LOCUS       NM_001321783            8699 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens transcription activation suppressor family member 2
            (TASOR2), transcript variant 2, mRNA.
ACCESSION   NM_001321783 XM_011519524
VERSION     NM_001321783.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8699)
  AUTHORS   Krishnamoorthy,V., Foglizzo,M., Dilley,R.L., Wu,A., Datta,A.,
            Dutta,P., Campbell,L.J., Degtjarik,O., Musgrove,L.J.,
            Calabrese,A.N., Zeqiraj,E. and Greenberg,R.A.
  TITLE     The SPATA5-SPATA5L1 ATPase complex directs replisome proteostasis
            to ensure genome integrity
  JOURNAL   Cell 187 (9), 2250-2268 (2024)
   PUBMED   38554706
REFERENCE   2  (bases 1 to 8699)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 8699)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 8699)
  AUTHORS   Schopp,T., Zoch,A., Berrens,R.V., Auchynnikava,T., Kabayama,Y.,
            Vasiliauskaite,L., Rappsilber,J., Allshire,R.C. and O'Carroll,D.
  TITLE     TEX15 is an essential executor of MIWI2-directed transposon DNA
            methylation and silencing
  JOURNAL   Nat Commun 11 (1), 3739 (2020)
   PUBMED   32719317
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8699)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 8699)
  AUTHORS   Yang,X., Coulombe-Huntington,J., Kang,S., Sheynkman,G.M., Hao,T.,
            Richardson,A., Sun,S., Yang,F., Shen,Y.A., Murray,R.R., Spirohn,K.,
            Begg,B.E., Duran-Frigola,M., MacWilliams,A., Pevzner,S.J.,
            Zhong,Q., Wanamaker,S.A., Tam,S., Ghamsari,L., Sahni,N., Yi,S.,
            Rodriguez,M.D., Balcha,D., Tan,G., Costanzo,M., Andrews,B.,
            Boone,C., Zhou,X.J., Salehi-Ashtiani,K., Charloteaux,B., Chen,A.A.,
            Calderwood,M.A., Aloy,P., Roth,F.P., Hill,D.E., Iakoucheva,L.M.,
            Xia,Y. and Vidal,M.
  TITLE     Widespread Expansion of Protein Interaction Capabilities by
            Alternative Splicing
  JOURNAL   Cell 164 (4), 805-817 (2016)
   PUBMED   26871637
REFERENCE   7  (bases 1 to 8699)
  AUTHORS   Sahni,N., Yi,S., Taipale,M., Fuxman Bass,J.I.,
            Coulombe-Huntington,J., Yang,F., Peng,J., Weile,J., Karras,G.I.,
            Wang,Y., Kovacs,I.A., Kamburov,A., Krykbaeva,I., Lam,M.H.,
            Tucker,G., Khurana,V., Sharma,A., Liu,Y.Y., Yachie,N., Zhong,Q.,
            Shen,Y., Palagi,A., San-Miguel,A., Fan,C., Balcha,D., Dricot,A.,
            Jordan,D.M., Walsh,J.M., Shah,A.A., Yang,X., Stoyanova,A.K.,
            Leighton,A., Calderwood,M.A., Jacob,Y., Cusick,M.E.,
            Salehi-Ashtiani,K., Whitesell,L.J., Sunyaev,S., Berger,B.,
            Barabasi,A.L., Charloteaux,B., Hill,D.E., Hao,T., Roth,F.P.,
            Xia,Y., Walhout,A.J.M., Lindquist,S. and Vidal,M.
  TITLE     Widespread macromolecular interaction perturbations in human
            genetic disorders
  JOURNAL   Cell 161 (3), 647-660 (2015)
   PUBMED   25910212
REFERENCE   8  (bases 1 to 8699)
  AUTHORS   Savage,S.A., Mirabello,L., Wang,Z., Gastier-Foster,J.M.,
            Gorlick,R., Khanna,C., Flanagan,A.M., Tirabosco,R., Andrulis,I.L.,
            Wunder,J.S., Gokgoz,N., Patino-Garcia,A., Sierrasesumaga,L.,
            Lecanda,F., Kurucu,N., Ilhan,I.E., Sari,N., Serra,M., Hattinger,C.,
            Picci,P., Spector,L.G., Barkauskas,D.A., Marina,N., de Toledo,S.R.,
            Petrilli,A.S., Amary,M.F., Halai,D., Thomas,D.M., Douglass,C.,
            Meltzer,P.S., Jacobs,K., Chung,C.C., Berndt,S.I., Purdue,M.P.,
            Caporaso,N.E., Tucker,M., Rothman,N., Landi,M.T., Silverman,D.T.,
            Kraft,P., Hunter,D.J., Malats,N., Kogevinas,M., Wacholder,S.,
            Troisi,R., Helman,L., Fraumeni,J.F. Jr., Yeager,M., Hoover,R.N. and
            Chanock,S.J.
