LOCUS       NM_176881               1017 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens taste 2 receptor member 39 (TAS2R39), mRNA.
ACCESSION   NM_176881
VERSION     NM_176881.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1017)
  AUTHORS   Yamazaki,T., Sagisaka,M., Ikeda,R., Nakamura,T., Matsuda,N.,
            Ishii,T., Nakayama,T. and Watanabe,T.
  TITLE     The human bitter taste receptor hTAS2R39 is the primary receptor
            for the bitterness of theaflavins
  JOURNAL   Biosci Biotechnol Biochem 78 (10), 1753-1756 (2014)
   PUBMED   25273142
  REMARK    GeneRIF: hTAS2R39 is the primary receptor for the bitterness of
            theaflavins
REFERENCE   2  (bases 1 to 1017)
  AUTHORS   Roland,W.S., Vincken,J.P., Gouka,R.J., van Buren,L., Gruppen,H. and
            Smit,G.
  TITLE     Soy isoflavones and other isoflavonoids activate the human bitter
            taste receptors hTAS2R14 and hTAS2R39
  JOURNAL   J Agric Food Chem 59 (21), 11764-11771 (2011)
   PUBMED   21942422
  REMARK    GeneRIF: TAS2R14 and TAS2R39 were activated by isoflavones and
            other isoflavonoids.
REFERENCE   3  (bases 1 to 1017)
  AUTHORS   Narukawa,M., Noga,C., Ueno,Y., Sato,T., Misaka,T. and Watanabe,T.
  TITLE     Evaluation of the bitterness of green tea catechins by a cell-based
            assay with the human bitter taste receptor hTAS2R39
  JOURNAL   Biochem Biophys Res Commun 405 (4), 620-625 (2011)
   PUBMED   21272567
  REMARK    GeneRIF: these results suggest the participation of hTAS2R39 in the
            detection of catechins in humans.
REFERENCE   4  (bases 1 to 1017)
  AUTHORS   Ueno,Y., Sakurai,T., Okada,S., Abe,K. and Misaka,T.
  TITLE     Human bitter taste receptors hTAS2R8 and hTAS2R39 with differential
            functions to recognize bitter peptides
  JOURNAL   Biosci Biotechnol Biochem 75 (6), 1188-1190 (2011)
   PUBMED   21670512
  REMARK    GeneRIF: Human bitter taste receptors hTAS2R8 and hTAS2R39 display
            differential functions to recognize bitter peptides.
REFERENCE   5  (bases 1 to 1017)
  AUTHORS   Meyerhof,W., Batram,C., Kuhn,C., Brockhoff,A., Chudoba,E., Bufe,B.,
            Appendino,G. and Behrens,M.
  TITLE     The molecular receptive ranges of human TAS2R bitter taste
            receptors
  JOURNAL   Chem Senses 35 (2), 157-170 (2010)
   PUBMED   20022913
REFERENCE   6  (bases 1 to 1017)
  AUTHORS   Go,Y., Satta,Y., Takenaka,O. and Takahata,N.
  TITLE     Lineage-specific loss of function of bitter taste receptor genes in
            humans and nonhuman primates
  JOURNAL   Genetics 170 (1), 313-326 (2005)
   PUBMED   15744053
REFERENCE   7  (bases 1 to 1017)
  AUTHORS   Fischer,A., Gilad,Y., Man,O. and Paabo,S.
  TITLE     Evolution of bitter taste receptors in humans and apes
  JOURNAL   Mol Biol Evol 22 (3), 432-436 (2005)
   PUBMED   15496549
  REMARK    Erratum:[Mol Biol Evol. 2005 Apr;22(4):1157]
REFERENCE   8  (bases 1 to 1017)
  AUTHORS   Zhang,Y., Hoon,M.A., Chandrashekar,J., Mueller,K.L., Cook,B.,
            Wu,D., Zuker,C.S. and Ryba,N.J.
  TITLE     Coding of sweet, bitter, and umami tastes: different receptor cells
            sharing similar signaling pathways
  JOURNAL   Cell 112 (3), 293-301 (2003)
   PUBMED   12581520
REFERENCE   9  (bases 1 to 1017)
  AUTHORS   Montmayeur,J.P. and Matsunami,H.
