LOCUS       NM_176884               1027 bp    mRNA    linear   PRI 02-JUN-2024
DEFINITION  Homo sapiens taste 2 receptor member 43 (TAS2R43), mRNA.
ACCESSION   NM_176884 XM_003846799 XM_005276417
VERSION     NM_176884.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1027)
  AUTHORS   Liszt,K.I., Wang,Q., Farhadipour,M., Segers,A., Thijs,T., Nys,L.,
            Deleus,E., Van der Schueren,B., Gerner,C., Neuditschko,B.,
            Ceulemans,L.J., Lannoo,M., Tack,J. and Depoortere,I.
  TITLE     Human intestinal bitter taste receptors regulate innate immune
            responses and metabolic regulators in obesity
  JOURNAL   J Clin Invest 132 (3) (2022)
   PUBMED   34784295
  REMARK    GeneRIF: Human intestinal bitter taste receptors regulate innate
            immune responses and metabolic regulators in obesity.
REFERENCE   2  (bases 1 to 1027)
  AUTHORS   Tiroch,J., Sterneder,S., Di Pizio,A., Lieder,B., Hoelz,K.,
            Holik,A.K., Pignitter,M., Behrens,M., Somoza,M., Ley,J.P. and
            Somoza,V.
  TITLE     Bitter Sensing TAS2R50 Mediates the trans-Resveratrol-Induced
            Anti-inflammatory Effect on Interleukin 6 Release in HGF-1 Cells in
            Culture
  JOURNAL   J Agric Food Chem 69 (45), 13339-13349 (2021)
   PUBMED   33461297
  REMARK    GeneRIF: Bitter Sensing TAS2R50 Mediates the
            trans-Resveratrol-Induced Anti-inflammatory Effect on Interleukin 6
            Release in HGF-1 Cells in Culture.
REFERENCE   3  (bases 1 to 1027)
  AUTHORS   Mennella,J.A., Roberts,K.M., Mathew,P.S. and Reed,D.R.
  TITLE     Children's perceptions about medicines: individual differences and
            taste
  JOURNAL   BMC Pediatr 15, 130 (2015)
   PUBMED   26391354
  REMARK    GeneRIF: those with at least one sensitive TAS2R38 allele (AP or PP
            genotype) were more likely to report rejecting liquid medications
            than were those without a taster allele (AA genotype
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1027)
  AUTHORS   Sandau,M.M., Goodman,J.R., Thomas,A., Rucker,J.B. and Rawson,N.E.
  TITLE     A functional comparison of the domestic cat bitter receptors
            Tas2r38 and Tas2r43 with their human orthologs
  JOURNAL   BMC Neurosci 16, 33 (2015)
   PUBMED   26037485
  REMARK    GeneRIF: Study demonstrates that the response profiles of the cat
            bitter receptors Tas2r38 and Tas2r43 are distinct from those of
            their orthologous human receptors
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1027)
  AUTHORS   Pirastu,N., Kooyman,M., Traglia,M., Robino,A., Willems,S.M.,
            Pistis,G., d'Adamo,P., Amin,N., d'Eustacchio,A., Navarini,L.,
            Sala,C., Karssen,L.C., van Duijn,C., Toniolo,D. and Gasparini,P.
  TITLE     Association analysis of bitter receptor genes in five isolated
            populations identifies a significant correlation between TAS2R43
            variants and coffee liking
  JOURNAL   PLoS One 9 (3), e92065 (2014)
   PUBMED   24647340
  REMARK    GeneRIF: The effect of the TAS2R43 gene on coffee liking is
            mediated by caffeine and in particular by the H212R variant.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1027)
  AUTHORS   Zhang,Y., Hoon,M.A., Chandrashekar,J., Mueller,K.L., Cook,B.,
            Wu,D., Zuker,C.S. and Ryba,N.J.
  TITLE     Coding of sweet, bitter, and umami tastes: different receptor cells
            sharing similar signaling pathways
  JOURNAL   Cell 112 (3), 293-301 (2003)
   PUBMED   12581520
REFERENCE   7  (bases 1 to 1027)
  AUTHORS   Bufe,B., Hofmann,T., Krautwurst,D., Raguse,J.D. and Meyerhof,W.
  TITLE     The human TAS2R16 receptor mediates bitter taste in response to
            beta-glucopyranosides
  JOURNAL   Nat Genet 32 (3), 397-401 (2002)
   PUBMED   12379855
REFERENCE   8  (bases 1 to 1027)
  AUTHORS   Montmayeur,J.P. and Matsunami,H.
  TITLE     Receptors for bitter and sweet taste
  JOURNAL   Curr Opin Neurobiol 12 (4), 366-371 (2002)
   PUBMED   12139982
  REMARK    Review article
REFERENCE   9  (bases 1 to 1027)
  AUTHORS   Margolskee,R.F.
