LOCUS       NM_001042552            2527 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens TatD DNase domain containing 3 (TATDN3), transcript
            variant 1, mRNA.
ACCESSION   NM_001042552 XM_375838 XM_931857 XM_937712 XM_943408
VERSION     NM_001042552.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2527)
  AUTHORS   Dorival,J. and Eichman,B.F.
  TITLE     Human and bacterial TatD enzymes exhibit apurinic/apyrimidinic (AP)
            endonuclease activity
  JOURNAL   Nucleic Acids Res 51 (6), 2838-2849 (2023)
   PUBMED   36881763
  REMARK    GeneRIF: Human and bacterial TatD enzymes exhibit
            apurinic/apyrimidinic (AP) endonuclease activity.
REFERENCE   2  (bases 1 to 2527)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 2527)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2527)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   5  (bases 1 to 2527)
  AUTHORS   Kutsenko,A.S., Gizatullin,R.Z., Al-Amin,A.N., Wang,F., Kvasha,S.M.,
            Podowski,R.M., Matushkin,Y.G., Gyanchandani,A., Muravenko,O.V.,
            Levitsky,V.G., Kolchanov,N.A., Protopopov,A.I., Kashuba,V.I.,
            Kisselev,L.L., Wasserman,W., Wahlestedt,C. and Zabarovsky,E.R.
  TITLE     NotI flanking sequences: a tool for gene discovery and verification
            of the human genome
  JOURNAL   Nucleic Acids Res 30 (14), 3163-3170 (2002)
   PUBMED   12136098
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC113638.1, AC104333.2 and DB351940.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001042552.2.
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.49027.1,
                                           SRR3476690.409040.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000366974.9/ ENSP00000355941.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1293              BC113638.1         11-1303
            1294-2294           AC104333.2         46024-47024
            2295-2522           DB351940.1         1-228               c
            2523-2527           AC104333.2         47253-47257
FEATURES             Location/Qualifiers
     source          1..2527
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.3"
     gene            1..2527
                     /gene="TATDN3"
                     /note="TatD DNase domain containing 3"
                     /db_xref="GeneID:128387"
                     /db_xref="HGNC:HGNC:27010"
     exon            1..94
                     /gene="TATDN3"
                     /inference="alignment:Splign:2.1.0"
     CDS             29..853
                     /gene="TATDN3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     putative deoxyribonuclease TATDN3"
                     /codon_start=1
                     /product="putative deoxyribonuclease TATDN3 isoform 1"
                     /protein_id="NP_001036017.1"
                     /db_xref="CCDS:CCDS31019.1"
                     /db_xref="GeneID:128387"
                     /db_xref="HGNC:HGNC:27010"
                     /translation="MRAAGVGLVDCHCHLSAPDFDRDLDDVLEKAKKANVVALVAVAE
                     HSGEFEKIMQLSERYNGFVLPCLGVHPVQGLPPEDQRSVTLKDLDVALPIIENYKDRL
                     LAIGEVGLDFSPRFAGTGEQKEEQRQVLIRQIQLAKRLNLPVNVHSRSAGRPTINLLQ
                     EQGAEKVLLHAFDGRPSVAMEGVRAGYFFSIPPSIIRSGQKQKLVKQLPLTSICLETD
                     SPALGPEKQVRNEPWNISISAEYIAQVKGISVEEVIEVTTQNALKLFPKLRHLLQK"
     exon            95..127
                     /gene="TATDN3"
                     /inference="alignment:Splign:2.1.0"
     exon            128..201
                     /gene="TATDN3"
                     /inference="alignment:Splign:2.1.0"
     exon            202..286
                     /gene="TATDN3"
                     /inference="alignment:Splign:2.1.0"
     exon            287..349
                     /gene="TATDN3"
                     /inference="alignment:Splign:2.1.0"
     exon            350..459
                     /gene="TATDN3"
                     /inference="alignment:Splign:2.1.0"
     exon            460..515
                     /gene="TATDN3"
                     /inference="alignment:Splign:2.1.0"
     exon            516..628
                     /gene="TATDN3"
                     /inference="alignment:Splign:2.1.0"
     exon            629..709
                     /gene="TATDN3"
