LOCUS       NM_019599               3005 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens taste 2 receptor member 1 (TAS2R1), transcript variant
            1, mRNA.
ACCESSION   NM_019599
VERSION     NM_019599.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3005)
  AUTHORS   Kang,W., Wang,Y., Li,J., Xie,W., Zhao,D., Wu,L., Wang,H. and Xie,S.
  TITLE     TAS2R supports odontoblastic differentiation of human dental pulp
            stem cells in the inflammatory microenvironment
  JOURNAL   Stem Cell Res Ther 13 (1), 374 (2022)
   PUBMED   35902880
  REMARK    GeneRIF: TAS2R supports odontoblastic differentiation of human
            dental pulp stem cells in the inflammatory microenvironment.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3005)
  AUTHORS   Watanabe,L.M., Pires,I.F., Noronha,N.Y., Pinhel,M.A.S. and
            Nonino,C.B.
  TITLE     The influence of bitter-taste receptor (TAS2R) expression in
            pharmacological response to Chloroquine in obese patients with
            COVID-19
  JOURNAL   Clinics (Sao Paulo) 75, e2181 (2020)
   PUBMED   32876108
  REMARK    GeneRIF: The influence of bitter-taste receptor (TAS2R) expression
            in pharmacological response to Chloroquine in obese patients with
            COVID-19.
REFERENCE   3  (bases 1 to 3005)
  AUTHORS   Sharma,P., Panebra,A., Pera,T., Tiegs,B.C., Hershfeld,A.,
            Kenyon,L.C. and Deshpande,D.A.
  TITLE     Antimitogenic effect of bitter taste receptor agonists on airway
            smooth muscle cells
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 310 (4), L365-L376 (2016)
   PUBMED   26684251
  REMARK    GeneRIF: TAS2R agonists block signaling downstream of
            phosphatidylinositol 3-kinase
REFERENCE   4  (bases 1 to 3005)
  AUTHORS   Wolfle,U., Elsholz,F.A., Kersten,A., Haarhaus,B., Muller,W.E. and
            Schempp,C.M.
  TITLE     Expression and functional activity of the bitter taste receptors
            TAS2R1 and TAS2R38 in human keratinocytes
  JOURNAL   Skin Pharmacol Physiol 28 (3), 137-146 (2015)
   PUBMED   25573083
  REMARK    GeneRIF: Expression and functional activity of the bitter taste
            receptors TAS2R1 and TAS2R38 in human keratinocytes
REFERENCE   5  (bases 1 to 3005)
  AUTHORS   Khor,S.S., Miyagawa,T., Toyoda,H., Yamasaki,M., Kawamura,Y.,
            Tanii,H., Okazaki,Y., Sasaki,T., Lin,L., Faraco,J., Rico,T.,
            Honda,Y., Honda,M., Mignot,E. and Tokunaga,K.
  TITLE     Genome-wide association study of HLA-DQB1*06:02 negative essential
            hypersomnia
  JOURNAL   PeerJ 1, e66 (2013)
   PUBMED   23646285
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3005)
  AUTHORS   Matsunami,H., Montmayeur,J.P. and Buck,L.B.
  TITLE     A family of candidate taste receptors in human and mouse
  JOURNAL   Nature 404 (6778), 601-604 (2000)
   PUBMED   10766242
REFERENCE   7  (bases 1 to 3005)
  AUTHORS   Firestein,S.
  TITLE     The good taste of genomics
  JOURNAL   Nature 404 (6778), 552-553 (2000)
   PUBMED   10766221
REFERENCE   8  (bases 1 to 3005)
  AUTHORS   Chandrashekar,J., Mueller,K.L., Hoon,M.A., Adler,E., Feng,L.,
            Guo,W., Zuker,C.S. and Ryba,N.J.
  TITLE     T2Rs function as bitter taste receptors
  JOURNAL   Cell 100 (6), 703-711 (2000)
   PUBMED   10761935
REFERENCE   9  (bases 1 to 3005)
  AUTHORS   Adler,E., Hoon,M.A., Mueller,K.L., Chandrashekar,J., Ryba,N.J. and
            Zuker,C.S.
  TITLE     A novel family of mammalian taste receptors
  JOURNAL   Cell 100 (6), 693-702 (2000)
   PUBMED   10761934
REFERENCE   10 (bases 1 to 3005)
  AUTHORS   Kinnamon,S.C.
