LOCUS       NM_181429                945 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens taste 2 receptor member 42 (TAS2R42), mRNA.
ACCESSION   NM_181429
VERSION     NM_181429.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 945)
  AUTHORS   Thalmann,S., Behrens,M. and Meyerhof,W.
  TITLE     Major haplotypes of the human bitter taste receptor TAS2R41 encode
            functional receptors for chloramphenicol
  JOURNAL   Biochem Biophys Res Commun 435 (2), 267-273 (2013)
   PUBMED   23632330
  REMARK    GeneRIF: Further studies revealed that TAS2R41 is a 'specialist'
            receptor highly selective for this antibiotic.
REFERENCE   2  (bases 1 to 945)
  AUTHORS   Hirai,R., Takao,K., Onoda,K., Kokubun,S. and Ikeda,M.
  TITLE     Patients with phantogeusia show increased expression of T2R taste
            receptor genes in their tongues
  JOURNAL   Ann Otol Rhinol Laryngol 121 (2), 113-118 (2012)
   PUBMED   22397221
  REMARK    GeneRIF: Our results show that the expression rate of some of the
            T2R taste receptor genes was increased significantly in patients
            with phantogeusia.
REFERENCE   3  (bases 1 to 945)
  AUTHORS   Meyerhof,W., Batram,C., Kuhn,C., Brockhoff,A., Chudoba,E., Bufe,B.,
            Appendino,G. and Behrens,M.
  TITLE     The molecular receptive ranges of human TAS2R bitter taste
            receptors
  JOURNAL   Chem Senses 35 (2), 157-170 (2010)
   PUBMED   20022913
REFERENCE   4  (bases 1 to 945)
  AUTHORS   Go,Y., Satta,Y., Takenaka,O. and Takahata,N.
  TITLE     Lineage-specific loss of function of bitter taste receptor genes in
            humans and nonhuman primates
  JOURNAL   Genetics 170 (1), 313-326 (2005)
   PUBMED   15744053
REFERENCE   5  (bases 1 to 945)
  AUTHORS   Fischer,A., Gilad,Y., Man,O. and Paabo,S.
  TITLE     Evolution of bitter taste receptors in humans and apes
  JOURNAL   Mol Biol Evol 22 (3), 432-436 (2005)
   PUBMED   15496549
  REMARK    Erratum:[Mol Biol Evol. 2005 Apr;22(4):1157]
REFERENCE   6  (bases 1 to 945)
  AUTHORS   Shi,P., Zhang,J., Yang,H. and Zhang,Y.P.
  TITLE     Adaptive diversification of bitter taste receptor genes in
            Mammalian evolution
  JOURNAL   Mol Biol Evol 20 (5), 805-814 (2003)
   PUBMED   12679530
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC244131.2.
            
            On Apr 15, 2014 this sequence version replaced NM_181429.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC131742.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000334266.1/ ENSP00000334050.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-945               AC244131.2         150029-150973
FEATURES             Location/Qualifiers
     source          1..945
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.2"
     gene            1..945
                     /gene="TAS2R42"
                     /gene_synonym="T2R24; T2R42; T2R55; TAS2R55"
                     /note="taste 2 receptor member 42"
                     /db_xref="GeneID:353164"
                     /db_xref="HGNC:HGNC:18888"
                     /db_xref="MIM:613966"
     CDS             1..945
                     /gene="TAS2R42"
                     /gene_synonym="T2R24; T2R42; T2R55; TAS2R55"
                     /note="candidate taste receptor hT2R55; taste receptor
                     type 2 member 55; taste receptor, type 2, member 42"
                     /codon_start=1
                     /product="taste receptor type 2 member 42"
                     /protein_id="NP_852094.2"
                     /db_xref="CCDS:CCDS31747.1"
                     /db_xref="GeneID:353164"
                     /db_xref="HGNC:HGNC:18888"
                     /db_xref="MIM:613966"
                     /translation="MATELDKIFLILAIAEFIISMLGNVFIGLVNCSEGIKNQKVFSA
                     DFILTCLAISTIGQLLVILFDSFLVGLASHLYTTYRLGKTVIMLWHMTNHLTTWLATC
                     LSIFYFFKIAHFPHSLFLWLRWRMNGMIVMLLILSLFLLIFDSLVLEIFIDISLNIID
                     KSNLTLYLDESKTLYDKLSILKTLLSLTSFIPFSLFLTSLLFLFLSLVRHTRNLKLSS
                     LGSRDSSTEAHRRAMKMVMSFLFLFIVHFFSLQVANWIFFMLWNNKCIKFVMLALNAF
                     PSCHSFILILGNSKLQQTAVRLLWHLRNYTKTPNPLPL"
     exon            1..945
                     /gene="TAS2R42"
                     /gene_synonym="T2R24; T2R42; T2R55; TAS2R55"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggccaccg aattggacaa aatctttctg attctggcaa tagcagaatt catcatcagc
       61 atgctgggga atgtgttcat tggactggta aactgctctg aagggatcaa gaaccaaaag
      121 gtcttctcag ctgacttcat cctcacctgc ttggctatct ccacaattgg acaactgttg
      181 gtgatactgt ttgattcatt tctagtggga cttgcttcac atttatatac cacatataga
      241 ctaggaaaaa ctgttattat gctttggcac atgactaatc acttgacaac ctggcttgcc
      301 acctgcctaa gcattttcta tttctttaag atagcccact tcccccactc ccttttcctc
      361 tggctgaggt ggaggatgaa cggaatgatt gttatgcttc ttatattgtc tttgttctta
      421 ctgatttttg acagtttagt gctagaaata tttattgata tctcactcaa tataatagat
      481 aaaagtaatc tgactttata tttagatgaa agtaaaactc tctatgataa actctctatt
      541 ttaaaaactc ttctcagctt gaccagtttt atcccctttt ctctgttcct gacctccttg
      601 ctttttttat ttctgtcctt ggtgagacat actagaaatt tgaagctcag ttccttgggc
      661 tctagagact ccagcacaga ggcccatagg agggccatga aaatggtgat gtctttcctt
      721 ttcctcttca tagttcattt tttttcctta caagtggcca attggatatt ttttatgttg
      781 tggaacaaca agtgcataaa gtttgtcatg ttagccttaa atgcctttcc ctcgtgccac
      841 tcatttattc tcattctggg aaacagcaag ctgcaacaga cagctgtgag gctactgtgg
      901 catcttagga actatacaaa aacaccaaac cctttacctt tgtag
//
