LOCUS       NM_023919               1096 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens taste 2 receptor member 7 (TAS2R7), mRNA.
ACCESSION   NM_023919
VERSION     NM_023919.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1096)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1096)
  AUTHORS   Su,Y., Jie,H., Zhu,Q., Zhao,X., Wang,Y., Yin,H., Kumar Mishra,S.
            and Li,D.
  TITLE     Effect of Bitter Compounds on the Expression of Bitter Taste
            Receptor T2R7 Downstream Signaling Effectors in
            cT2R7/pDisplay-Galpha16/gust44/pcDNA3.1 (+) Cells
  JOURNAL   Biomed Res Int 2019, 6301915 (2019)
   PUBMED   31781630
  REMARK    GeneRIF: Effect of Bitter Compounds on the Expression of Bitter
            Taste Receptor T2R7 Downstream Signaling Effectors in
            cT2R7/pDisplay-Galpha16/gust44/pcDNA3.1 (+) Cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1096)
  AUTHORS   Wang,Y., Zajac,A.L., Lei,W., Christensen,C.M., Margolskee,R.F.,
            Bouysset,C., Golebiowski,J., Zhao,H., Fiorucci,S. and Jiang,P.
  TITLE     Metal Ions Activate the Human Taste Receptor TAS2R7
  JOURNAL   Chem Senses 44 (5), 339-347 (2019)
   PUBMED   31066447
  REMARK    GeneRIF: The TAS2R7 may act as a metal cation receptor mediating
            bitterness of divalent and trivalent salts.
REFERENCE   4  (bases 1 to 1096)
  AUTHORS   Behrens,M., Redel,U., Blank,K. and Meyerhof,W.
  TITLE     The human bitter taste receptor TAS2R7 facilitates the detection of
            bitter salts
  JOURNAL   Biochem Biophys Res Commun 512 (4), 877-881 (2019)
   PUBMED   30928101
  REMARK    GeneRIF: TAS2R7 is a receptor for bitter tasting salts.
REFERENCE   5  (bases 1 to 1096)
  AUTHORS   Liu,K., Jaggupilli,A., Premnath,D. and Chelikani,P.
  TITLE     Plasticity of the ligand binding pocket in the bitter taste
            receptor T2R7
  JOURNAL   Biochim Biophys Acta Biomembr 1860 (5), 991-999 (2018)
   PUBMED   29355483
  REMARK    GeneRIF: Similar to majority of the Class A GPCRs, extracellular
            loop 2 in T2R7 plays a significant role in agonist binding and
            activation.
REFERENCE   6  (bases 1 to 1096)
  AUTHORS   Margolskee,R.F.
  TITLE     Molecular mechanisms of bitter and sweet taste transduction
  JOURNAL   J Biol Chem 277 (1), 1-4 (2002)
   PUBMED   11696554
  REMARK    Review article
REFERENCE   7  (bases 1 to 1096)
  AUTHORS   Matsunami,H., Montmayeur,J.P. and Buck,L.B.
  TITLE     A family of candidate taste receptors in human and mouse
  JOURNAL   Nature 404 (6778), 601-604 (2000)
   PUBMED   10766242
REFERENCE   8  (bases 1 to 1096)
  AUTHORS   Chandrashekar,J., Mueller,K.L., Hoon,M.A., Adler,E., Feng,L.,
            Guo,W., Zuker,C.S. and Ryba,N.J.
  TITLE     T2Rs function as bitter taste receptors
  JOURNAL   Cell 100 (6), 703-711 (2000)
   PUBMED   10761935
REFERENCE   9  (bases 1 to 1096)
  AUTHORS   Adler,E., Hoon,M.A., Mueller,K.L., Chandrashekar,J., Ryba,N.J. and
            Zuker,C.S.
  TITLE     A novel family of mammalian taste receptors
  JOURNAL   Cell 100 (6), 693-702 (2000)
   PUBMED   10761934
REFERENCE   10 (bases 1 to 1096)
  AUTHORS   Kinnamon,S.C.
  TITLE     A plethora of taste receptors
  JOURNAL   Neuron 25 (3), 507-510 (2000)
   PUBMED   10774719
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC093992.1 and BC069091.1.
            
            On Jun 23, 2005 this sequence version replaced NM_023919.1.
