LOCUS       NM_023920               1637 bp    mRNA    linear   PRI 02-JUN-2024
DEFINITION  Homo sapiens taste 2 receptor member 13 (TAS2R13), mRNA.
ACCESSION   NM_023920
VERSION     NM_023920.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1637)
  AUTHORS   Szczepaniak,O., Jokiel,M., Stuper-Szablewska,K., Szymanowska,D.,
            Dziedzinski,M. and Kobus-Cisowska,J.
  TITLE     Can cornelian cherry mask bitter taste of probiotic chocolate?
            Human TAS2R receptors and a sensory study with comprehensive
            characterisation of new functional product
  JOURNAL   PLoS One 16 (2), e0243871 (2021)
   PUBMED   33556063
  REMARK    GeneRIF: Can cornelian cherry mask bitter taste of probiotic
            chocolate? Human TAS2R receptors and a sensory study with
            comprehensive characterisation of new functional product.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1637)
  AUTHORS   Allen,A.L., McGeary,J.E. and Hayes,J.E.
  TITLE     Polymorphisms in TRPV1 and TAS2Rs associate with sensations from
            sampled ethanol
  JOURNAL   Alcohol Clin Exp Res 38 (10), 2550-2560 (2014)
   PUBMED   25257701
  REMARK    GeneRIF: Genetic variation in TRPV1 and TAS2Rs influence sensations
            from sampled EtOH and may potentially influence how individuals
            initially respond to alcoholic beverages.
REFERENCE   3  (bases 1 to 1637)
  AUTHORS   Zhang,X., Bedigian,A.V., Wang,W. and Eggert,U.S.
  TITLE     G protein-coupled receptors participate in cytokinesis
  JOURNAL   Cytoskeleton (Hoboken) 69 (10), 810-818 (2012)
   PUBMED   22888021
REFERENCE   4  (bases 1 to 1637)
  AUTHORS   Dotson,C.D., Wallace,M.R., Bartoshuk,L.M. and Logan,H.L.
  TITLE     Variation in the gene TAS2R13 is associated with differences in
            alcohol consumption in patients with head and neck cancer
  JOURNAL   Chem Senses 37 (8), 737-744 (2012)
   PUBMED   22824251
  REMARK    GeneRIF: It found a single nucleotide polymorphism (SNP) located
            within the TAS2R13 gene, which showed a significant association
            with measures of alcohol consumption assessed via the Alcohol Use
            Disorders Identification Test (AUDIT).
REFERENCE   5  (bases 1 to 1637)
  AUTHORS   Meyerhof,W., Batram,C., Kuhn,C., Brockhoff,A., Chudoba,E., Bufe,B.,
            Appendino,G. and Behrens,M.
  TITLE     The molecular receptive ranges of human TAS2R bitter taste
            receptors
  JOURNAL   Chem Senses 35 (2), 157-170 (2010)
   PUBMED   20022913
REFERENCE   6  (bases 1 to 1637)
  AUTHORS   Margolskee,R.F.
  TITLE     Molecular mechanisms of bitter and sweet taste transduction
  JOURNAL   J Biol Chem 277 (1), 1-4 (2002)
   PUBMED   11696554
  REMARK    Review article
REFERENCE   7  (bases 1 to 1637)
  AUTHORS   Matsunami,H., Montmayeur,J.P. and Buck,L.B.
  TITLE     A family of candidate taste receptors in human and mouse
  JOURNAL   Nature 404 (6778), 601-604 (2000)
   PUBMED   10766242
REFERENCE   8  (bases 1 to 1637)
  AUTHORS   Chandrashekar,J., Mueller,K.L., Hoon,M.A., Adler,E., Feng,L.,
            Guo,W., Zuker,C.S. and Ryba,N.J.
  TITLE     T2Rs function as bitter taste receptors
  JOURNAL   Cell 100 (6), 703-711 (2000)
   PUBMED   10761935
REFERENCE   9  (bases 1 to 1637)
  AUTHORS   Adler,E., Hoon,M.A., Mueller,K.L., Chandrashekar,J., Ryba,N.J. and
            Zuker,C.S.
  TITLE     A novel family of mammalian taste receptors
  JOURNAL   Cell 100 (6), 693-702 (2000)
   PUBMED   10761934
REFERENCE   10 (bases 1 to 1637)
  AUTHORS   Kinnamon,S.C.
  TITLE     A plethora of taste receptors
  JOURNAL   Neuron 25 (3), 507-510 (2000)
   PUBMED   10774719
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC095518.1 and AC006518.17.
            
            On Jun 17, 2005 this sequence version replaced NM_023920.1.
            
            Summary: This gene product belongs to the family of candidate taste
            receptors that are members of the G-protein-coupled receptor
            superfamily. These proteins are specifically expressed in the taste
            receptor cells of the tongue and palate epithelia. They are
            organized in the genome in clusters and are genetically linked to
            loci that influence bitter perception in mice and humans. In
            functional expression studies, they respond to bitter tastants.
