LOCUS       NM_016943               1101 bp    mRNA    linear   PRI 02-JUN-2024
DEFINITION  Homo sapiens taste 2 receptor member 3 (TAS2R3), mRNA.
ACCESSION   NM_016943
VERSION     NM_016943.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1101)
  AUTHORS   Szczepaniak,O., Jokiel,M., Stuper-Szablewska,K., Szymanowska,D.,
            Dziedzinski,M. and Kobus-Cisowska,J.
  TITLE     Can cornelian cherry mask bitter taste of probiotic chocolate?
            Human TAS2R receptors and a sensory study with comprehensive
            characterisation of new functional product
  JOURNAL   PLoS One 16 (2), e0243871 (2021)
   PUBMED   33556063
  REMARK    GeneRIF: Can cornelian cherry mask bitter taste of probiotic
            chocolate? Human TAS2R receptors and a sensory study with
            comprehensive characterisation of new functional product.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1101)
  AUTHORS   Zhang,L., Chen,X., Xu,L., Guan,S., Wang,D., Lin,Y. and Wang,Z.
  TITLE     Novel frameshift mutations of ANKUB1, GLI3, and TAS2R3 associated
            with polysyndactyly in a Chinese family
  JOURNAL   Mol Genet Genomic Med 8 (6), e1223 (2020)
   PUBMED   32253825
  REMARK    GeneRIF: Novel frameshift mutations of ANKUB1, GLI3, and TAS2R3
            associated with polysyndactyly in a Chinese family.
REFERENCE   3  (bases 1 to 1101)
  AUTHORS   Mikolajczyk-Stecyna,J., Malinowska,A.M. and Chmurzynska,A.
  TITLE     Polymorphism of TAS2R3, TAS2R5, TAS2R19, and TAS2R50 genes and
            bitter food intake frequency inelderly woman
  JOURNAL   Acta Sci Pol Technol Aliment 19 (1), 109-122 (2020)
   PUBMED   32227702
  REMARK    GeneRIF: Polymorphism of TAS2R3, TAS2R5, TAS2R19, and TAS2R50 genes
            and bitter food intake frequency inelderly woman.
REFERENCE   4  (bases 1 to 1101)
  AUTHORS   Choi,J.H., Lee,J., Yang,S., Lee,E.K., Hwangbo,Y. and Kim,J.
  TITLE     Genetic variations in TAS2R3 and TAS2R4 bitterness receptors modify
            papillary carcinoma risk and thyroid function in Korean females
  JOURNAL   Sci Rep 8 (1), 15004 (2018)
   PUBMED   30301923
  REMARK    GeneRIF: In summary, genetic variations in T2R3/4 bitterness
            receptors may modify the papillary thyroid carcinoma (PTC) risk,
            and the genetically modified thyroid hormone level by those
            variations may be linked with the PTC-T2Rs association
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1101)
  AUTHORS   Nolden,A.A., McGeary,J.E. and Hayes,J.E.
  TITLE     Differential bitterness in capsaicin, piperine, and ethanol
            associates with polymorphisms in multiple bitter taste receptor
            genes
  JOURNAL   Physiol Behav 156, 117-127 (2016)
   PUBMED   26785164
  REMARK    GeneRIF: differences in the bitterness from chemicals associated
            with genetic polymorphisms in bitter taste receptor genes,
            specifically in TAS2R3, -4, -5 as well as TAS2R38.
REFERENCE   6  (bases 1 to 1101)
  AUTHORS   Calvo,S.E., Pagliarini,D.J. and Mootha,V.K.
  TITLE     Upstream open reading frames cause widespread reduction of protein
            expression and are polymorphic among humans
  JOURNAL   Proc Natl Acad Sci U S A 106 (18), 7507-7512 (2009)
   PUBMED   19372376
  REMARK    GeneRIF: Includes the study of a polymorphic upstream ORF in this
            gene, and shows that it functions to reduce protein levels by ~58%.
REFERENCE   7  (bases 1 to 1101)
  AUTHORS   Matsunami,H., Montmayeur,J.P. and Buck,L.B.
  TITLE     A family of candidate taste receptors in human and mouse
  JOURNAL   Nature 404 (6778), 601-604 (2000)
   PUBMED   10766242
REFERENCE   8  (bases 1 to 1101)
  AUTHORS   Firestein,S.
  TITLE     The good taste of genomics
  JOURNAL   Nature 404 (6778), 552-553 (2000)
   PUBMED   10766221
REFERENCE   9  (bases 1 to 1101)
  AUTHORS   Chandrashekar,J., Mueller,K.L., Hoon,M.A., Adler,E., Feng,L.,
            Guo,W., Zuker,C.S. and Ryba,N.J.
  TITLE     T2Rs function as bitter taste receptors
  JOURNAL   Cell 100 (6), 703-711 (2000)
   PUBMED   10761935
REFERENCE   10 (bases 1 to 1101)
  AUTHORS   Adler,E., Hoon,M.A., Mueller,K.L., Chandrashekar,J., Ryba,N.J. and
            Zuker,C.S.
