LOCUS       NM_032026               1029 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens TatD DNase domain containing 1 (TATDN1), transcript
            variant 1, mRNA.
ACCESSION   NM_032026
VERSION     NM_032026.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1029)
  AUTHORS   Dorival,J. and Eichman,B.F.
  TITLE     Human and bacterial TatD enzymes exhibit apurinic/apyrimidinic (AP)
            endonuclease activity
  JOURNAL   Nucleic Acids Res 51 (6), 2838-2849 (2023)
   PUBMED   36881763
  REMARK    GeneRIF: Human and bacterial TatD enzymes exhibit
            apurinic/apyrimidinic (AP) endonuclease activity.
REFERENCE   2  (bases 1 to 1029)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 1029)
  AUTHORS   Shen,C., Xu,Y., Lu,T.F., Zhang,J.J., Qian,Y.B. and Xu,N.
  TITLE     LncRNA TATDN1 induces the progression of hepatocellular carcinoma
            via targeting miRNA-6089
  JOURNAL   Eur Rev Med Pharmacol Sci 23 (15), 6459-6466 (2019)
   PUBMED   31378885
  REMARK    GeneRIF: LncRNA TATDN1 induces the progression of hepatocellular
            carcinoma via targeting miRNA-6089.
REFERENCE   4  (bases 1 to 1029)
  AUTHORS   Yu,X.Y., Tian,J.R., Yang,D. and Tan,H.R.
  TITLE     TATDN1 promotes the development and progression of breast cancer by
            targeting microRNA-140-3p
  JOURNAL   Eur Rev Med Pharmacol Sci 23 (12), 5293-5300 (2019)
   PUBMED   31298381
  REMARK    GeneRIF: TATDN1 promotes the development and progression of breast
            cancer by targeting microRNA-140-3p.
REFERENCE   5  (bases 1 to 1029)
  AUTHORS   Wang,L., Shang,X. and Feng,Q.
  TITLE     LncRNA TATDN1 contributes to the cisplatin resistance of non-small
            cell lung cancer through TATDN1/miR-451/TRIM66 axis
  JOURNAL   Cancer Biol Ther 20 (3), 261-271 (2019)
   PUBMED   30481109
  REMARK    GeneRIF: TATDN1 enhanced the DDP-tolerance of NSCLC cells by
            upregulating TRIM66 expression via sponging miR-451, hinting a
            novel regulatory pathway of chemoresistance in DDP-tolerant NSCLC
            cells.
REFERENCE   6  (bases 1 to 1029)
  AUTHORS   Zequn,N., Xuemei,Z., Wei,L., Zongjuan,M., Yujie,Z., Yanli,H.,
            Yuping,Z., Xia,M., Wei,W., Wenjing,D., Na,F. and Shuanying,Y.
  TITLE     The role and potential mechanisms of LncRNA-TATDN1 on metastasis
            and invasion of non-small cell lung cancer
  JOURNAL   Oncotarget 7 (14), 18219-18228 (2016)
   PUBMED   26943769
  REMARK    GeneRIF: The data indicate that TATDN1 expression is associated
            with 95D cells' higher potential of invasion and metastasis, and
            suggest that TATDN1 may be a potential prognostic factor and
            therapeutic target for non-small cell lung cancer.
REFERENCE   7  (bases 1 to 1029)
  AUTHORS   Yang,H., Liu,C., Jamsen,J., Wu,Z., Wang,Y., Chen,J., Zheng,L. and
            Shen,B.
  TITLE     The DNase domain-containing protein TATDN1 plays an important role
            in chromosomal segregation and cell cycle progression during
            zebrafish eye development
  JOURNAL   Cell Cycle 11 (24), 4626-4632 (2012)
   PUBMED   23187801
REFERENCE   8  (bases 1 to 1029)
  AUTHORS   Kang,S.M., Shin,M.J., Kim,J.H. and Oh,J.W.
  TITLE     Proteomic profiling of cellular proteins interacting with the
            hepatitis C virus core protein
  JOURNAL   Proteomics 5 (8), 2227-2237 (2005)
   PUBMED   15846844
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC007066.1, BC064964.1, AF212250.1 and AV729364.1.
            
            On Nov 23, 2018 this sequence version replaced NM_032026.3.
