LOCUS       NM_152232               2520 bp    mRNA    linear   PRI 11-SEP-2024
DEFINITION  Homo sapiens taste 1 receptor member 2 (TAS1R2), mRNA.
ACCESSION   NM_152232 XM_938914
VERSION     NM_152232.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2520)
  AUTHORS   Li,Y., Pan,J., Li,H., Liu,Q., Ma,F., Xiao,L. and Zeng,X.
  TITLE     Association between LTF/MMP20/CA6/TAS1R2 polymorphisms and
            susceptibility to dental caries
  JOURNAL   Clin Oral Investig 28 (9), 508 (2024)
   PUBMED   39212776
  REMARK    GeneRIF: Association between LTF/MMP20/CA6/TAS1R2 polymorphisms and
            susceptibility to dental caries.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2520)
  AUTHORS   Hoti,Q., Akan,G., Tuncel,G., Evren,E.U., Evren,H., Suer,K.,
            Sanlidag,T. and Ergoren,M.C.
  TITLE     Altered expression levels of TAS1R2 and TAS1R3 genes among
            SARS-CoV-2 variants of concerns
  JOURNAL   Mol Biol Rep 50 (11), 9343-9351 (2023)
   PUBMED   37817023
  REMARK    GeneRIF: Altered expression levels of TAS1R2 and TAS1R3 genes among
            SARS-CoV-2 variants of concerns.
REFERENCE   3  (bases 1 to 2520)
  AUTHORS   Liang,Y., Yao,J., Qiu,R., Chen,A., Huang,H., Lin,H. and Yu,L.
  TITLE     The rs35874116 single nucleotide polymorphism increases sweet
            intake and the risk of severe early childhood caries: a
            case-control study
  JOURNAL   BMC Oral Health 22 (1), 471 (2022)
   PUBMED   36335309
  REMARK    GeneRIF: The rs35874116 single nucleotide polymorphism increases
            sweet intake and the risk of severe early childhood caries: a
            case-control study.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2520)
  AUTHORS   Chandrashekar,J., Hoon,M.A., Ryba,N.J. and Zuker,C.S.
  TITLE     The receptors and cells for mammalian taste
  JOURNAL   Nature 444 (7117), 288-294 (2006)
   PUBMED   17108952
  REMARK    Review article
REFERENCE   5  (bases 1 to 2520)
  AUTHORS   Galindo-Cuspinera,V., Winnig,M., Bufe,B., Meyerhof,W. and
            Breslin,P.A.
  TITLE     A TAS1R receptor-based explanation of sweet 'water-taste'
  JOURNAL   Nature 441 (7091), 354-357 (2006)
   PUBMED   16633339
  REMARK    GeneRIF: water rinses remove the inhibitor from the heteromeric
            sweetener receptor TAS1R2-TAS1R3, which activates cells and results
            in the perception of strong sweetness from pure water
REFERENCE   6  (bases 1 to 2520)
  AUTHORS   Zhao,G.Q., Zhang,Y., Hoon,M.A., Chandrashekar,J., Erlenbach,I.,
            Ryba,N.J. and Zuker,C.S.
  TITLE     The receptors for mammalian sweet and umami taste
  JOURNAL   Cell 115 (3), 255-266 (2003)
   PUBMED   14636554
  REMARK    GeneRIF: sweet and umami taste are strictly dependent on
            T1R-receptors, and show that selective elimination of T1R-subunits
            differentially abolishes detection and perception of these two
            taste modalities
REFERENCE   7  (bases 1 to 2520)
  AUTHORS   Spadaccini,R., Trabucco,F., Saviano,G., Picone,D., Crescenzi,O.,
            Tancredi,T. and Temussi,P.A.
  TITLE     The mechanism of interaction of sweet proteins with the T1R2-T1R3
            receptor: evidence from the solution structure of G16A-MNEI
  JOURNAL   J Mol Biol 328 (3), 683-692 (2003)
   PUBMED   12706725
  REMARK    GeneRIF: The mechanism of interaction of the sweet protein monellin
            with the T1R2-T1R3 receptor.
REFERENCE   8  (bases 1 to 2520)
  AUTHORS   Liao,J. and Schultz,P.G.
  TITLE     Three sweet receptor genes are clustered in human chromosome 1
  JOURNAL   Mamm Genome 14 (5), 291-301 (2003)
   PUBMED   12856281
REFERENCE   9  (bases 1 to 2520)
  AUTHORS   Li,X., Staszewski,L., Xu,H., Durick,K., Zoller,M. and Adler,E.
  TITLE     Human receptors for sweet and umami taste
  JOURNAL   Proc Natl Acad Sci U S A 99 (7), 4692-4696 (2002)
   PUBMED   11917125
REFERENCE   10 (bases 1 to 2520)
  AUTHORS   Hoon,M.A., Adler,E., Lindemeier,J., Battey,J.F., Ryba,N.J. and
            Zuker,C.S.
