LOCUS       NM_176887                930 bp    mRNA    linear   PRI 12-AUG-2024
DEFINITION  Homo sapiens taste 2 receptor member 46 (TAS2R46), transcript
            variant 1, mRNA.
ACCESSION   NM_176887
VERSION     NM_176887.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 930)
  AUTHORS   Lecchi,G., Mocchetti,C., Tunesi,D., Berto,A., Balasubramanian,H.B.,
            Biswas,S., Bagchi,A., Pollastro,F., Fresu,L.G. and Talmon,M.
  TITLE     Single-Nucleotide Polymorphisms of TAS2R46 Affect the Receptor
            Downstream Calcium Regulation in Histamine-Challenged Cells
  JOURNAL   Cells 13 (14), 1204 (2024)
   PUBMED   39056786
  REMARK    GeneRIF: Single-Nucleotide Polymorphisms of TAS2R46 Affect the
            Receptor Downstream Calcium Regulation in Histamine-Challenged
            Cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 930)
  AUTHORS   Talmon,M., Camillo,L., Vietti,I., Pollastro,F. and Fresu,L.G.
  TITLE     Bitter Taste Receptor 46 (hTAS2R46) Protects Monocytes/Macrophages
            from Oxidative Stress
  JOURNAL   Int J Mol Sci 25 (13), 7325 (2024)
   PUBMED   39000432
  REMARK    GeneRIF: Bitter Taste Receptor 46 (hTAS2R46) Protects
            Monocytes/Macrophages from Oxidative Stress.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 930)
  AUTHORS   Xu,W., Wu,L., Liu,S., Liu,X., Cao,X., Zhou,C., Zhang,J., Fu,Y.,
            Guo,Y., Wu,Y., Tan,Q., Wang,L., Liu,J., Jiang,L., Fan,Z., Pei,Y.,
            Yu,J., Cheng,J., Zhao,S., Hao,X., Liu,Z.J. and Hua,T.
  TITLE     Structural basis for strychnine activation of human bitter taste
            receptor TAS2R46
  JOURNAL   Science 377 (6612), 1298-1304 (2022)
   PUBMED   36108005
  REMARK    GeneRIF: Structural basis for strychnine activation of human bitter
            taste receptor TAS2R46.
REFERENCE   4  (bases 1 to 930)
  AUTHORS   Talmon,M., Rossi,S., Lim,D., Pollastro,F., Palattella,G.,
            Ruffinatti,F.A., Marotta,P., Boldorini,R., Genazzani,A.A. and
            Fresu,L.G.
  TITLE     Absinthin, an agonist of the bitter taste receptor hTAS2R46,
            uncovers an ER-to-mitochondria Ca2+-shuttling event
  JOURNAL   J Biol Chem 294 (33), 12472-12482 (2019)
   PUBMED   31248983
  REMARK    GeneRIF: Absinthin, an agonist of the bitter taste receptor
            hTAS2R46, uncovers an ER-to-mitochondria Ca(2+)-shuttling event.
REFERENCE   5  (bases 1 to 930)
  AUTHORS   Ryu,C.S., Sakong,J.H., Ahn,E.H., Kim,J.O., Ko,D., Kim,J.H.,
            Lee,W.S. and Kim,N.K.
  TITLE     Association study of the three functional polymorphisms
            (TAS2R46G>A, OR4C16G>A, and OR4X1A>T) with recurrent pregnancy loss
  JOURNAL   Genes Genomics 41 (1), 61-70 (2019)
   PUBMED   30203366
  REMARK    GeneRIF: TAS2R46G>A rs2708381 is not associated with recurrent
            pregnancy loss in Korean women.
REFERENCE   6  (bases 1 to 930)
  AUTHORS   Zhang,Y., Hoon,M.A., Chandrashekar,J., Mueller,K.L., Cook,B.,
            Wu,D., Zuker,C.S. and Ryba,N.J.
  TITLE     Coding of sweet, bitter, and umami tastes: different receptor cells
            sharing similar signaling pathways
  JOURNAL   Cell 112 (3), 293-301 (2003)
   PUBMED   12581520
REFERENCE   7  (bases 1 to 930)
  AUTHORS   Bufe,B., Hofmann,T., Krautwurst,D., Raguse,J.D. and Meyerhof,W.
  TITLE     The human TAS2R16 receptor mediates bitter taste in response to
            beta-glucopyranosides
  JOURNAL   Nat Genet 32 (3), 397-401 (2002)
   PUBMED   12379855
REFERENCE   8  (bases 1 to 930)
  AUTHORS   Montmayeur,J.P. and Matsunami,H.
  TITLE     Receptors for bitter and sweet taste
  JOURNAL   Curr Opin Neurobiol 12 (4), 366-371 (2002)
   PUBMED   12139982
  REMARK    Review article
REFERENCE   9  (bases 1 to 930)
  AUTHORS   Margolskee,R.F.
