LOCUS       NM_001365635            8177 bp    mRNA    linear   PRI 06-NOV-2022
DEFINITION  Homo sapiens transcription activation suppressor (TASOR),
            transcript variant 4, mRNA.
ACCESSION   NM_001365635 XM_005264999
VERSION     NM_001365635.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8177)
  AUTHORS   Vauthier V, Lasserre A, Morel M, Versapuech M, Berlioz-Torrent C,
            Zamborlini A, Margottin-Goguet F and Matkovic R.
  TITLE     HUSH-mediated HIV silencing is independent of TASOR phosphorylation
            on threonine 819
  JOURNAL   Retrovirology 19 (1), 23 (2022)
   PUBMED   36309692
  REMARK    GeneRIF: HUSH-mediated HIV silencing is independent of TASOR
            phosphorylation on threonine 819.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8177)
  AUTHORS   Matkovic R, Morel M, Lanciano S, Larrous P, Martin B, Bejjani F,
            Vauthier V, Hansen MMK, Emiliani S, Cristofari G, Gallois-Montbrun
            S and Margottin-Goguet F.
  TITLE     TASOR epigenetic repressor cooperates with a CNOT1 RNA degradation
            pathway to repress HIV
  JOURNAL   Nat Commun 13 (1), 66 (2022)
   PUBMED   35013187
  REMARK    GeneRIF: TASOR epigenetic repressor cooperates with a CNOT1 RNA
            degradation pathway to repress HIV.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8177)
  AUTHORS   Prigozhin DM, Douse CH, Farleigh LE, Albecka A, Tchasovnikarova IA,
            Timms RT, Oda SI, Adolf F, Freund SMV, Maslen S, Lehner PJ and
            Modis Y.
  TITLE     Periphilin self-association underpins epigenetic silencing by the
            HUSH complex
  JOURNAL   Nucleic Acids Res 48 (18), 10313-10328 (2020)
   PUBMED   32976585
  REMARK    GeneRIF: Periphilin self-association underpins epigenetic silencing
            by the HUSH complex.
REFERENCE   4  (bases 1 to 8177)
  AUTHORS   Douse CH, Tchasovnikarova IA, Timms RT, Protasio AV, Seczynska M,
            Prigozhin DM, Albecka A, Wagstaff J, Williamson JC, Freund SMV,
            Lehner PJ and Modis Y.
  TITLE     TASOR is a pseudo-PARP that directs HUSH complex assembly and
            epigenetic transposon control
  JOURNAL   Nat Commun 11 (1), 4940 (2020)
   PUBMED   33009411
  REMARK    GeneRIF: TASOR is a pseudo-PARP that directs HUSH complex assembly
            and epigenetic transposon control.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8177)
  AUTHORS   Robbez-Masson L, Tie CHC, Conde L, Tunbak H, Husovsky C,
            Tchasovnikarova IA, Timms RT, Herrero J, Lehner PJ and Rowe HM.
  TITLE     The HUSH complex cooperates with TRIM28 to repress young
            retrotransposons and new genes
  JOURNAL   Genome Res 28 (6), 836-845 (2018)
   PUBMED   29728366
  REMARK    GeneRIF: Genes co-repressed by TRIM28 and FAM208A are
            evolutionarily young, or exhibit tissue-specific expression, are
            enriched in young L1s, and display evidence for regulation through
            LTR promoters. Finally, we demonstrate that the HUSH complex is
            also required to repress L1 elements in human cells.