  TITLE     Genome-wide association study identifies two susceptibility loci
            for osteosarcoma
  JOURNAL   Nat Genet 45 (7), 799-803 (2013)
   PUBMED   23727862
REFERENCE   9  (bases 1 to 8699)
  AUTHORS   Oshikawa,M., Tsutsui,C., Ikegami,T., Fuchida,Y., Matsubara,M.,
            Toyama,S., Usami,R., Ohtoko,K. and Kato,S.
  TITLE     Full-length transcriptome analysis of human retina-derived cell
            lines ARPE-19 and Y79 using the vector-capping method
  JOURNAL   Invest Ophthalmol Vis Sci 52 (9), 6662-6670 (2011)
   PUBMED   21697133
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 8699)
  AUTHORS   Yu,H., Tardivo,L., Tam,S., Weiner,E., Gebreab,F., Fan,C.,
            Svrzikapa,N., Hirozane-Kishikawa,T., Rietman,E., Yang,X.,
            Sahalie,J., Salehi-Ashtiani,K., Hao,T., Cusick,M.E., Hill,D.E.,
            Roth,F.P., Braun,P. and Vidal,M.
  TITLE     Next-generation sequencing to generate interactome datasets
  JOURNAL   Nat Methods 8 (6), 478-480 (2011)
   PUBMED   21516116
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL365356.13 and AL596094.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 14, 2020 this sequence version replaced NM_001321783.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853559.3800.1,
                                           SRR14038191.1994257.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000695737.1/ ENSP00000512130.1
            RefSeq Select criteria :: based on manual assertion
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-338               AL365356.13        89697-90034
            339-434             AL365356.13        117682-117777
            435-507             AL365356.13        118994-119066
            508-599             AL365356.13        122518-122609
            600-724             AL365356.13        125403-125527
            725-744             AL365356.13        125614-125633
            745-844             AL365356.13        125730-125829
            845-945             AL365356.13        128536-128636
            946-1049            AL365356.13        129289-129392
            1050-1122           AL365356.13        131744-131816
            1123-1185           AL365356.13        131920-131982
            1186-1902           AL365356.13        135346-136062
            1903-2145           AL365356.13        140163-140405
            2146-3025           AL365356.13        144477-145356
            3026-3455           AL365356.13        146956-147385
            3456-7304           AL365356.13        151038-154886
            7305-7430           AL365356.13        161472-161597
            7431-7584           AL365356.13        162379-162532
            7585-7690           AL365356.13        163746-163851
            7691-7872           AL365356.13        166149-166330
            7873-7987           AL365356.13        167391-167505
            7988-8699           AL596094.2         2212-2923
FEATURES             Location/Qualifiers
     source          1..8699
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p15.1"
     gene            1..8699
                     /gene="TASOR2"
                     /gene_synonym="bA318E3.2; C10orf18; FAM208B"
                     /note="transcription activation suppressor family member
