LOCUS       NM_176885               1021 bp    mRNA    linear   PRI 02-JUN-2024
DEFINITION  Homo sapiens taste 2 receptor member 31 (TAS2R31), mRNA.
ACCESSION   NM_176885
VERSION     NM_176885.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1021)
  AUTHORS   Bobowski,N., Reed,D.R. and Mennella,J.A.
  TITLE     Variation in the TAS2R31 bitter taste receptor gene relates to
            liking for the nonnutritive sweetener Acesulfame-K among children
            and adults
  JOURNAL   Sci Rep 6, 39135 (2016)
   PUBMED   27966661
  REMARK    GeneRIF: Results show that NNS-sweetened products with acesulfame
            potassium (Ace-K) were consumed by 50% and 15% of mothers and
            children, respectively, with no association between intake and
            TAS2R31. The TAS2R31 WMVI haplotype was partly responsible for
            children's hedonic response to Ace-K, highlighting a potential role
            for inborn differences in vulnerability to overconsumption of
            Ace-K-containing products.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1021)
  AUTHORS   Hayes,J.E., Feeney,E.L., Nolden,A.A. and McGeary,J.E.
  TITLE     Quinine Bitterness and Grapefruit Liking Associate with Allelic
            Variants in TAS2R31
  JOURNAL   Chem Senses 40 (6), 437-443 (2015)
   PUBMED   26024668
  REMARK    GeneRIF: Genotypes for the Val240Ile (rs10772423) SNP in TAS2R31
            remains significant at a Bonferroni corrected alpha of 0.025.
REFERENCE   3  (bases 1 to 1021)
  AUTHORS   Hayes,J.E., Feeney,E.L. and Allen,A.L.
  TITLE     Do polymorphisms in chemosensory genes matter for human ingestive
            behavior?
  JOURNAL   Food Qual Prefer 30 (2), 202-216 (2013)
   PUBMED   23878414
REFERENCE   4  (bases 1 to 1021)
  AUTHORS   Allen,A.L., McGeary,J.E. and Hayes,J.E.
  TITLE     Rebaudioside A and Rebaudioside D bitterness do not covary with
            Acesulfame K bitterness or polymorphisms in TAS2R9 and TAS2R31
  JOURNAL   Chemosens Percept 6 (3) (2013)
   PUBMED   24187601
REFERENCE   5  (bases 1 to 1021)
  AUTHORS   Allen,A.L., McGeary,J.E., Knopik,V.S. and Hayes,J.E.
  TITLE     Bitterness of the non-nutritive sweetener acesulfame potassium
            varies with polymorphisms in TAS2R9 and TAS2R31
  JOURNAL   Chem Senses 38 (5), 379-389 (2013)
   PUBMED   23599216
REFERENCE   6  (bases 1 to 1021)
  AUTHORS   Zhang,Y., Hoon,M.A., Chandrashekar,J., Mueller,K.L., Cook,B.,
            Wu,D., Zuker,C.S. and Ryba,N.J.
  TITLE     Coding of sweet, bitter, and umami tastes: different receptor cells
            sharing similar signaling pathways
  JOURNAL   Cell 112 (3), 293-301 (2003)
   PUBMED   12581520
REFERENCE   7  (bases 1 to 1021)
  AUTHORS   Bufe,B., Hofmann,T., Krautwurst,D., Raguse,J.D. and Meyerhof,W.
  TITLE     The human TAS2R16 receptor mediates bitter taste in response to
            beta-glucopyranosides
  JOURNAL   Nat Genet 32 (3), 397-401 (2002)
   PUBMED   12379855
REFERENCE   8  (bases 1 to 1021)
  AUTHORS   Montmayeur,J.P. and Matsunami,H.
  TITLE     Receptors for bitter and sweet taste
  JOURNAL   Curr Opin Neurobiol 12 (4), 366-371 (2002)
   PUBMED   12139982
  REMARK    Review article
REFERENCE   9  (bases 1 to 1021)
  AUTHORS   Margolskee,R.F.
  TITLE     Molecular mechanisms of bitter and sweet taste transduction
  JOURNAL   J Biol Chem 277 (1), 1-4 (2002)
   PUBMED   11696554
  REMARK    Review article
REFERENCE   10 (bases 1 to 1021)
  AUTHORS   Conte,C., Ebeling,M., Marcuz,A., Nef,P. and Andres-Barquin,P.J.
