LOCUS       NM_023917               1075 bp    mRNA    linear   PRI 02-JUN-2024
DEFINITION  Homo sapiens taste 2 receptor member 9 (TAS2R9), mRNA.
ACCESSION   NM_023917
VERSION     NM_023917.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1075)
  AUTHORS   Bartakova,V., Kuricova,K., Zlamal,F., Belobradkova,J. and
            Kankova,K.
  TITLE     Differences in food intake and genetic variability in taste
            receptors between Czech pregnant women with and without gestational
            diabetes mellitus
  JOURNAL   Eur J Nutr 57 (2), 513-521 (2018)
   PUBMED   27757593
  REMARK    GeneRIF: genetic association studies in population of pregnant
            women in Czechoslovakia: Data suggest that an SNP in TAS2R9
            (rs3741845) is associated with gestational diabetes; such genetic
            variation may play role in food preferences and compliance with
            healthy diet that may help prevent gestational diabetes.
            Associations were not found for SNPs in TAS1R2 and TAS2R7.
REFERENCE   2  (bases 1 to 1075)
  AUTHORS   Dotson,C.D., Zhang,L., Xu,H., Shin,Y.K., Vigues,S., Ott,S.H.,
            Elson,A.E., Choi,H.J., Shaw,H., Egan,J.M., Mitchell,B.D., Li,X.,
            Steinle,N.I. and Munger,S.D.
  TITLE     Bitter taste receptors influence glucose homeostasis
  JOURNAL   PLoS One 3 (12), e3974 (2008)
   PUBMED   19092995
  REMARK    GeneRIF: A functionally compromised TAS2R receptor negatively
            impacts glucose homeostasis, providing an important link between
            alimentary chemosensation and metabolic disease.
REFERENCE   3  (bases 1 to 1075)
  AUTHORS   Go,Y., Satta,Y., Takenaka,O. and Takahata,N.
  TITLE     Lineage-specific loss of function of bitter taste receptor genes in
            humans and nonhuman primates
  JOURNAL   Genetics 170 (1), 313-326 (2005)
   PUBMED   15744053
REFERENCE   4  (bases 1 to 1075)
  AUTHORS   Fischer,A., Gilad,Y., Man,O. and Paabo,S.
  TITLE     Evolution of bitter taste receptors in humans and apes
  JOURNAL   Mol Biol Evol 22 (3), 432-436 (2005)
   PUBMED   15496549
  REMARK    Erratum:[Mol Biol Evol. 2005 Apr;22(4):1157]
REFERENCE   5  (bases 1 to 1075)
  AUTHORS   Zhang,Y., Hoon,M.A., Chandrashekar,J., Mueller,K.L., Cook,B.,
            Wu,D., Zuker,C.S. and Ryba,N.J.
  TITLE     Coding of sweet, bitter, and umami tastes: different receptor cells
            sharing similar signaling pathways
  JOURNAL   Cell 112 (3), 293-301 (2003)
   PUBMED   12581520
REFERENCE   6  (bases 1 to 1075)
  AUTHORS   Margolskee,R.F.
  TITLE     Molecular mechanisms of bitter and sweet taste transduction
  JOURNAL   J Biol Chem 277 (1), 1-4 (2002)
   PUBMED   11696554
  REMARK    Review article
REFERENCE   7  (bases 1 to 1075)
  AUTHORS   Matsunami,H., Montmayeur,J.P. and Buck,L.B.
  TITLE     A family of candidate taste receptors in human and mouse
  JOURNAL   Nature 404 (6778), 601-604 (2000)
   PUBMED   10766242
REFERENCE   8  (bases 1 to 1075)
  AUTHORS   Chandrashekar,J., Mueller,K.L., Hoon,M.A., Adler,E., Feng,L.,
            Guo,W., Zuker,C.S. and Ryba,N.J.
  TITLE     T2Rs function as bitter taste receptors
  JOURNAL   Cell 100 (6), 703-711 (2000)
   PUBMED   10761935
REFERENCE   9  (bases 1 to 1075)
  AUTHORS   Adler,E., Hoon,M.A., Mueller,K.L., Chandrashekar,J., Ryba,N.J. and
            Zuker,C.S.
  TITLE     A novel family of mammalian taste receptors
  JOURNAL   Cell 100 (6), 693-702 (2000)
   PUBMED   10761934
REFERENCE   10 (bases 1 to 1075)
  AUTHORS   Kinnamon,S.C.
  TITLE     A plethora of taste receptors
  JOURNAL   Neuron 25 (3), 507-510 (2000)
   PUBMED   10774719
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC095519.1 and BC069066.1.
