LOCUS       NM_152228               3475 bp    mRNA    linear   PRI 03-SEP-2023
DEFINITION  Homo sapiens taste 1 receptor member 3 (TAS1R3), mRNA.
ACCESSION   NM_152228 XM_371210
VERSION     NM_152228.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3475)
  AUTHORS   Ball L, Bauer J and Krautwurst D.
  TITLE     Heterodimerization of Chemoreceptors TAS1R3 and mGlu2 in Human
            Blood Leukocytes
  JOURNAL   Int J Mol Sci 24 (16), 12942 (2023)
   PUBMED   37629122
  REMARK    GeneRIF: Heterodimerization of Chemoreceptors TAS1R3 and mGlu2 in
            Human Blood Leukocytes.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3475)
  AUTHORS   Sanematsu K, Yamamoto M, Nagasato Y, Kawabata Y, Watanabe Y, Iwata
            S, Takai S, Toko K, Matsui T, Wada N and Shigemura N.
  TITLE     Prediction of dynamic allostery for the transmembrane domain of the
            sweet taste receptor subunit, TAS1R3
  JOURNAL   Commun Biol 6 (1), 340 (2023)
   PUBMED   37012338
  REMARK    GeneRIF: Prediction of dynamic allostery for the transmembrane
            domain of the sweet taste receptor subunit, TAS1R3.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3475)
  AUTHORS   Cecati M, Vignini A, Borroni F, Pugnaloni S, Alia S, Sabbatinelli
            J, Nicolai G, Taus M, Santarelli A, Fabri M, Mazzanti L and
            Emanuelli M.
  TITLE     TAS1R3 and TAS2R38 Polymorphisms Affect Sweet Taste Perception: An
            Observational Study on Healthy and Obese Subjects
  JOURNAL   Nutrients 14 (9), 1711 (2022)
   PUBMED   35565677
  REMARK    GeneRIF: TAS1R3 and TAS2R38 Polymorphisms Affect Sweet Taste
            Perception: An Observational Study on Healthy and Obese Subjects.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3475)
  AUTHORS   Chandrashekar J, Hoon MA, Ryba NJ and Zuker CS.
  TITLE     The receptors and cells for mammalian taste
  JOURNAL   Nature 444 (7117), 288-294 (2006)
   PUBMED   17108952
  REMARK    Review article
REFERENCE   5  (bases 1 to 3475)
  AUTHORS   Xu H, Staszewski L, Tang H, Adler E, Zoller M and Li X.
  TITLE     Different functional roles of T1R subunits in the heteromeric taste
            receptors
  JOURNAL   Proc Natl Acad Sci U S A 101 (39), 14258-14263 (2004)
   PUBMED   15353592
  REMARK    GeneRIF: findings demonstrate the different functional roles of
            T1R3 and T1R2 and the presence of multiple ligand binding sites on
            the sweet taste receptor
REFERENCE   6  (bases 1 to 3475)
  AUTHORS   Spadaccini R, Trabucco F, Saviano G, Picone D, Crescenzi O,
            Tancredi T and Temussi PA.
  TITLE     The mechanism of interaction of sweet proteins with the T1R2-T1R3
            receptor: evidence from the solution structure of G16A-MNEI
  JOURNAL   J Mol Biol 328 (3), 683-692 (2003)
   PUBMED   12706725
  REMARK    GeneRIF: The mechanism of interaction of the sweet protein monellin
            with T1R2-T1R3 receptor.
REFERENCE   7  (bases 1 to 3475)
  AUTHORS   Li X, Staszewski L, Xu H, Durick K, Zoller M and Adler E.
  TITLE     Human receptors for sweet and umami taste
  JOURNAL   Proc Natl Acad Sci U S A 99 (7), 4692-4696 (2002)
   PUBMED   11917125
REFERENCE   8  (bases 1 to 3475)
  AUTHORS   Nelson G, Chandrashekar J, Hoon MA, Feng L, Zhao G, Ryba NJ and
            Zuker CS.