                     2"
                     /db_xref="GeneID:54906"
                     /db_xref="HGNC:HGNC:23484"
     exon            1..338
                     /gene="TASOR2"
                     /gene_synonym="bA318E3.2; C10orf18; FAM208B"
                     /inference="alignment:Splign:2.1.0"
     exon            339..434
                     /gene="TASOR2"
                     /gene_synonym="bA318E3.2; C10orf18; FAM208B"
                     /inference="alignment:Splign:2.1.0"
     exon            435..507
                     /gene="TASOR2"
                     /gene_synonym="bA318E3.2; C10orf18; FAM208B"
                     /inference="alignment:Splign:2.1.0"
     exon            508..599
                     /gene="TASOR2"
                     /gene_synonym="bA318E3.2; C10orf18; FAM208B"
                     /inference="alignment:Splign:2.1.0"
     exon            600..724
                     /gene="TASOR2"
                     /gene_synonym="bA318E3.2; C10orf18; FAM208B"
                     /inference="alignment:Splign:2.1.0"
     CDS             699..7991
                     /gene="TASOR2"
                     /gene_synonym="bA318E3.2; C10orf18; FAM208B"
                     /note="isoform 1 is encoded by transcript variant 2;
                     protein FAM208B; family with sequence similarity 208
                     member B; protein TASOR 2"
                     /codon_start=1
                     /product="protein TASOR 2 isoform 1"
                     /protein_id="NP_001308712.2"
                     /db_xref="CCDS:CCDS41485.1"
                     /db_xref="GeneID:54906"
                     /db_xref="HGNC:HGNC:23484"
                     /translation="MAPPAHKSILERSENVLMSPWKGKLIVQDRMLCDIALWSTYGAM
                     IPTQLPQELDFKYVMKVSSLKKRLPEAAFRKQNYLEEKVCFQDLCFNLYEVELSNRQG
                     ENIDKLTECIKNKQLAIIKCLEDRGFFILLTSSALLSEPDFGGKQMGLHGLHLFRSPL
                     STGVKDLKVEDDISMKVIPILSTLNCALLETKKSLPEERIHPNTLVKRHFQELYKADR
                     SPSLSVAPQDRMKDPTFLGKLPSGFDLIPPAEKCPSESLTQLNSYFSDPSAYILEVST
                     ALDLLAEHPQSPCVSDGICDAGFSLVMTPDPEFLVSEAEVRKETETKKDSEEMLKAKK
                     RVFPLSPASNLRVQPKRKASMPHMVQSKKVNLCRPFPKRTASRADNSSDSPTTLKLVK
                     GQFPQKRKRGAEVLTAQFVQKTKLDRKNQEAPISKDVPVPTNAKRARKQEKSPVKTVP
                     RAKPPVKKSPQKQRVNIVKGNENPRNRKQLQPVKGETASKLQSEISRGCQEDGISINS
                     VQPENTTAAHNDLPENSIVNYDSQALNMLADLALSSATSSTPVSEARNLHCSSELPQN
                     DVLLSKENSLRGTSDHEYHRGVKTQKGELLPNPSSDRKSNSGSDLTVSQDEESLVPCS
                     QAPAKAQSALTEEMLESSDASQSSSVSVEHSYALLLTEHSKKHLQEREILSPLFPRNG
                     TKSPEAATPVGKVMPFRHQPGLLLQQKPPDDPVVKPKDRPPSARVKKSSCSRIVLSCD
                     DSVKITFKCETEYAFSLDSKYTNNPLEKTVVRALHGPWNTDLPDNVEEVKLLLHMWVA
                     LFYSNQNKIIRSSRKVVEHSNPAKYVSINSTLESCELREIEESLGLEKCSADSLLETN
                     EISRAHAAEVSFRDPNCLLPFIKTPLTQGLELCVQNEQKKTFARECDPDTQEDQNFIC
                     SYNNEVTGEEAKQESLETSNLVLSGIGSTQTNGPSVPSEEEIVQPLDSTRVASYSGTV
                     TQATFTRTYDGPGSQPVICQSSVYGTLENKVDILDAAVQTKTGTLQDLIQHGSPINNE
                     CHPSLERKDDNMGCAVINPEPITLTFEKNAHVPIQTEGVNTADERTTFKKELIKQVSP
                     AASLRHPVSTSENARTQGLRDIPSLVVAGQKGTKYLCASSVGGETLDKAVCSLQKETP
