LOCUS       NM_018980               1151 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens taste 2 receptor member 5 (TAS2R5), mRNA.
ACCESSION   NM_018980
VERSION     NM_018980.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1151)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1151)
  AUTHORS   Mikolajczyk-Stecyna,J., Malinowska,A.M. and Chmurzynska,A.
  TITLE     Polymorphism of TAS2R3, TAS2R5, TAS2R19, and TAS2R50 genes and
            bitter food intake frequency inelderly woman
  JOURNAL   Acta Sci Pol Technol Aliment 19 (1), 109-122 (2020)
   PUBMED   32227702
  REMARK    GeneRIF: Polymorphism of TAS2R3, TAS2R5, TAS2R19, and TAS2R50 genes
            and bitter food intake frequency inelderly woman.
REFERENCE   3  (bases 1 to 1151)
  AUTHORS   Wade,T.D., Gordon,S., Medland,S., Bulik,C.M., Heath,A.C.,
            Montgomery,G.W. and Martin,N.G.
  TITLE     Genetic variants associated with disordered eating
  JOURNAL   Int J Eat Disord 46 (6), 594-608 (2013)
   PUBMED   23568457
REFERENCE   4  (bases 1 to 1151)
  AUTHORS   Meyerhof,W., Batram,C., Kuhn,C., Brockhoff,A., Chudoba,E., Bufe,B.,
            Appendino,G. and Behrens,M.
  TITLE     The molecular receptive ranges of human TAS2R bitter taste
            receptors
  JOURNAL   Chem Senses 35 (2), 157-170 (2010)
   PUBMED   20022913
REFERENCE   5  (bases 1 to 1151)
  AUTHORS   Chandrashekar,J., Hoon,M.A., Ryba,N.J. and Zuker,C.S.
  TITLE     The receptors and cells for mammalian taste
  JOURNAL   Nature 444 (7117), 288-294 (2006)
   PUBMED   17108952
  REMARK    Review article
REFERENCE   6  (bases 1 to 1151)
  AUTHORS   Matsunami,H., Montmayeur,J.P. and Buck,L.B.
  TITLE     A family of candidate taste receptors in human and mouse
  JOURNAL   Nature 404 (6778), 601-604 (2000)
   PUBMED   10766242
REFERENCE   7  (bases 1 to 1151)
  AUTHORS   Firestein,S.
  TITLE     The good taste of genomics
  JOURNAL   Nature 404 (6778), 552-553 (2000)
   PUBMED   10766221
REFERENCE   8  (bases 1 to 1151)
  AUTHORS   Chandrashekar,J., Mueller,K.L., Hoon,M.A., Adler,E., Feng,L.,
            Guo,W., Zuker,C.S. and Ryba,N.J.
  TITLE     T2Rs function as bitter taste receptors
  JOURNAL   Cell 100 (6), 703-711 (2000)
   PUBMED   10761935
REFERENCE   9  (bases 1 to 1151)
  AUTHORS   Adler,E., Hoon,M.A., Mueller,K.L., Chandrashekar,J., Ryba,N.J. and
            Zuker,C.S.
  TITLE     A novel family of mammalian taste receptors
  JOURNAL   Cell 100 (6), 693-702 (2000)
   PUBMED   10761934
REFERENCE   10 (bases 1 to 1151)
  AUTHORS   Kinnamon,S.C.
  TITLE     A plethora of taste receptors
  JOURNAL   Neuron 25 (3), 507-510 (2000)
   PUBMED   10774719
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC095522.1, AW881072.1 and
            AC004979.1.
            
            On May 17, 2019 this sequence version replaced NM_018980.2.