  TITLE     Receptors for bitter and sweet taste
  JOURNAL   Curr Opin Neurobiol 12 (4), 366-371 (2002)
   PUBMED   12139982
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC073342.3.
            
            On Oct 31, 2006 this sequence version replaced NM_176881.1.
            
            Summary: The protein encoded by this gene is a bitter taste
            receptor that detects green tea catechins, soy isoflavones, and
            theaflavins. The encoded protein is gustducin-linked and may
            activate alpha gustducin. This gene is intronless. [provided by
            RefSeq, Dec 2015].
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC100947.2 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000446620.1/ ENSP00000405095.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1017              AC073342.3         101-1117
FEATURES             Location/Qualifiers
     source          1..1017
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q34"
     gene            1..1017
                     /gene="TAS2R39"
                     /gene_synonym="T2R39; T2R57"
                     /note="taste 2 receptor member 39"
                     /db_xref="GeneID:259285"
                     /db_xref="HGNC:HGNC:18886"
     CDS             1..1017
                     /gene="TAS2R39"
                     /gene_synonym="T2R39; T2R57"
                     /note="taste receptor type 2 member 57; taste receptor,
                     type 2, member 39"
                     /codon_start=1
                     /product="taste receptor type 2 member 39"
                     /protein_id="NP_795362.2"
                     /db_xref="CCDS:CCDS47729.1"
                     /db_xref="GeneID:259285"
                     /db_xref="HGNC:HGNC:18886"
                     /translation="MLGRCFPPDTKEKQQLRMTKLCDPAESELSPFLITLILAVLLAE
                     YLIGIIANGFIMAIHAAEWVQNKAVSTSGRILVFLSVSRIALQSLMMLEITISSTSLS
                     FYSEDAVYYAFKISFIFLNFCSLWFAAWLSFFYFVKIANFSYPLFLKLRWRITGLIPW
                     LLWLSVFISFSHSMFCINICTVYCNNSFPIHSSNSTKKTYLSEINVVGLAFFFNLGIV
                     TPLIMFILTATLLILSLKRHTLHMGSNATGSNDPSMEAHMGAIKAISYFLILYIFNAV
                     ALFIYLSNMFDINSLWNNLCQIIMAAYPASHSILLIQDNPGLRRAWKRLQLRLHLYPK
                     EWTL"
     exon            1..1017
                     /gene="TAS2R39"
                     /gene_synonym="T2R39; T2R57"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgctaggga gatgttttcc tccagacacc aaagagaagc aacagctcag aatgactaaa
       61 ctctgcgatc ctgcagaaag tgaattgtcg ccatttctca tcaccttaat tttagcagtt
      121 ttacttgctg aatacctcat tggtatcatt gcaaatggtt tcatcatggc tatacatgca
      181 gctgaatggg ttcaaaataa ggcagtttcc acaagtggca ggatcctggt tttcctgagt
      241 gtatccagaa tagctctcca aagcctcatg atgttagaaa ttaccatcag ctcaacctcc
      301 ctaagttttt attctgaaga cgctgtatat tatgcattca aaataagttt tatattctta
      361 aatttttgta gcctgtggtt tgctgcctgg ctcagtttct tctactttgt gaagattgcc
      421 aatttctcct accccctttt cctcaaactg aggtggagaa ttactggatt gataccctgg
      481 cttctgtggc tgtccgtgtt tatttccttc agtcacagca tgttctgcat caacatctgc
      541 actgtgtatt gtaacaattc tttccctatc cactcctcca actccactaa gaaaacatac
      601 ttgtctgaga tcaatgtggt cggtctggct tttttcttta acctggggat tgtgactcct
      661 ctgatcatgt tcatcctgac agccaccctg ctgatcctct ctctcaagag acacacccta
      721 cacatgggaa gcaatgccac agggtccaac gaccccagca tggaggctca catgggggcc
      781 atcaaagcta tcagctactt tctcattctc tacattttca atgcagttgc tctgtttatc
      841 tacctgtcca acatgtttga catcaacagt ctgtggaata atttgtgcca gatcatcatg
      901 gctgcctacc ctgccagcca ctcaattcta ctgattcaag ataaccctgg gctgagaaga
      961 gcctggaagc ggcttcagct tcgacttcat ctttacccaa aagagtggac tctgtga
//