            
            Summary: This gene product belongs to the family of candidate taste
            receptors that are members of the G-protein-coupled receptor
            superfamily. These proteins are specifically expressed in the taste
            receptor cells of the tongue and palate epithelia. They are
            organized in the genome in clusters and are genetically linked to
            loci that influence bitter perception in mice and humans. In
            functional expression studies, they respond to bitter tastants.
            This gene maps to the taste receptor gene cluster on chromosome
            12p13. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC093992.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000240687.2/ ENSP00000240687.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-158               BC093992.1         1-158
            159-1014            BC069091.1         102-957
            1015-1096           BC093992.1         1015-1096
FEATURES             Location/Qualifiers
     source          1..1096
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.2"
     gene            1..1096
                     /gene="TAS2R7"
                     /gene_synonym="T2R7; TRB4"
                     /note="taste 2 receptor member 7"
                     /db_xref="GeneID:50837"
                     /db_xref="HGNC:HGNC:14913"
                     /db_xref="MIM:604793"
     exon            1..1096
                     /gene="TAS2R7"
                     /gene_synonym="T2R7; TRB4"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..1014
                     /gene="TAS2R7"
                     /gene_synonym="T2R7; TRB4"
                     /note="taste receptor, family B, member 4; taste receptor,
                     type 2, member 7"
                     /codon_start=1
                     /product="taste receptor type 2 member 7"
                     /protein_id="NP_076408.1"
                     /db_xref="CCDS:CCDS8631.1"
                     /db_xref="GeneID:50837"
                     /db_xref="HGNC:HGNC:14913"
                     /db_xref="MIM:604793"
                     /translation="MADKVQTTLLFLAVGEFSVGILGNAFIGLVNCMDWVKKRKIASI
                     DLILTSLAISRICLLCVILLDCFILVLYPDVYATGKEMRIIDFFWTLTNHLSIWFATC
                     LSIYYFFKIGNFFHPLFLWMKWRIDRVISWILLGCVVLSVFISLPATENLNADFRFCV
                     KAKRKTNLTWSCRVNKTQHASTKLFLNLATLLPFCVCLMSFFLLILSLRRHIRRMQLS
                     ATGCRDPSTEAHVRALKAVISFLLLFIAYYLSFLIATSSYFMPETELAVIFGESIALI
                     YPSSHSFILILGNNKLRHASLKVIWKVMSILKGRKFQQHKQI"
ORIGIN      
        1 gcaggtgtgg atgtcaaact ccatcaggtc aactagaaac taattgcata tttaaacatg
       61 gcagataaag tgcagactac tttattgttc ttagcagttg gagagttttc agtggggatc
      121 ttagggaatg cattcattgg attggtaaac tgcatggact gggtcaagaa gaggaaaatt
      181 gcctccattg atttaatcct cacaagtctg gccatatcca gaatttgtct attgtgcgta
      241 atactattag attgttttat attggtgcta tatccagatg tctatgccac tggtaaagaa
      301 atgagaatca ttgacttctt ctggacacta accaatcatt taagtatctg gtttgcaacc
      361 tgcctcagca tttactattt cttcaagata ggtaatttct ttcacccact tttcctctgg
      421 atgaagtgga gaattgacag ggtgatttcc tggattctac tggggtgcgt ggttctctct
      481 gtgtttatta gccttccagc cactgagaat ttgaacgctg atttcaggtt ttgtgtgaag
      541 gcaaagagga aaacaaactt aacttggagt tgcagagtaa ataaaactca acatgcttct
      601 accaagttat ttctcaacct ggcaacgctg ctcccctttt gtgtgtgcct aatgtccttt
      661 ttcctcttga tcctctccct gcggagacat atcaggcgaa tgcagctcag tgccacaggg
      721 tgcagagacc ccagcacaga agcccatgtg agagccctga aagctgtcat ttccttcctt
      781 ctcctcttta ttgcctacta tttgtccttt ctcattgcca cctccagcta ctttatgcca
      841 gagacggaat tagctgtgat ttttggtgag tccatagctc taatctaccc ctcaagtcat
      901 tcatttatcc taatactggg gaacaataaa ttaagacatg catctctaaa ggtgatttgg
      961 aaagtaatgt ctattctaaa aggaagaaaa ttccaacaac ataaacaaat ctgaagagaa
     1021 actatgcttt tctaggacaa acaaagataa gatgtttcta aattaacttc agttcttgca
     1081 ttaatgtttt atgtga
//