  TITLE     Putative mammalian taste receptors: a class of taste-specific GPCRs
            with distinct topographic selectivity
  JOURNAL   Cell 96 (4), 541-551 (1999)
   PUBMED   10052456
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX537160.6 and AL831755.9.
            
            On Nov 11, 2021 this sequence version replaced NM_152232.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BK000151.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA2151887
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375371.4/ ENSP00000364520.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-182               BX537160.6         4829-5010           c
            183-483             BX537160.6         2681-2981           c
            484-1257            AL831755.9         89404-90177         c
            1258-1467           AL831755.9         84532-84741         c
            1468-1591           AL831755.9         76920-77043         c
            1592-2520           AL831755.9         74790-75718         c
FEATURES             Location/Qualifiers
     source          1..2520
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.13"
     gene            1..2520
                     /gene="TAS1R2"
                     /gene_synonym="GPR71; T1R2; TR2"
                     /note="taste 1 receptor member 2"
                     /db_xref="GeneID:80834"
                     /db_xref="HGNC:HGNC:14905"
                     /db_xref="MIM:606226"
     CDS             1..2520
                     /gene="TAS1R2"
                     /gene_synonym="GPR71; T1R2; TR2"
                     /note="sweet taste receptor T1R2; G-protein coupled
                     receptor 71; taste receptor, type 1, member 2"
                     /codon_start=1
                     /product="taste receptor type 1 member 2 precursor"
                     /protein_id="NP_689418.2"
                     /db_xref="CCDS:CCDS187.1"
                     /db_xref="GeneID:80834"
                     /db_xref="HGNC:HGNC:14905"
                     /db_xref="MIM:606226"
                     /translation="MGPRAKTISSLFFLLWVLAEPAENSDFYLPGDYLLGGLFSLHAN
                     MKGIVHLNFLQVPMCKEYEVKVIGYNLMQAMRFAVEEINNDSSLLPGVLLGYEIVDVC
                     YISNNVQPVLYFLAHEDNLLPIQEDYSNYISRVVAVIGPDNSESVMTVANFLSLFLLP
                     QITYSAISDELRDKVRFPALLRTTPSADHHIEAMVQLMLHFRWNWIIVLVSSDTYGRD
                     NGQLLGERVARRDICIAFQETLPTLQPNQNMTSEERQRLVTIVDKLQQSTARVVVVFS
                     PDLTLYHFFNEVLRQNFTGAVWIASESWAIDPVLHNLTELRHLGTFLGITIQSVPIPG
                     FSEFREWGPQAGPPPLSRTSQSYTCNQECDNCLNATLSFNTILRLSGERVVYSVYSAV
                     YAVAHALHSLLGCDKSTCTKRVVYPWQLLEEIWKVNFTLLDHQIFFDPQGDVALHLEI
                     VQWQWDRSQNPFQSVASYYPLQRQLKNIQDISWHTINNTIPMSMCSKRCQSGQKKKPV
                     GIHVCCFECIDCLPGTFLNHTEDEYECQACPNNEWSYQSETSCFKRQLVFLEWHEAPT
                     IAVALLAALGFLSTLAILVIFWRHFQTPIVRSAGGPMCFLMLTLLLVAYMVVPVYVGP
                     PKVSTCLCRQALFPLCFTICISCIAVRSFQIVCAFKMASRFPRAYSYWVRYQGPYVSM
                     AFITVLKMVIVVIGMLATGLSPTTRTDPDDPKITIVSCNPNYRNSLLFNTSLDLLLSV
                     VGFSFAYMGKELPTNYNEAKFITLSMTFYFTSSVSLCTFMSAYSGVLVTIVDLLVTVL
                     NLLAISLGYFGPKCYMILFYPERNTPAYFNSMIQGYTMRRD"
     exon            1..182
                     /gene="TAS1R2"
                     /gene_synonym="GPR71; T1R2; TR2"
                     /inference="alignment:Splign:2.1.0"
     exon            183..483
                     /gene="TAS1R2"
                     /gene_synonym="GPR71; T1R2; TR2"
                     /inference="alignment:Splign:2.1.0"
     exon            484..1257
                     /gene="TAS1R2"