  TITLE     Molecular mechanisms of bitter and sweet taste transduction
  JOURNAL   J Biol Chem 277 (1), 1-4 (2002)
   PUBMED   11696554
  REMARK    Review article
REFERENCE   10 (bases 1 to 1027)
  AUTHORS   Conte,C., Ebeling,M., Marcuz,A., Nef,P. and Andres-Barquin,P.J.
  TITLE     Identification and characterization of human taste receptor genes
            belonging to the TAS2R family
  JOURNAL   Cytogenet Genome Res 98 (1), 45-53 (2002)
   PUBMED   12584440
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC018630.40.
            
            On or before Aug 31, 2013 this sequence version replaced
            XM_005276417.1, XM_003846799.1, NM_176884.1.
            
            Summary: TAS2R43 belongs to the large TAS2R receptor family. TAS2Rs
            are expressed on the surface of taste receptor cells and mediate
            the perception of bitterness through a G protein-coupled second
            messenger pathway (Conte et al., 2002 [PubMed 12584440]). For
            further information on TAS2Rs, see MIM 604791.[supplied by OMIM,
            Mar 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC117423.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000531678.1/ ENSP00000431719.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1027              AC018630.40        48375-49401
FEATURES             Location/Qualifiers
     source          1..1027
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.2"
     gene            1..1027
                     /gene="TAS2R43"
                     /gene_synonym="T2R43; T2R52"
                     /note="taste 2 receptor member 43"
                     /db_xref="GeneID:259289"
                     /db_xref="HGNC:HGNC:18875"
                     /db_xref="MIM:612668"
     exon            1..1027
                     /gene="TAS2R43"
                     /gene_synonym="T2R43; T2R52"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..1014
                     /gene="TAS2R43"
                     /gene_synonym="T2R43; T2R52"
                     /note="taste receptor type 2 member 52; taste receptor,
                     type 2, member 43"
                     /codon_start=1
                     /product="taste receptor type 2 member 43"
                     /protein_id="NP_795365.2"
                     /db_xref="CCDS:CCDS53749.1"
                     /db_xref="GeneID:259289"
                     /db_xref="HGNC:HGNC:18875"
                     /db_xref="MIM:612668"
                     /translation="MITFLPIIFSSLVVVTFVIGNFANGFIALVNSIEWFKRQKISFA
                     DQILTALAVSRVGLLWVLLLNWYSTVLNPAFNSVEVRTTAYNIWAVINHFSNWLATTL
                     SIFYLLKIANFSNFIFLHLKRRVKSVILVMLLGPLLFLACHLFVINMNEIVRTKEFEG
                     NMTWKIKLKSAMYFSNMTVTMVANLVPFTLTLLSFMLLICSLCKHLKKMQLHGKGSQD
                     PSTKVHIKALQTVISFLLLCAIYFLSIMISVWSFGSLENKPVFMFCKAIRFSYPSIHP
                     FILIWGNKKLKQTFLSVFWQMRYWVKGEKTSSP"
ORIGIN      
        1 tcagcgagac cacgaaccca cctgcaggaa ccaattccgg acacaacacc agcatttaaa
       61 aaaatttttt ttgtctgttc agacatgata acttttctac ccatcatttt ttccagtctg
      121 gtagtggtta catttgttat tggaaatttt gctaatggct tcatagcact ggtaaattcc
      181 attgagtggt tcaagagaca aaagatctcc tttgctgacc aaattctcac tgctctggcg
      241 gtctccagag ttggtttgct ctgggtatta ttattaaact ggtattcaac tgtgttgaat
      301 ccagctttta atagtgtaga agtaagaact actgcttata atatctgggc agtgatcaac
      361 catttcagca actggcttgc tactaccctc agcatatttt atttgctcaa gattgccaat
      421 ttctccaact ttatttttct tcacttaaag aggagagtta agagtgtcat tctggtgatg
      481 ttgttggggc ctttgctatt tttggcttgt catctttttg tgataaacat gaatgagatt
      541 gtgcggacaa aagaatttga aggaaacatg acttggaaga tcaaattgaa gagtgcaatg
      601 tacttttcaa atatgactgt aaccatggta gcaaacttag tacccttcac tctgacccta
      661 ctatctttta tgctgttaat ctgttctttg tgtaaacatc tcaagaagat gcagctccat
      721 ggtaaaggat ctcaagatcc cagcaccaag gtccacataa aagctttgca aactgtgatc
      781 tccttcctct tgttatgtgc catttacttt ctgtccataa tgatatcagt ttggagtttt
      841 ggaagtctgg aaaacaaacc tgtcttcatg ttctgcaaag ctattagatt cagctatcct
      901 tcaatccacc cattcatcct gatttgggga aacaagaagc taaagcagac ttttctttca
      961 gttttttggc aaatgaggta ctgggtgaaa ggagagaaga cttcatctcc atagattcac
     1021 gagaggg
//