  TITLE     Molecular mechanisms of bitter and sweet taste transduction
  JOURNAL   J Biol Chem 277 (1), 1-4 (2002)
   PUBMED   11696554
  REMARK    Review article
REFERENCE   10 (bases 1 to 930)
  AUTHORS   Conte,C., Ebeling,M., Marcuz,A., Nef,P. and Andres-Barquin,P.J.
  TITLE     Identification and characterization of human taste receptor genes
            belonging to the TAS2R family
  JOURNAL   Cytogenet Genome Res 98 (1), 45-53 (2002)
   PUBMED   12584440
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC018630.40.
            
            On Nov 3, 2006 this sequence version replaced NM_176887.1.
            
            Summary: TAS2R46 belongs to the large TAS2R receptor family. TAS2Rs
            are expressed on the surface of taste receptor cells and mediate
            the perception of bitterness through a G protein-coupled second
            messenger pathway (Conte et al., 2002 [PubMed 12584440]). For
            further information on TAS2Rs, see MIM 604791.[supplied by OMIM,
            Sep 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000533467.1/ ENSP00000436450.1
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-930               AC018630.40        78394-79323
FEATURES             Location/Qualifiers
     source          1..930
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.2"
     gene            1..930
                     /gene="TAS2R46"
                     /gene_synonym="T2R46; T2R54"
                     /note="taste 2 receptor member 46"
                     /db_xref="GeneID:259292"
                     /db_xref="HGNC:HGNC:18877"
                     /db_xref="MIM:612774"
     CDS             1..930
                     /gene="TAS2R46"
                     /gene_synonym="T2R46; T2R54"
                     /note="isoform 1 is encoded by transcript variant 1; taste
                     receptor type 2 member 54; taste receptor, type 2, member
                     46"
                     /codon_start=1
                     /product="taste receptor type 2 member 46 isoform 1"
                     /protein_id="NP_795368.2"
                     /db_xref="CCDS:CCDS53748.1"
                     /db_xref="GeneID:259292"
                     /db_xref="HGNC:HGNC:18877"
                     /db_xref="MIM:612774"
                     /translation="MITFLPIIFSILIVVTFVIGNFANGFIALVNSIEWFKRQKISFA
                     DQILTALAVSRVGLLWVLVLNWYATELNPAFNSIEVRITAYNVWAVINHFSNWLATSL
                     SIFYLLKIANFSNLIFLHLKRRVKSVVLVILLGPLLFLVCHLFVINMNQIIWTKEYEG
                     NMTWKIKLRSAMYLSNTTVTILANLVPFTLTLISFLLLICSLCKHLKKMQLHGKGSQD
                     PSMKVHIKALQTVTSFLLLCAIYFLSIIMSVWSFESLENKPVFMFCEAIAFSYPSTHP
                     FILIWGNKKLKQTFLSVLWHVRYWVKGEKPSSS"
     exon            1..930
                     /gene="TAS2R46"
                     /gene_synonym="T2R46; T2R54"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgataactt ttctgcccat cattttttcc attctaatag tggttacatt tgtgattgga
       61 aattttgcta atggcttcat agcattggta aattccattg agtggttcaa gagacaaaag
      121 atctcttttg ctgaccaaat tctcactgct ctggcagtct ccagagttgg tttactctgg
      181 gtattagtat taaattggta tgcaactgag ttgaatccag cttttaacag tatagaagta
      241 agaattactg cttacaatgt ctgggcagta atcaaccatt tcagcaactg gcttgctact
      301 agcctcagca tattttattt gctcaagatt gccaatttct ccaaccttat ttttcttcac
      361 ttaaagagga gagttaagag tgttgttctg gtgatactat tggggccttt gctatttttg
      421 gtttgtcatc tttttgtgat aaacatgaat cagattatat ggacaaaaga atatgaagga
      481 aacatgactt ggaagatcaa actgaggagt gcaatgtacc tttcaaatac aacggtaacc
      541 atcctagcaa acttagttcc cttcactctg accctgatat cttttctgct gttaatctgt
      601 tctctgtgta aacatctcaa aaagatgcag ctccatggca aaggatctca agatcccagc
      661 atgaaggtcc acataaaagc tttgcaaact gtgacctcct tcctcttgtt atgtgccatt
      721 tactttctgt ccataatcat gtcagtttgg agttttgaga gtctggaaaa caaacctgtc
      781 ttcatgttct gcgaagctat tgcattcagc tatccttcaa cccacccatt catcctgatt
      841 tggggaaaca agaagctaaa gcagactttt ctttcagttt tgtggcatgt gaggtactgg
      901 gtgaaaggag agaagccttc atcttcatag
//
