LOCUS       NM_176890               1000 bp    mRNA    linear   PRI 04-FEB-2024
DEFINITION  Homo sapiens taste 2 receptor member 50 (TAS2R50), mRNA.
ACCESSION   NM_176890
VERSION     NM_176890.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1000)
  AUTHORS   Tiroch,J., Sterneder,S., Di Pizio,A., Lieder,B., Hoelz,K.,
            Holik,A.K., Pignitter,M., Behrens,M., Somoza,M., Ley,J.P. and
            Somoza,V.
  TITLE     Bitter Sensing TAS2R50 Mediates the trans-Resveratrol-Induced
            Anti-inflammatory Effect on Interleukin 6 Release in HGF-1 Cells in
            Culture
  JOURNAL   J Agric Food Chem 69 (45), 13339-13349 (2021)
   PUBMED   33461297
  REMARK    GeneRIF: Bitter Sensing TAS2R50 Mediates the
            trans-Resveratrol-Induced Anti-inflammatory Effect on Interleukin 6
            Release in HGF-1 Cells in Culture.
REFERENCE   2  (bases 1 to 1000)
  AUTHORS   Kaufman,A.C., Colquitt,L., Ruckenstein,M.J., Bigelow,D.C.,
            Eliades,S.J., Xiong,G., Lin,C., Reed,D.R. and Cohen,N.A.
  TITLE     Bitter Taste Receptors and Chronic Otitis Media
  JOURNAL   Otolaryngol Head Neck Surg 165 (2), 290-299 (2021)
   PUBMED   33433247
  REMARK    GeneRIF: Bitter Taste Receptors and Chronic Otitis Media.
REFERENCE   3  (bases 1 to 1000)
  AUTHORS   Mikolajczyk-Stecyna,J., Malinowska,A.M. and Chmurzynska,A.
  TITLE     Polymorphism of TAS2R3, TAS2R5, TAS2R19, and TAS2R50 genes and
            bitter food intake frequency inelderly woman
  JOURNAL   Acta Sci Pol Technol Aliment 19 (1), 109-122 (2020)
   PUBMED   32227702
  REMARK    GeneRIF: Polymorphism of TAS2R3, TAS2R5, TAS2R19, and TAS2R50 genes
            and bitter food intake frequency inelderly woman.
REFERENCE   4  (bases 1 to 1000)
  AUTHORS   Risso,D.S., Giuliani,C., Antinucci,M., Morini,G., Garagnani,P.,
            Tofanelli,S. and Luiselli,D.
  TITLE     A bio-cultural approach to the study of food choice: The
            contribution of taste genetics, population and culture
  JOURNAL   Appetite 114, 240-247 (2017)
   PUBMED   28366770
  REMARK    GeneRIF: genetic association studies in populations in Northern
            Europe, Maghreb, and Sri Lanka: Data suggest that SNPs in TAS2R50
            (rs1376251), TRPM5 (rs800345), and TAS2R16 (rs860170) are
            associated with cultural food preferences; TAS2R16 (rs860170)
            strongly differentiates populations and is associated to salicin
            bitterness perception. (TRPM5 = transient receptor potential cation
            channel subfamily M member 5)
REFERENCE   5  (bases 1 to 1000)
  AUTHORS   Akao,H., Polisecki,E., Kajinami,K., Trompet,S., Robertson,M.,
            Ford,I., Jukema,J.W., de Craen,A.J., Westendorp,R.G., Shepherd,J.,
            Packard,C., Buckley,B.M. and Schaefer,E.J.
  TITLE     KIF6, LPA, TAS2R50, and VAMP8 genetic variation, low density
            lipoprotein cholesterol lowering response to pravastatin, and heart
            disease risk reduction in the elderly
  JOURNAL   Atherosclerosis 220 (2), 456-462 (2012)
   PUBMED   22192511
  REMARK    GeneRIF: Assessment of KIF6 genotype is not useful in predicting
            low density lipoprotein cholesterol lowering response to
            pravastatin, and heart disease risk reduction in the elderly.
REFERENCE   6  (bases 1 to 1000)
  AUTHORS   Zhang,Y., Hoon,M.A., Chandrashekar,J., Mueller,K.L., Cook,B.,
            Wu,D., Zuker,C.S. and Ryba,N.J.
  TITLE     Coding of sweet, bitter, and umami tastes: different receptor cells
            sharing similar signaling pathways
  JOURNAL   Cell 112 (3), 293-301 (2003)
   PUBMED   12581520
REFERENCE   7  (bases 1 to 1000)
  AUTHORS   Bufe,B., Hofmann,T., Krautwurst,D., Raguse,J.D. and Meyerhof,W.
  TITLE     The human TAS2R16 receptor mediates bitter taste in response to
            beta-glucopyranosides
  JOURNAL   Nat Genet 32 (3), 397-401 (2002)
   PUBMED   12379855
REFERENCE   8  (bases 1 to 1000)
  AUTHORS   Montmayeur,J.P. and Matsunami,H.