REFERENCE   6  (bases 1 to 8177)
  AUTHORS   Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein
            C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J and
            Hentze MW.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   7  (bases 1 to 8177)
  AUTHORS   Lango Allen H, Estrada K, Lettre G, Berndt SI, Weedon MN,
            Rivadeneira F, Willer CJ, Jackson AU, Vedantam S, Raychaudhuri S,
            Ferreira T, Wood AR, Weyant RJ, Segre AV, Speliotes EK, Wheeler E,
            Soranzo N, Park JH, Yang J, Gudbjartsson D, Heard-Costa NL, Randall
            JC, Qi L, Vernon Smith A, Magi R, Pastinen T, Liang L, Heid IM,
            Luan J, Thorleifsson G, Winkler TW, Goddard ME, Sin Lo K, Palmer C,
            Workalemahu T, Aulchenko YS, Johansson A, Zillikens MC, Feitosa MF,
            Esko T, Johnson T, Ketkar S, Kraft P, Mangino M, Prokopenko I,
            Absher D, Albrecht E, Ernst F, Glazer NL, Hayward C, Hottenga JJ,
            Jacobs KB, Knowles JW, Kutalik Z, Monda KL, Polasek O, Preuss M,
            Rayner NW, Robertson NR, Steinthorsdottir V, Tyrer JP, Voight BF,
            Wiklund F, Xu J, Zhao JH, Nyholt DR, Pellikka N, Perola M, Perry
            JR, Surakka I, Tammesoo ML, Altmaier EL, Amin N, Aspelund T,
            Bhangale T, Boucher G, Chasman DI, Chen C, Coin L, Cooper MN, Dixon
            AL, Gibson Q, Grundberg E, Hao K, Juhani Junttila M, Kaplan LM,
            Kettunen J, Konig IR, Kwan T, Lawrence RW, Levinson DF, Lorentzon
            M, McKnight B, Morris AP, Muller M, Suh Ngwa J, Purcell S, Rafelt
            S, Salem RM, Salvi E, Sanna S, Shi J, Sovio U, Thompson JR, Turchin
            MC, Vandenput L, Verlaan DJ, Vitart V, White CC, Ziegler A, Almgren
            P, Balmforth AJ, Campbell H, Citterio L, De Grandi A, Dominiczak A,
            Duan J, Elliott P, Elosua R, Eriksson JG, Freimer NB, Geus EJ,
            Glorioso N, Haiqing S, Hartikainen AL, Havulinna AS, Hicks AA, Hui
            J, Igl W, Illig T, Jula A, Kajantie E, Kilpelainen TO, Koiranen M,
            Kolcic I, Koskinen S, Kovacs P, Laitinen J, Liu J, Lokki ML,
            Marusic A, Maschio A, Meitinger T, Mulas A, Pare G, Parker AN,
            Peden JF, Petersmann A, Pichler I, Pietilainen KH, Pouta A,
            Ridderstrale M, Rotter JI, Sambrook JG, Sanders AR, Schmidt CO,
            Sinisalo J, Smit JH, Stringham HM, Bragi Walters G, Widen E, Wild
            SH, Willemsen G, Zagato L, Zgaga L, Zitting P, Alavere H, Farrall
            M, McArdle WL, Nelis M, Peters MJ, Ripatti S, van Meurs JB, Aben
            KK, Ardlie KG, Beckmann JS, Beilby JP, Bergman RN, Bergmann S,
            Collins FS, Cusi D, den Heijer M, Eiriksdottir G, Gejman PV, Hall
            AS, Hamsten A, Huikuri HV, Iribarren C, Kahonen M, Kaprio J,
            Kathiresan S, Kiemeney L, Kocher T, Launer LJ, Lehtimaki T,
            Melander O, Mosley TH Jr, Musk AW, Nieminen MS, O'Donnell CJ,
            Ohlsson C, Oostra B, Palmer LJ, Raitakari O, Ridker PM, Rioux JD,
            Rissanen A, Rivolta C, Schunkert H, Shuldiner AR, Siscovick DS,
            Stumvoll M, Tonjes A, Tuomilehto J, van Ommen GJ, Viikari J, Heath
            AC, Martin NG, Montgomery GW, Province MA, Kayser M, Arnold AM,
            Atwood LD, Boerwinkle E, Chanock SJ, Deloukas P, Gieger C, Gronberg
            H, Hall P, Hattersley AT, Hengstenberg C, Hoffman W, Lathrop GM,
            Salomaa V, Schreiber S, Uda M, Waterworth D, Wright AF, Assimes TL,
            Barroso I, Hofman A, Mohlke KL, Boomsma DI, Caulfield MJ, Cupples
            LA, Erdmann J, Fox CS, Gudnason V, Gyllensten U, Harris TB, Hayes
            RB, Jarvelin MR, Mooser V, Munroe PB, Ouwehand WH, Penninx BW,
            Pramstaller PP, Quertermous T, Rudan I, Samani NJ, Spector TD,
            Volzke H, Watkins H, Wilson JF, Groop LC, Haritunians T, Hu FB,
            Kaplan RC, Metspalu A, North KE, Schlessinger D, Wareham NJ, Hunter
            DJ, O'Connell JR, Strachan DP, Wichmann HE, Borecki IB, van Duijn
            CM, Schadt EE, Thorsteinsdottir U, Peltonen L, Uitterlinden AG,
            Visscher PM, Chatterjee N, Loos RJ, Boehnke M, McCarthy MI,
            Ingelsson E, Lindgren CM, Abecasis GR, Stefansson K, Frayling TM
            and Hirschhorn JN.
  TITLE     Hundreds of variants clustered in genomic loci and biological
            pathways affect human height
  JOURNAL   Nature 467 (7317), 832-838 (2010)
   PUBMED   20881960
REFERENCE   8  (bases 1 to 8177)
  AUTHORS   Nakayama M, Kikuno R and Ohara O.