  TITLE     A novel family of mammalian taste receptors
  JOURNAL   Cell 100 (6), 693-702 (2000)
   PUBMED   10761934
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC095523.1 and AC004979.1.
            
            On Jun 17, 2005 this sequence version replaced NM_016943.1.
            
            Summary: This gene encodes a member of a family of candidate taste
            receptors that are members of the G protein-coupled receptor
            superfamily and that are specifically expressed by taste receptor
            cells of the tongue and palate epithelia. These apparently
            intronless taste receptor genes encode a 7-transmembrane receptor
            protein, functioning as a bitter taste receptor. This gene is
            clustered with another 3  candidate taste receptor genes in
            chromosome 7 and is genetically linked to loci that influence
            bitter perception. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC095523.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000247879.2/ ENSP00000247879.2
            RefSeq Select criteria :: based on single protein-coding transcript
            regulatory uORF        :: PMID: 19372376
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-868               BC095523.1         1-868
            869-1101            AC004979.1         18382-18614
FEATURES             Location/Qualifiers
     source          1..1101
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q34"
     gene            1..1101
                     /gene="TAS2R3"
                     /gene_synonym="T2R3"
                     /note="taste 2 receptor member 3"
                     /db_xref="GeneID:50831"
                     /db_xref="HGNC:HGNC:14910"
                     /db_xref="MIM:604868"
     exon            1..1101
                     /gene="TAS2R3"
                     /gene_synonym="T2R3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      17..61
                     /regulatory_class="uORF"
                     /gene="TAS2R3"
                     /gene_synonym="T2R3"
                     /experiment="DESCRIPTION:regulatory uORF[PMID:19372376]"
                     /note="this uORF is predicted to encode a 14 aa peptide
                     (PMID:19372376)"
     CDS             63..1013
                     /gene="TAS2R3"
                     /gene_synonym="T2R3"
                     /note="candidate taste receptor T2R3; taste receptor, type
                     2, member 3"
                     /codon_start=1
                     /product="taste receptor type 2 member 3"
                     /protein_id="NP_058639.1"
                     /db_xref="CCDS:CCDS5867.1"
                     /db_xref="GeneID:50831"
                     /db_xref="HGNC:HGNC:14910"
                     /db_xref="MIM:604868"
                     /translation="MMGLTEGVFLILSGTQFTLGILVNCFIELVNGSSWFKTKRMSLS
                     DFIITTLALLRIILLCIILTDSFLIEFSPNTHDSGIIMQIIDVSWTFTNHLSIWLATC
                     LGVLYCLKIASFSHPTFLWLKWRVSRVMVWMLLGALLLSCGSTASLINEFKLYSVFRG
                     IEATRNVTEHFRKKRSEYYLIHVLGTLWYLPPLIVSLASYSLLIFSLGRHTRQMLQNG
                     TSSRDPTTEAHKRAIRIILSFFFLFLLYFLAFLIASFGNFLPKTKMAKMIGEVMTMFY
                     PAGHSFILILGNSKLKQTFVVMLRCESGHLKPGSKGPIFS"
ORIGIN      
        1 tcagtgagga gattctatgt atcaacagaa agaacaaaga tcagggctgc ctaattgctg
       61 acatgatggg actcaccgag ggggtgttcc tgattctgtc tggcactcag ttcacactgg
      121 gaattctggt caattgtttc attgagttgg tcaatggtag cagctggttc aagaccaaga
      181 gaatgtcttt gtctgacttc atcatcacca ccctggcact cttgaggatc attctgctgt
      241 gtattatctt gactgatagt tttttaatag aattctctcc caacacacat gattcaggga
      301 taataatgca aattattgat gtttcctgga catttacaaa ccatctgagc atttggcttg
      361 ccacctgtct tggtgtcctc tactgcctga aaatcgccag tttctctcac cccacattcc
      421 tctggctcaa gtggagagtt tctagggtga tggtatggat gctgttgggt gcactgctct
      481 tatcctgtgg tagtaccgca tctctgatca atgagtttaa gctctattct gtctttaggg
      541 gaattgaggc caccaggaat gtgactgaac acttcagaaa gaagaggagt gagtattatc
      601 tgatccatgt tcttgggact ctgtggtacc tgcctccctt aattgtgtcc ctggcctcct
      661 actctttgct catcttctcc ctggggaggc acacacggca gatgctgcaa aatgggacaa
      721 gctccagaga tccaaccact gaggcccaca agagggccat cagaatcatc ctttccttct
      781 tctttctctt cttactttac tttcttgctt tcttaattgc atcatttggt aatttcctac
      841 caaaaaccaa gatggctaag atgattggcg aagtaatgac aatgttttat cctgctggcc
      901 actcatttat tctcattctg gggaacagta agctgaagca gacatttgta gtgatgctcc
      961 ggtgtgagtc tggtcatctg aagcctggat ccaagggacc cattttctct tagagtaaca
     1021 gagggcatgg ggtggagccc ttgagccttt tggcctggct caagactaca ggactcttcc
     1081 tgaccttcct atgttaccag t
//
