LOCUS       NM_176889               2344 bp    mRNA    linear   PRI 10-JUN-2024
DEFINITION  Homo sapiens taste 2 receptor member 20 (TAS2R20), mRNA.
ACCESSION   NM_176889
VERSION     NM_176889.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2344)
  AUTHORS   Hayakawa,T., Suzuki-Hashido,N., Matsui,A. and Go,Y.
  TITLE     Frequent expansions of the bitter taste receptor gene repertoire
            during evolution of mammals in the Euarchontoglires clade
  JOURNAL   Mol Biol Evol 31 (8), 2018-2031 (2014)
   PUBMED   24758778
REFERENCE   2  (bases 1 to 2344)
  AUTHORS   Ozyildirim,A.M., Wistow,G.J., Gao,J., Wang,J., Dickinson,D.P.,
            Frierson,H.F. Jr. and Laurie,G.W.
  TITLE     The lacrimal gland transcriptome is an unusually rich source of
            rare and poorly characterized gene transcripts
  JOURNAL   Invest Ophthalmol Vis Sci 46 (5), 1572-1580 (2005)
   PUBMED   15851553
REFERENCE   3  (bases 1 to 2344)
  AUTHORS   Go,Y., Satta,Y., Takenaka,O. and Takahata,N.
  TITLE     Lineage-specific loss of function of bitter taste receptor genes in
            humans and nonhuman primates
  JOURNAL   Genetics 170 (1), 313-326 (2005)
   PUBMED   15744053
REFERENCE   4  (bases 1 to 2344)
  AUTHORS   Fischer,A., Gilad,Y., Man,O. and Paabo,S.
  TITLE     Evolution of bitter taste receptors in humans and apes
  JOURNAL   Mol Biol Evol 22 (3), 432-436 (2005)
   PUBMED   15496549
  REMARK    Erratum:[Mol Biol Evol. 2005 Apr;22(4):1157]
REFERENCE   5  (bases 1 to 2344)
  AUTHORS   Zhang,Y., Hoon,M.A., Chandrashekar,J., Mueller,K.L., Cook,B.,
            Wu,D., Zuker,C.S. and Ryba,N.J.
  TITLE     Coding of sweet, bitter, and umami tastes: different receptor cells
            sharing similar signaling pathways
  JOURNAL   Cell 112 (3), 293-301 (2003)
   PUBMED   12581520
REFERENCE   6  (bases 1 to 2344)
  AUTHORS   Bufe,B., Hofmann,T., Krautwurst,D., Raguse,J.D. and Meyerhof,W.
  TITLE     The human TAS2R16 receptor mediates bitter taste in response to
            beta-glucopyranosides
  JOURNAL   Nat Genet 32 (3), 397-401 (2002)
   PUBMED   12379855
REFERENCE   7  (bases 1 to 2344)
  AUTHORS   Montmayeur,J.P. and Matsunami,H.
  TITLE     Receptors for bitter and sweet taste
  JOURNAL   Curr Opin Neurobiol 12 (4), 366-371 (2002)
   PUBMED   12139982
  REMARK    Review article
REFERENCE   8  (bases 1 to 2344)
  AUTHORS   Margolskee,R.F.
  TITLE     Molecular mechanisms of bitter and sweet taste transduction
  JOURNAL   J Biol Chem 277 (1), 1-4 (2002)
   PUBMED   11696554
  REMARK    Review article
REFERENCE   9  (bases 1 to 2344)
  AUTHORS   Conte,C., Ebeling,M., Marcuz,A., Nef,P. and Andres-Barquin,P.J.
  TITLE     Identification and characterization of human taste receptor genes
            belonging to the TAS2R family
  JOURNAL   Cytogenet Genome Res 98 (1), 45-53 (2002)
   PUBMED   12584440
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC018630.40, BC100916.2,
            CD722569.1 and C20782.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 13, 2020 this sequence version replaced NM_176889.3.
            
            Summary: This gene encodes a member of the taste receptor two
            family of class C G-protein coupled receptors. Receptors of this
            family have a short extracellular N-terminus, seven transmembrane
            helices, three extracellular loops and three intracellular loops,
            and an intracellular C-terminus. Members of this family are
            expressed in a subset of taste receptor cells, where they function
            in bitter taste reception, as well as in non-gustatory cells
            including those of the brain, reproductive organs, respiratory
            system, and gastrointestinal system. This gene maps to the taste
            receptor gene cluster on chromosome 12p13. [provided by RefSeq, Jul
            2016].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC100918.2 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000538986.2/ ENSP00000441624.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-429               AC018630.40        142384-142812
            430-1359            BC100916.2         1-930
            1360-1810           CD722569.1         164-614
            1811-2281           AC018630.40        144194-144664
            2282-2343           C20782.1           73-134
            2344-2344           AC018630.40        144727-144727
FEATURES             Location/Qualifiers
     source          1..2344
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.2"
     gene            1..2344
                     /gene="TAS2R20"
                     /gene_synonym="T2R20; T2R49; T2R56; TAS2R49"
                     /note="taste 2 receptor member 20"
