LOCUS       NM_014760               4937 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens TatD DNase domain containing 2 (TATDN2), mRNA.
ACCESSION   NM_014760 XM_376203
VERSION     NM_014760.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4937)
  AUTHORS   Jaiswal,A.S., Dutta,A., Srinivasan,G., Yuan,Y., Zhou,D.,
            Shaheen,M., Sadideen,D.T., Kirby,A., Williamson,E.A., Gupta,Y.K.,
            Olsen,S.K., Xu,M., Loranc,E., Mukhopadhyay,P., Pertsemlidis,A.,
            Bishop,A.J.R., Sung,P., Nickoloff,J.A. and Hromas,R.
  TITLE     TATDN2 resolution of R-loops is required for survival of
            BRCA1-mutant cancer cells
  JOURNAL   Nucleic Acids Res 51 (22), 12224-12241 (2023)
   PUBMED   37953292
  REMARK    GeneRIF: TATDN2 resolution of R-loops is required for survival of
            BRCA1-mutant cancer cells.
REFERENCE   2  (bases 1 to 4937)
  AUTHORS   Flachsbart,F., Franke,A., Kleindorp,R., Caliebe,A., Blanche,H.,
            Schreiber,S. and Nebel,A.
  TITLE     Investigation of genetic susceptibility factors for human longevity
            - a targeted nonsynonymous SNP study
  JOURNAL   Mutat Res 694 (1-2), 13-19 (2010)
   PUBMED   20800603
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   3  (bases 1 to 4937)
  AUTHORS   Seim,I., Carter,S.L., Herington,A.C. and Chopin,L.K.
  TITLE     Complex organisation and structure of the ghrelin antisense strand
            gene GHRLOS, a candidate non-coding RNA gene
  JOURNAL   BMC Mol Biol 9, 95 (2008)
   PUBMED   18954468
  REMARK    GeneRIF: Describes transcription of the non-coding RNA GHRLOS,
            including potential read-through transcription from the TATDN2
            locus.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4937)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC022384.5, BP249277.1, BC090935.1, BC101776.1, BG674405.1 and
            AW274827.1.
            
            On Nov 23, 2018 this sequence version replaced NM_014760.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC090935.1, DRR138525.433503.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000448281.7/ ENSP00000408736.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                AC022384.5         127661-127694
            35-38               BP249277.1         1-4
            39-453              AC022384.5         127699-128113
            454-1380            BC090935.1         1-927
            1381-1381           BC101776.1         837-837
            1382-3768           BC090935.1         929-3315
            3769-3769           BG674405.1         190-190
            3770-4607           BC090935.1         3317-4154
            4608-4937           AW274827.1         7-336               c
FEATURES             Location/Qualifiers
     source          1..4937
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p25.3"
     gene            1..4937
                     /gene="TATDN2"
                     /note="TatD DNase domain containing 2"
                     /db_xref="GeneID:9797"
                     /db_xref="HGNC:HGNC:28988"
                     /db_xref="MIM:619330"
     exon            1..609
                     /gene="TATDN2"
                     /inference="alignment:Splign:2.1.0"
     exon            610..1029
                     /gene="TATDN2"
                     /inference="alignment:Splign:2.1.0"
     CDS             616..2901
                     /gene="TATDN2"
                     /codon_start=1
                     /product="putative deoxyribonuclease TATDN2"
                     /protein_id="NP_055575.3"
                     /db_xref="CCDS:CCDS33698.1"
                     /db_xref="GeneID:9797"
                     /db_xref="HGNC:HGNC:28988"
                     /db_xref="MIM:619330"
                     /translation="MASERGKVKHNWSSTSEGCPRKRSCLREPCDVAPSSRPAQRSAS
                     RSGGPSSPKRLKAQKEDDVACSRRLSWGSSRRRNNSSSSFSPHFLGPGVGGAASKGCL
                     IRNTRGFLSSGGSPLRPANASLEEMASLEEEACSLKVDSKDSSHNSTNSEFAAEAEGQ