  TITLE     Protein-protein interactions between large proteins: two-hybrid
            screening using a functionally classified library composed of long
            cDNAs
  JOURNAL   Genome Res 12 (11), 1773-1784 (2002)
   PUBMED   12421765
REFERENCE   9  (bases 1 to 8177)
  AUTHORS   Eichmuller S, Usener D, Dummer R, Stein A, Thiel D and Schadendorf
            D.
  TITLE     Serological detection of cutaneous T-cell lymphoma-associated
            antigens
  JOURNAL   Proc Natl Acad Sci U S A 98 (2), 629-634 (2001)
   PUBMED   11149944
REFERENCE   10 (bases 1 to 8177)
  AUTHORS   Li Q, Wen H and Ao S.
  TITLE     Identification and cloning of the cDNA of a Rb-associated protein
            RAP140a
  JOURNAL   Sci China C Life Sci 43 (6), 637-647 (2000)
   PUBMED   18726359
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC099781.2.
            
            On Jun 2, 2019 this sequence version replaced NM_001365635.1.
            
            Transcript Variant: This variant (4) encodes the longest isoform
            (d).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.81428.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000683822.1/ ENSP00000508241.1
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-590               AC099781.2         88352-88941         c
            591-736             AC099781.2         79256-79401         c
            737-829             AC099781.2         77276-77368         c
            830-902             AC099781.2         75749-75821         c
            903-994             AC099781.2         75376-75467         c
            995-1156            AC099781.2         74073-74234         c
            1157-1281           AC099781.2         71936-72060         c
            1282-1313           AC099781.2         69217-69248         c
            1314-1419           AC099781.2         68061-68166         c
            1420-1523           AC099781.2         66590-66693         c
            1524-1627           AC099781.2         66407-66510         c
            1628-1700           AC099781.2         54661-54733         c
            1701-1772           AC099781.2         54498-54569         c
            1773-2474           AC099781.2         52198-52899         c
            2475-2878           AC099781.2         47025-47428         c
            2879-3023           AC099781.2         45662-45806         c
            3024-3083           AC099781.2         44382-44441         c
            3084-4006           AC099781.2         38720-39642         c
            4007-4129           AC099781.2         34168-34290         c
            4130-4289           AC099781.2         33258-33417         c
            4290-4398           AC099781.2         32713-32821         c
            4399-4577           AC099781.2         30504-30682         c
            4578-4742           AC099781.2         30155-30319         c
            4743-8177           AC099781.2         25808-29242         c
FEATURES             Location/Qualifiers
     source          1..8177
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p14.3"
     gene            1..8177
                     /gene="TASOR"
                     /gene_synonym="C3orf63; FAM208A; RAP140; se89-1; TASOR1"
                     /note="transcription activation suppressor"
                     /db_xref="GeneID:23272"
                     /db_xref="HGNC:HGNC:30314"
                     /db_xref="MIM:616493"
     exon            1..590
                     /gene="TASOR"
                     /gene_synonym="C3orf63; FAM208A; RAP140; se89-1; TASOR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             260..5272
                     /gene="TASOR"
