LOCUS       NM_025159               1792 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens TLR adaptor interacting with endolysosomal SLC15A4
            (TASL), mRNA.
ACCESSION   NM_025159
VERSION     NM_025159.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1792)
  AUTHORS   Park,J.Y., Kim,H.S., Hyung,H., Jang,S., Ko,J., Lee,J.H., Kim,S.Y.,
            Park,S., Yi,J., Park,S., Lim,S.G., Kim,S., Lee,S., Kim,M.O.,
            Jang,S. and Ryoo,Z.Y.
  TITLE     TASL mediates keratinocyte differentiation by regulating
            intracellular calcium levels and lysosomal function
  JOURNAL   Sci Rep 14 (1), 10978 (2024)
   PUBMED   38744928
  REMARK    GeneRIF: TASL mediates keratinocyte differentiation by regulating
            intracellular calcium levels and lysosomal function.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1792)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1792)
  AUTHORS   Heinz,L.X., Lee,J., Kapoor,U., Kartnig,F., Sedlyarov,V.,
            Papakostas,K., Cesar-Razquin,A., Essletzbichler,P., Goldmann,U.,
            Stefanovic,A., Bigenzahn,J.W., Scorzoni,S., Pizzagalli,M.D.,
            Bensimon,A., Muller,A.C., King,F.J., Li,J., Girardi,E., Mbow,M.L.,
            Whitehurst,C.E., Rebsamen,M. and Superti-Furga,G.
  TITLE     TASL is the SLC15A4-associated adaptor for IRF5 activation by
            TLR7-9
  JOURNAL   Nature 581 (7808), 316-322 (2020)
   PUBMED   32433612
  REMARK    GeneRIF: identification of TASL as the component that links
            endolysosomal TLRs to the IRF5 transcription factor via SLC15A4
            provides a mechanistic explanation for the involvement of these
            proteins in systemic lupus erythematosus
REFERENCE   4  (bases 1 to 1792)
  AUTHORS   Harris,V.M., Koelsch,K.A., Kurien,B.T., Harley,I.T.W., Wren,J.D.,
            Harley,J.B. and Scofield,R.H.
  TITLE     Characterization of cxorf21 Provides Molecular Insight Into
            Female-Bias Immune Response in SLE Pathogenesis
  JOURNAL   Front Immunol 10, 2160 (2019)
   PUBMED   31695690
  REMARK    GeneRIF: Characterization of cxorf21 Provides Molecular Insight
            Into Female-Bias Immune Response in SLE Pathogenesis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1792)
  AUTHORS   Odhams,C.A., Roberts,A.L., Vester,S.K., Duarte,C.S.T., Beales,C.T.,
            Clarke,A.J., Lindinger,S., Daffern,S.J., Zito,A., Chen,L.,
            Jones,L.L., Boteva,L., Morris,D.L., Small,K.S., Fernando,M.M.A.,
            Cunninghame Graham,D.S. and Vyse,T.J.
  TITLE     Interferon inducible X-linked gene CXorf21 may contribute to sexual
            dimorphism in Systemic Lupus Erythematosus
  JOURNAL   Nat Commun 10 (1), 2164 (2019)
   PUBMED   31092820
  REMARK    GeneRIF: Through combined genetic, in silico, in vitro, and ex vivo
            approaches, study defines CXorf21, a gene of hitherto unknown
            function, which escapes X-chromosome inactivation, as a candidate
            underlying the Xp21.2 systemic lupus erythematosus association and
            demonstrates that CXorf21 is an IFN-response gene and that the
            sexual dimorphism in expression is magnified by immunological
            challenge.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1792)
  AUTHORS   Harris,V.M., Harley,I.T.W., Kurien,B.T., Koelsch,K.A. and
            Scofield,R.H.
