LOCUS       NM_023922               1854 bp    mRNA    linear   PRI 15-JUL-2024
DEFINITION  Homo sapiens taste 2 receptor member 14 (TAS2R14), mRNA.
ACCESSION   NM_023922
VERSION     NM_023922.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1854)
  AUTHORS   Hu,X., Ao,W., Gao,M., Wu,L., Pei,Y., Liu,S., Wu,Y., Zhao,F.,
            Sun,Q., Liu,J., Jiang,L., Wang,X., Li,Y., Tan,Q., Cheng,J.,
            Yang,F., Yang,C., Sun,J., Hua,T. and Liu,Z.J.
  TITLE     Bitter taste TAS2R14 activation by intracellular tastants and
            cholesterol
  JOURNAL   Nature 631 (8020), 459-466 (2024)
   PUBMED   38776963
  REMARK    GeneRIF: Bitter taste TAS2R14 activation by intracellular tastants
            and cholesterol.
REFERENCE   2  (bases 1 to 1854)
  AUTHORS   Woo,J.A., Castano,M., Kee,T.R., Lee,J., Koziol-White,C.J., An,S.S.,
            Kim,D., Kang,D.E. and Liggett,S.B.
  TITLE     A Par3/LIM Kinase/Cofilin Pathway Mediates Human Airway Smooth
            Muscle Relaxation by TAS2R14
  JOURNAL   Am J Respir Cell Mol Biol 68 (4), 417-429 (2023)
   PUBMED   36662576
  REMARK    GeneRIF: A Par3/LIM Kinase/Cofilin Pathway Mediates Human Airway
            Smooth Muscle Relaxation by TAS2R14.
REFERENCE   3  (bases 1 to 1854)
  AUTHORS   Zhao,W., Li,D., Wang,Y., Kan,R., Ji,H., Su,L., Yu,Z. and Li,J.
  TITLE     Identification and molecular docking of peptides from Mizuhopecten
            yessoensis myosin as human bitter taste receptor T2R14 blockers
  JOURNAL   Food Funct 12 (23), 11966-11973 (2021)
   PUBMED   34747964
  REMARK    GeneRIF: Identification and molecular docking of peptides from
            Mizuhopecten yessoensis myosin as human bitter taste receptor T2R14
            blockers.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1854)
  AUTHORS   Carey,R.M., Adappa,N.D., Palmer,J.N. and Lee,R.J.
  TITLE     Neuropeptide Y Reduces Nasal Epithelial T2R Bitter Taste
            Receptor-Stimulated Nitric Oxide Production
  JOURNAL   Nutrients 13 (10), 3392 (2021)
   PUBMED   34684394
  REMARK    GeneRIF: Neuropeptide Y Reduces Nasal Epithelial T2R Bitter Taste
            Receptor-Stimulated Nitric Oxide Production.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1854)
  AUTHORS   Medapati,M.R., Singh,N., Bhagirath,A.Y., Duan,K., Triggs-Raine,B.,
            Batista,E.L. Jr. and Chelikani,P.
  TITLE     Bitter taste receptor T2R14 detects quorum sensing molecules from
            cariogenic Streptococcus mutans and mediates innate immune
            responses in gingival epithelial cells
  JOURNAL   FASEB J 35 (3), e21375 (2021)
   PUBMED   33559200
  REMARK    GeneRIF: Bitter taste receptor T2R14 detects quorum sensing
            molecules from cariogenic Streptococcus mutans and mediates innate
            immune responses in gingival epithelial cells.
REFERENCE   6  (bases 1 to 1854)
  AUTHORS   Margolskee,R.F.
  TITLE     Molecular mechanisms of bitter and sweet taste transduction
  JOURNAL   J Biol Chem 277 (1), 1-4 (2002)
   PUBMED   11696554
  REMARK    Review article
REFERENCE   7  (bases 1 to 1854)
  AUTHORS   Matsunami,H., Montmayeur,J.P. and Buck,L.B.
  TITLE     A family of candidate taste receptors in human and mouse
  JOURNAL   Nature 404 (6778), 601-604 (2000)
   PUBMED   10766242
REFERENCE   8  (bases 1 to 1854)
  AUTHORS   Chandrashekar,J., Mueller,K.L., Hoon,M.A., Adler,E., Feng,L.,
            Guo,W., Zuker,C.S. and Ryba,N.J.
  TITLE     T2Rs function as bitter taste receptors
  JOURNAL   Cell 100 (6), 703-711 (2000)
   PUBMED   10761935
REFERENCE   9  (bases 1 to 1854)
  AUTHORS   Adler,E., Hoon,M.A., Mueller,K.L., Chandrashekar,J., Ryba,N.J. and
            Zuker,C.S.
  TITLE     A novel family of mammalian taste receptors
  JOURNAL   Cell 100 (6), 693-702 (2000)
   PUBMED   10761934
REFERENCE   10 (bases 1 to 1854)
  AUTHORS   Kinnamon,S.C.
  TITLE     A plethora of taste receptors
  JOURNAL   Neuron 25 (3), 507-510 (2000)
   PUBMED   10774719
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC006518.17.
            
            On Nov 11, 2021 this sequence version replaced NM_023922.1.
            
            Summary: This gene product belongs to the family of candidate taste
            receptors that are members of the G-protein-coupled receptor
            superfamily. These proteins are specifically expressed in the taste
            receptor cells of the tongue and palate epithelia. They are
            organized in the genome in clusters and are genetically linked to
            loci that influence bitter perception in mice and humans. In
            functional expression studies, they respond to bitter tastants.