                     /gene_synonym="C3orf63; FAM208A; RAP140; se89-1; TASOR1"
                     /note="isoform d is encoded by transcript variant 4;
                     retinoblastoma-associated protein 140; CTCL tumor antigen
                     se89-1; retinoblastoma-associated protein RAP140; protein
                     FAM208A; transgene activation suppressor protein; protein
                     TASOR; family with sequence similarity 208 member A"
                     /codon_start=1
                     /product="protein TASOR isoform d"
                     /protein_id="NP_001352564.1"
                     /db_xref="CCDS:CCDS93292.1"
                     /db_xref="GeneID:23272"
                     /db_xref="HGNC:HGNC:30314"
                     /db_xref="MIM:616493"
                     /translation="MATAVETEACQPTDASWESGGGGDDEMKQALPELESSQQNGGGG
                     GLNIAEPSGGAGREENAGAEAAQSLSHEQPQDSSEAGAAALPRGPEEPERPVRRSFQI
                     PRKSREKKALFQPLTPGSREFEDVVNILHSSYLEPTSVTNFNYRRACLVHNELLEKEF
                     TEKRRELKFDGRLDKELSESYAFLMVDRYQVQTICEKGLHVGQSKITILGSPSMGVYL
                     SRYADLLQANPLDTGAMGDVVIFKIMKGKIKSIYDPMGVKSLESMLNKSALDPTPKHE
                     CHVSKNANRITSLLAYRAYELTQYYFYEYGFDELRRRPRHVCPYAVVSFTYKDDIQTP
                     KFVPSSRSNSFNTDRNIDKYNYTLWKGQLLNKGKLLCYISLRSATRAFLPIKLPEKLD
                     VETVMSIDHLKQKIPPALFYKETYLGPNEVLKNGMYCSLYEVVEKTRIGSNMESLLQK
                     LDREKLVLVKPLGDRGYLFLLSPYQMVPPYEYQTAKSRVLHALFLFQEPRSIVTSQKG
                     STNAAPQERHESMPDVLKIAQFLQFSLIQCRKEFKNISAINFHSVVEKYVSEFFKRGF
                     GSGKREFIMFPYDSRLDDKKFLYSAPRNKSHIDTCLHAYIFRPEVYQLPICKLKELFE
                     ENRKLQQFSPLSDYEGQEEEMNGTKMKFGKRNNSRGEAIISGKQRSSHSLDYDKDRVK
                     ELINLIQCRKKSVGGDSDTEDMRSKTVLKRKLEDLPENMRKLAKTSNLSENCHLYEES
                     PQPIGSLGHDADLRRQQQDTCNSGIADIHRLFNWLSETLANARHSDASLTDTVNKALG
                     LSTDDAYEELRQKHEYELNSTPDKKDYEQPTCAKVENAQFKGTQSLLLEVDATSKYSV
                     AISTSEVGTDHKLHLKEDPNLISVNNFEDCSLCPSVPIEHGFRRQQSKSNNVEETEIH
                     WKLIPITGGNARSPEDQLGKHGEKQTPGMKSPEEQLVCVPPQEAFPNDPRVINRQRSS
                     DYQFPSSPFTDTLKGTTEDDVLTGQVEEQCVPAAEAEPPAVSETTERTVLGEYNLFSR
                     KIEEILKQKNVSYVSTVSTPIFSTQEKMKRLSEFIYSKTSKAGVQEFVDGLHEKLNTI
                     IIKASAKGGNLPPVSPNDSGAKIASNPLERHVIPVSSSDFNNKHLLEPLCSDPLKDTN
                     SDEQHSTSALTEVEMNQPQHATELMVTSDHIVPGDMAREPVEETTKSPSDVNISAQPA
                     LSNFISQLEPEVFNSLVKIMKDVQKNTVKFYIHEEEESVLCKEIKEYLIKLGNTECHP
                     EQFLERRSKLDKLLIIIQNEDIAGFIHKIPGLVTLKKLPCVSFAGVDSLDDVKNHTYN
                     ELFVSGGFIVSDESILNPEVVTVENLKNFLTFLEELSTPEGKWQWKVHCKFQKKLKEL
                     GRLNAKALSLLTLLNVYQKKHLVEILSYHNCDSQTRNAPELDCLIRLQAQNIQQRHIV
                     FLTEKNIKMLSSYTDNGIVVATAEDFMQNFKNLVGYHNSITEENLPQLGANENLESQS
                     ALLENDEKDEEDMSLDSGDEISHIEVCSNFHSEIWEKETKGSRGTDQKKNTQIELQSS
                     PDVQNSLLEDKTYLDSEERTSIDIVCSEGENSNSTEQDSYSNFQVYHSQLNMSHQFSH
                     FNVLTHQTFLGTPYALSSSQSQENENYFLSAYTESLDRDKSPPPLSWGKSDSSRPYSQ
                     EK"
     exon            591..736
                     /gene="TASOR"
                     /gene_synonym="C3orf63; FAM208A; RAP140; se89-1; TASOR1"
                     /inference="alignment:Splign:2.1.0"
     exon            737..829
                     /gene="TASOR"
                     /gene_synonym="C3orf63; FAM208A; RAP140; se89-1; TASOR1"
                     /inference="alignment:Splign:2.1.0"
     exon            830..902
                     /gene="TASOR"
                     /gene_synonym="C3orf63; FAM208A; RAP140; se89-1; TASOR1"
                     /inference="alignment:Splign:2.1.0"
