LOCUS       NM_176883                924 bp    mRNA    linear   PRI 02-JUN-2024
DEFINITION  Homo sapiens taste 2 receptor member 41 (TAS2R41), mRNA.
ACCESSION   NM_176883
VERSION     NM_176883.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 924)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 924)
  AUTHORS   Thalmann,S., Behrens,M. and Meyerhof,W.
  TITLE     Major haplotypes of the human bitter taste receptor TAS2R41 encode
            functional receptors for chloramphenicol
  JOURNAL   Biochem Biophys Res Commun 435 (2), 267-273 (2013)
   PUBMED   23632330
REFERENCE   3  (bases 1 to 924)
  AUTHORS   Meyerhof,W., Batram,C., Kuhn,C., Brockhoff,A., Chudoba,E., Bufe,B.,
            Appendino,G. and Behrens,M.
  TITLE     The molecular receptive ranges of human TAS2R bitter taste
            receptors
  JOURNAL   Chem Senses 35 (2), 157-170 (2010)
   PUBMED   20022913
REFERENCE   4  (bases 1 to 924)
  AUTHORS   Go,Y., Satta,Y., Takenaka,O. and Takahata,N.
  TITLE     Lineage-specific loss of function of bitter taste receptor genes in
            humans and nonhuman primates
  JOURNAL   Genetics 170 (1), 313-326 (2005)
   PUBMED   15744053
REFERENCE   5  (bases 1 to 924)
  AUTHORS   Fischer,A., Gilad,Y., Man,O. and Paabo,S.
  TITLE     Evolution of bitter taste receptors in humans and apes
  JOURNAL   Mol Biol Evol 22 (3), 432-436 (2005)
   PUBMED   15496549
  REMARK    Erratum:[Mol Biol Evol. 2005 Apr;22(4):1157]
REFERENCE   6  (bases 1 to 924)
  AUTHORS   Zhang,Y., Hoon,M.A., Chandrashekar,J., Mueller,K.L., Cook,B.,
            Wu,D., Zuker,C.S. and Ryba,N.J.
  TITLE     Coding of sweet, bitter, and umami tastes: different receptor cells
            sharing similar signaling pathways
  JOURNAL   Cell 112 (3), 293-301 (2003)
   PUBMED   12581520
REFERENCE   7  (bases 1 to 924)
  AUTHORS   Bufe,B., Hofmann,T., Krautwurst,D., Raguse,J.D. and Meyerhof,W.
  TITLE     The human TAS2R16 receptor mediates bitter taste in response to
            beta-glucopyranosides
  JOURNAL   Nat Genet 32 (3), 397-401 (2002)
   PUBMED   12379855
REFERENCE   8  (bases 1 to 924)
  AUTHORS   Montmayeur,J.P. and Matsunami,H.
  TITLE     Receptors for bitter and sweet taste
  JOURNAL   Curr Opin Neurobiol 12 (4), 366-371 (2002)
   PUBMED   12139982
  REMARK    Review article
REFERENCE   9  (bases 1 to 924)
  AUTHORS   Margolskee,R.F.
  TITLE     Molecular mechanisms of bitter and sweet taste transduction
  JOURNAL   J Biol Chem 277 (1), 1-4 (2002)
   PUBMED   11696554
  REMARK    Review article
REFERENCE   10 (bases 1 to 924)
  AUTHORS   Conte,C., Ebeling,M., Marcuz,A., Nef,P. and Andres-Barquin,P.J.
  TITLE     Identification and characterization of human taste receptor genes
            belonging to the TAS2R family
  JOURNAL   Cytogenet Genome Res 98 (1), 45-53 (2002)
   PUBMED   12584440
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY114093.1.
            
            On Oct 19, 2006 this sequence version replaced NM_176883.1.
