LOCUS       NM_006024               3423 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens Tax1 binding protein 1 (TAX1BP1), transcript variant
            1, mRNA.
ACCESSION   NM_006024
VERSION     NM_006024.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3423)
  AUTHORS   Qian,T., Huo,B., Deng,X., Song,X., Jiang,Y., Yang,J. and Hao,F.
  TITLE     Decreased TAX1BP1 participates in systemic lupus erythematosus by
            regulating monocyte/macrophage function
  JOURNAL   Int Immunol 35 (10), 483-495 (2023)
   PUBMED   37465957
  REMARK    GeneRIF: Decreased TAX1BP1 participates in systemic lupus
            erythematosus by regulating monocyte/macrophage function.
REFERENCE   2  (bases 1 to 3423)
  AUTHORS   Le Guerroue,F., Bunker,E.N., Rosencrans,W.M., Nguyen,J.T.,
            Basar,M.A., Werner,A., Chou,T.F., Wang,C. and Youle,R.J.
  TITLE     TNIP1 inhibits selective autophagy via bipartite interaction with
            LC3/GABARAP and TAX1BP1
  JOURNAL   Mol Cell 83 (6), 927-941 (2023)
   PUBMED   36898370
  REMARK    GeneRIF: TNIP1 inhibits selective autophagy via bipartite
            interaction with LC3/GABARAP and TAX1BP1.
REFERENCE   3  (bases 1 to 3423)
  AUTHORS   Turco,E., Savova,A., Gere,F., Ferrari,L., Romanov,J., Schuschnig,M.
            and Martens,S.
  TITLE     Reconstitution defines the roles of p62, NBR1 and TAX1BP1 in
            ubiquitin condensate formation and autophagy initiation
  JOURNAL   Nat Commun 12 (1), 5212 (2021)
   PUBMED   34471133
  REMARK    GeneRIF: Reconstitution defines the roles of p62, NBR1 and TAX1BP1
            in ubiquitin condensate formation and autophagy initiation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3423)
  AUTHORS   Bell,S.L., Lopez,K.L., Cox,J.S., Patrick,K.L. and Watson,R.O.
  TITLE     Galectin-8 Senses Phagosomal Damage and Recruits Selective
            Autophagy Adapter TAX1BP1 To Control Mycobacterium tuberculosis
            Infection in Macrophages
  JOURNAL   mBio 12 (4), e0187120 (2021)
   PUBMED   34225486
  REMARK    GeneRIF: Galectin-8 Senses Phagosomal Damage and Recruits Selective
            Autophagy Adapter TAX1BP1 To Control Mycobacterium tuberculosis
            Infection in Macrophages.
REFERENCE   5  (bases 1 to 3423)
  AUTHORS   Schlutermann,D., Berleth,N., Deitersen,J., Wallot-Hieke,N.,
            Friesen,O., Wu,W., Stuhldreier,F., Sun,Y., Berning,L.,
            Friedrich,A., Mendiburo,M.J., Peter,C., Wiek,C., Hanenberg,H.,
            Stefanski,A., Stuhler,K. and Stork,B.
  TITLE     FIP200 controls the TBK1 activation threshold at
            SQSTM1/p62-positive condensates
  JOURNAL   Sci Rep 11 (1), 13863 (2021)
   PUBMED   34226595
  REMARK    GeneRIF: FIP200 controls the TBK1 activation threshold at
            SQSTM1/p62-positive condensates.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3423)
  AUTHORS   Dodon,M.D., Hamaia,S., Martin,J. and Gazzolo,L.
  TITLE     Heterogeneous nuclear ribonucleoprotein A1 interferes with the
            binding of the human T cell leukemia virus type 1 rex regulatory
            protein to its response element
  JOURNAL   J Biol Chem 277 (21), 18744-18752 (2002)
   PUBMED   11893730
REFERENCE   7  (bases 1 to 3423)
  AUTHORS   Klinkenberg,M., Van Huffel,S., Heyninck,K. and Beyaert,R.
  TITLE     Functional redundancy of the zinc fingers of A20 for inhibition of
            NF-kappaB activation and protein-protein interactions
  JOURNAL   FEBS Lett 498 (1), 93-97 (2001)
   PUBMED   11389905
REFERENCE   8  (bases 1 to 3423)
  AUTHORS   Ling,L. and Goeddel,D.V.
