LOCUS       NM_016944               5018 bp    mRNA    linear   PRI 09-JUL-2024
DEFINITION  Homo sapiens taste 2 receptor member 4 (TAS2R4), mRNA.
ACCESSION   NM_016944
VERSION     NM_016944.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5018)
  AUTHORS   Nolden,A.A., Behrens,M., McGeary,J.E., Meyerhof,W. and Hayes,J.E.
  TITLE     Differential Activation of TAS2R4 May Recover Ability to Taste
            Propylthiouracil for Some TAS2R38 AVI Homozygotes
  JOURNAL   Nutrients 16 (9), 1357 (2024)
   PUBMED   38732607
  REMARK    GeneRIF: Differential Activation of TAS2R4 May Recover Ability to
            Taste Propylthiouracil for Some TAS2R38 AVI Homozygotes.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5018)
  AUTHORS   Turner,A., Veysey,M., Keely,S., Scarlett,C.J., Lucock,M. and
            Beckett,E.L.
  TITLE     Genetic Variation in the Bitter Receptors Responsible for
            Epicatechin Detection Are Associated with BMI in an Elderly Cohort
  JOURNAL   Nutrients 13 (2), 571 (2021)
   PUBMED   33572225
  REMARK    GeneRIF: Genetic Variation in the Bitter Receptors Responsible for
            Epicatechin Detection Are Associated with BMI in an Elderly Cohort.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5018)
  AUTHORS   Zhu,H., Liu,L., Ren,L., Chen,J., Peng,L., Shi,C., Wang,X., Hu,S.,
            Zhang,C., Gu,M. and Li,X.
  TITLE     Bitter receptor member TAS2R4 may have neurobiological function
            beyond acting as a bitter receptor
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 52 (4), 460-462 (2020)
   PUBMED   32159211
  REMARK    GeneRIF: Bitter receptor member TAS2R4 may have neurobiological
            function beyond acting as a bitter receptor.
REFERENCE   4  (bases 1 to 5018)
  AUTHORS   Singh,N., Shaik,F.A., Myal,Y. and Chelikani,P.
  TITLE     Chemosensory bitter taste receptors T2R4 and T2R14 activation
            attenuates proliferation and migration of breast cancer cells
  JOURNAL   Mol Cell Biochem 465 (1-2), 199-214 (2020)
   PUBMED   31894529
  REMARK    GeneRIF: Chemosensory bitter taste receptors T2R4 and T2R14
            activation attenuates proliferation and migration of breast cancer
            cells.
REFERENCE   5  (bases 1 to 5018)
  AUTHORS   Choi,J.H., Lee,J., Yang,S., Lee,E.K., Hwangbo,Y. and Kim,J.
  TITLE     Genetic variations in TAS2R3 and TAS2R4 bitterness receptors modify
            papillary carcinoma risk and thyroid function in Korean females
  JOURNAL   Sci Rep 8 (1), 15004 (2018)
   PUBMED   30301923
  REMARK    GeneRIF: In summary, genetic variations in T2R3/4 bitterness
            receptors may modify the papillary thyroid carcinoma (PTC) risk,
            and the genetically modified thyroid hormone level by those
            variations may be linked with the PTC-T2Rs association
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5018)
  AUTHORS   Matsunami,H., Montmayeur,J.P. and Buck,L.B.
  TITLE     A family of candidate taste receptors in human and mouse
  JOURNAL   Nature 404 (6778), 601-604 (2000)
   PUBMED   10766242
REFERENCE   7  (bases 1 to 5018)
  AUTHORS   Firestein,S.
  TITLE     The good taste of genomics
  JOURNAL   Nature 404 (6778), 552-553 (2000)
   PUBMED   10766221
REFERENCE   8  (bases 1 to 5018)
  AUTHORS   Chandrashekar,J., Mueller,K.L., Hoon,M.A., Adler,E., Feng,L.,
            Guo,W., Zuker,C.S. and Ryba,N.J.
  TITLE     T2Rs function as bitter taste receptors
  JOURNAL   Cell 100 (6), 703-711 (2000)
   PUBMED   10761935
REFERENCE   9  (bases 1 to 5018)
  AUTHORS   Adler,E., Hoon,M.A., Mueller,K.L., Chandrashekar,J., Ryba,N.J. and
            Zuker,C.S.