            This gene maps to the taste receptor gene cluster on chromosome
            12p13. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC069148.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000537503.2/
                                                ENSP00000441949.1
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1854              AC006518.17        136321-138174       c
FEATURES             Location/Qualifiers
     source          1..1854
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.2"
     gene            1..1854
                     /gene="TAS2R14"
                     /gene_synonym="T2R14; TRB1"
                     /note="taste 2 receptor member 14"
                     /db_xref="GeneID:50840"
                     /db_xref="HGNC:HGNC:14920"
                     /db_xref="MIM:604790"
     exon            1..1854
                     /gene="TAS2R14"
                     /gene_synonym="T2R14; TRB1"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..1010
                     /gene="TAS2R14"
                     /gene_synonym="T2R14; TRB1"
                     /note="taste receptor, family B, member 1; taste receptor,
                     type 2, member 14"
                     /codon_start=1
                     /product="taste receptor type 2 member 14"
                     /protein_id="NP_076411.1"
                     /db_xref="CCDS:CCDS8637.1"
                     /db_xref="GeneID:50840"
                     /db_xref="HGNC:HGNC:14920"
                     /db_xref="MIM:604790"
                     /translation="MGGVIKSIFTFVLIVEFIIGNLGNSFIALVNCIDWVKGRKISSV
                     DRILTALAISRISLVWLIFGSWCVSVFFPALFATEKMFRMLTNIWTVINHFSVWLATG
                     LGTFYFLKIANFSNSIFLYLKWRVKKVVLVLLLVTSVFLFLNIALINIHINASINGYR
                     RNKTCSSDSSNFTRFSSLIVLTSTVFIFIPFTLSLAMFLLLIFSMWKHRKKMQHTVKI
                     SGDASTKAHRGVKSVITFFLLYAIFSLSFFISVWTSERLEENLIILSQVMGMAYPSCH
                     SCVLILGNKKLRQASLSVLLWLRYMFKDGEPSGHKEFRESS"
     regulatory      1832..1837
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TAS2R14"
                     /gene_synonym="T2R14; TRB1"
                     /note="hexamer: AATAAA"
     polyA_site      1854
                     /gene="TAS2R14"
                     /gene_synonym="T2R14; TRB1"
                     /note="major polyA site"
ORIGIN      
        1 tgcattaaga agtcttcagc agtgatatta gacattgggg catgctctta caggcaatgg
       61 gtggtgtcat aaagagcata tttacattcg ttttaattgt ggaatttata attggaaatt
      121 taggaaatag tttcatagca ctggtgaact gtattgactg ggtcaaggga agaaagatct
      181 cttcggttga tcggatcctc actgctttgg caatctctcg aattagcctg gtttggttaa
      241 tattcggaag ctggtgtgtg tctgtgtttt tcccagcttt atttgccact gaaaaaatgt
      301 tcagaatgct tactaatatc tggacagtga tcaatcattt tagtgtctgg ttagctacag
      361 gcctcggtac tttttatttt ctcaagatag ccaatttttc taactctatt tttctctacc
      421 taaagtggag ggttaaaaag gtggttttgg tgctgcttct tgtgacttcg gtcttcttgt
      481 ttttaaatat tgcactgata aacatccata taaatgccag tatcaatgga tacagaagaa
      541 acaagacttg cagttctgat tcaagtaact ttacacgatt ttccagtctt attgtattaa
      601 ccagcactgt gttcattttc atacccttta ctttgtccct ggcaatgttt cttctcctca
      661 tcttctccat gtggaaacat cgcaagaaga tgcagcacac tgtcaaaata tccggagacg
      721 ccagcaccaa agcccacaga ggagttaaaa gtgtgatcac tttcttccta ctctatgcca
      781 ttttctctct gtcttttttc atatcagttt ggacctctga aaggttggag gaaaatctaa
      841 ttattctttc ccaggtgatg ggaatggctt atccttcatg tcactcatgt gttctgattc
      901 ttggaaacaa gaagctgaga caggcctctc tgtcagtgct actgtggctg aggtacatgt
      961 tcaaagatgg ggagccctca ggtcacaaag aatttagaga atcatcttga atatattaga
     1021 aaaaaaatag ctcctaagaa attcttgtat gttatataaa tttatacttc cttaagattc
     1081 tttcattgtg tataactttg tgaattttac aaagatatgc ttggaatcaa caccatccaa
     1141 acatatcaca aattaggata tatgaaagta tgtatattac catacagaga agaatgcgaa
     1201 tactataaag agttcttata caaacagata atatagattt tgtatcaatc attcaccttt
     1261 tttgagattt ttaaatgaga aaacctataa tgtataaaat acatgtgtgt atgtatgtat
     1321 gtgacacagt tactaaaaat aggcttctta aacttacatc tcaatctggt agataaagta
     1381 cataaaagaa tatggaattt tagtacctat attaagtgtt tttaattttt gtataatatt
     1441 tagtacctga ttagcgtgta tgcaaaaaag taatttgctt cgtttgttga attagaagcc
     1501 agctgcctta ctaaactacc acatttgctt tgctcattct cttggctttg cagatagaaa
     1561 attatatcat ctgcatatag tgacttataa tgattatttt acttctccat tttactactt
     1621 gtaattcttt tttggtatca gttgtataat gaaatggttt gaacattcaa agtgttaagt
     1681 aatcctgatc gtaactgctg tctttgcaaa tggagtgttt tctagtgttt taacaataaa
     1741 cgtaatactg actctagctt tgagataaat tcttttaaaa atattcttca gggagaatat
     1801 ttgtttccta tcttcctgtg tatagtattg taataaaatc tctgttaaaa acta
//