  TITLE     Receptors for bitter and sweet taste
  JOURNAL   Curr Opin Neurobiol 12 (4), 366-371 (2002)
   PUBMED   12139982
  REMARK    Review article
REFERENCE   9  (bases 1 to 1000)
  AUTHORS   Margolskee,R.F.
  TITLE     Molecular mechanisms of bitter and sweet taste transduction
  JOURNAL   J Biol Chem 277 (1), 1-4 (2002)
   PUBMED   11696554
  REMARK    Review article
REFERENCE   10 (bases 1 to 1000)
  AUTHORS   Conte,C., Ebeling,M., Marcuz,A., Nef,P. and Andres-Barquin,P.J.
  TITLE     Identification and characterization of human taste receptor genes
            belonging to the TAS2R family
  JOURNAL   Cytogenet Genome Res 98 (1), 45-53 (2002)
   PUBMED   12584440
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC112100.1.
            
            On Aug 9, 2007 this sequence version replaced NM_176890.1.
            
            Summary: TAS2R50 belongs to the large TAS2R receptor family. TAS2Rs
            are expressed on the surface of taste receptor cells and mediate
            the perception of bitterness through a G protein-coupled second
            messenger pathway (Conte et al., 2002 [PubMed 12584440]). See also
            TAS2R10 (MIM 604791).[supplied by OMIM, Mar 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC112100.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000506868.1/ ENSP00000424040.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1000
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.2"
     gene            1..1000
                     /gene="TAS2R50"
                     /gene_synonym="T2R50; T2R51; TAS2R51"
                     /note="taste 2 receptor member 50"
                     /db_xref="GeneID:259296"
                     /db_xref="HGNC:HGNC:18882"
                     /db_xref="MIM:609627"
     exon            1..1000
                     /gene="TAS2R50"
                     /gene_synonym="T2R50; T2R51; TAS2R51"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..952
                     /gene="TAS2R50"
                     /gene_synonym="T2R50; T2R51; TAS2R51"
                     /note="taste receptor type 2 member 51; taste receptor,
                     type 2, member 50"
                     /codon_start=1
                     /product="taste receptor type 2 member 50"
                     /protein_id="NP_795371.2"
                     /db_xref="CCDS:CCDS8638.1"
                     /db_xref="GeneID:259296"
                     /db_xref="HGNC:HGNC:18882"
                     /db_xref="MIM:609627"
                     /translation="MITFLYIFFSILIMVLFVLGNFANGFIALVNFIDWVKRKKISSA
                     DQILTALAVSRIGLLWALLLNWYLTVLNPAFYSVELRITSYNAWVVTNHFSMWLAANL
                     SIFYLLKIANFSNLLFLHLKRRVRSVILVILLGTLIFLVCHLLVANMDESMWAEEYEG
                     NMTGKMKLRNTVHLSYLTVTTLWSFIPFTLSLISFLMLICSLCKHLKKMQLHGEGSQD
                     LSTKVHIKALQTLISFLLLCAIFFLFLIVSVWSPRRLRNDPVVMVSKAVGNIYLAFDS
                     FILIWRTKKLKHTFLLILCQIRC"
ORIGIN      
        1 tcacaaccag tgatattagg cttgcatttt ctttcttttt ttctgctcag atatgataac
       61 ttttctatac attttttttt caattctaat aatggtttta tttgttctcg gaaactttgc
      121 caatggcttc atagcactgg taaatttcat tgactgggtg aagagaaaaa agatctcctc
      181 agctgaccaa attctcactg ctctggcggt ctccagaatt ggtttgctct gggcattatt
      241 attaaattgg tatttaactg tgttgaatcc agctttttat agtgtagaat taagaattac
      301 ttcttataat gcctgggttg taaccaacca tttcagcatg tggcttgctg ctaacctcag
      361 catattttat ttgctcaaga ttgccaattt ctccaacctt ctttttcttc atttaaagag
      421 gagagttagg agtgtcattc tggtgatact gttggggact ttgatatttt tggtttgtca
      481 tcttcttgtg gcaaacatgg atgagagtat gtgggcagaa gaatatgaag gaaacatgac
      541 tgggaagatg aaattgagga atacagtaca tctttcatat ttgactgtaa ctaccctatg
      601 gagcttcata ccctttactc tgtccctgat atcttttctg atgctaatct gttctctgtg
      661 taaacatctc aagaagatgc agctccatgg agaaggatcg caagatctca gcaccaaggt
      721 ccacataaaa gctttgcaaa ctctgatctc cttcctcttg ttatgtgcca ttttctttct
      781 attcctaatc gtttcggttt ggagtcctag gaggctgcgg aatgacccgg ttgtcatggt
      841 tagcaaggct gttggaaaca tatatcttgc attcgactca ttcatcctaa tttggagaac
      901 caagaagcta aaacacacct ttcttttgat tttgtgtcag attaggtgct gagtaaaaga
      961 cctgaaactc tcaactctct agattcacaa gtgggacatt
//