  TITLE     An amino-acid taste receptor
  JOURNAL   Nature 416 (6877), 199-202 (2002)
   PUBMED   11894099
  REMARK    GeneRIF: sequence differences in T1R receptors within and between
            species (human and mouse) can significantly influence the
            selectivity and specificity of taste responses
REFERENCE   9  (bases 1 to 3475)
  AUTHORS   Max M, Shanker YG, Huang L, Rong M, Liu Z, Campagne F, Weinstein H,
            Damak S and Margolskee RF.
  TITLE     Tas1r3, encoding a new candidate taste receptor, is allelic to the
            sweet responsiveness locus Sac
  JOURNAL   Nat Genet 28 (1), 58-63 (2001)
   PUBMED   11326277
REFERENCE   10 (bases 1 to 3475)
  AUTHORS   Montmayeur JP, Liberles SD, Matsunami H and Buck LB.
  TITLE     A candidate taste receptor gene near a sweet taste locus
  JOURNAL   Nat Neurosci 4 (5), 492-498 (2001)
   PUBMED   11319557
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL139287.24.
            
            On Nov 23, 2018 this sequence version replaced NM_152228.2.
            
            Summary: The protein encoded by this gene is a G-protein coupled
            receptor involved in taste responses. The encoded protein can form
            a heterodimeric receptor with TAS1R1 to elicit the umami taste
            response, or it can bind with TAS1R2 to form a receptor for the
            sweet taste response. [provided by RefSeq, Nov 2015].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BK000152.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000339381.6/ ENSP00000344411.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-257               AL139287.24        31233-31489
            258-558             AL139287.24        31591-31891
            559-1341            AL139287.24        31977-32759
            1342-1545           AL139287.24        32874-33077
            1546-1666           AL139287.24        33212-33332
            1667-3475           AL139287.24        33459-35267
FEATURES             Location/Qualifiers
     source          1..3475
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.33"
     gene            1..3475
                     /gene="TAS1R3"
                     /gene_synonym="T1R3"
                     /note="taste 1 receptor member 3"
                     /db_xref="GeneID:83756"
                     /db_xref="HGNC:HGNC:15661"
                     /db_xref="MIM:605865"
     exon            1..257
                     /gene="TAS1R3"
                     /gene_synonym="T1R3"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..2625
                     /gene="TAS1R3"
                     /gene_synonym="T1R3"
                     /note="sweet taste receptor T1R3; taste receptor, type 1,
                     member 3"
                     /codon_start=1
                     /product="taste receptor type 1 member 3 precursor"
                     /protein_id="NP_689414.2"
                     /db_xref="CCDS:CCDS30556.1"
                     /db_xref="GeneID:83756"
                     /db_xref="HGNC:HGNC:15661"
                     /db_xref="MIM:605865"
                     /translation="MLGPAVLGLSLWALLHPGTGAPLCLSQQLRMKGDYVLGGLFPLG
                     EAEEAGLRSRTRPSSPVCTRFSSNGLLWALAMKMAVEEINNKSDLLPGLRLGYDLFDT
