LOCUS       NM_176888               1002 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens taste 2 receptor member 19 (TAS2R19), mRNA.
ACCESSION   NM_176888
VERSION     NM_176888.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1002)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1002)
  AUTHORS   Mikolajczyk-Stecyna,J., Malinowska,A.M. and Chmurzynska,A.
  TITLE     Polymorphism of TAS2R3, TAS2R5, TAS2R19, and TAS2R50 genes and
            bitter food intake frequency inelderly woman
  JOURNAL   Acta Sci Pol Technol Aliment 19 (1), 109-122 (2020)
   PUBMED   32227702
  REMARK    GeneRIF: Polymorphism of TAS2R3, TAS2R5, TAS2R19, and TAS2R50 genes
            and bitter food intake frequency inelderly woman.
REFERENCE   3  (bases 1 to 1002)
  AUTHORS   Reed,D.R., Zhu,G., Breslin,P.A., Duke,F.F., Henders,A.K.,
            Campbell,M.J., Montgomery,G.W., Medland,S.E., Martin,N.G. and
            Wright,M.J.
  TITLE     The perception of quinine taste intensity is associated with common
            genetic variants in a bitter receptor cluster on chromosome 12
  JOURNAL   Hum Mol Genet 19 (21), 4278-4285 (2010)
   PUBMED   20675712
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   4  (bases 1 to 1002)
  AUTHORS   Meyerhof,W., Batram,C., Kuhn,C., Brockhoff,A., Chudoba,E., Bufe,B.,
            Appendino,G. and Behrens,M.
  TITLE     The molecular receptive ranges of human TAS2R bitter taste
            receptors
  JOURNAL   Chem Senses 35 (2), 157-170 (2010)
   PUBMED   20022913
REFERENCE   5  (bases 1 to 1002)
  AUTHORS   Go,Y., Satta,Y., Takenaka,O. and Takahata,N.
  TITLE     Lineage-specific loss of function of bitter taste receptor genes in
            humans and nonhuman primates
  JOURNAL   Genetics 170 (1), 313-326 (2005)
   PUBMED   15744053
REFERENCE   6  (bases 1 to 1002)
  AUTHORS   Fischer,A., Gilad,Y., Man,O. and Paabo,S.
  TITLE     Evolution of bitter taste receptors in humans and apes
  JOURNAL   Mol Biol Evol 22 (3), 432-436 (2005)
   PUBMED   15496549
  REMARK    Erratum:[Mol Biol Evol. 2005 Apr;22(4):1157]
REFERENCE   7  (bases 1 to 1002)
  AUTHORS   Zhang,Y., Hoon,M.A., Chandrashekar,J., Mueller,K.L., Cook,B.,
            Wu,D., Zuker,C.S. and Ryba,N.J.
  TITLE     Coding of sweet, bitter, and umami tastes: different receptor cells
            sharing similar signaling pathways
  JOURNAL   Cell 112 (3), 293-301 (2003)
   PUBMED   12581520
REFERENCE   8  (bases 1 to 1002)
  AUTHORS   Bufe,B., Hofmann,T., Krautwurst,D., Raguse,J.D. and Meyerhof,W.
  TITLE     The human TAS2R16 receptor mediates bitter taste in response to
            beta-glucopyranosides
  JOURNAL   Nat Genet 32 (3), 397-401 (2002)
   PUBMED   12379855
REFERENCE   9  (bases 1 to 1002)
  AUTHORS   Montmayeur,J.P. and Matsunami,H.
  TITLE     Receptors for bitter and sweet taste
  JOURNAL   Curr Opin Neurobiol 12 (4), 366-371 (2002)
   PUBMED   12139982
  REMARK    Review article
REFERENCE   10 (bases 1 to 1002)
  AUTHORS   Margolskee,R.F.
  TITLE     Molecular mechanisms of bitter and sweet taste transduction
  JOURNAL   J Biol Chem 277 (1), 1-4 (2002)
   PUBMED   11696554
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC101804.1.
