LOCUS       NM_177437                957 bp    mRNA    linear   PRI 02-JUN-2024
DEFINITION  Homo sapiens taste 2 receptor member 60 (TAS2R60), mRNA.
ACCESSION   NM_177437
VERSION     NM_177437.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 957)
  AUTHORS   Thalmann,S., Behrens,M. and Meyerhof,W.
  TITLE     Major haplotypes of the human bitter taste receptor TAS2R41 encode
            functional receptors for chloramphenicol
  JOURNAL   Biochem Biophys Res Commun 435 (2), 267-273 (2013)
   PUBMED   23632330
REFERENCE   2  (bases 1 to 957)
  AUTHORS   Meyerhof,W., Batram,C., Kuhn,C., Brockhoff,A., Chudoba,E., Bufe,B.,
            Appendino,G. and Behrens,M.
  TITLE     The molecular receptive ranges of human TAS2R bitter taste
            receptors
  JOURNAL   Chem Senses 35 (2), 157-170 (2010)
   PUBMED   20022913
REFERENCE   3  (bases 1 to 957)
  AUTHORS   Go,Y., Satta,Y., Takenaka,O. and Takahata,N.
  TITLE     Lineage-specific loss of function of bitter taste receptor genes in
            humans and nonhuman primates
  JOURNAL   Genetics 170 (1), 313-326 (2005)
   PUBMED   15744053
REFERENCE   4  (bases 1 to 957)
  AUTHORS   Fischer,A., Gilad,Y., Man,O. and Paabo,S.
  TITLE     Evolution of bitter taste receptors in humans and apes
  JOURNAL   Mol Biol Evol 22 (3), 432-436 (2005)
   PUBMED   15496549
  REMARK    Erratum:[Mol Biol Evol. 2005 Apr;22(4):1157]
REFERENCE   5  (bases 1 to 957)
  AUTHORS   Shi,P., Zhang,J., Yang,H. and Zhang,Y.P.
  TITLE     Adaptive diversification of bitter taste receptor genes in
            Mammalian evolution
  JOURNAL   Mol Biol Evol 20 (5), 805-814 (2003)
   PUBMED   12679530
REFERENCE   6  (bases 1 to 957)
  AUTHORS   Zhang,Y., Hoon,M.A., Chandrashekar,J., Mueller,K.L., Cook,B.,
            Wu,D., Zuker,C.S. and Ryba,N.J.
  TITLE     Coding of sweet, bitter, and umami tastes: different receptor cells
            sharing similar signaling pathways
  JOURNAL   Cell 112 (3), 293-301 (2003)
   PUBMED   12581520
REFERENCE   7  (bases 1 to 957)
  AUTHORS   Montmayeur,J.P. and Matsunami,H.
  TITLE     Receptors for bitter and sweet taste
  JOURNAL   Curr Opin Neurobiol 12 (4), 366-371 (2002)
   PUBMED   12139982
  REMARK    Review article
REFERENCE   8  (bases 1 to 957)
  AUTHORS   Margolskee,R.F.
  TITLE     Molecular mechanisms of bitter and sweet taste transduction
  JOURNAL   J Biol Chem 277 (1), 1-4 (2002)
   PUBMED   11696554
  REMARK    Review article
REFERENCE   9  (bases 1 to 957)
  AUTHORS   Conte,C., Ebeling,M., Marcuz,A., Nef,P. and Andres-Barquin,P.J.
  TITLE     Identification and characterization of human taste receptor genes
            belonging to the TAS2R family
  JOURNAL   Cytogenet Genome Res 98 (1), 45-53 (2002)
   PUBMED   12584440
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY114094.1.
            
            Summary: This gene encodes a member of the bitter taste receptor
            family which belong to the G protein-coupled receptor superfamily
            and are predominantly expressed in taste receptor cells of the
            tongue and palate epithelia. This intronless taste receptor gene
            encodes a seven-transmembrane receptor protein, functioning as a
            bitter taste receptor. This gene is clustered together with eight
            other taste receptor genes on chromosome 7. [provided by RefSeq,
            Jul 2017].
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC100938.2 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000332690.1/ ENSP00000327724.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..957
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q35"
     gene            1..957
                     /gene="TAS2R60"
                     /gene_synonym="T2R56; T2R60"
                     /note="taste 2 receptor member 60"
                     /db_xref="GeneID:338398"
                     /db_xref="HGNC:HGNC:20639"
                     /db_xref="MIM:613968"
     CDS             1..957
                     /gene="TAS2R60"
                     /gene_synonym="T2R56; T2R60"
                     /note="taste receptor type 2 member 56; taste receptor,
                     type 2, member 60"
                     /codon_start=1
                     /product="taste receptor type 2 member 60"
                     /protein_id="NP_803186.1"
                     /db_xref="CCDS:CCDS5885.1"
                     /db_xref="GeneID:338398"
                     /db_xref="HGNC:HGNC:20639"
                     /db_xref="MIM:613968"
                     /translation="MNGDHMVLGSSVTDKKAIILVTILLLLRLVAIAGNGFITAALGV
                     EWVLRRMLLPCDKLLVSLGASRFCLQSVVMGKTIYVFLHPMAFPYNPVLQFLAFQWDF
                     LNAATLWSSTWLSVFYCVKIATFTHPVFFWLKHKLSGWLPWMLFSSVGLSSFTTILFF
                     IGNHRMYQNYLRNHLQPWNVTGDSIRSYCEKFYLFPLKMITWTMPTAVFFICMILLIT
                     SLGRHRKKALLTTSGFREPSVQAHIKALLALLSFAMLFISYFLSLVFSAAGIFPPLDF
                     KFWVWESVIYLCAAVHPIILLFSNCRLRAVLKSRRSSRCGTP"
     exon            1..957
                     /gene="TAS2R60"
                     /gene_synonym="T2R56; T2R60"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgaatggag accacatggt tctaggatct tcggtgactg acaagaaggc catcatcttg
       61 gttaccattt tactcctttt acgcctggta gcaatagcag gcaatggctt catcactgct
      121 gctctgggcg tggagtgggt gctacggaga atgttgttgc cttgtgataa gttattggtt
      181 agcctagggg cctctcgctt ctgtctgcag tcagtggtaa tgggtaagac catttatgtt
      241 ttcttgcatc cgatggcctt cccatacaac cctgtactgc agtttctagc tttccagtgg
      301 gacttcctga atgctgccac cttatggtcc tctacctggc tcagtgtctt ctattgtgtg
      361 aaaattgcta ccttcaccca ccctgtcttc ttctggctaa agcacaagtt gtctgggtgg
      421 ctaccatgga tgctcttcag ctctgtaggg ctctccagct tcaccaccat tctatttttc
      481 ataggcaacc acagaatgta tcagaactat ttaaggaacc atctacaacc ttggaatgtc
      541 actggcgata gcatacggag ctactgtgag aaattctatc tcttccctct aaaaatgatt
      601 acttggacaa tgcccactgc tgtctttttc atttgcatga ttttgctcat cacatctctg
      661 ggaagacaca ggaagaaggc tctccttaca acctcaggat tccgagagcc cagtgtgcag
      721 gcacacataa aggctctgct ggctctcctc tcttttgcca tgctcttcat ctcatatttc
      781 ctgtcactgg tgttcagtgc tgcaggtatt tttccacctc tggactttaa attctgggtg
      841 tgggagtcag tgatttatct gtgtgcagca gttcacccca tcattctgct cttcagcaac
      901 tgcaggctga gagctgtgct gaagagtcgt cgttcctcaa ggtgtgggac accttga
//