                     CSEPVVAMKPSLMFLAKAGSRDIAAYCNYTQYQPRVLAVIGPHSSELAMVTGKFFSFF
                     LMPQVSYGASMELLSARETFPSFFRTVPSDRVQLTAAAELLQEFGWNWVAALGSDDEY
                     GRQGLSIFSALAAARGICIAHEGLVPLPRADDSRLGKVQDVLHQVNQSSVQVVLLFAS
                     VHAAHALFNYSISSRLSPKVWVASEAWLTSDLVMGLPGMAQMGTVLGFLQRGAQLHEF
                     PQYVKTHLALATDPAFCSALGEREQGLEEDVVGQRCPQCDCITLQNVSAGLNHHQTFS
                     VYAAVYSVAQALHNTLQCNASGCPAQDPVKPWQLLENMYNLTFHVGGLPLRFDSSGNV
                     DMEYDLKLWVWQGSVPRLHDVGRFNGSLRTERLKIRWHTSDNQKPVSRCSRQCQEGQV
                     RRVKGFHSCCYDCVDCEAGSYRQNPDDIACTFCGQDEWSPERSTRCFRRRSRFLAWGE
                     PAVLLLLLLLSLALGLVLAALGLFVHHRDSPLVQASGGPLACFGLVCLGLVCLSVLLF
                     PGQPSPARCLAQQPLSHLPLTGCLSTLFLQAAEIFVESELPLSWADRLSGCLRGPWAW
                     LVVLLAMLVEVALCTWYLVAFPPEVVTDWHMLPTEALVHCRTRSWVSFGLAHATNATL
                     AFLCFLGTFLVRSQPGCYNRARGLTFAMLAYFITWVSFVPLLANVQVVLRPAVQMGAL
                     LLCVLGILAAFHLPRCYLLMRQPGLNTPEFFLGGGPGDAQGQNDGNTGNQGKHE"
     exon            258..558
                     /gene="TAS1R3"
                     /gene_synonym="T1R3"
                     /inference="alignment:Splign:2.1.0"
     exon            559..1341
                     /gene="TAS1R3"
                     /gene_synonym="T1R3"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1545
                     /gene="TAS1R3"
                     /gene_synonym="T1R3"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1666
                     /gene="TAS1R3"
                     /gene_synonym="T1R3"
                     /inference="alignment:Splign:2.1.0"
     exon            1667..3475
                     /gene="TAS1R3"
                     /gene_synonym="T1R3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3448..3453
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TAS1R3"
                     /gene_synonym="T1R3"
                     /note="hexamer: ATTAAA"
     polyA_site      3475
                     /gene="TAS1R3"
                     /gene_synonym="T1R3"
                     /note="major polyA site"
ORIGIN      
        1 gctcactcca tgtgaggccc cagtcggggc agccacctgc cgtgcctgtt ggaagttgcc
       61 tctgccatgc tgggccctgc tgtcctgggc ctcagcctct gggctctcct gcaccctggg
      121 acgggggccc cattgtgcct gtcacagcaa cttaggatga agggggacta cgtgctgggg
      181 gggctgttcc ccctgggcga ggccgaggag gctggcctcc gcagccggac acggcccagc
      241 agccctgtgt gcaccaggtt ctcctcaaac ggcctgctct gggcactggc catgaaaatg
      301 gccgtggagg agatcaacaa caagtcggat ctgctgcccg ggctgcgcct gggctacgac
      361 ctctttgata cgtgctcgga gcctgtggtg gccatgaagc ccagcctcat gttcctggcc
      421 aaggcaggca gccgcgacat cgccgcctac tgcaactaca cgcagtacca gccccgtgtg
      481 ctggctgtca tcgggcccca ctcgtcagag ctcgccatgg tcaccggcaa gttcttcagc
      541 ttcttcctca tgccccaggt cagctacggt gctagcatgg agctgctgag cgcccgggag
      601 accttcccct ccttcttccg caccgtgccc agcgaccgtg tgcagctgac ggccgccgcg
      661 gagctgctgc aggagttcgg ctggaactgg gtggccgccc tgggcagcga cgacgagtac
      721 ggccggcagg gcctgagcat cttctcggcc ctggccgcgg cacgcggcat ctgcatcgcg
      781 cacgagggcc tggtgccgct gccccgtgcc gatgactcgc ggctggggaa ggtgcaggac
      841 gtcctgcacc aggtgaacca gagcagcgtg caggtggtgc tgctgttcgc ctccgtgcac