     exon            903..994
                     /gene="TASOR"
                     /gene_synonym="C3orf63; FAM208A; RAP140; se89-1; TASOR1"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1156
                     /gene="TASOR"
                     /gene_synonym="C3orf63; FAM208A; RAP140; se89-1; TASOR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1281
                     /gene="TASOR"
                     /gene_synonym="C3orf63; FAM208A; RAP140; se89-1; TASOR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..1313
                     /gene="TASOR"
                     /gene_synonym="C3orf63; FAM208A; RAP140; se89-1; TASOR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1419
                     /gene="TASOR"
                     /gene_synonym="C3orf63; FAM208A; RAP140; se89-1; TASOR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1420..1523
                     /gene="TASOR"
                     /gene_synonym="C3orf63; FAM208A; RAP140; se89-1; TASOR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..1627
                     /gene="TASOR"
                     /gene_synonym="C3orf63; FAM208A; RAP140; se89-1; TASOR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1628..1700
                     /gene="TASOR"
                     /gene_synonym="C3orf63; FAM208A; RAP140; se89-1; TASOR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1701..1772
                     /gene="TASOR"
                     /gene_synonym="C3orf63; FAM208A; RAP140; se89-1; TASOR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1773..2474
                     /gene="TASOR"
                     /gene_synonym="C3orf63; FAM208A; RAP140; se89-1; TASOR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2475..2878
                     /gene="TASOR"
                     /gene_synonym="C3orf63; FAM208A; RAP140; se89-1; TASOR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2879..3023
                     /gene="TASOR"
                     /gene_synonym="C3orf63; FAM208A; RAP140; se89-1; TASOR1"
                     /inference="alignment:Splign:2.1.0"
     exon            3024..3083
                     /gene="TASOR"
                     /gene_synonym="C3orf63; FAM208A; RAP140; se89-1; TASOR1"
                     /inference="alignment:Splign:2.1.0"
     exon            3084..4006
                     /gene="TASOR"
                     /gene_synonym="C3orf63; FAM208A; RAP140; se89-1; TASOR1"
                     /inference="alignment:Splign:2.1.0"
     exon            4007..4129
                     /gene="TASOR"
                     /gene_synonym="C3orf63; FAM208A; RAP140; se89-1; TASOR1"
                     /inference="alignment:Splign:2.1.0"
     exon            4130..4289
                     /gene="TASOR"
                     /gene_synonym="C3orf63; FAM208A; RAP140; se89-1; TASOR1"
                     /inference="alignment:Splign:2.1.0"
     exon            4290..4398
                     /gene="TASOR"
                     /gene_synonym="C3orf63; FAM208A; RAP140; se89-1; TASOR1"
                     /inference="alignment:Splign:2.1.0"
     exon            4399..4577
                     /gene="TASOR"
                     /gene_synonym="C3orf63; FAM208A; RAP140; se89-1; TASOR1"
                     /inference="alignment:Splign:2.1.0"
     exon            4578..4742
                     /gene="TASOR"
                     /gene_synonym="C3orf63; FAM208A; RAP140; se89-1; TASOR1"
                     /inference="alignment:Splign:2.1.0"
     exon            4743..8177
                     /gene="TASOR"
                     /gene_synonym="C3orf63; FAM208A; RAP140; se89-1; TASOR1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5428..5433