  TITLE     A novel family of mammalian taste receptors
  JOURNAL   Cell 100 (6), 693-702 (2000)
   PUBMED   10761934
REFERENCE   10 (bases 1 to 5018)
  AUTHORS   Kinnamon,S.C.
  TITLE     A plethora of taste receptors
  JOURNAL   Neuron 25 (3), 507-510 (2000)
   PUBMED   10774719
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC004979.1.
            
            On Nov 22, 2019 this sequence version replaced NM_016944.1.
            
            Summary: This gene encodes a member of a family of candidate taste
            receptors that are members of the G protein-coupled receptor
            superfamily and that are specifically expressed by taste receptor
            cells of the tongue and palate epithelia. These apparently
            intronless genes encode a 7-transmembrane receptor protein,
            functioning as a bitter taste receptor. This gene is clustered with
            another 3 candidate taste receptor genes in chromosome 7 and is
            genetically linked to loci that influence bitter perception.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR1803615.226850.1,
                                        SRR1660805.122680.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000247881.4/ ENSP00000247881.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5018              AC004979.1         30091-35108
FEATURES             Location/Qualifiers
     source          1..5018
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q34"
     gene            1..5018
                     /gene="TAS2R4"
                     /gene_synonym="T2R4"
                     /note="taste 2 receptor member 4"
                     /db_xref="GeneID:50832"
                     /db_xref="HGNC:HGNC:14911"
                     /db_xref="MIM:604869"
     exon            1..5018
                     /gene="TAS2R4"
                     /gene_synonym="T2R4"
                     /inference="alignment:Splign:2.1.0"
     CDS             1816..2715
                     /gene="TAS2R4"
                     /gene_synonym="T2R4"
                     /note="candidate taste receptor T2R4; taste receptor, type
                     2, member 4"
                     /codon_start=1
                     /product="taste receptor type 2 member 4"
                     /protein_id="NP_058640.1"
                     /db_xref="CCDS:CCDS5868.1"
                     /db_xref="GeneID:50832"
                     /db_xref="HGNC:HGNC:14911"
                     /db_xref="MIM:604869"
                     /translation="MLRLFYFSAIIASVILNFVGIIMNLFITVVNCKTWVKSHRISSS
                     DRILFSLGITRFLMLGLFLVNTIYFVSSNTERSVYLSAFFVLCFMFLDSSSVWFVTLL
                     NILYCVKITNFQHSVFLLLKRNISPKIPRLLLACVLISAFTTCLYITLSQASPFPELV
                     TTRNNTSFNISEGILSLVVSLVLSSSLQFIINVTSASLLIHSLRRHIQKMQKNATGFW
                     NPQTEAHVGAMKLMVYFLILYIPYSVATLVQYLPFYAGMDMGTKSICLIFATLYSPGH
                     SVLIIITHPKLKTTAKKILCFKK"
     polyA_site      3221
                     /gene="TAS2R4"
                     /gene_synonym="T2R4"
                     /note="major polyA site"
     regulatory      4120..4125
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TAS2R4"
                     /gene_synonym="T2R4"
                     /note="hexamer: AATAAA"
     polyA_site      4145
                     /gene="TAS2R4"
                     /gene_synonym="T2R4"