                     LPVSLPSDKTMVMEALSLAKSSSHLSPSEEVRCTQDFLSQTQSLLGLSSEGLLELTQV
                     EVDSSSASTTLGRQCSLNCISSGCHTSGDSLELRKNHKNGPNTENMNLEAFDSVFIKQ
                     TSLSVSREVSLELSEEDSDIDLALTISPPTSPREEMPAGEIEQFEEAPFSNLELQDVA
                     EEIGEPEEVALTESREVSSADNVSVYPSVSEEPVENKERKGDNLQPVTLILSKENCTL
                     EIAEEINVTSDFPFDSVIEEVSPASSPEPPVPVKETRPYQAVTPCILKLHGTQCEKSN
                     QISQCESEDLGITEKENVFVGPTHPVGQDNFTQVQQMQVSAEMPLILTDHPGRTGRPT
                     LPGKVTEEIVSSEHDEGLSFSGKVQCYGRELNQPASAAKCTGDFSPSPEKLVKSGNPL
                     QPVSIENRNLDLKHLVLESSEPPFGPRNVIENKSLSDTLVSTTAPSGIVNVSVKQQTS
                     PKSSQNHLFPGDLKTDEGIYLQVKSLTAASVDGAYSTQGCMCSVVPTLCSSSDNATLT
                     HYVRPINAEPVFQAQEIPAGRMASLLKNGEPEAELHKETTGPGTAGPQSNTTSSLKGE
                     RKAIHTLQDVSTCETKELLNVGVSSLCAGPYQNTADTKENLSKEPLASFVSESFDTSV
                     CGIATEHVEIENSGEGLRAEAGSETLGRDGEVGVNSDMHYELSGDSDLDLLGDCRNPR
                     LDLEDSYTLRGSYTRKKDVPTDGYESSLNFHNNNQEDWGCSSWVPGMETSLPPGHWTA
                     AVKKEEKCVPPYVQIRDLHGILRTYANFSITKELKDTMRTSHGLRRHPSFSANCGLPS
                     SWTSTWQVADDLTQNTLDLEYLRFAHKLKQTIKNGDSQHSASSANVFPKESPTQISIG
                     AFPSTKISEAPFLHPAPRSRSPLLVTVVESDPRPQGQPRRGYTASSLDSSSSWRERCS
                     HNRDLRNSQRNHTVSFHLNKLKYNSTVKESRNDISLILNEYAEFNKVMKNSNQFIFQD
                     KELNDVSGEATAQEMYLPFPGRSASYEDIIIDVCTNLHVKLRSVVKEACKSTFLFYLV
                     ETEDKSFFVRTKNLLRKGGHTEIEPQHFCQAFHRENDTLIIIIRNEDISSHLHQIPSL
                     LKLKHFPSVIFAGVDSPGDVLDHTYQELFRAGGFVISDDKILEAVTLVQLKEIIKILE
                     KLNGNGRWKWLLHYRENKKLKEDERVDSTAHKKNIMLKSFQSANIIELLHYHQCDSRS
                     STKAEILKCLLNLQIQHIDARFAVLLTDKPTIPREVFENSGILVTDVNNFIENIEKIA
                     APFRSSYW"
     exon            725..744
                     /gene="TASOR2"
                     /gene_synonym="bA318E3.2; C10orf18; FAM208B"
                     /inference="alignment:Splign:2.1.0"
     exon            745..844
                     /gene="TASOR2"
                     /gene_synonym="bA318E3.2; C10orf18; FAM208B"
                     /inference="alignment:Splign:2.1.0"
     exon            845..945
                     /gene="TASOR2"
                     /gene_synonym="bA318E3.2; C10orf18; FAM208B"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1049
                     /gene="TASOR2"
                     /gene_synonym="bA318E3.2; C10orf18; FAM208B"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1122
                     /gene="TASOR2"
                     /gene_synonym="bA318E3.2; C10orf18; FAM208B"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1185
                     /gene="TASOR2"
                     /gene_synonym="bA318E3.2; C10orf18; FAM208B"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1902
                     /gene="TASOR2"
                     /gene_synonym="bA318E3.2; C10orf18; FAM208B"
                     /inference="alignment:Splign:2.1.0"
     exon            1903..2145
                     /gene="TASOR2"
                     /gene_synonym="bA318E3.2; C10orf18; FAM208B"
                     /inference="alignment:Splign:2.1.0"
     exon            2146..3025