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TASOR"
                     /gene_synonym="C3orf63; FAM208A; RAP140; se89-1; TASOR1"
                     /note="hexamer: AATAAA"
     polyA_site      5450
                     /gene="TASOR"
                     /gene_synonym="C3orf63; FAM208A; RAP140; se89-1; TASOR1"
                     /note="major polyA site"
     regulatory      8157..8162
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TASOR"
                     /gene_synonym="C3orf63; FAM208A; RAP140; se89-1; TASOR1"
                     /note="hexamer: AATAAA"
     polyA_site      8177
                     /gene="TASOR"
                     /gene_synonym="C3orf63; FAM208A; RAP140; se89-1; TASOR1"
                     /note="major polyA site"
ORIGIN      
        1 gcgcgcacgt tgagtggcgg gggaaggcag aagaactgcc cgagggagga gcggctccga
       61 ggaccgggca gcgcatttgg ggtgcccgct acagggcccc ccaagaggct gccaggtcgg
      121 gagcgcagcc tgaggccacg gggggaaggg ggtgggtggg ctgagagcag ctcggcggcg
      181 agactggccc gccgcccctt ccccccacac ccgtcgacct tgtgggcaga agcttcccag
      241 agctccttag gccggcgcga tggcgactgc tgtggagacg gaggcctgtc agccgacgga
      301 tgcgagttgg gaaagtggcg gcggcggaga cgacgagatg aagcaggcgc ttccggagct
      361 tgagtcctcc caacaaaatg gcggcggcgg cggcctcaac atcgctgagc ccagcggcgg
      421 cgctgggcgt gaggagaacg cgggggccga ggccgcccag agcctcagcc acgagcagcc
      481 tcaggactcc tctgaggcgg gcgcggccgc cctgcccaga ggccccgaag agcccgaaag
      541 gcctgttagg aggagttttc agatccccag gaagagcaga gaaaagaaag cacttttcca
      601 gccattaact ccaggctctc gagaatttga agatgttgta aatattctcc attcttctta
      661 ccttgaacca acctcagtaa caaattttaa ctacagacgt gcttgcttgg tacacaatga
      721 gcttttggaa aaggagttta cagaaaagcg aagagaactg aagtttgatg gtcgtttaga
      781 taaggaactt tcagaatcct atgcatttct gatggttgat cgataccagg ttcaaaccat
      841 atgtgaaaaa ggattacatg tgggtcagtc caaaataaca attcttggca gtccttccat
      901 gggtgtctat ctttctaggt atgctgattt attacaagcg aatcctttgg acacgggggc
      961 aatgggtgat gttgttattt ttaaaataat gaagggtaaa ataaagagta tatatgaccc
     1021 catgggtgta aaaagtttgg aatctatgtt aaataagagt gctttggacc ccacaccaaa
     1081 gcatgaatgt cacgtgtcaa agaatgccaa tcgaattaca tcacttttgg cttacagagc
     1141 ctatgagctt actcagtatt atttttatga gtatggcttt gatgagctaa ggcgaagacc
     1201 aagacacgtt tgtccatatg cagttgtgtc ttttacttac aaagatgata tacaaactcc
     1261 gaagtttgta ccttcatcaa gatctaacag ctttaataca gatagaaaca tagataaata
     1321 taactatacc ttgtggaaag gacagctttt aaataaagga aaacttttgt gttatatttc
     1381 tctgaggtca gccactcgtg cttttttgcc tatcaaacta cctgagaaat tagatgttga
     1441 aacagttatg agtattgatc atctgaaaca gaaaatccct ccagcactgt tttataagga
     1501 aacatactta ggtccaaatg aagttttgaa gaatggaatg tattgcagcc tttatgaagt
     1561 tgtggaaaag acaagaattg gaagtaacat ggagagttta ctgcaaaaac tagacagaga
     1621 aaaacttgtt cttgttaaac ctttgggaga ccgaggatac ctttttcttc tctcccctta
     1681 tcagatggtt cctccatatg aatatcagac tgccaagtct cgagtcctac atgctttgtt
     1741 tctatttcaa gaacctagaa gcatagttac ttcacaaaaa ggttcaacca atgcagcacc
     1801 acaggagagg catgagagca tgccagatgt attaaaaata gctcagtttt tacaattttc
     1861 tttgattcag tgtcgaaagg aattcaaaaa tataagcgcc ataaattttc attctgttgt
     1921 tgaaaagtat gtaagtgaat tttttaagcg aggttttggt tcaggtaaac gagagtttat
     1981 tatgtttcca tatgattcac gattagatga taaaaaattc ttatactcag ctcccagaaa
     2041 taaatcccat attgatactt gtttgcatgc ctatattttt cggcctgaag tgtatcagtt
     2101 acctatttgt aaattaaaag aactatttga agaaaataga aaacttcagc agtttagtcc
     2161 actttcagat tatgaaggtc aagaagaaga aatgaatggt acaaaaatga aatttggaaa
     2221 acgaaataac tcaagaggtg aagccattat atctggaaag caaagatcat ctcattcttt
     2281 ggattatgat aaggatagag tcaaagaatt gattaattta attcagtgta ggaaaaagag