            This gene maps to the taste receptor gene cluster on chromosome
            12p13. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC095518.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000390677.2/ ENSP00000375095.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1025              BC095518.1         1-1025
            1026-1637           AC006518.17        106837-107448       c
FEATURES             Location/Qualifiers
     source          1..1637
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.2"
     gene            1..1637
                     /gene="TAS2R13"
                     /gene_synonym="T2R13; TRB3"
                     /note="taste 2 receptor member 13"
                     /db_xref="GeneID:50838"
                     /db_xref="HGNC:HGNC:14919"
                     /db_xref="MIM:604792"
     exon            1..1637
                     /gene="TAS2R13"
                     /gene_synonym="T2R13; TRB3"
                     /inference="alignment:Splign:2.1.0"
     CDS             265..1176
                     /gene="TAS2R13"
                     /gene_synonym="T2R13; TRB3"
                     /note="taste receptor, family B, member 3; taste receptor,
                     type 2, member 13"
                     /codon_start=1
                     /product="taste receptor type 2 member 13"
                     /protein_id="NP_076409.1"
                     /db_xref="CCDS:CCDS8635.1"
                     /db_xref="GeneID:50838"
                     /db_xref="HGNC:HGNC:14919"
                     /db_xref="MIM:604792"
                     /translation="MESALPSIFTLVIIAEFIIGNLSNGFIVLINCIDWVSKRELSSV
                     DKLLIILAISRIGLIWEILVSWFLALHYLAIFVSGTGLRIMIFSWIVSNHFNLWLATI
                     FSIFYLLKIASFSSPAFLYLKWRVNKVILMILLGTLVFLFLNLIQINMHIKDWLDRYE
                     RNTTWNFSMSDFETFSVSVKFTMTMFSLTPFTVAFISFLLLIFSLQKHLQKMQLNYKG
                     HRDPRTKVHTNALKIVISFLLFYASFFLCVLISWISELYQNTVIYMLCETIGVFSPSS
                     HSFLLILGNAKLRQAFLLVAAKVWAKR"
ORIGIN      
        1 tctgcccatg gtgaagacat aaatatctta gctagggctc agcagagaaa ttgaagaaaa
       61 ataaagatat caccagaaca gttatgtgaa gatcgatcag caaactttag agatttctgc
      121 tttgacgttg agccaacaat gaaagaagga gcagaaaaag gagaaggaag aagaactcca
      181 ctggacactc aaggatgtga atagcatttt agatcagtga ataaccagca gtgacattag
      241 acattgaact ttctctgttc tgacatggaa agtgccctgc cgagtatctt cactcttgta
      301 ataattgcag aattcataat tgggaatttg agcaatggat ttatagtact gatcaactgc
      361 attgactggg tcagtaaaag agagctgtcc tcagtcgata aactcctcat tatcttggca
      421 atctccagaa ttgggctgat ctgggaaata ttagtaagtt ggtttttagc tctgcattat
      481 ctagccatat ttgtgtctgg aacaggatta agaattatga tttttagctg gatagtttct
      541 aatcacttca atctctggct tgctacaatc ttcagcatct tttatttgct caaaatagcg
      601 agtttctcta gccctgcttt tctctatttg aagtggagag taaacaaagt gattctgatg
      661 atactgctag gaaccttggt cttcttattt ttaaatctga tacaaataaa catgcatata
      721 aaagactggc tggaccgata tgaaagaaac acaacttgga atttcagtat gagtgacttt
      781 gaaacatttt cagtgtcggt caaattcact atgactatgt tcagtctaac accatttact
      841 gtggccttca tctcttttct cctgttaatt ttctccctgc agaaacatct ccagaaaatg
      901 caactcaatt acaaaggaca cagagacccc aggaccaagg tccatacaaa tgccttgaaa
      961 attgtgatct cattcctttt attctatgct agtttctttc tatgtgttct catatcatgg
     1021 atttctgagc tgtatcagaa cacagtgatc tacatgcttt gtgagacgat tggagtcttc
     1081 tctccttcaa gccactcctt tcttctgatt ctaggaaacg ctaagttaag acaggccttt
     1141 cttttggtgg cagctaaggt atgggctaaa cgatgagaaa ctcacaattt cataagccat
     1201 tcagaccaca gattattgaa tattgcagac agaaacagga gtctacaagg agtttaaaag
     1261 atattttatg cttcccctgg tttcttttat tgtgaaggtc actgtaaatg ttttaaattc
     1321 ttctctataa tagcatctta cctaagaata ttatgtattt atgacatgta tttctacatt
     1381 attaggaatt tgaaacttat ttgaggaaat tattggcaga ttctattgta aattaaaaac
     1441 atatactaca gcatacttag atgttaattg taaatctaca atcttttgtt tggcaatggc
     1501 tcttcaattc taaatcattc attgagatgg gtgatttagg taattatttt attatctcaa
     1561 gtactcctat ttaaatggtg agctacagat aattagaaca gttatttgga atagaattag
     1621 ggaagtttgg acttgcc
//
