LOCUS       NM_023921               1140 bp    mRNA    linear   PRI 12-JUN-2024
DEFINITION  Homo sapiens taste 2 receptor member 10 (TAS2R10), mRNA.
ACCESSION   NM_023921
VERSION     NM_023921.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1140)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1140)
  AUTHORS   Seo,Y., Kim,Y.S., Lee,K.E., Park,T.H. and Kim,Y.
  TITLE     Anti-cancer stemness and anti-invasive activity of bitter taste
            receptors, TAS2R8 and TAS2R10, in human neuroblastoma cells
  JOURNAL   PLoS One 12 (5), e0176851 (2017)
   PUBMED   28467517
  REMARK    GeneRIF: targets cancer stem cells by suppressing cancer stemness
            characteristics and neuroblastoma cell invasion
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1140)
  AUTHORS   Born,S., Levit,A., Niv,M.Y., Meyerhof,W. and Behrens,M.
  TITLE     The human bitter taste receptor TAS2R10 is tailored to accommodate
            numerous diverse ligands
  JOURNAL   J Neurosci 33 (1), 201-213 (2013)
   PUBMED   23283334
  REMARK    GeneRIF: The human bitter taste receptor TAS2R10 is tailored to
            accommodate numerous diverse ligands
REFERENCE   4  (bases 1 to 1140)
  AUTHORS   Meyerhof,W., Batram,C., Kuhn,C., Brockhoff,A., Chudoba,E., Bufe,B.,
            Appendino,G. and Behrens,M.
  TITLE     The molecular receptive ranges of human TAS2R bitter taste
            receptors
  JOURNAL   Chem Senses 35 (2), 157-170 (2010)
   PUBMED   20022913
REFERENCE   5  (bases 1 to 1140)
  AUTHORS   Mueller,K.L., Hoon,M.A., Erlenbach,I., Chandrashekar,J., Zuker,C.S.
            and Ryba,N.J.
  TITLE     The receptors and coding logic for bitter taste
  JOURNAL   Nature 434 (7030), 225-229 (2005)
   PUBMED   15759003
  REMARK    Erratum:[Nature. 2007 Mar 15;446(7133):342]
REFERENCE   6  (bases 1 to 1140)
  AUTHORS   Margolskee,R.F.
  TITLE     Molecular mechanisms of bitter and sweet taste transduction
  JOURNAL   J Biol Chem 277 (1), 1-4 (2002)
   PUBMED   11696554
  REMARK    Review article
REFERENCE   7  (bases 1 to 1140)
  AUTHORS   Matsunami,H., Montmayeur,J.P. and Buck,L.B.
  TITLE     A family of candidate taste receptors in human and mouse
  JOURNAL   Nature 404 (6778), 601-604 (2000)
   PUBMED   10766242
REFERENCE   8  (bases 1 to 1140)
  AUTHORS   Chandrashekar,J., Mueller,K.L., Hoon,M.A., Adler,E., Feng,L.,
            Guo,W., Zuker,C.S. and Ryba,N.J.
  TITLE     T2Rs function as bitter taste receptors
  JOURNAL   Cell 100 (6), 703-711 (2000)
   PUBMED   10761935
REFERENCE   9  (bases 1 to 1140)
  AUTHORS   Adler,E., Hoon,M.A., Mueller,K.L., Chandrashekar,J., Ryba,N.J. and
            Zuker,C.S.
  TITLE     A novel family of mammalian taste receptors
  JOURNAL   Cell 100 (6), 693-702 (2000)
   PUBMED   10761934
REFERENCE   10 (bases 1 to 1140)
  AUTHORS   Kinnamon,S.C.
  TITLE     A plethora of taste receptors
  JOURNAL   Neuron 25 (3), 507-510 (2000)
   PUBMED   10774719
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC006518.17.
            
            On Nov 18, 2021 this sequence version replaced NM_023921.1.
            
            Summary: This gene product belongs to the family of candidate taste
            receptors that are members of the G-protein-coupled receptor
            superfamily. These proteins are specifically expressed in the taste
            receptor cells of the tongue and palate epithelia. They are
            organized in the genome in clusters and are genetically linked to
            loci that influence bitter perception in mice and humans. In
            functional expression studies, they respond to bitter tastants.