     2341 tgtgggtggg gactcagaca cagaagatat gagaagcaaa actgtcttga agaggaagct
     2401 tgaggatcta cctgaaaata tgagaaagct cgccaaaacc agtaatttat ctgaaaattg
     2461 ccatctgtat gaagagtctc cacagcctat tggctcactt ggacatgatg ctgacttgag
     2521 gcggcagcag caggatacct gtaactccgg cattgctgac atccataggc tgtttaattg
     2581 gttatcagaa acactagcaa atgcgcgcca ttctgatgca tctctgacag acacagtcaa
     2641 caaagcctta ggattgagca ctgatgatgc ctatgaagag ctgaggcaaa aacatgagta
     2701 tgagttgaac tctaccccag ataagaaaga ctatgagcag cctacttgtg caaaagttga
     2761 aaatgcacag tttaagggta ctcagagctt attactagaa gttgatgcaa catctaagta
     2821 ttctgttgct atttctacca gcgaagtggg cactgaccat aagctacatt tgaaagaaga
     2881 tccaaattta attagcgtga ataattttga agattgcagt ttgtgtccca gtgttcccat
     2941 tgaacatgga tttcgtagac aacagtctaa gtcaaataat gttgaagaga ctgaaataca
     3001 ttggaaactg attccaatta caggagggaa tgcaagaagc ccagaagacc agctggggaa
     3061 acatggtgag aaacaaacac caggtatgaa atcaccagaa gaacaactgg tgtgtgtgcc
     3121 accacaggag gcctttccta acgacccccg ggtaataaat agacagagaa gttctgatta
     3181 ccagtttcca tcctctccat ttacagacac actaaagggc accactgagg atgacgtgtt
     3241 gacaggtcag gtggaggagc agtgtgtgcc agcagcagag gcagagccgc ctgcagtgag
     3301 cgaaaccaca gagaggacag tgttaggaga gtacaatctc ttttctagga agatagaaga
     3361 gattttgaag caaaagaatg tttcatatgt cagtacagtt tccacaccta tcttttcaac
     3421 acaagagaag atgaaacggc tttccgagtt catatattct aagacttcca aagctggtgt
     3481 gcaggagttt gtagatggtt tgcatgagaa gctaaatact attattatta aagcatcagc
     3541 caagggtggg aatttgccac cagtcagtcc taacgattct ggtgctaaga tagcatcgaa
     3601 tcctctggaa aggcatgtca taccagtttc ctcaagtgac ttcaacaata aacatctcct
     3661 tgagccactg tgtagtgatc ctttgaaaga taccaactct gatgagcagc attccacttc
     3721 ggctttaact gaagtagaaa tgaaccagcc tcaacatgcc acagagttaa tggtgacttc
     3781 tgatcatatt gtacctggtg atatggcccg ggaaccagta gaagaaacaa caaaatcccc
     3841 cagtgatgta aacatttctg ctcaaccagc tctttcaaat tttataagcc agttagaacc
     3901 tgaagtattt aatagtttgg ttaaaatcat gaaagacgtc cagaaaaata ctgtgaaatt
     3961 ttatattcat gaagaagaag agagtgtgct ctgtaaagaa ataaaggaat atcttatcaa
     4021 attaggcaat acagaatgtc atcctgaaca gtttttggaa agaagatcaa aattagataa
     4081 actattgatt attattcaaa atgaagacat tgcaggtttc attcacaaga tacctggctt
     4141 ggtgacttta aagaagctcc cctgtgttag ttttgctggt gttgatagcc tggatgatgt
     4201 taaaaatcat acatacaatg aattatttgt atctggaggt tttatcgtat ctgatgaatc
     4261 aattctaaac ccagaggttg tcacagttga gaaccttaaa aattttttga cattccttga
     4321 ggaacttagt actccagaag gaaaatggca atggaaagtc cactgtaaat ttcagaagaa
     4381 actaaaggaa ctaggcagat tgaatgctaa agctctaagt ctgttgacgc ttctgaatgt
     4441 ctatcagaag aaacatctgg ttgaaatttt gtcataccac aattgtgatt cacaaactcg
     4501 aaatgctcca gaattggatt gccttatcag acttcaggct cagaacatac agcaacgaca
     4561 catagtcttt ttaacagaga agaacatcaa gatgctttcc agttatacag ataatggaat
     4621 agtggttgca actgctgaag acttcatgca aaactttaaa aatcttgtgg gctatcacaa
     4681 ttcaatcaca gaagaaaacc ttccacagct tggtgctaat gagaatcttg agtcgcagtc
     4741 agctctttta gaaaacgatg aaaaggatga agaggatatg tctctggatt caggggatga
     4801 aatctcacat atagaagtat gcagcaattt tcattcagaa atatgggaga aagagaccaa
     4861 aggatcacgt ggaacagatc aaaaaaagaa tactcaaatt gagttgcaat cgtctcctga
     4921 tgtgcaaaac agtttattag aagataagac ttaccttgat tctgaagaga gaacttctat
     4981 tgatatagta tgctctgaag gagagaacag caattcaaca gaacaagatt catatagtaa
     5041 ctttcaggtt tatcatagtc aattaaatat gtcccatcag tttagtcatt ttaatgttct
     5101 cactcatcag acatttttgg ggacaccata tgccctttca tcaagtcagt ctcaagaaaa
     5161 tgagaattac ttcttatctg cttatactga aagcttggat agagataaat ctccacctcc
     5221 cttaagttgg gggaaaagtg attcttccag gccatattca caagagaaat aactgtagta