                     /inference="alignment:Splign:2.1.0"
     exon            710..2527
                     /gene="TATDN3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      999..1004
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TATDN3"
                     /note="hexamer: AATAAA"
     polyA_site      1024
                     /gene="TATDN3"
                     /note="major polyA site"
     regulatory      2300..2305
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TATDN3"
                     /note="hexamer: AATAAA"
     polyA_site      2319
                     /gene="TATDN3"
                     /note="major polyA site"
     regulatory      2342..2347
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TATDN3"
                     /note="hexamer: AATAAA"
     polyA_site      2361
                     /gene="TATDN3"
     regulatory      2497..2502
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TATDN3"
                     /note="hexamer: ATTAAA"
     polyA_site      2527
                     /gene="TATDN3"
ORIGIN      
        1 ggtctaaagc ggcagccgcc ggggcgcaat gcgagcggct ggcgtaggct tggtggactg
       61 tcactgccac ctctccgccc cggactttga ccgcgatttg gatgatgtgt tggagaaagc
      121 caagaaggcc aatgttgtgg cccttgtggc agttgccgaa cattcaggag aatttgaaaa
      181 gattatgcaa ctttcagaaa ggtataatgg gtttgtcctg ccatgcttgg gtgttcatcc
      241 agttcaagga cttccaccag aagaccaaag aagtgtcaca ctaaaggatt tggatgtagc
      301 tttgcccatt attgagaatt ataaggatcg gttgttggca attggagagg ttggactaga
      361 tttctccccc agatttgctg gcactggtga acagaaggaa gagcaaagac aagtcctaat
      421 cagacagatc cagttagcca aaagactaaa tttgcctgta aatgtgcact cacgctctgc
      481 tggaagacct accatcaacc ttttacaaga gcaaggtgct gagaaggtac tgctgcatgc
      541 atttgatggt cggccatctg tagccatgga aggagtaaga gctgggtact tcttctcaat
      601 tcccccttct atcataagaa gtggacagaa gcagaaactt gtgaaacaat tgcctttaac
      661 ttctatatgc ttagaaacag attcacctgc actaggacca gaaaaacagg tacggaatga
      721 gccctggaac atttctattt cagcagaata tattgcccag gtgaaaggga tctcagtgga
      781 agaagttata gaagtgacga cacagaatgc attaaaactg tttcctaagc tccgacactt
      841 gctccagaaa tagcttcaaa accatccatt acaaaatcga atcaactgca gggggcagca
      901 tttgaaaaat agaaatgttc tgatgaagaa tctgaactga agaagctgtt ttatagggtt
      961 atagaagatt gtaattgtag agaaatattt ctcttagaaa taaaactggg cttggatcct
     1021 gaaaccctgg gttctgattc tagccttgtg ctgcttttca attagccgag ttctggcagg
     1081 atattgggaa aatactgcta cttcttacat tgccctttta tatagaacca ccacctgaac
     1141 tgaaaccatt gctactggga agggtggctc ccacaggaag agtataagca ctactgtgat
     1201 gaggatggag taagctaaag tatacttttt tttttttttg atggagtttc gctgttgttg
     1261 cccaggctgg agtgcaatgg cacgatcttg gctcactgca acctccactt cccaggttct
     1321 agcgagtctc ctccctcagc ctcccaagta gctgggatta caggcatgtg ccaccatgcc
     1381 cagctaattt tgtattttta gtagagacag ggtttctcca tgttggtcag gctggtctcg
     1441 aactcccgac ctcaggtgat ccgcccgcct cggcctccca aagtgctggg attacaggca
     1501 tgagccactg cgccagccta aagtgtgttc ttaccaccta tttttcttcc cataggagtt
     1561 agccagtgaa gggagaatgt ctggttttct atgctgtcag aaatctcttt tctaggtttg
     1621 taaaattgaa cttttagtac ttcgaattat ttctctttaa gataaaaatg catacgattt
     1681 ttacactgat cttagatttt tgacttatga ggccagtggt ttaaacaatc attattgaat
     1741 accaagccca aaagtttagt taatacacca attgtaagtt ctggtctgaa ttttgtcaac
     1801 atatttagaa tgtaaatggc attattaaaa atgtatctga tttctctgtg aacagtaata
     1861 tttcatattt ttaagtttaa aaatgttagt gtaagccagg cacagtggca ttcacctgta
     1921 gtgccaacca ctcaggaggc tgagatggga gaccttttaa gcctgagttt gagtcaggcc
     1981 tgggcaacat agatgtgagc acctatctct aaaaatgtaa ataaataaaa atctcaaaaa
     2041 aattaaaaat ctcaagtgta aaaacagttc tgtagataga tggtagtgat ggtagcacat
     2101 caatgtgaag gtatttaatg ccactgaact gtacacttat aacgaattag gataaatttt
     2161 atgttatgtg tatttactac aattttttaa aaatcgtata tgtagtttaa caggtgtggt
     2221 caatatcaaa acttaggtat ttaatcttgt taaattatat aagcagaaaa tgctggaaaa
     2281 agtacctgtc atagaaaaaa ataaacttcc taaatcaaag tgattttatg aaatgatctt
     2341 caataaatat tttgaaatga attcatttat ggaagaatca aaactaggtc agattgtcca
     2401 aaccagacta agaaactgaa tagggtattt tatgaggtat ttaatgactc atcagcacca
     2461 ttttaaatga aattcctaca tttaacagga gattatatta aaactggact tttaagctct
     2521 cttccaa
//