  TITLE     Lysosomal pH Is Regulated in a Sex Dependent Manner in Immune Cells
            Expressing CXorf21
  JOURNAL   Front Immunol 10, 578 (2019)
   PUBMED   31001245
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1792)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC020611.1, BX281759.1, AC005913.2 and AK021639.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_025159.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.142432.1, AK021639.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMN03267779
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000378962.4/ ENSP00000368245.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-871               BC020611.1         79-949
            872-872             BX281759.1         482-482
            873-1493            BC020611.1         951-1571
            1494-1494           AC005913.2         25828-25828         c
            1495-1532           BC020611.1         1573-1610
            1533-1533           AC005913.2         25789-25789         c
            1534-1777           AK021639.1         1565-1808
            1778-1792           AC005913.2         25530-25544         c
FEATURES             Location/Qualifiers
     source          1..1792
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp21.2"
     gene            1..1792
                     /gene="TASL"
                     /gene_synonym="CXorf21"
                     /note="TLR adaptor interacting with endolysosomal SLC15A4"
                     /db_xref="GeneID:80231"
                     /db_xref="HGNC:HGNC:25667"
                     /db_xref="MIM:301049"
     exon            1..129
                     /gene="TASL"
                     /gene_synonym="CXorf21"
                     /inference="alignment:Splign:2.1.0"
     exon            130..244
                     /gene="TASL"
                     /gene_synonym="CXorf21"
                     /inference="alignment:Splign:2.1.0"
     exon            245..1792
                     /gene="TASL"
                     /gene_synonym="CXorf21"
                     /inference="alignment:Splign:2.1.0"
     CDS             246..1151
                     /gene="TASL"
                     /gene_synonym="CXorf21"
                     /note="5430427O19Rik; uncharacterized protein CXorf21; TLR
                     adaptor interacting with SLC15A4 on the lysosome"
                     /codon_start=1
                     /product="TLR adapter interacting with SLC15A4 on the
                     lysosome"
                     /protein_id="NP_079435.1"
                     /db_xref="CCDS:CCDS14224.1"
                     /db_xref="GeneID:80231"
                     /db_xref="HGNC:HGNC:25667"
                     /db_xref="MIM:301049"
                     /translation="MLSEGYLSGLEYWNDIHWSCASYNEQVAGEKEEETNSVATLSYS
                     SVDETQVRSLYVSCKSSGKFISSVHSRESQHSRSQRVTVLQTNPNPVFESPNLAAVEI
                     CRDASRETYLVPSSCKSICKNYNDLQIAGGQVMAINSVTTDFPSESSFEYGPLLKSSE
                     IPLPMEDSISTQPSDFPQKPIQRYSSYWRITSIKEKSSLQMQNPISNAVLNEYLEQKV
                     VELYKQYIMDTVFHDSSPTQILASELIMTSVDQISLQVSREKNLETSKARDIVFSRLL
                     QLMSTEITEISTPSLHISQYSNVNP"
     regulatory      1394..1399
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TASL"
                     /gene_synonym="CXorf21"
                     /note="hexamer: AATAAA"
     polyA_site      1412
                     /gene="TASL"
                     /gene_synonym="CXorf21"
                     /note="major polyA site"
ORIGIN      
        1 agtctactgg tctcatcagt gaaaggcttg tgaaaatttc tggaaagagc attggctggc
       61 ttgttcatct ctctgtttgg tcagttgctg tgtttctgcc ggatcagatg agcagattgg
      121 ttagtgaagg tcagtgtgag aagaagattg tttctgagct tgagaagctt ctggaggatt
      181 gaagagtatt tgaagtctgt gtcaaacatc catatcataa gtggaatttt ggagatattc
      241 aaagaatgct gtcagaaggg tatctcagtg gacttgagta ctggaatgac atccactgga
      301 gttgtgcctc ttataatgag caggtggctg gggaaaagga agaggagaca aattctgttg
      361 ctaccctttc ctattcctct gtggatgaaa cacaagtcag aagtctctac gtgagctgca
      421 aatcatctgg caagtttatc tcttcagtgc attcaagaga gagccaacat agcagaagtc
      481 agagagtcac agtgctgcag acaaacccca atcctgtgtt tgaaagccca aacttggctg
      541 cagttgaaat atgtagagat gccagcagag agacctactt ggttccatct tcttgcaaaa
      601 gtatttgcaa gaattataat gacttacaga ttgcaggggg ccaggtgatg gccattaatt
      661 cagtgacaac agattttccc tctgagagca gttttgaata tggccctttg ctgaagtcat
      721 ctgagattcc tttacccatg gaggattcca tttctactca gcccagtgac tttccccaaa
      781 aacctatcca gcggtactca tcctattgga gaataacaag catcaaagag aaaagcagct
      841 tgcaaatgca gaatcctatt tctaatgcag ttctgaatga gtacctggag cagaaggttg
      901 tggagttata taaacagtac attatggaca ccgtgtttca tgacagttct cctacccaga
      961 ttctggcgtc tgaactcatc atgacaagtg tagaccaaat cagtcttcaa gtgtctagag
     1021 agaagaatct ggagacctca aaagccagag atatagtctt tagccgccta ttgcaattga
     1081 tgtcaactga aattactgaa attagcactc ctagtctcca tatttctcag tatagcaatg
     1141 taaatccata gagaggatgc ttccattact gtctcgcatt tacttaaaca tgaagcaaca
     1201 ctttatccat ttattctgag aatgtgcagg aggggttagt gaaggggaat taagggctag
     1261 agaagtaaag atcagctgga agtcatgtgt gaatcatgga gaaatctcat aatattacac
     1321 ttgatgaagg aatatggtaa gaggagccat aaggaatgat ttcaaagaga ggtgtgtaca
     1381 gcaaggaagc aaaaataaaa atgatcaaaa aagaaacggt taattcattt gaagaaacat
     1441 aggaattaaa aaagaagaca gtcaaatgag atgaaacaaa aaggccaaaa ggtggccggg
     1501 tgtagtggct cacgcctgta atcccagcat ttcggaggct gatgtgggtg gattacctga
     1561 cgtcaggaat tcgagaccgg cctggccaat atggtgaaac cccatctcta ctaaaaatac
     1621 aaaaaattag ctggacatgg tggtgggtac ctgtaatccc agctactagg gaggctgagg
     1681 caggagaatc tcttgaacct gagaggcaga ggttgcagtg agccgaggtc gctccattgc
     1741 actccagcct gggcaacaag agtgagactc ccgtctcaaa aaaaaaaaaa aa
//