      901 gccgcccacg ccctcttcaa ctacagcatc agcagcaggc tctcgcccaa ggtgtgggtg
      961 gccagcgagg cctggctgac ctctgacctg gtcatggggc tgcccggcat ggcccagatg
     1021 ggcacggtgc ttggcttcct ccagaggggt gcccagctgc acgagttccc ccagtacgtg
     1081 aagacgcacc tggccctggc caccgacccg gccttctgct ctgccctggg cgagagggag
     1141 cagggtctgg aggaggacgt ggtgggccag cgctgcccgc agtgtgactg catcacgctg
     1201 cagaacgtga gcgcagggct aaatcaccac cagacgttct ctgtctacgc agctgtgtat
     1261 agcgtggccc aggccctgca caacactctt cagtgcaacg cctcaggctg ccccgcgcag
     1321 gaccccgtga agccctggca gctcctggag aacatgtaca acctgacctt ccacgtgggc
     1381 gggctgccgc tgcggttcga cagcagcgga aacgtggaca tggagtacga cctgaagctg
     1441 tgggtgtggc agggctcagt gcccaggctc cacgacgtgg gcaggttcaa cggcagcctc
     1501 aggacagagc gcctgaagat ccgctggcac acgtctgaca accagaagcc cgtgtcccgg
     1561 tgctcgcggc agtgccagga gggccaggtg cgccgggtca aggggttcca ctcctgctgc
     1621 tacgactgtg tggactgcga ggcgggcagc taccggcaaa acccagacga catcgcctgc
     1681 accttttgtg gccaggatga gtggtccccg gagcgaagca cacgctgctt ccgccgcagg
     1741 tctcggttcc tggcatgggg cgagccggct gtgctgctgc tgctcctgct gctgagcctg
     1801 gcgctgggcc ttgtgctggc tgctttgggg ctgttcgttc accatcggga cagcccactg
     1861 gttcaggcct cgggggggcc cctggcctgc tttggcctgg tgtgcctggg cctggtctgc
     1921 ctcagcgtcc tcctgttccc tggccagccc agccctgccc gatgcctggc ccagcagccc
     1981 ttgtcccacc tcccgctcac gggctgcctg agcacactct tcctgcaggc ggccgagatc
     2041 ttcgtggagt cagaactgcc tctgagctgg gcagaccggc tgagtggctg cctgcggggg
     2101 ccctgggcct ggctggtggt gctgctggcc atgctggtgg aggtcgcact gtgcacctgg
     2161 tacctggtgg ccttcccgcc ggaggtggtg acggactggc acatgctgcc cacggaggcg
     2221 ctggtgcact gccgcacacg ctcctgggtc agcttcggcc tagcgcacgc caccaatgcc
     2281 acgctggcct ttctctgctt cctgggcact ttcctggtgc ggagccagcc gggctgctac
     2341 aaccgtgccc gtggcctcac ctttgccatg ctggcctact tcatcacctg ggtctccttt
     2401 gtgcccctcc tggccaatgt gcaggtggtc ctcaggcccg ccgtgcagat gggcgccctc
     2461 ctgctctgtg tcctgggcat cctggctgcc ttccacctgc ccaggtgtta cctgctcatg
     2521 cggcagccag ggctcaacac ccccgagttc ttcctgggag ggggccctgg ggatgcccaa
     2581 ggccagaatg acgggaacac aggaaatcag gggaaacatg agtgacccaa ccctgtgatc
     2641 tcagccccgg tgaacccaga cttagctgcg atccccccca agccagcaat gacccgtgtc
     2701 tcgctacaga gaccctcccg ctctaggttc tgaccccagg ttgtctcctg accctgaccc
     2761 cacagtgagc cctaggcctg gagcacgtgg acacccctgt gaccatctgg gccccagagc
     2821 caagctgtgt ccctgtccct ctgtgcccag accaggcctg cccaggtaac ccagacccac
     2881 tgttctggaa agaggcccgg agggctccca gggtacccgc aacccacacc gtgagctcag
     2941 gaaaaggacg cagggaggcc ccggccagat ggctggaagc ccaaatcagg ccctgccgac
     3001 ctgaccatgt cccaccaggg cccccatcct gcaccctgcc aggcaccaca gcagtgggag
     3061 gccaggtggg ggcacacagg catatgccca gggcagagcc cgccgaggta ggggtggcac
     3121 ccagcttcct actctgccct ttgcccagtg ggtagacagc atcatgactg tcaccagtac
     3181 cagggacaga gcccaggtgg ggtgggggcg gggtccagca ccacggccag caccgaccac
     3241 caggaccccg gagccagcac catggacaga aaactgccca ccaggatctg acgccagcac
     3301 gccgccaggc ccacacaggg tctccggtca gagtcccagg gtcagctccc agcagggcct
     3361 aggggaggct ggaccagctc cctgtgcctc attccaaggc agcccagccg gagagaaggg
     3421 gcacaggcca cacatctgtc ccataaaatt aaacgctttt tagtgtttaa aataa
//