            
            On Dec 18, 2014 this sequence version replaced NM_176888.1.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC101804.1, BC111998.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000390673.2/ ENSP00000375091.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1002
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.2"
     gene            1..1002
                     /gene="TAS2R19"
                     /gene_synonym="MSTP058; T2R19; T2R23; T2R48; TAS2R23;
                     TAS2R48"
                     /note="taste 2 receptor member 19"
                     /db_xref="GeneID:259294"
                     /db_xref="HGNC:HGNC:19108"
                     /db_xref="MIM:613961"
     exon            1..1002
                     /gene="TAS2R19"
                     /gene_synonym="MSTP058; T2R19; T2R23; T2R48; TAS2R23;
                     TAS2R48"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..949
                     /gene="TAS2R19"
                     /gene_synonym="MSTP058; T2R19; T2R23; T2R48; TAS2R23;
                     TAS2R48"
                     /note="taste receptor, type 2, member 48; taste receptor,
                     type 2, member 23; taste receptor, type 2, member 19"
                     /codon_start=1
                     /product="taste receptor type 2 member 19"
                     /protein_id="NP_795369.1"
                     /db_xref="CCDS:CCDS8640.1"
                     /db_xref="GeneID:259294"
                     /db_xref="HGNC:HGNC:19108"
                     /db_xref="MIM:613961"
                     /translation="MMCFLLIISSILVVFAFVLGNVANGFIALVNVIDWVNTRKISSA
                     EQILTALVVSRIGLLWVMLFLWYATVFNSALYGLEVRIVASNAWAVTNHFSMWLAASL
                     SIFCLLKIANFSNLISLHLKKRIKSVVLVILLGPLVFLICNLAVITMDERVWTKEYEG
                     NVTWKIKLRNAIHLSSLTVTTLANLIPFTLSLICFLLLICSLCKHLKKMRLHSKGSQD
                     PSTKVHIKALQTVTSFLMLFAIYFLCIITSTWNLRTQQSKLVLLLCQTVAIMYPSFHS
                     FILIMGSRKLKQTFLSVLWQMTR"
ORIGIN      
        1 ggactcagaa caagtgttac taagcctgca tttttttatc tgttcaaaca tgatgtgttt
       61 tctgctcatc atttcatcaa ttctggtagt gtttgcattt gttcttggaa atgttgccaa
      121 tggcttcata gccctagtaa atgtcattga ctgggttaac acacgaaaga tctcctcagc
      181 tgagcaaatt ctcactgctc tggtggtctc cagaattggt ttactctggg tcatgttatt
      241 cctttggtat gcaactgtgt ttaattctgc tttatatggt ttagaagtaa gaattgttgc
      301 ttctaatgcc tgggctgtaa cgaaccattt cagcatgtgg cttgctgcta gcctcagcat
      361 attttgtttg ctcaagattg ccaatttctc caaccttatt tctctccacc taaagaagag
      421 aattaagagt gttgttctgg tgatactgtt ggggcccttg gtatttctga tttgtaatct
      481 tgctgtgata accatggatg agagagtgtg gacaaaagaa tatgaaggaa atgtgacttg
      541 gaagatcaaa ttgaggaatg caatacacct ttcaagcttg actgtaacta ctctagcaaa
      601 cctcataccc tttactctga gcctaatatg ttttctgctg ttaatctgtt ctctttgtaa
      661 acatctcaag aagatgcggc tccatagcaa aggatctcaa gatcccagca ccaaggtcca
      721 tataaaagct ttgcaaactg tgacctcctt cctcatgtta tttgccattt actttctgtg
      781 tataatcaca tcaacttgga atcttaggac acagcagagc aaacttgtac tcctgctttg
      841 ccaaactgtt gcaatcatgt atccttcatt ccactcattc atcctgatta tgggaagtag
      901 gaagctaaaa cagacctttc tttcagtttt gtggcagatg acacgctgag tgaaagaaga
      961 gaaaccctca actccataga ttcacaaggg gagcatcgtg gg
//
