LOCUS       NM_016945                997 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens taste 2 receptor member 16 (TAS2R16), mRNA.
ACCESSION   NM_016945
VERSION     NM_016945.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 997)
  AUTHORS   Inokaityte,I., Gedvilaite,G. and Liutkeviciene,R.
  TITLE     Association of TAS2R16 gene (rs860170, rs978739, rs1357949)
            polymorphisms and TAS2R16 serum levels in patients with age-related
            macular degeneration
  JOURNAL   Ophthalmic Genet 45 (1), 28-37 (2024)
   PUBMED   38111140
  REMARK    GeneRIF: Association of TAS2R16 gene (rs860170, rs978739,
            rs1357949) polymorphisms and TAS2R16 serum levels in patients with
            age-related macular degeneration.
REFERENCE   2  (bases 1 to 997)
  AUTHORS   Zhou,Z., Xi,R., Liu,J., Peng,X., Zhao,L., Zhou,X., Li,J., Zheng,X.
            and Xu,X.
  TITLE     TAS2R16 Activation Suppresses LPS-Induced Cytokine Expression in
            Human Gingival Fibroblasts
  JOURNAL   Front Immunol 12, 726546 (2021)
   PUBMED   34975834
  REMARK    GeneRIF: TAS2R16 Activation Suppresses LPS-Induced Cytokine
            Expression in Human Gingival Fibroblasts.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 997)
  AUTHORS   Rhyu,M.R., Kim,Y. and Misaka,T.
  TITLE     Suppression of hTAS2R16 Signaling by Umami Substances
  JOURNAL   Int J Mol Sci 21 (19), 7045 (2020)
   PUBMED   32987926
  REMARK    GeneRIF: Suppression of hTAS2R16 Signaling by Umami Substances.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 997)
  AUTHORS   Fierro,F., Giorgetti,A., Carloni,P., Meyerhof,W. and
            Alfonso-Prieto,M.
  TITLE     Dual binding mode of 'bitter sugars' to their human bitter taste
            receptor target
  JOURNAL   Sci Rep 9 (1), 8437 (2019)
   PUBMED   31186454
  REMARK    GeneRIF: Dual binding mode of ''bitter sugars'' to their human
            bitter taste receptor target.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 997)
  AUTHORS   Barontini,J., Antinucci,M., Tofanelli,S., Cammalleri,M., Dal
            Monte,M., Gemignani,F., Vodicka,P., Marangoni,R., Vodickova,L.,
            Kupcinskas,J., Vymetalkova,V., Forsti,A., Canzian,F., Stein,A.,
            Moreno,V., Mastrodonato,N., Tavano,F., Panza,A., Barale,R.,
            Landi,S. and Campa,D.
  TITLE     Association between polymorphisms of TAS2R16 and susceptibility to
            colorectal cancer
  JOURNAL   BMC Gastroenterol 17 (1), 104 (2017)
   PUBMED   28915899
  REMARK    GeneRIF: We did not find any statistically significant association
            between risk of developing sporadic colorectal cancer and selected
            single nucleotide polymorphisms. However, after stratification by
            histology (colon vs. rectum) we found that rs1525489 was associated
            with increased risk of rectal cancer with a (Ptrend of = 0.0071).
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 997)
  AUTHORS   Matsunami,H., Montmayeur,J.P. and Buck,L.B.
  TITLE     A family of candidate taste receptors in human and mouse
  JOURNAL   Nature 404 (6778), 601-604 (2000)
   PUBMED   10766242
REFERENCE   7  (bases 1 to 997)
  AUTHORS   Firestein,S.
  TITLE     The good taste of genomics
  JOURNAL   Nature 404 (6778), 552-553 (2000)
   PUBMED   10766221
REFERENCE   8  (bases 1 to 997)
  AUTHORS   Chandrashekar,J., Mueller,K.L., Hoon,M.A., Adler,E., Feng,L.,
            Guo,W., Zuker,C.S. and Ryba,N.J.
  TITLE     T2Rs function as bitter taste receptors
  JOURNAL   Cell 100 (6), 703-711 (2000)
   PUBMED   10761935
REFERENCE   9  (bases 1 to 997)
  AUTHORS   Adler,E., Hoon,M.A., Mueller,K.L., Chandrashekar,J., Ryba,N.J. and
            Zuker,C.S.
  TITLE     A novel family of mammalian taste receptors
  JOURNAL   Cell 100 (6), 693-702 (2000)
   PUBMED   10761934
REFERENCE   10 (bases 1 to 997)
  AUTHORS   Kinnamon,S.C.