                     /note="major polyA site"
     regulatory      4995..5000
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TAS2R4"
                     /gene_synonym="T2R4"
                     /note="hexamer: AATAAA"
     polyA_site      5018
                     /gene="TAS2R4"
                     /gene_synonym="T2R4"
                     /note="major polyA site"
ORIGIN      
        1 ctagaaacat agttgatgtt cttaccctta tcatataagg ataagattat ccttatcatc
       61 cttatcatca tgataaggaa aacagctagg aagtttaacc ataggtcaaa ttctcatgca
      121 tagggagaaa gggttctgct aacacttttc ctatactgac ccttgtggaa ataacttcta
      181 actgaatgag ctcattcatt gattgtgcta gccaacctta tcacatctta attatagcac
      241 ttcctcctac agagaaccca acaatttggt atagtacatt ctagatagag tttgttacta
      301 tctaattctg ggattcctgc tcttttggcc acatttatct gttatggctt actctatatc
      361 atttattcta tttaaatgtg atgttagtaa tatttcaact tcaccacttt aatgcagcca
      421 tctatggata agtaattgga aatctgtgct ataattttcc ttttagtcat agtcttcctg
      481 gctcattctg tttgcctgct tacctgatgt gggcatgcct ctatcagtgc ctgttagttt
      541 tgaataaaaa gcttctgtaa gcacctgggc accaggtcag agaatttctc caggctaggc
      601 ttcctgtcat ctgtcttaaa gggcctcatg aatgtattcc cctcttctgg acctgattat
      661 tattaaatct tagctccttt ttcttgtctg tttctatttg gacttggcag taggactttg
      721 tgctgtacct tgatgctact ttggtaacat ctgtggctgc atccaggatt gcaccttggt
      781 ttcattcagc tgctagagaa gataagagat gccatactct tacattcacc tatgggcctc
      841 cataatatca tttgccaggg atattttgcc atttcccatc tgagcaagta cagagaaatc
      901 cagcaatgag atgcctagct gtttggctca caaaactaca actaatgcat tactgtgtat
      961 ctcattccag ggtacctgga ttgacagtta aatgcctaag agaaaatagc cacatatgat
     1021 ctaaacataa acccagattt ataaaggaaa cacctacaag ggctgactta attttttcta
     1081 aggaaaacca gaacatagca aatggttatg gcacaaatct atgtatgtag atagagaagg
     1141 caaagcaaag ggcatcagaa agaatgggat taattgagaa aggttttctc aaggaggtat
     1201 tgggtctttg aacttgatct attagatcac tgtaaatcgc tataggtgaa tcactgaggt
     1261 tgaaagagtg gcattggcat ggccaattgg tgaaacttgt tgtggcagca acagattaga
     1321 ggggagagag aaattggatt ctggtcatcc atgaatatgt ggctaggagg tgggtgggta
     1381 ggagtgagga attaggattt ccaccatatt ctggcatttt tatgaagaaa aactttaccg
     1441 taaaacattg acagaaacat tgctggactc aagctctctg gtttggattc taagtttttg
     1501 gagcctgctg tgactcttcc ctctcgccct cctgctcttg gaggagtgga ctcccagcat
     1561 cacctaggct tgctgtaatt aggcatttct aaggagaaca ggatactaat gaagaaatag
     1621 taatgtaatc cttggaagat ttgcatctca gtaaaatcag gtggcccttg atcatgaatg
     1681 gctcatttgc catgctggga aaaattaaaa aggagatgtc cttcctggct ggatactggt
     1741 gtctgcttat acattttggt atttcttctg cctccactat cagcaccaca actgctgaat
     1801 cctcaatgag taaagatgct tcggttattc tatttctctg ctattattgc ctcagttatt
     1861 ttaaattttg taggaatcat tatgaatctg tttattacag tggtcaattg caaaacttgg
     1921 gtcaaaagcc atagaatctc ctcttctgat aggattctgt tcagcctggg catcaccagg
     1981 tttcttatgc tgggactatt tctggtgaac accatctact tcgtctcttc aaatacggaa
     2041 aggtcagtct acctgtctgc tttttttgtg ttgtgtttca tgtttttgga ctcgagcagt
     2101 gtctggtttg tgaccttgct caatatcttg tactgtgtga agattactaa cttccaacac
     2161 tcagtgtttc tcctgctgaa gcggaatatc tccccaaaga tccccaggct gctgctggcc
     2221 tgtgtgctga tttctgcttt caccacttgc ctgtacatca cgcttagcca ggcatcacct
     2281 tttcctgaac ttgtgactac gagaaataac acatcattta atatcagtga gggcatcttg