                     /gene="TASOR2"
                     /gene_synonym="bA318E3.2; C10orf18; FAM208B"
                     /inference="alignment:Splign:2.1.0"
     exon            3026..3455
                     /gene="TASOR2"
                     /gene_synonym="bA318E3.2; C10orf18; FAM208B"
                     /inference="alignment:Splign:2.1.0"
     exon            3456..7304
                     /gene="TASOR2"
                     /gene_synonym="bA318E3.2; C10orf18; FAM208B"
                     /inference="alignment:Splign:2.1.0"
     exon            7305..7430
                     /gene="TASOR2"
                     /gene_synonym="bA318E3.2; C10orf18; FAM208B"
                     /inference="alignment:Splign:2.1.0"
     exon            7431..7584
                     /gene="TASOR2"
                     /gene_synonym="bA318E3.2; C10orf18; FAM208B"
                     /inference="alignment:Splign:2.1.0"
     exon            7585..7690
                     /gene="TASOR2"
                     /gene_synonym="bA318E3.2; C10orf18; FAM208B"
                     /inference="alignment:Splign:2.1.0"
     exon            7691..7872
                     /gene="TASOR2"
                     /gene_synonym="bA318E3.2; C10orf18; FAM208B"
                     /inference="alignment:Splign:2.1.0"
     exon            7873..7987
                     /gene="TASOR2"
                     /gene_synonym="bA318E3.2; C10orf18; FAM208B"
                     /inference="alignment:Splign:2.1.0"
     exon            7988..8699
                     /gene="TASOR2"
                     /gene_synonym="bA318E3.2; C10orf18; FAM208B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8679..8684
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TASOR2"
                     /gene_synonym="bA318E3.2; C10orf18; FAM208B"
                     /note="hexamer: AATAAA"
     polyA_site      8699
                     /gene="TASOR2"
                     /gene_synonym="bA318E3.2; C10orf18; FAM208B"
                     /note="major polyA site"
ORIGIN      
        1 gcttccggtt gctagcgccg gtcagagaga aagtcggcat gttctcgcag gctgccgggc
       61 gtcccggggt tgcctcttgc ccgtgaccct gacgggagac agagcgcggg cggccgcggc
      121 gtccctgtca gcgcccgcgg cgaggacccc ggggctgggg cggacggcgt gcccctgagg
      181 ggggtccccg cgggagcgcg gagccggcga ctggtgcttc ccacgtgcgc cggtgtcgcg
      241 agggcccggg aggacgcaga gcacggccgg gagaagcatg ggaaggaggc cgagccggga
      301 tctcaggtcc tcgggggcgg cggccacgcc aaggacggta caaaactttt taccaacaaa
      361 aaaaagcaag tagttatact caggaagaac ttcaagacac ttacgggttt cttctgtttg
      421 atactgaaaa gcaggcaaaa ttggtatgtc agtgtggact ccgtgttggc agcagtgctg
      481 ttaccactct gggtgatcca gccaaaggtg tatacatttc caaatactcc gactgtcttc
      541 attcaagacc atggtatcat gggaaatctg gttatgttgt aatttttaat ataattaagt
      601 attactttta cgaactttca ggcaacaccg ttattgaacg acccagacag atctgtcctt
      661 atgtaattgt agcttttcga tacagggaat ctaaaactat ggcaccacca gctcataaaa
      721 gcatacttga acgcagtgaa aatgttctca tgtctccatg gaaagggaaa ttaattgttc
      781 aagaccgtat gctatgtgat atagctcttt ggtccactta cggtgcaatg attccaacac
      841 agctaccgca ggaactagat tttaaatatg taatgaaagt gtcttccttg aaaaaaagac
      901 taccagaggc tgccttcaga aaacagaatt acttggagga gaaagtctgt tttcaagatt