                     NDTIEEPNKVQKRKRDRLRDQGSTMIYLKAIQGILGKSMPKRKGEAATRAKPSAAEHP
                     SHGEGPARSEGPAKTAEGAARSVTVTAAQKEKDATPEVSMEEDKTVPERSSFYDRRVV
                     IDPQEKPSEEPLGDRRTVIDKCSPPLEFLDDSDSHLEIQKHKDREVVMEHPSSGSDWS
                     DVEEISTVRFSQEEPVSLKPSAVPEPSSFTTDYVMYPPHLYSSPWCDYASYWTSSPKP
                     SSYPSTGSSSNDAAQVGKSSRSRMSDYSPNSTGSVQNTSRDMEASEEGWSQNSRSFRF
                     SRSSEEREVKEKRTFQEEMPPRPCGGHASSSLPKSHLEPSLEEGFIDTHCHLDMLYSK
                     LSFQGTFTKFRKIYSSSFPKEFQGCISDFCDPRTLTDCLWEELLKEDLVWGAFGCHPH
                     FARYYSESQERNLLQALRHPKAVAFGEMGLDYSYKCTTPVPEQHKVFERQLQLAVSLK
                     KPLVIHCREADEDLLEIMKKFVPPDYKIHRHCFTGSYPVIEPLLKYFPNMSVGFTAVL
                     TYSSAWEAREALRQIPLERIIVETDAPYFLPRQVPKSLCQYAHPGLALHTVREIARVK
                     DQPLSLTLAALRENTSRLYSL"
     exon            1030..1563
                     /gene="TATDN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1564..2448
                     /gene="TATDN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2449..2576
                     /gene="TATDN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2577..2760
                     /gene="TATDN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2761..2939
                     /gene="TATDN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2940..4937
                     /gene="TATDN2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4912..4917
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TATDN2"
                     /note="hexamer: AATAAA"
     polyA_site      4937
                     /gene="TATDN2"
                     /note="major polyA site"
ORIGIN      
        1 gtcgctctcc ggcctgcggg ccgcagggct cgttccggag ggcgggcgcc acggaggccg
       61 gagtggtcgc agttcgggcg gaggccgggc caggcggggc tgtagggctg gggcaggcgg
      121 cgggctgccc ggcgggacag ctgcggcagc cggcgggggg cgtcctgagt tggcggtcga
      181 gggcgctgcc agctcccgag gggccgctcg ggccccttcc ggcccgggtc tggttgggcc
      241 gcaggagcag ggcgggctgc ggcgcccggg tctggccctg gcctacgggc taagcgcccg
      301 gccccggggc cgcggatccg gcagccatgt gtggatcttg aagcgccatg tggtcttctg
      361 aagcgcttga cagttctaaa gggctttata ttgcaaactg atcaaagcgc ttcgtagccc
      421 cggaagcgct taggcatctc cgaagtagcg ctgggcaaag tgaaggcttc ctgatctcag
      481 aagcacgttg tgggcttgga aaccgacggc agcctttagt caattttgga tcgctttgac
      541 ttctccaaca cggtttggca tctctgaaac cttgagaact gtgatgggca gtggaaagaa
      601 gagggaaagg tgcccatggc gtccgagcgg ggcaaggtca agcacaactg gagcagcacg
      661 tcggaagggt gtccccgcaa gcgcagctgc ctccgggagc cctgtgatgt ggccccctcc
      721 agccggccag ctcagaggtc tgcgtcgcgt tctggagggc ccagcagccc caagcgcctg
      781 aaagcccaga aggaggacga tgtggcttgc tcgcggaggt tatcctgggg ctcatcccgc
      841 cgcagaaata actcctcctc ctccttctcc ccacatttct tgggccctgg tgtgggcggg
      901 gccgcctcca aaggctgcct gattcggaac actcgggggt tcctgtcttc agggggatcc
      961 cctctgcgtc ctgccaacgc ctctttggaa gaaatggctt ctctagagga ggaagcctgc
     1021 agccttaagg ttgattccaa agatagttct cataactcca caaactctga atttgcagct
     1081 gaagctgagg gtcagaatga tacaattgag gaacccaaca aggtccagaa aaggaagagg
     1141 gatagacttc gagaccaggg ctccacaatg atctacctga aggctatcca gggcatcctg
     1201 gggaaatcga tgccaaaaag gaagggagag gctgccactc gggcaaaacc aagcgcagca
     1261 gagcatccca gccatggaga aggaccagcc aggagtgaag gaccagccaa gactgcagaa
     1321 ggagcagcca ggagtgtcac agtcactgct gctcagaagg agaaagacgc aaccccagag
     1381 gtcagcatgg aggaggataa gacagtgcca gagaggagca gcttctatga caggagagta
     1441 gttatagacc ctcaagagaa acccagtgag gagccccttg gggaccgaag gactgtcatt
     1501 gacaaatgct ctccacccct agagttcttg gatgactctg actctcattt agaaatccaa
     1561 aagcataaag atagggaggt ggtgatggag cacccctctt ctggaagtga ctggtctgat
     1621 gttgaggaga tctccacagt cagattctct caggaggaac ctgtctccct gaaaccttca
     1681 gccgttccgg agccttcttc cttcaccacc gactatgtca tgtaccctcc tcatttgtac
     1741 agtagtcctt ggtgtgacta cgccagctat tggaccagca gccccaagcc ttctagctac