     5281 actttttttt taagagattg ttgtggactt tgtttattaa caatttatat ttcattctct
     5341 aaacaaaagg ttcttgttct ttctcaaatg ttttttcttt tatttaaatc atgatggcct
     5401 gtaacagttg aagcatctaa aaattgaaat aaatatatat ttttaacata tattgtactt
     5461 gaattatctc atgttggcac ttctaagttt tactttttgt atgttacctg tacttaggct
     5521 tcaaattgaa gcctgtttta tgtgtaaaat cagatgcttg caggaggacg gtaaacagca
     5581 aaggctttac ttctttttct ctaatgtcac ctgatataaa gtacttttgt tgaagtgaat
     5641 tattttgatg taggcttttg tatactgtgt ttacacaggt ataagtcagt aatagcagtg
     5701 ttaatattta caggattttg gctcgatacc tcaagattta tctaacagtg cagtttcatt
     5761 tagataataa actatgtaca taggacacat tttttatctc taggcttagt catgtaaaaa
     5821 ctgcctattg ctaaaattct ggtaactttt tgagagtatt ggataatttt cagtacctgc
     5881 gcaatccttg atttaatgaa attaaatttt ttatttcaaa agataggctt ctgtttatca
     5941 aaggcgttga acaatttgat ttttaaatta gttttagcaa aatggaagta taatgggaat
     6001 atatttttga ggtggtctta gtagtaatta ccatttgttg aacacattaa tgctatacta
     6061 gacagataca gtggagatag ctttcaaacc cgtatctatt cctaactact gcctctaata
     6121 ctaattacta acttgttact aatgctaact tttaaaaatg tttttgaaaa ttgcaatttc
     6181 tacaaataaa tgtcatagtg caaataaatg tcaggattta gagaaggagc ctaaactgaa
     6241 tttgtgttat ttcagtaaaa gttatggagt tatgggtcta gacgtgttaa taagttagac
     6301 agaactttgg cactttagaa caaatgcatg agtggtattt cagttcctaa gttacataaa
     6361 aagtgtgaaa gaacactgtg aggtcccagc aacgccagac tatattaagg taagtagaaa
     6421 gtgtttttat agggcttcaa tacccaggtg gtgacagagc agaagaaccg gttttttttt
     6481 tttttttttt actactaagc ttttacaaaa gaagtatctg ttttattgta tagaacaagt
     6541 acagcatttt actacatagt atacaagttt ttaatgagca tttaaaaaaa taagtaaatc
     6601 taggctattt gaaaaataca gttgagccag tgagcacatt ttataatttg gaagacacaa
     6661 atcaaatgtg aaggatttga ttttctacat ttaaaatgaa gaaccaaaac tctcttcttg
     6721 attttcagct aaaggcagga gactactttc caactccttt tgcttctgga gaaggccctg
     6781 aaatcacatt gatatatgtt tgttagtaaa atgtgcacac ctgacttgca atgttgtgtt
     6841 aaactagaat tatattcact tggaaaacat atcgcttagg ataaaatttt gtcattcaaa
     6901 aattttttca gaaatgcttg tactagacca cctcatttgg atatatagct atcacatttg
     6961 taagattctg tttttagcat aaaaatcaat agggatgaaa attttcttag aactcaagac
     7021 tccataacta tgggggtaaa tgaagtcatc ccttctcccc cagtccaccc ccaagtgctc
     7081 ttagatactg aaggagtctc ccttaacata cagtgttttt tttttgttgt tgttgttttg
     7141 tttttttttg gagatggagt ctcgctctgt cgcccaagct ggagtacagt ggtgcaatct
     7201 cactgcaagc tctgcctccc aggttcacac cattctcctg cctcaacctc ccgaatggct
     7261 gggactacag gcacccacca ccacgcctgg ctaactaact aactaacttt ttgtattttt
     7321 agtagagaca gggtttcact gtgttagcca ggatggtctt gatctcctga cctcatgatc
     7381 tgcctgcctc agcctcccaa agtgctggga ttacaggctt gagccactgc tcctggccaa
     7441 catccagtat tttatcttga ctgtcctaac cttaccttag atgctaacag aagggtcctg
     7501 ctgaaataac actgggtgct atattgatgg gtaaatgtgt acatcctatt ccttcctctt
     7561 tatctcacaa tttttgtctc cactaagcaa gaagtaaact aacacttcgt cactctaaag
     7621 aaataactta tgtaaaactc ttagtaaccc tgtttgtctt caaatgagta aatagaccaa
     7681 agtgggggga caattttcta gttctgtaga gggaaaaaca tctgagtcaa cattttgaaa
     7741 tgcagagggt attggtacat gacgacatgg aaaagggcac ttttaaacac agcttactct
     7801 tcctcaagta cagagagtat atagtgaatc aaaactaact acagccattc tttttaaagc
     7861 ccaagggatg gagcaaaggt gtaaggatgt tacctgtttg ttttaatcag agagcaaaaa
     7921 gaagtcacaa tagtttggga gaaaaagtag tatggtgagt aaggttatgc gtataatttc
     7981 atactgaatt tattactatt tgggatgtac gtcaatgttc taacaaacac tgccaacacg
     8041 tcaatttttt aaaaagcgtg ggccacattg ctaagaattt gttaaagcat aactgtattt
     8101 tttgttttag ggccttattg atgttttgcc gttccaatgt atgcattttt ttactcaata
     8161 aacttgtctt aatttta
//