      961 tgtgcttcaa tttgtatgag gtagaactgt caaacagaca aggggaaaat atagataaat
     1021 taacagaatg tattaaaaac aagcaattgg caatcatcaa atgcttagaa gatcgagggt
     1081 ttttcatttt acttacatca tcagccttac tatcagaacc agattttgga ggcaagcaga
     1141 tgggtctgca tgggttacat ttatttcgtt cacccctgtc aacaggggtg aaagatttga
     1201 aagttgaaga tgacatctca atgaaggtga tacctatttt atctaccctt aattgtgccc
     1261 tgctagaaac aaagaaatca cttcctgaag aaagaatcca tccaaacaca ttagtaaagc
     1321 gtcatttcca agaattgtac aaggcggaca gaagcccttc attgagtgtt gctcctcagg
     1381 atagaatgaa agaccctaca ttcttgggga aactgcccag tggttttgac ttgattcctc
     1441 cagctgaaaa gtgcccttca gagtctttaa ctcagttgaa ctcttatttt tcagacccta
     1501 gtgcttacat tttggaagtg tctactgctt tggacttgct agcagagcat cctcagtctc
     1561 cttgtgtttc agacggaatt tgtgatgctg gattttcctt agttatgact ccagatcctg
     1621 aatttcttgt ctcagaggca gaagtgagaa aagaaactga aacaaaaaag gattctgaag
     1681 aaatgttgaa agcaaagaag agagtttttc cattgagtcc agcgtcaaat ctgagagtgc
     1741 agcctaagag gaaggccagc atgccccaca tggtgcagag taaaaaggtg aacttgtgcc
     1801 gcccctttcc caaaagaact gcttccagag cagacaacag ctcggactct ccaacaactc
     1861 ttaagttagt taaaggacag tttcctcaga aaagaaaaag aggtgcggaa gtgctgactg
     1921 cacagtttgt acagaaaacc aaattggata ggaaaaacca agaagctcct atttctaaag
     1981 atgttccagt gccaacaaat gctaaaaggg caaggaaaca agagaaatct ccagtcaaaa
     2041 ctgttccaag ggctaagcca cctgtgaaga aatctccaca aaaacagaga gtaaatatag
     2101 taaaaggcaa tgagaacccc agaaacagaa agcagctaca acctgtcaaa ggagaaactg
     2161 cttcaaagct tcaatcagaa atttcaagag gttgtcaaga agatgggatt agcataaata
     2221 gtgttcaacc agaaaatacc acagcggctc acaatgatct tcctgaaaac tccatcgtca
     2281 actatgactc ccaggcccta aatatgttag ccgatctagc attaagctct gctacttctt
     2341 ccacaccagt atctgaggct agaaatcttc actgttcctc tgaattgcca caaaatgatg
     2401 ttttgctctc taaagaaaat tctttgcgag gtacatctga ccatgaatat catagaggag
     2461 ttaaaactca aaaaggtgaa ttactaccta acccatcttc tgataggaag agtaattctg
     2521 gatcagactt aacagttagc caagatgaag aaagcttggt tccttgtagt caggcccctg
     2581 ctaaagccca gtcagcactt actgaggaaa tgctagaatc ttcagatgca agccaaagct
     2641 cttctgtttc tgtggaacat tcatatgccc tgctccttac agaacattca aagaaacatc
     2701 tacaggagag agagatacta agccctctgt ttcccaggaa tgggacaaaa agccctgaag
     2761 cagcaacccc agtggggaaa gtcatgccat ttcggcatca gcccggcctt ttgcttcagc
     2821 aaaagcctcc tgacgacccc gtggtgaagc ccaaggatcg accaccgtct gcccgtgtga
     2881 aaaaatcttc ttgctctcgt atagtgctta gctgtgatga ctccgttaag atcactttca
     2941 aatgtgaaac agaatatgca ttcagtttag acagcaaata taccaacaac ccactggaga
     3001 aaactgtagt aagagcatta catgggccct ggaatactga tttgcctgat aatgtggaag
     3061 aagtgaagct tttacttcat atgtgggtag ctctgtttta cagcaatcag aacaaaatca
     3121 tacgatcttc ccgaaaggtt gtagaacaca gcaacccagc aaaatatgtg tctataaata
     3181 gcacgttaga atcttgtgag ctccgtgaaa ttgaggagtc ccttggtttg gaaaaatgtt
     3241 ctgcagactc tctgttggag actaacgaaa tttccagggc tcatgctgct gaagtatcct
     3301 tccgtgatcc taactgcttg cttcctttca ttaaaacacc acttacccaa ggcttggaac
     3361 tctgtgtaca aaatgaacag aaaaaaactt ttgcaagaga gtgtgatcca gacacccaag
     3421 aagaccagaa tttcatctgt tcttacaata atgaggtaac tggggaagaa gctaaacaag
     3481 aatcattgga gacttctaat cttgtgcttt cgggtattgg aagtacacaa actaatggac