  TITLE     T6BP, a TRAF6-interacting protein involved in IL-1 signaling
  JOURNAL   Proc Natl Acad Sci U S A 97 (17), 9567-9572 (2000)
   PUBMED   10920205
REFERENCE   9  (bases 1 to 3423)
  AUTHORS   De Valck,D., Jin,D.Y., Heyninck,K., Van de Craen,M., Contreras,R.,
            Fiers,W., Jeang,K.T. and Beyaert,R.
  TITLE     The zinc finger protein A20 interacts with a novel anti-apoptotic
            protein which is cleaved by specific caspases
  JOURNAL   Oncogene 18 (29), 4182-4190 (1999)
   PUBMED   10435631
REFERENCE   10 (bases 1 to 3423)
  AUTHORS   Gachon,F., Peleraux,A., Thebault,S., Dick,J., Lemasson,I.,
            Devaux,C. and Mesnard,J.M.
  TITLE     CREB-2, a cellular CRE-dependent transcription repressor, functions
            in association with Tax as an activator of the human T-cell
            leukemia virus type 1 promoter
  JOURNAL   J Virol 72 (10), 8332-8337 (1998)
   PUBMED   9733879
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC424592.1, AL136586.1 and
            BU679319.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 13, 2020 this sequence version replaced NM_006024.6.
            
            Summary: This gene encodes a HTLV-1 tax1 binding protein. The
            encoded protein interacts with TNFAIP3, and inhibits TNF-induced
            apoptosis by mediating the TNFAIP3 anti-apoptotic activity.
            Degradation of this protein by caspase-3-like family proteins is
            associated with apoptosis induced by TNF. This protein may also
            have a role in the inhibition of inflammatory signaling pathways.
            Alternatively spliced transcript variants encoding different
            isoforms have been found for this gene.[provided by RefSeq, May
            2011].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL136586.1, AK314292.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000396319.7/ ENSP00000379612.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-417               DC424592.1         65-481
            418-2537            AL136586.1         391-2510
            2538-2917           AL136586.1         2512-2891
            2918-3423           BU679319.1         17-522              c
FEATURES             Location/Qualifiers
     source          1..3423
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p15.2"
     gene            1..3423
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /note="Tax1 binding protein 1"
                     /db_xref="GeneID:8887"
                     /db_xref="HGNC:HGNC:11575"
                     /db_xref="MIM:605326"
     exon            1..108
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /inference="alignment:Splign:2.1.0"
     exon            109..277
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..2485
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /note="isoform 1 is encoded by transcript variant 1;
                     TRAF6-binding protein; Tax1 (human T-cell leukemia virus
                     type I) binding protein 1"
                     /codon_start=1
                     /product="tax1-binding protein 1 isoform 1"
                     /protein_id="NP_006015.4"
                     /db_xref="CCDS:CCDS5415.1"
                     /db_xref="GeneID:8887"
                     /db_xref="HGNC:HGNC:11575"
                     /db_xref="MIM:605326"
                     /translation="MTSFQEVPLQTSNFAHVIFQNVAKSYLPNAHLECHYTLTPYIHP
                     HPKDWVGIFKVGWSTARDYYTFLWSPMPEHYVEGSTVNCVLAFQGYYLPNDDGEFYQF
                     CYVTHKGEIRGASTPFQFRASSPVEELLTMEDEGNSDMLVVTTKAGLLELKIEKTMKE
                     KEELLKLIAVLEKETAQLREQVGRMERELNHEKERCDQLQAEQKGLTEVTQSLKMENE
                     EFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTE
