata
     4861 aaatgattta tttaatttgg atatcctgat cactgtcaag tgaaatggat ctctctcttt
     4921 ggtatttaag gaagtttgtc tttaaaaaaa aaatagagtg ttttcataca tttttgctta
     4981 tcccataagt acagttgatc aaagtcatag taggtaaatg ctttatggga cagctgacac
     5041 cttttagacc ctaccaggta ttgctagcat gtgagctgca gttgtggggt ctgagatatt
     5101 tctttgtggt agtttcatac ccatactata gagtcatgta tttatttttg cctgttgtgt
     5161 gatgtaatgc aatcatgttc ctttgagtct ccatcccttg gaaatctgac ttcttgcaga
     5221 aggagtaggc acatcaagat attcaggggt gccccaagag tctgggactt tcaaaaaaaa
     5281 aagatcaggc tgaaactgca gtcagattta tgacagctga cagtttttca gaggtcgcac
     5341 acagtgactc tcctctctca ggatgacgag gacctgtgcc ttcaacaagc aaaatgctgc
     5401 tcacggttgt cctgcttgca gccagtcact gtgtaaagcc tctctgatgt gcacttaaga
     5461 gtgggttgct ttctcacaaa gatggggttc tgtgcagtca caggtcactt ccttgacaac
     5521 acaatcattt ctgatcttta tcactgtaac cacgtcttct attccatagg agtttctttt
     5581 gattctctca gttgcggggg gcatctctta atcctggggt aaaaggagag attgccatac
     5641 ttagactcac tgtgagtctc cccggccatt tcacgaggag accacagtgc tgccaccagt
     5701 gcctaaacag gtggctggca ttcgagactt cctcctgttc cctgggtcag aggatagcgg
     5761 tttccatcat aaaccaagat gatgagttca gcctttatcc ctcgtggttc cgctagatgt
     5821 aacttatagg agttaacatt tgaggacttt gttctgcatc agatcttact atttgaatgt
     5881 ttactgttgg attttgggca tcttattact gttactcaaa aacattgact ctgcatcaag
     5941 aaagaaacaa gaaagcaata aaacaagaaa taattcatgc tcaca
//