     2341 tctttagtgg tttctttggt cttgagctca tctctccagt tcatcattaa tgtgacttct
     2401 gcttccttgc taatacactc cttgaggaga catatacaga agatgcagaa aaatgccact
     2461 ggtttctgga atccccagac ggaagctcat gtaggtgcta tgaagctgat ggtctatttc
     2521 ctcatcctct acattccata ttcagttgct accctggtcc agtatctccc cttttatgca
     2581 gggatggata tggggaccaa atccatttgt ctgatttttg ccacccttta ctctccagga
     2641 cattctgttc tcattattat cacacatcct aaactgaaaa caacagcaaa gaagattctt
     2701 tgtttcaaaa aatagtggaa tttcagtaaa caatacctag atttacctga tggtttgggg
     2761 gcaagatttt ctgtttgcag ttttcccagt gatctgggga attcagtttt gtgattgctg
     2821 atctgacatc ataggctttt gagtgcctga atttcagttc attctgtaat tttttttttt
     2881 tggtatgtaa gtattttaaa ataaggcaca ttctgtaaga aacttttttg aggcattatt
     2941 tgtcatgtat tttgcatggc cattgaatcc atgtataatg gaaatcatca cattgtttca
     3001 ttgtctattg aagtataatg ggaaattctt ccaaattaga gaacacattg gggtgcacgt
     3061 gatgagttag atatttgtgg tttagctgag gagccctgag taagggctca gcagtggata
     3121 ggtggtcact gggagccact ggactgaccg aaagcagagg aagggggttc agtgcaaaga
     3181 gaaaaggaaa aaaggaaggt ttcagagaga aaagaaggaa agagaaaggt gaagagaaat
     3241 aggcgtacac tgggccaggc gcggtggctc atgcttgtaa tcccagctct ttgggaggcc
     3301 gaggcaggtg aatcgtgagg tcaggagatc gagaccatcc tggctaacac ggtgaaaccc
     3361 tgtctctact aaaaatacaa aaaaattagc tgggcgtggt ggcgggcacc tgtagtccca
     3421 gctactcggg aggctgaggc aggagaatgg cttcaaccca ggaggcggag cttgcagtga
     3481 gatgagatcg cgccactgca ctccagtctg ggcgacagag caagactctg tctcaaaaaa
     3541 agaaatagac gtacactctg ggacaagaca gaaaaagtat cctcacactt gctgggtaat
     3601 agtaactgtg ctattcctag caagaaaccc taaggtttct aggcttgttc tggaaaagag
     3661 gatattgcca gagttggtaa gtagaggaaa gtgattagta tttaagaaac tgaatcaaga
     3721 atggttccaa aaatcttaaa atccagggaa accagcttaa ggtcaaaggc aagtgctaga
     3781 taatgaaatt aacaccatat gagtacaaat ttacaaaata ctgtacttca ccataggcta
     3841 tggaactcag tggaaagcca aaaaagcact ggacaggtgg tgggagtgct tgacttgtgg
     3901 tgaatttatt tcatctgctt atacatttgt acacagcaca gttcttctcc agaatgttgt
     3961 ttctgtggct gggaccattg gactgtggct ccaaaagaac aacagtctga agatgggatg
     4021 ttgacaagtt ttggaatgtc aattggggaa tcataatttg tatttattta ggtttttttt
     4081 ggtgttcata aaatgcttat gtaatattta catatgtcaa ataaatctta aaattttata
     4141 aattacatga cttttctcat tctggccacc agaatcttga ctgcaatatt cagtaaaaat
     4201 tacccaagcc aatattttgt gctatgaaac ctggaggtat tcatcatgtt aaatcctaag
     4261 agagataaaa ggattactga gagtgattaa atgcatacta tgtcttaaga actctaaatg
     4321 agtggcagaa accctcattg gtccctcagt atctgttctt tctcctctct tccatagtaa
     4381 tcaaatcatt agctgttcag aattttggca gcaaattcca ttattgccat gtatgtgagc
     4441 agaaaagatg tatataattt ctgggtggta cttcggagca gtcctacctt cccttcttta
     4501 atcttttctt tgttactccc tccatgagct ggaatgctga catcatgatt gtctatcttg
     4561 gacaatgcag atgaggtgaa tgcttgggat agtgaagtaa ttctccatcc tagagctggc
     4621 tccatggttc ttcacactgt ggacttgtaa caccagctct ggactgctca agcctgaact
     4681 ccaggactgt tgatgagaaa tcagtgtctc cattctttca ggtgctggag ttttggtctc
     4741 tgttacctta gtcaaataac ctatgctata ccttaaatat acacaataat atatatcttt
     4801 atgatgaaat agtatgtatt taccatctta ttagtcaaag aaccttttta tatgacctac
     4861 taagtgaaat tgaaataaaa cctgtacatg tggtataata ccattttttt tggtaaaaat
     4921 gtgtacatat gaagaaaagt ctaaaaggaa atatataaaa atgtaaacag taattatttt
     4981 aggtgggagg aatcaataaa tttttttgtg tatttcaa
//
