LOCUS       NM_176817               1143 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens taste 2 receptor member 38 (TAS2R38), mRNA.
ACCESSION   NM_176817
VERSION     NM_176817.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1143)
  AUTHORS   Pifferi,M., Boner,A., Maj,D., Michelucci,A., Donzelli,G.,
            Cangiotti,A.M., Guazzo,R., Bertolucci,G., Bertini,V., Doccioli,C.,
            Piazza,M., Valetto,A., Caligo,M.A., Peroni,D. and Bush,A.
  TITLE     Impact of TAS2R38 polymorphisms on nasal nitric oxide and
            Pseudomonas infections in primary ciliary dyskinesia: relation to
            genotype
  JOURNAL   Thorax 79 (11), 1069-1076 (2024)
   PUBMED   39181709
  REMARK    GeneRIF: Impact of TAS2R38 polymorphisms on nasal nitric oxide and
            Pseudomonas infections in primary ciliary dyskinesia: relation to
            genotype.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1143)
  AUTHORS   Kim,H.Y. and Choi,J.H.
  TITLE     TAS2R38 bitterness receptor genetic variation is associated with
            diet quality in Koreans
  JOURNAL   Appetite 200, 107561 (2024)
   PUBMED   38905855
  REMARK    GeneRIF: TAS2R38 bitterness receptor genetic variation is
            associated with diet quality in Koreans.
REFERENCE   3  (bases 1 to 1143)
  AUTHORS   Piatti,G., Girotto,G., Concas,M.P., Braga,L., Ambrosetti,U. and
            Alde,M.
  TITLE     TAS2R38 Genotype Does Not Affect SARS-CoV-2 Infection in Primary
            Ciliary Dyskinesia
  JOURNAL   Int J Mol Sci 25 (16), 8635 (2024)
   PUBMED   39201321
  REMARK    GeneRIF: TAS2R38 Genotype Does Not Affect SARS-CoV-2 Infection in
            Primary Ciliary Dyskinesia.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1143)
  AUTHORS   Nolden,A.A., Behrens,M., McGeary,J.E., Meyerhof,W. and Hayes,J.E.
  TITLE     Differential Activation of TAS2R4 May Recover Ability to Taste
            Propylthiouracil for Some TAS2R38 AVI Homozygotes
  JOURNAL   Nutrients 16 (9), 1357 (2024)
   PUBMED   38732607
  REMARK    GeneRIF: Differential Activation of TAS2R4 May Recover Ability to
            Taste Propylthiouracil for Some TAS2R38 AVI Homozygotes.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1143)
  AUTHORS   Lukasiewicz-Smietanska,D., Godlewski,D., Nowakowska,E., Szpak,A.,
            Chabros,E., Juszczyk,G., Charzewska,J. and Rybaczyk-Pathak,D.
  TITLE     Association of the bitter taste genes TAS2R38 and CA6 and breast
            cancer risk; a case-control study of Polish women in Poland and
            Polish immigrants in USA
  JOURNAL   PLoS One 19 (4), e0300061 (2024)
   PUBMED   38687739
  REMARK    GeneRIF: Association of the bitter taste genes TAS2R38 and CA6 and
            breast cancer risk; a case-control study of Polish women in Poland
            and Polish immigrants in USA.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1143)
  AUTHORS   Zhang,Y., Hoon,M.A., Chandrashekar,J., Mueller,K.L., Cook,B.,
            Wu,D., Zuker,C.S. and Ryba,N.J.
  TITLE     Coding of sweet, bitter, and umami tastes: different receptor cells
            sharing similar signaling pathways
  JOURNAL   Cell 112 (3), 293-301 (2003)
   PUBMED   12581520
REFERENCE   7  (bases 1 to 1143)
  AUTHORS   Bufe,B., Hofmann,T., Krautwurst,D., Raguse,J.D. and Meyerhof,W.
  TITLE     The human TAS2R16 receptor mediates bitter taste in response to
            beta-glucopyranosides
  JOURNAL   Nat Genet 32 (3), 397-401 (2002)
   PUBMED   12379855
REFERENCE   8  (bases 1 to 1143)
  AUTHORS   Montmayeur,J.P. and Matsunami,H.
  TITLE     Receptors for bitter and sweet taste
  JOURNAL   Curr Opin Neurobiol 12 (4), 366-371 (2002)
   PUBMED   12139982
  REMARK    Review article
REFERENCE   9  (bases 1 to 1143)
  AUTHORS   Margolskee,R.F.