     3541 cttctgttcc tagtgaagaa gaaattgttc agccactgga tagcacaaga gtggcttctt
     3601 acagtggcac tgttactcaa gccacattca ccaggactta cgatgggcct ggcagtcagc
     3661 cagtgatatg tcagagctct gtgtacggca cccttgaaaa caaagtggat attcttgatg
     3721 cagcagtgca aacaaaaaca ggtactttac aggaccttat ccaacatggc agccccataa
     3781 acaatgaatg tcacccttcc ttggaaagaa aggatgataa tatggggtgt gcagtgatta
     3841 acccggaacc aattactctc acctttgaaa aaaatgcaca tgtaccaata cagacagaag
     3901 gtgtaaatac tgctgatgaa cgtacaacct ttaagaagga gttgattaag caagtatcac
     3961 ctgctgcaag ccttagacat cctgtatcca cctcggaaaa tgcacgaaca caaggcctga
     4021 gggacattcc ctctctagta gttgcaggac agaagggcac taagtacctt tgtgcctcgt
     4081 cagtaggtgg agagacactt gataaagcag tgtgttcatt acagaaggag acgccccttc
     4141 cagtctctct accatctgat aaaacaatgg tcatggaggc actatcatta gctaaaagtt
     4201 ctagtcatct atcacccagt gaagaagtga gatgcactca ggatttcctt tcacagactc
     4261 agagtctcct cggcctatct tcagaagggc ttctagaact gacacaggtt gaagtggact
     4321 catcatcagc ctctaccacc ttgggaaggc agtgttcact taactgcatt tcgtcaggat
     4381 gccacacatc aggtgactct ttagaactaa ggaagaatca caagaatggt ccaaacactg
     4441 aaaatatgaa tttggaagcg tttgattcag tatttatcaa acaaacaagc ctgtctgtga
     4501 gtagagaggt cagcctagag ttatcagagg aagattctga cattgactta gctctaacaa
     4561 tatcaccacc tacaagtccc agagaagaaa tgccagctgg tgaaatagag caatttgagg
     4621 aggccccatt ctcaaattta gaacttcagg atgtagctga ggaaataggt gaaccggaag
     4681 aggtggctct cacagaaagc agagaagtga gttctgctga caatgtgtca gtatatccct
     4741 cagtgtcaga agaaccagta gaaaataagg agagaaaggg ggataattta caaccagtta
     4801 ctttaatact ttctaaagaa aattgcaccc ttgagattgc agaggaaatt aatgtgacct
     4861 ctgattttcc ctttgattct gtaattgaag aagtatcacc agcgtctagt cctgaacctc
     4921 cagtaccagt taaagagaca cgaccatatc aggctgtgac tccatgcatt ttaaaacttc
     4981 atggtacaca gtgtgagaag agcaaccaaa tctcccaatg tgagtcagaa gacttaggca
     5041 taacagaaaa agaaaatgtt tttgttggtc ctacccatcc agtggggcaa gataacttta
     5101 cccaggtaca acaaatgcag gtctctgccg aaatgcctct aatattaact gatcatccag
     5161 gaagaacagg tagaccaacc cttcctggta aagtaactga ggaaattgtc tcaagtgagc
     5221 atgatgaggg tttatctttc tcaggaaagg tgcagtgcta tggtagggag ttaaaccagc
     5281 ctgcctcagc tgccaaatgc acaggtgact tcagtccttc tcctgaaaaa ctggtaaaat
     5341 caggaaatcc attgcagcca gttagtatag agaatagaaa tttggactta aaacatcttg
     5401 tcttggagtc cagtgaacct ccatttggtc ctagaaatgt tattgaaaat aagtctttgt
     5461 ctgacacatt ggtttccaca actgcaccaa gtggtatagt gaatgtgtca gtaaaacagc
     5521 agactagccc taaaagcagt cagaaccatc tctttcccgg tgatttgaaa acagatgaag
     5581 gcatttatct gcaggtgaag tccttgacag ctgcctcggt tgatggagct tattctacac
     5641 agggatgcat gtgctcagtg gtccccacgc tttgttcttc ctcagacaat gctacattaa
     5701 cccattatgt aagaccaata aatgcagagc cagtgtttca agcacaggaa ataccagcag
     5761 gcagaatggc cagtttgctt aagaatggtg agcctgaagc tgagttacat aaagaaacca
     5821 caggtccagg cactgctggc cctcagtcca acaccacatc ttctctaaaa ggtgaacgca
     5881 aagccatcca cacgctgcaa gatgtgtcaa catgtgaaac aaaggagcta ttgaatgtcg
     5941 gggtttcctc cctttgtgct ggtccctacc aaaatacagc agacaccaag gaaaacctca
     6001 gtaaagagcc tttggcctcc tttgtttcag aatcctttga tacttctgtt tgtggaatag
     6061 ccacagagca cgtagaaatt gagaacagtg gggaggggct cagggctgag gctggttctg