                     KDEKELYKVHLKNTEIENTKLMSEVQTLKNLDGNKESVITHFKEEIGRLQLCLAEKEN
                     LQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMADLH
                     TARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYK
                     EKFKECQRLQKQINKLSDQSANNNNVFTKKTGNQQKVNDASVNTDPATSASTVDVKPS
                     PSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKYADELAKMELKW
                     KEQVKIAENVKLELAEVQDNYKELKRSLENPAERKMEGQNSQSPQCFKTCSEQNGYVL
                     TLSNAQPVLQYGNPYASQETRDGADGAFYPDEIQRPPVRVPSWGLEDNVVCSQPARNF
                     SRPDGLEDSEDSKEDENVPTAPDPPSQHLRGHGTGFCFDSSFDVHKKCPLCELMFPPN
                     YDQSKFEEHVESHWKVCPMCSEQFPPDYDQQVFERHVQTHFDQNVLNFD"
     exon            278..380
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /inference="alignment:Splign:2.1.0"
     exon            381..568
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /inference="alignment:Splign:2.1.0"
     exon            569..727
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /inference="alignment:Splign:2.1.0"
     exon            728..876
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /inference="alignment:Splign:2.1.0"
     exon            877..967
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1153
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1378
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..1525
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /inference="alignment:Splign:2.1.0"
     exon            1526..1649
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /inference="alignment:Splign:2.1.0"
     exon            1650..1753
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /inference="alignment:Splign:2.1.0"
     exon            1754..1879
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /inference="alignment:Splign:2.1.0"
     exon            1880..2051
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /inference="alignment:Splign:2.1.0"
     exon            2052..2200
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /inference="alignment:Splign:2.1.0"
     exon            2201..2283
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /inference="alignment:Splign:2.1.0"
     exon            2284..3423
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2895..2900
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /note="hexamer: AATAAA"
     polyA_site      2917
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /note="major polyA site"
     regulatory      3307..3312
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /note="hexamer: ATTAAA"
     polyA_site      3333
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /note="major polyA site"
     regulatory      3388..3393
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /note="hexamer: ATTAAA"
     regulatory      3392..3397
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /note="hexamer: AAGAAA"
     polyA_site      3406
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
     polyA_site      3423
                     /gene="TAX1BP1"
                     /gene_synonym="CALCOCO3; T6BP; TXBP151"
                     /note="major polyA site"
ORIGIN      
        1 ggtctttggg ggtaggcggt agtggcggaa gaggttcggc ggctgatggc ggatcaggat
       61 cggaagcctg cgtaactttc tcccttgatc cgggagtctt tccactggat tcacaatgac
      121 atcctttcaa gaagtcccat tgcagacttc caactttgcc catgtcatct ttcaaaatgt
      181 ggccaagagt taccttccta atgcacacct ggaatgtcat tacaccttaa ctccatatat
      241 tcatccacat ccaaaagatt gggttggtat attcaaggtt ggatggagta ctgctcgtga
      301 ttattacacg tttttatggt cccctatgcc tgaacattat gtggaaggat caacagtcaa
      361 ttgtgtacta gcattccaag gatattacct tccaaatgat gatggagaat tttatcagtt
      421 ctgttacgtt acccataagg gtgaaattcg tggagcaagt acacctttcc agtttcgagc