  TITLE     Molecular mechanisms of bitter and sweet taste transduction
  JOURNAL   J Biol Chem 277 (1), 1-4 (2002)
   PUBMED   11696554
  REMARK    Review article
REFERENCE   10 (bases 1 to 1143)
  AUTHORS   Anne-Spence,M., Falk,C.T., Neiswanger,K., Field,L.L.,
            Marazita,M.L., Allen,F.H. Jr., Siervogel,R.M., Roche,A.F.,
            Crandall,B.F. and Sparkes,R.S.
  TITLE     Estimating the recombination frequency for the PTC-Kell linkage
  JOURNAL   Hum Genet 67 (2), 183-186 (1984)
   PUBMED   6745938
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC073647.9.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_176817.4.
            
            Summary: This gene encodes a seven-transmembrane G protein-coupled
            receptor that controls the ability to taste glucosinolates, a
            family of bitter-tasting compounds found in plants of the Brassica
            sp. Synthetic compounds phenylthiocarbamide (PTC) and
            6-n-propylthiouracil (PROP) have been identified as ligands for
            this receptor and have been used to test the genetic diversity of
            this gene. Although several allelic forms of this gene have been
            identified worldwide, there are two predominant common forms
            (taster and non-taster) found outside of Africa. These alleles
            differ at three nucleotide positions resulting in amino acid
            changes in the protein (A49P, A262V, and V296I) with the amino acid
            combination PAV identifying the taster variant (and AVI identifying
            the non-taster variant). [provided by RefSeq, Oct 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC104933.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000547270.1/ ENSP00000448219.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1143              AC073647.9         55055-56197
FEATURES             Location/Qualifiers
     source          1..1143
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q34"
     gene            1..1143
                     /gene="TAS2R38"
                     /gene_synonym="PTC; T2R38; T2R61; THIOT"
                     /note="taste 2 receptor member 38"
                     /db_xref="GeneID:5726"
                     /db_xref="HGNC:HGNC:9584"
                     /db_xref="MIM:607751"
     exon            1..1143
                     /gene="TAS2R38"
                     /gene_synonym="PTC; T2R38; T2R61; THIOT"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctttctgca ctgggtggca accaggtctt tagattagcc aactagagaa gagaagtaga
       61 atagccaatt agagaagtga catcatgttg actctaactc gcatccgcac tgtgtcctat
      121 gaagtcagga gtacatttct gttcatttca gtcctggagt ttgcagtggg gtttctgacc
      181 aatgccttcg ttttcttggt gaatttttgg gatgtagtga agaggcaggc actgagcaac
      241 agtgattgtg tgctgctgtg tctcagcatc agccggcttt tcctgcatgg actgctgttc
      301 ctgagtgcta tccagcttac ccacttccag aagttgagtg aaccactgaa ccacagctac
      361 caagccatca tcatgctatg gatgattgca aaccaagcca acctctggct tgctgcctgc
      421 ctcagcctgc tttactgctc caagctcatc cgtttctctc acaccttcct gatctgcttg
      481 gcaagctggg tctccaggaa gatctcccag atgctcctgg gtattattct ttgctcctgc
      541 atctgcactg tcctctgtgt ttggtgcttt tttagcagac ctcacttcac agtcacaact
      601 gtgctattca tgaataacaa tacaaggctc aactggcaga ttaaagatct caatttattt
      661 tattcctttc tcttctgcta tctgtggtct gtgcctcctt tcctattgtt tctggtttct
      721 tctgggatgc tgactgtctc cctgggaagg cacatgagga caatgaaggt ctataccaga
      781 aactctcgtg accccagcct ggaggcccac attaaagccc tcaagtctct tgtctccttt
      841 ttctgcttct ttgtgatatc atcctgtgct gccttcatct ctgtgcccct actgattctg
      901 tggcgcgaca aaataggggt gatggtttgt gttgggataa tggcagcttg tccctctggg
      961 catgcagcca tcctgatctc aggcaatgcc aagttgagga gagctgtgat gaccattctg
     1021 ctctgggctc agagcagcct gaaggtaaga gccgaccaca aggcagattc ccggacactg
     1081 tgctgagaat ggacatgaaa tgagctcttc attaatacgc ctgtgagtct tcataaatat
     1141 gcc
//