     6121 aaaccctagg cagagatgga gaggtcggtg tgaattccga catgcactat gaactctctg
     6181 gagattctga tctagacctg cttggtgatt gtagaaatcc cagactggat ttggaggatt
     6241 cttatacttt aagaggtagt tacaccagga aaaaagatgt tcccacagat ggctatgagt
     6301 cgtcgttgaa cttccacaac aacaaccaag aggactgggg ctgctctagc tgggttccag
     6361 gcatggagac gagcctccct cccgggcact ggactgctgc ggtaaagaaa gaagagaagt
     6421 gtgtgccgcc ttacgtccaa atccgagatc tccacgggat cctcaggact tacgccaact
     6481 tctctataac aaaagaactc aaagatacca tgagaacttc acacggcctg aggaggcacc
     6541 cgagtttcag tgcaaactgt ggcctgccca gctcctggac aagcacttgg caggtggcag
     6601 acgacctcac ccagaacact ttagacctgg agtatctgcg ttttgcacat aaactaaaac
     6661 agaccataaa gaatggggat tctcagcatt ctgcctcctc tgccaatgtc tttccaaagg
     6721 agtcaccaac ccagatctcc attggtgctt tcccttcgac aaaaatctct gaggccccat
     6781 ttctgcatcc tgcacctagg agcagaagcc cccttctggt aacagttgtg gagtcagatc
     6841 ccagaccaca ggggcagccc aggagaggct acacagccag cagtctggac agctcttcct
     6901 cttggagaga gagatgtagt cataatagag atcttagaaa ttctcaaaga aatcacactg
     6961 tttcattcca cctcaacaaa ctgaaataca acagtactgt gaaggaatct cggaatgata
     7021 tttcacttat tctcaatgag tatgctgaat tcaacaaggt gatgaagaat agcaaccaat
     7081 tcattttcca agacaaagag ctaaatgatg tttctggaga agccactgct caagagatgt
     7141 atctgccttt cccaggacgg tcagcctcct atgaagacat aatcatagac gtgtgcacca
     7201 atttgcacgt caaactaaga agtgttgtga aagaggcttg taaaagtacc ttcctgttct
     7261 accttgtcga aacagaagac aaatcattct ttgtaagaac aaagaacctt ctgaggaaag
     7321 gaggccatac agaaattgaa cctcagcact tctgtcaagc tttccacaga gagaatgata
     7381 cactaatcat catcatcaga aatgaagata tatcatcaca tttgcatcag attccttctt
     7441 tgctgaagct gaagcatttc cccagtgtca tctttgctgg agtagacagc cctggagatg
     7501 ttcttgatca cacctaccaa gaactgtttc gtgcaggagg ctttgtgata tcagatgaca
     7561 agatactaga agctgtaaca ttagttcaac tgaaggaaat tatcaaaatc ctggaaaaac
     7621 taaatggaaa tggaagatgg aagtggttgc ttcactacag ggaaaataaa aagctaaaag
     7681 aagatgaaag agtggattca actgcacata agaagaacat aatgttgaag tcatttcaga
     7741 gtgcaaatat cattgaattg cttcattatc accagtgtga ctctcgatca tcaacaaaag
     7801 cagaaattct gaaatgtttg ctaaacctgc aaattcagca tattgatgcc aggtttgctg
     7861 tcctcctaac agacaagcct actatcccca gagaagtctt tgaaaatagt ggaatccttg
     7921 ttacagatgt aaataacttt atagaaaaca tagaaaaaat agcagctcca tttaggagta
     7981 gctattggtg actcaactac agcctgcctg gatatggatg atgccaataa aaaattagta
     8041 ttttcccttt ggaaaacttg tgaacatgtg aatacacatg tgaacagtct tacatttgaa
     8101 aaaccaatgt tctacaactt ggaaagtttt cattttttat attttgctga aatatgtcac
     8161 agtggcattg cagttgtctg ttagctttgg gttgcagtgc tagatattgt tttaaattat
     8221 tttcatttta aacaagatgc cttctaagct attgagctta ttaaaaataa ttttacatgt
     8281 ttacttagtt ggagcaaaaa taagtctatt ttaacaaata gctttgtttt tgcatgctaa
     8341 tgtcagaaag gcatacgatg cacattatgc tctgttttaa aggttttacc acccttgtaa
     8401 aaactataat cttaaatggt tttatttgct gttacacaaa caacactaca taaaacattt
     8461 tttcctaaat ggtacaaatt tataaactat catttttcac ttacggtatt tgtaaatact
     8521 acactacaaa aatcagcttt ctgagaaaga aataatcatt tatttatgat attgaaaatt
     8581 tctacagtaa acactcaaaa ccaagcaaaa aacatttgta agatacacgg tatctatttg
     8641 gagcaacggt ttttgtaact aatgtgtttc attttttaaa taaagacaac taaaaataa
//