  TITLE     Identification and characterization of human taste receptor genes
            belonging to the TAS2R family
  JOURNAL   Cytogenet Genome Res 98 (1), 45-53 (2002)
   PUBMED   12584440
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC018630.40.
            
            On Oct 17, 2006 this sequence version replaced NM_176885.1.
            
            Summary: TAS2R44 belongs to the large TAS2R receptor family. TAS2Rs
            are expressed on the surface of taste receptor cells and mediate
            the perception of bitterness through a G protein-coupled second
            messenger pathway (Conte et al., 2002 [PubMed 12584440]). For
            further information on TAS2Rs, see MIM 604791.[supplied by OMIM,
            Mar 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC117421.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000390675.2/ ENSP00000375093.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1021              AC018630.40        109281-110301
FEATURES             Location/Qualifiers
     source          1..1021
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.2"
     gene            1..1021
                     /gene="TAS2R31"
                     /gene_synonym="T2R31; T2R44; T2R53; TAS2R44"
                     /note="taste 2 receptor member 31"
                     /db_xref="GeneID:259290"
                     /db_xref="HGNC:HGNC:19113"
                     /db_xref="MIM:612669"
     exon            1..1021
                     /gene="TAS2R31"
                     /gene_synonym="T2R31; T2R44; T2R53; TAS2R44"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..1002
                     /gene="TAS2R31"
                     /gene_synonym="T2R31; T2R44; T2R53; TAS2R44"
                     /note="taste receptor type 2 member 44; taste receptor
                     type 2 member 53; taste receptor, type 2, member 31"
                     /codon_start=1
                     /product="taste receptor type 2 member 31"
                     /protein_id="NP_795366.2"
                     /db_xref="CCDS:CCDS53747.1"
                     /db_xref="GeneID:259290"
                     /db_xref="HGNC:HGNC:19113"
                     /db_xref="MIM:612669"
                     /translation="MTTFIPIIFSSVVVVLFVIGNFANGFIALVNSIERVKRQKISFA
                     DQILTALAVSRVGLLWVLLLNWYSTVFNPAFYSVEVRTTAYNVWAVTGHFSNWLATSL
                     SIFYLLKIANFSNLIFLHLKRRVKSVILVMLLGPLLFLACQLFVINMKEIVRTKEYEG
                     NLTWKIKLRSAVYLSDATVTTLGNLVPFTLTLLCFLLLICSLCKHLKKMQLHGKGSQD
                     PSTKVHIKALQTVIFFLLLCAVYFLSIMISVWSFGSLENKPVFMFCKAIRFSYPSIHP
                     FILIWGNKKLKQTFLSVLRQVRYWVKGEKPSSP"
ORIGIN      
        1 cgaacccacc tgcaggaacc aactccggac acaacaccag cattaaaaca attttttttt
       61 gtctgttcag acatgacaac ttttataccc atcatttttt ccagtgtggt agtggttcta
      121 tttgttattg gaaattttgc taatggcttc atagcattgg taaattccat tgagcgggtc
      181 aagagacaaa agatctcttt tgctgaccag attctcactg ctctggcggt ctccagagtt
      241 ggtttgctct gggtattatt attaaattgg tattcaactg tgtttaatcc agctttttat
      301 agtgtagaag taagaactac tgcttataat gtctgggcag taaccggcca tttcagcaac
      361 tggcttgcta ctagcctcag catattttat ttgctcaaga ttgccaattt ctccaacctt
      421 atttttcttc acttaaagag gagagttaag agtgtcattc tggtgatgct gttggggcct
      481 ttactatttt tggcttgtca actttttgtg ataaacatga aagagattgt acggacaaaa
      541 gaatatgaag gaaacttgac ttggaagatc aaattgagga gtgcagtgta cctttcagat
      601 gcgactgtaa ccacgctagg aaacttagtg cccttcactc tgaccctgct atgttttttg
      661 ctgttaatct gttctctgtg taaacatctc aagaagatgc agctccatgg taaaggatct
      721 caagatccca gcaccaaggt ccacataaaa gctttgcaaa ctgtgatctt tttcctcttg
      781 ttatgtgccg tttactttct gtccataatg atatcagttt ggagttttgg gagtctggaa
      841 aacaaacctg tcttcatgtt ctgcaaagct attagattca gctatccttc aatccaccca
      901 ttcatcctga tttggggaaa caagaagcta aagcagactt ttctttcagt tttgcggcaa
      961 gtgaggtact gggtgaaagg agagaagcct tcatctccat agattcatga gaggggcatt
     1021 g
//