            
            Summary: This gene encodes a member of the bitter taste receptor
            family which belong to the G protein-coupled receptor superfamily
            and are predominantly expressed in taste receptor cells of the
            tongue and palate epithelia. This intronless taste receptor gene
            encodes a seven-transmembrane receptor protein, functioning as a
            bitter taste receptor. This gene is clustered together with eight
            other taste receptor genes on chromosome 7. Chloramphenicol is an
            agonist for the encoded protein. [provided by RefSeq, Jul 2017].
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC101157.3 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000408916.1/ ENSP00000386201.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..924
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q35"
     gene            1..924
                     /gene="TAS2R41"
                     /gene_synonym="T2R41; T2R59"
                     /note="taste 2 receptor member 41"
                     /db_xref="GeneID:259287"
                     /db_xref="HGNC:HGNC:18883"
                     /db_xref="MIM:613965"
     CDS             1..924
                     /gene="TAS2R41"
                     /gene_synonym="T2R41; T2R59"
                     /note="taste receptor type 2 member 59; taste receptor,
                     type 2, member 41"
                     /codon_start=1
                     /product="taste receptor type 2 member 41"
                     /protein_id="NP_795364.2"
                     /db_xref="CCDS:CCDS43663.1"
                     /db_xref="GeneID:259287"
                     /db_xref="HGNC:HGNC:18883"
                     /db_xref="MIM:613965"
                     /translation="MQAALTAFFVLLFSLLSLLGIAANGFIVLVLGREWLRYGRLLPL
                     DMILISLGASRFCLQLVGTVHNFYYSAQKVEYSGGLGRQFFHLHWHFLNSATFWFCSW
                     LSVLFCVKIANITHSTFLWLKWRFPGWVPWLLLGSVLISFIITLLFFWVNYPVYQEFL
                     IRKFSGNMTYKWNTRIETYYFPSLKLVIWSIPFSVFLVSIMLLINSLRRHTQRMQHNG
                     HSLQDPSTQAHTRALKSLISFLILYALSFLSLIIDAAKFISMQNDFYWPWQIAVYLCI
                     SVHPFILIFSNLKLRSVFSQLLLLARGFWVA"
     exon            1..924
                     /gene="TAS2R41"
                     /gene_synonym="T2R41; T2R59"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgcaagcag cactgacggc cttcttcgtg ttgctcttta gcctgctgag tcttctgggg
       61 attgcagcga atggcttcat tgtgctggtg ctgggcaggg agtggctgcg atatggcagg
      121 ttgctgccct tggatatgat cctcattagc ttgggtgcct cccgcttctg cctgcagttg
      181 gttgggacgg tgcacaactt ctactactct gcccagaagg tcgagtactc tgggggtctc
      241 ggccgacagt tcttccatct acactggcac ttcctgaact cagccacctt ctggttttgc
      301 agctggctca gtgtcctgtt ctgtgtgaag attgctaaca tcacacactc caccttcctg
      361 tggctgaagt ggaggttccc agggtgggtg ccctggctcc tgttgggctc tgtcctgatc
      421 tccttcatca taaccctgct gtttttttgg gtgaactacc ctgtatatca agaattttta
      481 attagaaaat tttctgggaa catgacctac aagtggaata caaggataga aacatactat
      541 ttcccatccc tgaaactggt catctggtca attccttttt ctgtttttct ggtctcaatt
      601 atgctgttaa ttaattctct gaggaggcat actcagagaa tgcagcacaa cgggcacagc
      661 ctgcaggacc ccagcaccca ggctcacacc agagctctga agtccctcat ctccttcctc
      721 attctttatg ctctgtcctt tctgtccctg atcattgatg ccgcaaaatt tatctccatg
      781 cagaacgact tttactggcc atggcaaatt gcagtctacc tgtgcatatc tgtccatccc
      841 ttcatcctca tcttcagcaa cctcaagctt cgaagcgtgt tctcgcagct cctgttgttg
      901 gcaaggggct tctgggtggc ctag
//