                     /db_xref="GeneID:259295"
                     /db_xref="HGNC:HGNC:19109"
                     /db_xref="MIM:613962"
     exon            1..2344
                     /gene="TAS2R20"
                     /gene_synonym="T2R20; T2R49; T2R56; TAS2R49"
                     /inference="alignment:Splign:2.1.0"
     CDS             430..1359
                     /gene="TAS2R20"
                     /gene_synonym="T2R20; T2R49; T2R56; TAS2R49"
                     /note="taste receptor, type 2, member 49; taste receptor
                     type 2 member 56"
                     /codon_start=1
                     /product="taste receptor type 2 member 20"
                     /protein_id="NP_795370.2"
                     /db_xref="CCDS:CCDS8639.1"
                     /db_xref="GeneID:259295"
                     /db_xref="HGNC:HGNC:19109"
                     /db_xref="MIM:613962"
                     /translation="MMSFLHIVFSILVVVAFILGNFANGFIALINFIAWVKRQKISSA
                     DQIIAALAVSRVGLLWVILLHWYSTVLNPTSSNLKVIIFISNAWAVTNHFSIWLATSL
                     SIFYLLKIVNFSRLIFHHLKRKAKSVVLVIVLGSLFFLVCHLVMKHTYINVWTEECEG
                     NVTWKIKLRNAMHLSNLTVAMLANLIPFTLTLISFLLLIYSLCKHLKKMQLHGKGSQD
                     PSTKIHIKALQTVTSFLILLAIYFLCLIISFWNFKMRPKEIVLMLCQAFGIIYPSFHS
                     FILIWGNKTLKQTFLSVLWQVTCWAKGQNQSTP"
     regulatory      2321..2326
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TAS2R20"
                     /gene_synonym="T2R20; T2R49; T2R56; TAS2R49"
                     /note="hexamer: AATAAA"
     polyA_site      2344
                     /gene="TAS2R20"
                     /gene_synonym="T2R20; T2R49; T2R56; TAS2R49"
                     /note="major polyA site"
ORIGIN      
        1 ctgggtatta aaatttcccc aacaactgaa gggctgaaca caaattatgg aaaggtgaaa
       61 caaggaaaaa attgcaaagc aatgaaagag gatatgtctt tatttgaatg ctagcaaatg
      121 agaattcagc tttcccttca acatcagtat gaaaaatttc agcctatagc aagaatagag
      181 actttatgaa taagaattaa tttgagttgt tttgggacta acagtatttc ccataaaggc
      241 agcattgaac tcattcatta gtttaagctg gtgcttttct gttgacattg ttcacagaat
      301 ttaaaagtat aaagaatgtt attggacatt caggaatcaa gtgcatattt aacttaaagt
      361 cttgaatatc agaggagtca ccatcagtga cattaggcct gaatttttta cttgcttttt
      421 tgtttagaca tgatgagttt tctacacatt gttttttcca ttctagtagt ggttgcattt
      481 attcttggaa attttgccaa tggctttata gcactgataa atttcattgc ctgggtcaag
      541 agacaaaaga tctcctcagc tgatcaaatt attgctgctc tggcagtctc cagagttggt
      601 ttgctctggg taatattatt acattggtat tcaactgtgt tgaatccaac ttcatctaat
      661 ttaaaagtaa taatttttat ttctaatgcc tgggcagtaa ccaatcattt cagcatctgg
      721 cttgctacta gcctcagcat attttatttg ctcaagatcg tcaatttctc cagacttatt
      781 tttcatcact taaaaaggaa ggctaagagt gtagttctgg tgatagtgtt ggggtctttg
      841 ttctttttgg tttgtcacct tgtgatgaaa cacacgtata taaatgtgtg gacagaagaa
      901 tgtgaaggaa acgtaacttg gaagatcaaa ctgaggaatg caatgcacct ttccaacttg
      961 actgtagcca tgctagcaaa cttgatacca ttcactctga ccctgatatc ttttctgctg
     1021 ttaatctact ctctgtgtaa acatctgaag aagatgcagc tccatggcaa aggatctcaa
     1081 gatcccagca ccaagatcca cataaaagct ctgcaaactg tgacctcctt cctcatatta
     1141 cttgccattt actttctgtg tctaatcata tcgttttgga attttaagat gcgaccaaaa
     1201 gaaattgtct taatgctttg ccaagctttt ggaatcatat atccatcatt ccactcattc
     1261 attctgattt gggggaacaa gacgctaaag cagacctttc tttcagtttt gtggcaggtg
     1321 acttgctggg caaaaggaca gaaccagtca actccataga ttcacaagag gtgcattgtg
     1381 tgttttctag cagaaaacaa attgatggtg tctggaacat tttatatttc ccacaagttt
     1441 ttccgtagtc tatgtatttg agtaatttcc aaaagttgac atagaaaagt cttttaccta
     1501 agtttattat ataaaagtat atatatataa tatacatttg cgtgtgtgtg tatgtctgaa
     1561 tgtatatgaa aatttaatat ttaccataac atacctttaa tcaacttttc atataaactg
     1621 ttcagttata ccaaagtagg ataagaaatt tctcagaatt atgaacccat gtgtatttca
     1681 cacatttttt tatatgatat ttcatttgag gaatttatga tctctattta taattaagaa
     1741 ctgacagctt atatcagaaa atcattgctg tttttcgttg taaaatcatt gctgtttttc
     1801 gttgtaattt gtatcacgta tatgtaccat agtgtgttta actgtttaac tatcattgtt
     1861 tgaacctcta attttttgga tggtaaggac atttaattct aaatcgatga gaatgtgtct
     1921 ttggggtagg tttttttgtt ttttttttaa tcatgaattc tttttttctt ttttttgaga
     1981 tggagtcttg ccctgttgtc caggctggaa tgcagtagca caatcttggc tcaccacaac
     2041 gttcacctct ggggttcaag tgatttccat gcgtcagcct cctgagtggc tgggactcca
     2101 ggcatgcgct accacacgtg gctaattttt tgtatttttc tttttttttt tagtagagat
     2161 ggggtttcac catgctggcc aggctggtct cgaactcttg acctcaagtg atccactgcc
     2221 tcagcctccc aaagtgctgg gattatagac attcatgatg aattcttatt ttatgtttaa
     2281 tataaagcaa atacaattat tgttagataa caatgcacaa aataaaattc aagggtgaaa
     2341 aata
//