            
            On Jun 23, 2005 this sequence version replaced NM_023917.1.
            
            Summary: This gene product belongs to the family of candidate taste
            receptors that are members of the G-protein-coupled receptor
            superfamily. These proteins are specifically expressed in the taste
            receptor cells of the tongue and palate epithelia. They are
            organized in the genome in clusters and are genetically linked to
            loci that influence bitter perception in mice and humans. In
            functional expression studies, they respond to bitter tastants.
            This gene maps to the taste receptor gene cluster on chromosome
            12p13. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC095519.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000240691.4/ ENSP00000240691.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-652               BC095519.1         2-653
            653-1032            BC069066.1         560-939
            1033-1075           BC095519.1         1034-1076
FEATURES             Location/Qualifiers
     source          1..1075
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.2"
     gene            1..1075
                     /gene="TAS2R9"
                     /gene_synonym="T2R9; TRB6"
                     /note="taste 2 receptor member 9"
                     /db_xref="GeneID:50835"
                     /db_xref="HGNC:HGNC:14917"
                     /db_xref="MIM:604795"
     exon            1..1075
                     /gene="TAS2R9"
                     /gene_synonym="T2R9; TRB6"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..1032
                     /gene="TAS2R9"
                     /gene_synonym="T2R9; TRB6"
                     /note="taste receptor, family B, member 6; taste receptor,
                     type 2, member 9"
                     /codon_start=1
                     /product="taste receptor type 2 member 9"
                     /protein_id="NP_076406.1"
                     /db_xref="CCDS:CCDS8633.1"
                     /db_xref="GeneID:50835"
                     /db_xref="HGNC:HGNC:14917"
                     /db_xref="MIM:604795"
                     /translation="MPSAIEAIYIILIAGELTIGIWGNGFIVLVNCIDWLKRRDISLI
                     DIILISLAISRICLLCVISLDGFFMLLFPGTYGNSVLVSIVNVVWTFANNSSLWFTSC
                     LSIFYLLKIANISHPFFFWLKLKINKVMLAILLGSFLISLIISVPKNDDMWYHLFKVS
                     HEENITWKFKVSKIPGTFKQLTLNLGVMVPFILCLISFFLLLFSLVRHTKQIRLHATG
                     FRDPSTEAHMRAIKAVIIFLLLLIVYYPVFLVMTSSALIPQGKLVLMIGDIVTVIFPS
                     SHSFILIMGNSKLREAFLKMLRFVKCFLRRRKPFVP"
ORIGIN      
        1 gtctaagagg cagacagata cattgttctt cactggtcag ctgaaagtca attcatcatc
       61 agtgatattc aaaaatcaca agtctttgct ggcatgccaa gtgcaataga ggcaatatat
      121 attattttaa ttgctggtga attgaccata gggatttggg gaaatggatt cattgtacta
      181 gttaactgca ttgactggct caaaagaaga gatatttcct tgattgacat catcctgatc
      241 agcttggcca tctccagaat ctgtctgctg tgtgtaatat cattagatgg cttctttatg
      301 ctgctctttc caggtacata tggcaatagc gtgctagtaa gcattgtgaa tgttgtctgg
      361 acatttgcca ataattcaag tctctggttt acttcttgcc tcagtatctt ctatttactc
      421 aagatagcca atatatcgca cccatttttc ttctggctga agctaaagat caacaaggtc
      481 atgcttgcga ttcttctggg gtcctttctt atctctttaa ttattagtgt tccaaagaat
      541 gatgatatgt ggtatcacct tttcaaagtc agtcatgaag aaaacattac ttggaaattc
      601 aaagtgagta aaattccagg tactttcaaa cagttaaccc tgaacctggg ggtgatggtt
      661 ccctttatcc tttgcctgat ctcatttttc ttgttacttt tctccctagt tagacacacc
      721 aagcagattc gactgcatgc tacagggttc agagacccca gtacagaggc ccacatgagg
      781 gccataaagg cagtgatcat ctttctgctc ctcctcatcg tgtactaccc agtctttctt
      841 gttatgacct ctagcgctct gattcctcag ggaaaattag tgttgatgat tggtgacata
      901 gtaactgtca ttttcccatc aagccattca ttcattctaa ttatgggaaa tagcaagttg
      961 agggaagctt ttctgaagat gttaagattt gtgaagtgtt tccttagaag aagaaagcct
     1021 tttgttccat agagacccct aaagagtatc ctgactacaa ggatgaaaga aatca
//