  TITLE     A plethora of taste receptors
  JOURNAL   Neuron 25 (3), 507-510 (2000)
   PUBMED   10774719
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC034214.5.
            
            On Nov 21, 2019 this sequence version replaced NM_019599.2.
            
            Summary: This gene encodes a member of a family of candidate taste
            receptors that are members of the G protein-coupled receptor
            superfamily and that are specifically expressed by taste receptor
            cells of the tongue and palate epithelia. This intronless taste
            receptor gene encodes a 7-transmembrane receptor protein,
            functioning as a bitter taste receptor. This gene is mapped to
            chromosome 5p15, the location of a genetic locus (PROP) that
            controls the detection of the bitter compound
            6-n-propyl-2-thiouracil. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC095521.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000382492.4/ ENSP00000371932.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3005              AC034214.5         4435-7439
FEATURES             Location/Qualifiers
     source          1..3005
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p15.31-p15.2"
     gene            1..3005
                     /gene="TAS2R1"
                     /gene_synonym="T2R1; TRB7"
                     /note="taste 2 receptor member 1"
                     /db_xref="GeneID:50834"
                     /db_xref="HGNC:HGNC:14909"
                     /db_xref="MIM:604796"
     exon            1..3005
                     /gene="TAS2R1"
                     /gene_synonym="T2R1; TRB7"
                     /inference="alignment:Splign:2.1.0"
     CDS             320..1219
                     /gene="TAS2R1"
                     /gene_synonym="T2R1; TRB7"
                     /note="isoform 1 is encoded by transcript variant 1; taste
                     receptor, family B, member 7; taste receptor, type 2,
                     member 1"
                     /codon_start=1
                     /product="taste receptor type 2 member 1 isoform 1"
                     /protein_id="NP_062545.1"
                     /db_xref="CCDS:CCDS3876.1"
                     /db_xref="GeneID:50834"
                     /db_xref="HGNC:HGNC:14909"
                     /db_xref="MIM:604796"
                     /translation="MLESHLIIYFLLAVIQFLLGIFTNGIIVVVNGIDLIKHRKMAPL
                     DLLLSCLAVSRIFLQLFIFYVNVIVIFFIEFIMCSANCAILLFINELELWLATWLGVF
                     YCAKVASVRHPLFIWLKMRISKLVPWMILGSLLYVSMICVFHSKYAGFMVPYFLRKFF
                     SQNATIQKEDTLAIQIFSFVAEFSVPLLIFLFAVLLLIFSLGRHTRQMRNTVAGSRVP
                     GRGAPISALLSILSFLILYFSHCMIKVFLSSLKFHIRRFIFLFFILVIGIYPSGHSLI
                     LILGNPKLKQNAKKFLLHSKCCQ"
     regulatory      1565..1570
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TAS2R1"
                     /gene_synonym="T2R1; TRB7"
                     /note="hexamer: ATTAAA"
     polyA_site      1589
                     /gene="TAS2R1"
                     /gene_synonym="T2R1; TRB7"
                     /note="major polyA site"
     regulatory      2984..2989
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TAS2R1"
                     /gene_synonym="T2R1; TRB7"
                     /note="hexamer: AATAAA"
     polyA_site      3004
                     /gene="TAS2R1"
                     /gene_synonym="T2R1; TRB7"
ORIGIN      
        1 ttctcccagc tgtctgaagg tgtctgattc cattatttgc ctgtgatgac tttgaaagct
       61 aggtaaacct gtaaaatgca aaagccatca ataagaagca aattgatgct agagtatctc