      481 ttcttctcca gttgaagagc tgcttactat ggaagatgaa ggaaattctg acatgttagt
      541 ggtgaccaca aaagcaggcc ttcttgagtt gaaaattgag aaaaccatga aagaaaaaga
      601 agaactgtta aagttaattg ccgttctgga aaaagaaaca gcacaacttc gagaacaagt
      661 tgggagaatg gaaagagaac ttaaccatga gaaagaaaga tgtgaccaac tgcaagcaga
      721 acaaaagggt cttactgaag taacacaaag cttaaaaatg gaaaatgaag agtttaagaa
      781 gaggttcagt gatgctacat ccaaagccca tcagcttgag gaagatattg tgtcagtaac
      841 acataaagca attgaaaaag aaaccgaatt agacagttta aaggacaaac tcaagaaggc
      901 acaacatgaa agagaacaac ttgaatgtca gttgaagaca gagaaggatg aaaaggaact
      961 ttataaggta catttgaaga atacagaaat agaaaatacc aagcttatgt cagaggtcca
     1021 gactttaaaa aatttagatg ggaacaaaga aagcgtgatt actcatttca aagaagagat
     1081 tggcaggctg cagttatgtt tggctgaaaa ggaaaatctg caaagaactt tcctgcttac
     1141 aacctcaagt aaagaagata cttgtttttt aaaggagcaa cttcgtaaag cagaggaaca
     1201 ggttcaggca actcggcaag aagttgtctt tctggctaaa gaactcagtg atgctgtcaa
     1261 cgtacgagac agaacgatgg cagacctgca tactgcacgc ttggaaaacg agaaagtgaa
     1321 aaagcagtta gctgatgcag tggcagaact taaactaaat gctatgaaaa aagatcagga
     1381 caagactgat acactggaac acgaactaag aagagaagtt gaagatctga aactccgtct
     1441 tcagatggct gcagaccatt ataaagaaaa atttaaggaa tgccaaaggc tccaaaaaca
     1501 aataaacaaa ctttcagatc aatcagctaa taataataat gtcttcacaa agaaaacggg
     1561 gaatcagcag aaagtgaatg atgcttcagt aaacacagac ccagccactt ctgcctctac
     1621 tgtagatgta aagccatcac cttctgcagc agaggcagat tttgacatag taacaaaggg
     1681 gcaagtctgt gaaatgacca aagaaattgc tgacaaaaca gaaaagtata ataaatgtaa
     1741 acaactcttg caggatgaga aagcaaaatg caataaatat gctgatgaac ttgcaaaaat
     1801 ggagctgaaa tggaaagaac aagtgaaaat tgctgaaaat gtaaaacttg aactagctga
     1861 agtacaggac aattataaag aacttaaaag gagtctagaa aatccagcag aaaggaaaat
     1921 ggaaggtcag aattcccaga gtcctcaatg tttcaaaaca tgctcagagc aaaatggtta
     1981 tgttctcaca ttgtcaaatg cacaaccagt tctgcaatat ggtaatcctt atgcatctca
     2041 ggaaacaaga gatggagcag atggtgcttt ttacccagat gaaatacaaa ggccacctgt
     2101 cagagtcccc tcttggggac tggaagacaa tgttgtctgc agccagcctg ctcgaaactt
     2161 tagtcggcct gatggcttag aggactctga ggatagcaaa gaagatgaga atgtgcctac
     2221 tgctcctgat cctccaagtc aacatttacg tgggcatggg acaggctttt gctttgattc
     2281 cagctttgat gttcacaaga agtgtcccct ctgtgagtta atgtttcctc ctaactatga
     2341 tcagagcaaa tttgaagaac atgttgaaag tcactggaag gtgtgcccga tgtgcagcga
     2401 gcagttccct cctgactatg accagcaggt gtttgaaagg catgtgcaga cccattttga
     2461 tcagaatgtt ctaaattttg actagttact ttttattatg agttaatata gtttagcagt
     2521 aaaaaaaaaa aaaaaaacca cacctaaaat agaccactga ggagaccata gagcggatgc
     2581 tttcatgcac cctttactgc actttctgac caggagctac tttgagtttg gtgttactag
     2641 gatcagggtc agtctttggc ttatcaataa attttaatct ctgttaatct tacctgcttt
     2701 aaaaaaaagt tcttgtgtgt tcgtatcttt atttattccc tagtttgcag aactgtctga
     2761 ataaaggata caaggattat ttcaatgtta ctgcactgaa aaacgtgtat gtattagtgt
     2821 gctagattat ttagcagaat attcacaagt ttctgttgac cttgttgatt gagcatgact
     2881 actaaatatt atgtaataaa aagcatttgt cataacagtc ttatgaagta gttcttcgaa
     2941 tatagaaagt tctataattt agcccatgaa atgataggtt tttaattttc agaaatggag
     3001 ctgcatgtag aatgagatca catgctttta tatgtgaaat attggtttta gcaattaaca
     3061 gaaggcatac tttgctaatt ttatggcaaa attttagaat aacctgaatg attattttta
     3121 aactatcttg aagttgtatg tatatatcta atgggaaaat ggaacaagag atgtcagtat
     3181 aattgttttc ctattaaatg atctcataac aggggtgttt gtggcataaa aatcatagaa
     3241 tatatatcag tatctttttt acattttcct gatgagaata taaatttgaa atattctcag
     3301 taagtgatta aaagtacaat acataaaccc aaatcaaagt aatgtgtttc ttcagttatg
     3361 tctgtgctgt atagaactgt cactaacatt aaagaaagag gacacatttt tcaagatctg
     3421 taa
//