            This gene maps to the taste receptor gene cluster on chromosome
            12p13. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC101764.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000240619.3/ ENSP00000240619.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1140              AC006518.17        24130-25269         c
FEATURES             Location/Qualifiers
     source          1..1140
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.2"
     gene            1..1140
                     /gene="TAS2R10"
                     /gene_synonym="T2R10; TRB2"
                     /note="taste 2 receptor member 10"
                     /db_xref="GeneID:50839"
                     /db_xref="HGNC:HGNC:14918"
                     /db_xref="MIM:604791"
     exon            1..1140
                     /gene="TAS2R10"
                     /gene_synonym="T2R10; TRB2"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..1013
                     /gene="TAS2R10"
                     /gene_synonym="T2R10; TRB2"
                     /note="taste receptor, family B, member 2; taste receptor,
                     type 2, member 10"
                     /codon_start=1
                     /product="taste receptor type 2 member 10"
                     /protein_id="NP_076410.1"
                     /db_xref="CCDS:CCDS8634.1"
                     /db_xref="GeneID:50839"
                     /db_xref="HGNC:HGNC:14918"
                     /db_xref="MIM:604791"
                     /translation="MLRVVEGIFIFVVVSESVFGVLGNGFIGLVNCIDCAKNKLSTIG
                     FILTGLAISRIFLIWIIITDGFIQIFSPNIYASGNLIEYISYFWVIGNQSSMWFATSL
                     SIFYFLKIANFSNYIFLWLKSRTNMVLPFMIVFLLISSLLNFAYIAKILNDYKTKNDT
                     VWDLNMYKSEYFIKQILLNLGVIFFFTLSLITCIFLIISLWRHNRQMQSNVTGLRDSN
                     TEAHVKAMKVLISFIILFILYFIGMAIEISCFTVRENKLLLMFGMTTTAIYPWGHSFI
                     LILGNSKLKQASLRVLQQLKCCEKRKNLRVT"
     regulatory      1119..1124
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TAS2R10"
                     /gene_synonym="T2R10; TRB2"
                     /note="hexamer: ATTAAA"
     polyA_site      1140
                     /gene="TAS2R10"
                     /gene_synonym="T2R10; TRB2"
                     /note="major polyA site"
ORIGIN      
        1 cacttccgtc gagcagccaa tatatgcctc attctgcagc aggtaatcta agatagatgt
       61 aacagaagca atattaagaa ttagcagata tgctacgtgt agtggaaggc atcttcattt
      121 ttgttgtagt tagtgagtca gtgtttgggg ttttggggaa tggatttatt ggacttgtaa
      181 actgcattga ctgtgccaag aataagttat ctacgattgg ctttattctc accggcttag
      241 ctatttcaag aatttttctg atatggataa taattacaga tggatttata cagatattct
      301 ctccaaatat atatgcctcc ggtaacctaa ttgaatatat tagttacttt tgggtaattg
      361 gtaatcaatc aagtatgtgg tttgccacca gcctcagcat cttctatttc ctgaagatag
      421 caaatttttc caactacata tttctctggt tgaagagcag aacaaatatg gttcttccct
      481 tcatgatagt attcttactt atttcatcgt tacttaattt tgcatacatt gcgaagattc
      541 ttaatgatta taaaacgaag aatgacacag tctgggatct caacatgtat aaaagtgaat
      601 actttattaa acagattttg ctaaatctgg gagtcatttt cttctttaca ctatccctaa
      661 ttacatgtat ttttttaatc atttcccttt ggagacacaa caggcagatg caatcgaatg
      721 tgacaggatt gagagactcc aacacagaag ctcatgtgaa ggcaatgaaa gttttgatat
      781 ctttcatcat cctctttatc ttgtatttta taggcatggc catagaaata tcatgtttta
      841 ctgtgcgaga aaacaaactg ctgcttatgt ttggaatgac aaccacagcc atctatccct
      901 ggggtcactc atttatctta attctaggaa acagcaagct aaagcaagcc tctttgaggg
      961 tactgcagca attgaagtgc tgtgagaaaa ggaaaaatct cagagtcaca tagacacctt
     1021 gggaagagat ggatgttcca cgaaaggaat ccagtgaata aatccttgaa gatctgtttc
     1081 attgcactgc attcttgcat tgtcttttta actgtgtcat taaagatcac tgaaatcttc
//