      121 ctccttattt gactgtctca gaactaaata gagaaagcag tgacataaac aaatgtacac
      181 caccttcctg ccccatgcct ttattgttag tcttcttccc cagaggagtc ctgatctaat
      241 tgaagagcgt gaacaaccca acctgtccaa aactttataa cttcattatt ttttaagtaa
      301 ataatttttt attcctaaaa tgctagagtc tcacctcatt atctattttc ttcttgcagt
      361 gatacaattt cttcttggga ttttcacaaa tggcatcatt gtggtggtga atggcattga
      421 cttgatcaag cacagaaaaa tggctccgct ggatctcctt ctttcttgtc tggcagtttc
      481 tagaattttt ctgcagttgt tcatcttcta cgttaatgtg attgttatct tcttcataga
      541 attcatcatg tgttctgcga attgtgcaat tctcttattt ataaatgaat tggaactttg
      601 gcttgccaca tggctcggcg ttttctattg tgccaaggtt gccagcgtcc gtcacccact
      661 cttcatctgg ttgaagatga ggatatccaa gctggtccca tggatgatcc tggggtctct
      721 gctatatgta tctatgattt gtgttttcca tagcaaatat gcagggttta tggtcccata
      781 cttcctaagg aaatttttct cccaaaatgc cacaattcaa aaagaagata cactggctat
      841 acagattttc tcttttgttg ctgagttctc agtgccattg cttatcttcc tttttgctgt
      901 tttgctcttg attttctctc tggggaggca cacccggcaa atgagaaaca cagtggccgg
      961 cagcagggtt cctggcaggg gtgcacccat cagcgcgttg ctgtctatcc tgtccttcct
     1021 gatcctctac ttctcccact gcatgataaa agtttttctc tcttctctaa agtttcacat
     1081 cagaaggttc atctttctgt tcttcatcct tgtgattggt atataccctt ctggacactc
     1141 tctcatctta attttaggaa atcctaaatt gaaacaaaat gcaaaaaagt tcctcctcca
     1201 cagtaagtgc tgtcagtgag agagaagttg gatcagttca aagaacccat gattcaatga
     1261 tttacccatg cctgccacac ttccctcagc cagacaaagc agcctgttca taaatataca
     1321 acatgtcccc ttcaggcctg tttatccagc ctgaggtatt tctgtggata tgctactttt
     1381 tcaagcagtt aaactgattt tgaaagcaca acatatgttg atggattaca tcaatttcaa
     1441 tatcctggta gtgatattgt actatcatcg tgcaagttgt taccattggg aaaactgagt
     1501 aaatggttca gggtctttct gtattccttc ttacaaatgc attcaaatct acaattattt
     1561 caaaattaaa agtttgatga aaaagaaaag cacttgtttg aactcgtgat gtcagaagga
     1621 cacatgaatg ctgtatggtc catgaatatc tgacgccttg tctttgatgg tttttcctga
     1681 ccttaacggg ctgactgttc atttcttgtc tacctggata ttatttctgt tctgtctgtt
     1741 ggagttgcag gcagtggagc cattctttct cctcagatca caaaggaagc aaggacaagc
     1801 aggccttctc catccttata agcatattct cctacttcat cctgcagaga gcctagatgc
     1861 catggtgaca tggccaatca actgataaag gggaagacag atggaggagg aggaggagta
     1921 gaggactgaa tgcctgtttt ccatttctcc tagctgtgca ctctgaacag acaataactt
     1981 gcaaagatgt tttattttgt atttgtgtgc ctgactttga gaccctttca acccagagtg
     2041 gtaatttgga actcctcctg cattgcctgt cttcccaatg aagcaacatc agtaggtggg
     2101 tggggctggg ggtgtctccg tctgcttcaa gtcacaaatg cattttctgt ttggttgaga
     2161 ttttgaatac taagagatag atagatagat agatagatag atagatagat agatagatag
     2221 ataaattatg gagatagata tacttgtata tttccaaaac agcttcagaa ccattttgct
     2281 tccagacaag taaatgaagt aaaaaatgtt cttaagctca gcggtaactt gtagttcagg
     2341 cgtgatgatg caaagcaggt ttaggtttag atttttcaat caccagtaat aggaacccaa
     2401 atacagcttt tctaacccaa gccacgcagg cctggttata atacaccaat gaaggatttt
     2461 gcttcaggag attcagggac gtacttatct tcttgggcat gggaactaag ctctgagtgt
     2521 actctcaact tcccacaggt ttcacacttc attccccaag gagcaaaatg acagcctcca
     2581 tcttcctgct atttcatttt cccacgtccc actaggtagg aaggtttgta gctaatcacg
     2641 cactcaggaa gccagctgtg ggaagatcag ttgtatcctg ggtgtaatta ttgcttctga
     2701 atgggggaaa ggacaatgaa aagtcacttt tctttttctc aagttcagag aatattctgt
     2761 tccttgaatc tgtgatacgt gtacctgaaa gagtgggagc aatttcaaac attcagggag
     2821 aaatttgtca tgatacaact ctcatgtgtt tttttttctg atactaaatt ctgattctat
     2881 ttcatgcaac tcctgcttta ataacgttag ctaattagat aactattaag atatgactag
     2941 gtttttatac tgttatcaag aaatgtttaa aaaaagaatt cataataaaa caattctaaa
     3001 aacat
//