            
            Summary: This gene encodes a bitter taste receptor; bitter taste
            receptors are members of the G protein-coupled receptor superfamily
            and are specifically expressed by taste receptor cells of the
            tongue and palate epithelia. Each of these apparently intronless
            taste receptor genes encodes a 7-transmembrane receptor protein,
            functioning as a bitter taste receptor. This gene is clustered with
            another 3 candidate taste receptor genes on chromosome 7 and is
            genetically linked to loci that influence bitter perception.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC095522.1, SRR1660803.244645.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000247883.5/ ENSP00000247883.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1012              BC095522.1         1-1012
            1013-1150           AW881072.1         9-146               c
            1151-1151           AC004979.1         44784-44784
FEATURES             Location/Qualifiers
     source          1..1151
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q34"
     gene            1..1151
                     /gene="TAS2R5"
                     /gene_synonym="T2R5"
                     /note="taste 2 receptor member 5"
                     /db_xref="GeneID:54429"
                     /db_xref="HGNC:HGNC:14912"
                     /db_xref="MIM:605062"
     exon            1..1151
                     /gene="TAS2R5"
                     /gene_synonym="T2R5"
                     /inference="alignment:Splign:2.1.0"
     CDS             146..1045
                     /gene="TAS2R5"
                     /gene_synonym="T2R5"
                     /note="taste receptor, type 2, member 5"
                     /codon_start=1
                     /product="taste receptor type 2 member 5"
                     /protein_id="NP_061853.1"
                     /db_xref="CCDS:CCDS5869.1"
                     /db_xref="GeneID:54429"
                     /db_xref="HGNC:HGNC:14912"
                     /db_xref="MIM:605062"
                     /translation="MLSAGLGLLMLVAVVEFLIGLIGNGSLVVWSFREWIRKFNWSSY
                     NLIILGLAGCRFLLQWLIILDLSLFPLFQSSRWLRYLSIFWVLVSQASLWFATFLSVF
                     YCKKITTFDRPAYLWLKQRAYNLSLWCLLGYFIINLLLTVQIGLTFYHPPQGNSSIRY
                     PFESWQYLYAFQLNSGSYLPLVVFLVSSGMLIVSLYTHHKKMKVHSAGRRDVRAKAHI
                     TALKSLGCFLLLHLVYIMASPFSITSKTYPPDLTSVFIWETLMAAYPSLHSLILIMGI
                     PRVKQTCQKILWKTVCARRCWGP"
ORIGIN      
        1 cagctgttca gtctcgcttg aagacagatt acggaaggac gaggccaaat ccagattttg
       61 tggtgtgaaa atttaccctg gtgtgttatc actaccaggg gatctgacct cagccaggag
      121 cagtgagagc ctcctctccc cagccatgct gagcgctggc ctaggactgc tgatgctggt
      181 ggcagtggtt gaatttctca tcggtttaat tggaaatgga agcctggtgg tctggagttt
      241 tagagaatgg atcagaaaat tcaactggtc ctcatataac ctcattatcc tgggcctggc
      301 tggctgccga tttctcctgc agtggctgat cattttggac ttaagcttgt ttccactttt
      361 ccagagcagc cgttggcttc gctatcttag tatcttctgg gtcctggtaa gccaggccag
      421 cttatggttt gccaccttcc tcagtgtctt ctattgcaag aagatcacga ccttcgatcg
      481 cccggcctac ttgtggctga agcagagggc ctataacctg agtctctggt gccttctggg
      541 ctactttata atcaatttgt tacttacagt ccaaattggc ttaacattct atcatcctcc
      601 ccaaggaaac agcagcattc ggtatccctt tgaaagctgg cagtacctgt atgcatttca
      661 gctcaattca ggaagttatt tgcctttagt ggtgtttctt gtttcctctg ggatgctgat
      721 tgtctctttg tatacacacc acaagaagat gaaggtccat tcagctggta ggagggatgt
      781 ccgggccaag gctcacatca ctgcgctgaa gtccttgggc tgcttcctct tacttcacct
      841 ggtttatatc atggccagcc ccttctccat cacctccaag acttatcctc ctgatctcac
      901 cagtgtcttc atctgggaga cactcatggc agcctatcct tctcttcatt ctctcatatt
      961 gatcatgggg attcctaggg tgaagcagac ttgtcagaag atcctgtgga agacagtgtg
     1021 tgctcggaga tgctggggcc catgatctgg gaagaaaagt gtggtcagga cactcttggg
     1081 acgctctttt gatagctctc tataagggag ctgctttcca tgtcttttaa gattttcctt
     1141 cttttacacc a
//