            
            Transcript Variant: This variant (1) uses an alternate in-frame
            splice site and lacks an alternate exon in the 3' coding region
            compared to variant 4. The encoded isoform (a) is shorter than
            isoform c.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.111986.1,
                                           SRR5189652.52088.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000276692.11/ ENSP00000276692.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                BC007066.1         4-16
            14-520              BC064964.1         1-507
            521-1019            AF212250.1         507-1005
            1020-1029           AV729364.1         342-351
FEATURES             Location/Qualifiers
     source          1..1029
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.13"
     gene            1..1029
                     /gene="TATDN1"
                     /gene_synonym="CDA11"
                     /note="TatD DNase domain containing 1"
                     /db_xref="GeneID:83940"
                     /db_xref="HGNC:HGNC:24220"
                     /db_xref="MIM:619364"
     exon            1..61
                     /gene="TATDN1"
                     /gene_synonym="CDA11"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..933
                     /gene="TATDN1"
                     /gene_synonym="CDA11"
                     /note="isoform a is encoded by transcript variant 1;
                     putative deoxyribonuclease TATDN1; hepatocarcinoma high
                     expression protein"
                     /codon_start=1
                     /product="deoxyribonuclease TATDN1 isoform a"
                     /protein_id="NP_114415.1"
                     /db_xref="CCDS:CCDS6351.1"
                     /db_xref="GeneID:83940"
                     /db_xref="HGNC:HGNC:24220"
                     /db_xref="MIM:619364"
                     /translation="MSRFKFIDIGINLTDPMFRGIYRGVQKHQDDLQDVIGRAVEIGV
                     KKFMITGGNLQDSKDALHLAQTNGMFFSTVGCHPTRCGEFEKNNPDLYLKELLNLAEN
                     NKGKVVAIGECGLDFDRLQFCPKDTQLKYFEKQFELSEQTKLPMFLHCRNSHAEFLDI
                     MKRNRDRCVGGVVHSFDGTKEAAAALIDLDLYIGFNGCSLKTEANLEVLKSIPSEKLM
                     IETDAPWCGVKSTHAGSKYIRTAFPTKKKWESGHCLKDRNEPCHIIQILEIMSAVRDE
                     DPLELANTLYNNTIKVFFPGI"
     exon            62..127
                     /gene="TATDN1"
                     /gene_synonym="CDA11"
                     /inference="alignment:Splign:2.1.0"
     exon            128..177
                     /gene="TATDN1"
                     /gene_synonym="CDA11"
                     /inference="alignment:Splign:2.1.0"
     exon            178..241
                     /gene="TATDN1"
                     /gene_synonym="CDA11"
                     /inference="alignment:Splign:2.1.0"
     exon            242..385
                     /gene="TATDN1"
                     /gene_synonym="CDA11"
                     /inference="alignment:Splign:2.1.0"
     exon            386..428
                     /gene="TATDN1"
                     /gene_synonym="CDA11"
                     /inference="alignment:Splign:2.1.0"
     exon            429..514
                     /gene="TATDN1"
                     /gene_synonym="CDA11"
                     /inference="alignment:Splign:2.1.0"
     exon            515..555
                     /gene="TATDN1"
                     /gene_synonym="CDA11"
                     /inference="alignment:Splign:2.1.0"
     exon            556..632
                     /gene="TATDN1"
                     /gene_synonym="CDA11"
                     /inference="alignment:Splign:2.1.0"
     exon            633..703
                     /gene="TATDN1"
                     /gene_synonym="CDA11"
                     /inference="alignment:Splign:2.1.0"
     exon            704..830
                     /gene="TATDN1"
                     /gene_synonym="CDA11"
                     /inference="alignment:Splign:2.1.0"
     exon            831..1029
                     /gene="TATDN1"
                     /gene_synonym="CDA11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1000..1005
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TATDN1"
                     /gene_synonym="CDA11"
                     /note="hexamer: AATAAA"
     regulatory      1004..1009
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TATDN1"
                     /gene_synonym="CDA11"
                     /note="hexamer: AAGAAA"
     polyA_site      1019
                     /gene="TATDN1"
                     /gene_synonym="CDA11"
                     /note="major polyA site"
     polyA_site      1029
                     /gene="TATDN1"
                     /gene_synonym="CDA11"
ORIGIN      
        1 cacttccgct tccgctgggg aggtcctcca tgcgcagtca tgagtcgctt caagtttatc
       61 gatattggta tcaacttgac tgaccctatg ttcagaggaa tttatagggg ggttcaaaag
      121 catcaagatg acttacagga tgtaataggg agagctgtcg agattggtgt taaaaagttt
      181 atgattacag gtggaaatct acaagacagt aaagatgcac tgcatttggc acaaacaaat
      241 ggtatgtttt tcagtacagt tggatgtcat cctacaagat gtggtgaatt tgaaaagaat
      301 aaccctgatc tttacttaaa ggagttgcta aatcttgctg aaaacaataa agggaaagtt
      361 gtggcaatag gagaatgcgg acttgatttt gaccgactgc agttttgtcc caaagatact
      421 caactcaaat attttgaaaa acagtttgaa ctgtcagaac aaacaaaatt accaatgttt
      481 cttcattgtc gaaactcaca tgctgaattt ttggacataa tgaaaagaaa tagagatcgg
      541 tgtgtagggg gagtggtgca ttcatttgat ggtaccaagg aagcagcagc tgctttgatt
      601 gacttggatc tttatatagg atttaatggt tgctcactga aaactgaagc taatttggaa
      661 gttttgaagt caattcctag tgaaaaatta atgattgaga cagatgcacc ttggtgtgga
      721 gtcaaaagta cacatgctgg atcaaaatat ataagaactg catttcctac caaaaagaag
      781 tgggaaagtg ggcactgctt aaaagacaga aatgaaccct gccatataat tcaaatattg
      841 gagataatgt cagcagtgag agatgaggat ccactggaat tagccaatac actatataac
      901 aatactatta aagtattttt tcctggaata taattggtat atgtcttcca ctttccatca
      961 tgtatgtaaa atttcatagt aaaacttcct gatagtttca ataaagaaat tatctgcaag
     1021 ttgtctaaa
//