     1801 ccctccacag gcagcagcag caacgatgca gcccaggttg ggaagagcag ccggagccgc
     1861 atgagtgatt attcccccaa ctctacaggg agtgtccaaa acacctccag agacatggag
     1921 gcctcagagg aaggctggtc ccagaattct cgttcatttc gcttctccag aagctcagaa
     1981 gaaagagagg tgaaggagaa aagaacattc caagaggaga tgcctccgcg tccttgtgga
     2041 ggacacgcat ccagctccct gccaaagagc cacctggagc caagcctaga ggagggcttc
     2101 attgacactc attgtcacct ggacatgctc tattccaagc tatctttcca agggaccttt
     2161 acaaagttca gaaaaattta cagcagctcc ttccctaagg aatttcaggg ctgcatctct
     2221 gacttctgtg atccccgcac cctgacagat tgcctatggg aggagctgtt gaaagaggat
     2281 ctggtctggg gggcctttgg ctgtcaccct cattttgcac gttactacag tgagagtcaa
     2341 gaaagaaatc ttttgcaagc cttaaggcac cctaaggctg tggcatttgg agaaatgggc
     2401 ttggattact cttacaagtg caccacgcct gtcccagaac agcacaaggt atttgagaga
     2461 cagctgcagc tggctgtgtc tctaaagaag cccttggtga tccactgccg agaagctgat
     2521 gaagatctgc tagaaatcat gaaaaagttt gtgccccctg actacaagat ccataggcat
     2581 tgcttcaccg gcagctaccc ggtcattgag cccctgctga agtactttcc caacatgtct
     2641 gtgggcttca cggcagtgct gacatactcc tctgcctggg aggcccggga agccttgagg
     2701 cagatcccac tggagagaat catcgtggaa acggatgctc cctatttcct ccctcgccag
     2761 gttcccaaaa gcctttgcca gtatgcccac ccgggcctgg ccttgcatac ggtccgagag
     2821 attgccagag tcaaagatca gccactctcc ctcaccttgg ctgccttgcg tgagaacacc
     2881 agtcgcctct acagtcttta agcagagaag gtacagtcct cgggagtctc ctagaaaagg
     2941 gcgaccagca gcctgacaga acacaggctg gcttgaagtc tgtgtctcag gtcgaggatg
     3001 tgtttagaga gctgattgga acacagaaaa ccaggacagg atgttttcct ccaagcgggt
     3061 cataaggctt cagcttctgg gtggtgggtg gggtggggtg ggcatggaat gaggggtatg
     3121 gggactgcct gtaatagcac tgggattttg cctcccagcc aaaatgctcc agggtaggca
     3181 gcaaagaaga aagagtgcga tatgagggta cagtgagttt ggcagtccaa attctgttct
     3241 ctgcagcctg tttttgagta gttggtgaat aaagtcaccc gcctacttgt ctaagcacat
     3301 gtgggtgtgt aactcagttc ctggttctcg gttctaaaaa cagacttcca actgggaaac
     3361 tttttggggg aaattaactg gacacctatc tcggaggttt attttcttgc aaccagtgaa
     3421 gtcgtcctcc tcccttccct ggataactct tcagtttgac tgtcactgtt ctggtgtcaa
     3481 ctccagcgtc ggcacaggca gaaggacttc agctgctggt ctcattggtt ccactgccat
     3541 tgatatgggg gggtgcagag gagcactcat tgtccatgat ggagatccag gacagactgg
     3601 gggactccgg gaagaggctt tcttggggaa gaggacccca aaggaggtac ttcctcctca
     3661 ctgatgccct cagggctgct gtgtgggtgt gttaagctga taaggttcag tttgcggcgg
     3721 aaactacctg ctagtcttgt gtcaggggct gccagcctcc ttttgtttca cttttgcccc
     3781 cttcttggga acatttgacc aaaaataatc ctcatttcat cttgtgtaca gtcctttgtg
     3841 taccccgccc aggttgagag gtgaatcagc gtaattctcc gaagctctgc tgggcagctc
     3901 agccatgtta cattgtctat gcagaataag caggcctggt gtctgcaaat gtaccagtcc
     3961 ttctcccgca tctcctgggt gcccccttgg ctttgcctct cctgtgtcct gtctttctgc
     4021 gttttagaag tgagagcctc tccttcacct tttgagcaac tgagtcatct caagtcctga
     4081 gctctgctct gccgcctgct ggtgccttgt aaaggtatac tcgttacagg ccctagaggt
     4141 tctaatggtc cagggttaag tgagaggaga ctgtactttg tttcaaagga tccttcaccc
     4201 tgatctgcag tgaggtggat agatcacctg gagtccctcg tctgtggtct tggaggctta
     4261 aattgtaaaa tacatccctt atggaatcct aaattcctct aggtgttttt ggaaggcgca
     4321 tttgagcctt gtgagctaaa atggaatgga tttaatattt cctatctggc atttccatct
     4381 tgcccctggt acacaagtca ctggcctgga actcagcctt gattcactgt ccgtcttcac
     4441 ggattagctg tgctgttatg ttgtctgtgc tgcagattgg cccatgtggg aagtcggggg
     4501 ggacctgatt tcctgcttgg aagacttggg ggactgccga gcatatcaaa gtgtttatag
     4561 tcaccaagtg aactgcagca caaccatctc ctctccagca agccctgaag tcagtagtgc
     4621 ctgcaggtga aaccaaccag ccctgtgtta gaggaggaaa agcggagatg acatggaagt
     4681 ctccaagcct gtgccatcca cctgccaagg aaaagcacaa ggtgctatct acttttctct
     4741 ctaggattta gattatcatt tatgtgctgt tgcacagtga aacctcacct gtgtgggcgt
     4801 gaaagctgat tggcattgtt tttgattcag ctttttggat ggctaattgt tttcactgtg
     4861 ctgtgggaat gcctctgtat tttttcccct ctttggccat ctttttctga aaataaagtg
     4921 atggatcctc tagccaa
//