                     /gene_synonym="GPR71; T1R2; TR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1467
                     /gene="TAS1R2"
                     /gene_synonym="GPR71; T1R2; TR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1591
                     /gene="TAS1R2"
                     /gene_synonym="GPR71; T1R2; TR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1592..2520
                     /gene="TAS1R2"
                     /gene_synonym="GPR71; T1R2; TR2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggggccca gggcaaagac catctcctcc ctgttcttcc tcctatgggt cctggctgag
       61 ccggctgaga actcggactt ctacctgcct ggggattacc tcctgggtgg cctcttctcc
      121 ctccatgcca acatgaaggg cattgttcac cttaacttcc tgcaggtgcc catgtgcaag
      181 gagtatgaag tgaaggtgat aggctacaac ctcatgcagg ccatgcgctt tgcggtggag
      241 gagatcaaca atgacagcag cctgctgcct ggtgtgctgc tgggctatga gatcgtggat
      301 gtgtgctaca tctccaacaa tgtccagccg gtgctctact tcctggcaca cgaggacaac
      361 ctccttccca tccaagagga ctacagtaac tacatttccc gtgtggtggc tgtcattggc
      421 cctgacaact ccgagtctgt catgactgtg gccaacttcc tctccctatt tctccttcca
      481 cagatcacct acagcgccat cagcgatgag ctgcgagaca aggtgcgctt cccggctttg
      541 ctgcgtacca cacccagcgc cgaccaccac atcgaggcca tggtgcagct gatgctgcac
      601 ttccgctgga actggatcat tgtgctggtg agcagcgaca cctatggccg cgacaatggc
      661 cagctgcttg gcgagcgcgt ggcccggcgc gacatctgca tcgccttcca ggagacgctg
      721 cccacactgc agcccaacca gaacatgacg tcagaggagc gccagcgcct ggtgaccatt
      781 gtggacaagc tgcagcagag cacagcgcgc gtcgtggtcg tgttctcgcc cgacctgacc
      841 ctgtaccact tcttcaatga ggtgctgcgc cagaacttca ctggcgccgt gtggatcgcc
      901 tccgagtcct gggccatcga cccggtcctg cacaacctca cggagctgcg ccacttgggc
      961 accttcctgg gcatcaccat ccagagcgtg cccatcccgg gcttcagtga gttccgcgag
     1021 tggggcccac aggctgggcc gccacccctc agcaggacca gccagagcta tacctgcaac
     1081 caggagtgcg acaactgcct gaacgccacc ttgtccttca acaccattct caggctctct
     1141 ggggagcgtg tcgtctacag cgtgtactct gcggtctatg ctgtggccca tgccctgcac
     1201 agcctcctcg gctgtgacaa aagcacctgc accaagaggg tggtctaccc ctggcagctg
     1261 cttgaggaga tctggaaggt caacttcact ctcctggacc accaaatctt cttcgacccg
     1321 caaggggacg tggctctgca cttggagatt gtccagtggc aatgggaccg gagccagaat
     1381 cccttccaga gcgtcgcctc ctactacccc ctgcagcgac agctgaagaa catccaagac
     1441 atctcctggc acaccatcaa caacacgatc cctatgtcca tgtgttccaa gaggtgccag
     1501 tcagggcaaa agaagaagcc tgtgggcatc cacgtctgct gcttcgagtg catcgactgc
     1561 cttcccggca ccttcctcaa ccacactgaa gatgaatatg aatgccaggc ctgcccgaat
     1621 aacgagtggt cctaccagag tgagacctcc tgcttcaagc ggcagctggt cttcctggaa
     1681 tggcatgagg cacccaccat cgctgtggcc ctgctggccg ccctgggctt cctcagcacc
     1741 ctggccatcc tggtgatatt ctggaggcac ttccagacac ccatagttcg ctcggctggg
     1801 ggccccatgt gcttcctgat gctgacactg ctgctggtgg catacatggt ggtcccggtg
     1861 tacgtggggc cgcccaaggt ctccacctgc ctctgccgcc aggccctctt tcccctctgc
     1921 ttcacaatct gcatctcctg tatcgccgtg cgttctttcc agatcgtctg cgccttcaag
     1981 atggccagcc gcttcccacg cgcctacagc tactgggtcc gctaccaggg gccctacgtc
     2041 tctatggcat ttatcacggt actcaaaatg gtcattgtgg taattggcat gctggccacg
     2101 ggcctcagtc ccaccacccg tactgacccc gatgacccca agatcacaat tgtctcctgt
     2161 aaccccaact accgcaacag cctgctgttc aacaccagcc tggacctgct gctctcagtg
     2221 gtgggtttca gcttcgccta catgggcaaa gagctgccca ccaactacaa cgaggccaag
     2281 ttcatcaccc tcagcatgac cttctatttc acctcatccg tctccctctg caccttcatg
     2341 tctgcctaca gcggggtgct ggtcaccatc gtggacctct tggtcactgt gctcaacctc
     2401 ctggccatca gcctgggcta cttcggcccc aagtgctaca tgatcctctt ctacccggag
     2461 cgcaacacgc ccgcctactt caacagcatg atccagggct acaccatgag gagggactag
//