  TITLE     A plethora of taste receptors
  JOURNAL   Neuron 25 (3), 507-510 (2000)
   PUBMED   10774719
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC095524.1 and AC004838.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_016945.2.
            
            Summary: This gene encodes a member of a family of candidate taste
            receptors that are members of the G protein-coupled receptor
            superfamily. These family members are specifically expressed by
            taste receptor cells of the tongue and palate epithelia. Each of
            these apparently intronless genes encodes a 7-transmembrane
            receptor protein, functioning as a bitter taste receptor. This gene
            is clustered with another 3 candidate taste receptor genes in
            chromosome 7 and is genetically linked to loci that influence
            bitter perception. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC095524.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000249284.3/ ENSP00000249284.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-730               BC095524.1         1-730
            731-996             AC004838.2         11632-11897
            997-997             AC004838.2         11898-11898
FEATURES             Location/Qualifiers
     source          1..997
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q31.32"
     gene            1..997
                     /gene="TAS2R16"
                     /gene_synonym="BGLPT; T2R16"
                     /note="taste 2 receptor member 16"
                     /db_xref="GeneID:50833"
                     /db_xref="HGNC:HGNC:14921"
                     /db_xref="MIM:604867"
     exon            1..997
                     /gene="TAS2R16"
                     /gene_synonym="BGLPT; T2R16"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..942
                     /gene="TAS2R16"
                     /gene_synonym="BGLPT; T2R16"
                     /note="candidate taste receptor T2R16; taste receptor,
                     type 2, member 16"
                     /codon_start=1
                     /product="taste receptor type 2 member 16"
                     /protein_id="NP_058641.1"
                     /db_xref="CCDS:CCDS5785.1"
                     /db_xref="GeneID:50833"
                     /db_xref="HGNC:HGNC:14921"
                     /db_xref="MIM:604867"
                     /translation="MIPIQLTVFFMIIYVLESLTIIVQSSLIVAVLGREWLQVRRLMP
                     VDMILISLGISRFCLQWASMLNNFCSYFNLNYVLCNLTITWEFFNILTFWLNSLLTVF
                     YCIKVSSFTHHIFLWLRWRILRLFPWILLGSLMITCVTIIPSAIGNYIQIQLLTMEHL
                     PRNSTVTDKLENFHQYQFQAHTVALVIPFILFLASTIFLMASLTKQIQHHSTGHCNPS
                     MKARFTALRSLAVLFIVFTSYFLTILITIIGTLFDKRCWLWVWEAFVYAFILMHSTSL
                     MLSSPTLKRILKGKC"
ORIGIN      
        1 tctctacctg gaaattggta cagagattca gagtctttgt ccaggaagac actttggagt
       61 agaagaatga tacccatcca actcactgtc ttcttcatga tcatctatgt gcttgagtcc
      121 ttgacaatta ttgtgcagag cagcctaatt gttgcagtgc tgggcagaga atggctgcaa
      181 gtcagaaggc tgatgcctgt ggacatgatt ctcatcagcc tgggcatctc tcgcttctgt
      241 ctacagtggg catcaatgct gaacaatttt tgctcctatt ttaatttgaa ttatgtactt
      301 tgcaacttaa caatcacctg ggaatttttt aatatcctta cattctggtt aaacagcttg
      361 cttaccgtgt tctactgcat caaggtctct tctttcaccc atcacatctt tctctggctg
      421 aggtggagaa ttttgaggtt gtttccctgg atattactgg gttctctgat gattacttgt
      481 gtaacaatca tcccttcagc tattgggaat tacattcaaa ttcagttact caccatggag
      541 catctaccaa gaaacagcac tgtaactgac aaacttgaaa attttcatca gtatcagttc
      601 caggctcata cagttgcatt ggttattcct ttcatcctgt tcctggcctc caccatcttt
      661 ctcatggcat cactgaccaa gcagatacaa catcatagca ctggtcactg caatccaagc
      721 atgaaagcgc gcttcactgc cctgaggtcc cttgccgtct tatttattgt gtttacctct
      781 tactttctaa ccatactcat caccattata ggtactctat ttgataagag atgttggtta
      841 tgggtctggg aagcttttgt ctatgctttc atcttaatgc attccacttc actgatgctg
      901 agcagcccta cgttgaaaag gattctaaag ggaaagtgct aggcctagag gttgcctgag
      961 gcacaggata aaagactccc gagcaattga tataatt
//
