LOCUS       NM_138697               2764 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens taste 1 receptor member 1 (TAS1R1), transcript variant
            2, mRNA.
ACCESSION   NM_138697
VERSION     NM_138697.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2764)
  AUTHORS   Stavrou,M.R., So,S.S., Finch,A.M., Ballouz,S. and Smith,N.J.
  TITLE     Gene expression analyses of TAS1R taste receptors relevant to the
            treatment of cardiometabolic disease
  JOURNAL   Chem Senses 48 (2023)
   PUBMED   37539767
  REMARK    GeneRIF: Gene expression analyses of TAS1R taste receptors relevant
            to the treatment of cardiometabolic disease.
REFERENCE   2  (bases 1 to 2764)
  AUTHORS   Farinella,R., Erbi,I., Bedini,A., Donato,S., Gentiluomo,M.,
            Angelucci,C., Lupetti,A., Cuttano,A., Moscuzza,F., Tuoni,C.,
            Rizzato,C., Ciantelli,M. and Campa,D.
  TITLE     Polymorphic variants in Sweet and Umami taste receptor genes and
            birthweight
  JOURNAL   Sci Rep 11 (1), 4971 (2021)
   PUBMED   33654187
  REMARK    GeneRIF: Polymorphic variants in Sweet and Umami taste receptor
            genes and birthweight.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2764)
  AUTHORS   Arid,J., Antunes,L.A.A., Koch,L.F.A., Evangelista,S.S.,
            Vasconcelos,K.R.F., Brancher,J.A., Gabardo,M.C.L., Milani,A.J.,
            Dutra,A.L.T., Antunes,L.S., Vieira,A.R., Feltrin-Souza,J. and
            KUchler,E.C.
  TITLE     Association of taste receptor gene polymorphisms with dental caries
  JOURNAL   Braz Oral Res 34, e055 (2020)
   PUBMED   32578798
  REMARK    GeneRIF: Association of taste receptor gene polymorphisms with
            dental caries.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2764)
  AUTHORS   Chandrashekar,J., Hoon,M.A., Ryba,N.J. and Zuker,C.S.
  TITLE     The receptors and cells for mammalian taste
  JOURNAL   Nature 444 (7117), 288-294 (2006)
   PUBMED   17108952
  REMARK    Review article
REFERENCE   5  (bases 1 to 2764)
  AUTHORS   Xu,H., Staszewski,L., Tang,H., Adler,E., Zoller,M. and Li,X.
  TITLE     Different functional roles of T1R subunits in the heteromeric taste
            receptors
  JOURNAL   Proc Natl Acad Sci U S A 101 (39), 14258-14263 (2004)
   PUBMED   15353592
  REMARK    GeneRIF: findings demonstrate the different functional roles of
            T1R3 and T1R2 and the presence of multiple ligand binding sites on
            the sweet taste receptor
REFERENCE   6  (bases 1 to 2764)
  AUTHORS   Liao,J. and Schultz,P.G.
  TITLE     Three sweet receptor genes are clustered in human chromosome 1
  JOURNAL   Mamm Genome 14 (5), 291-301 (2003)
   PUBMED   12856281
REFERENCE   7  (bases 1 to 2764)
  AUTHORS   Li,X., Staszewski,L., Xu,H., Durick,K., Zoller,M. and Adler,E.
  TITLE     Human receptors for sweet and umami taste
  JOURNAL   Proc Natl Acad Sci U S A 99 (7), 4692-4696 (2002)
   PUBMED   11917125
REFERENCE   8  (bases 1 to 2764)
  AUTHORS   Nelson,G., Chandrashekar,J., Hoon,M.A., Feng,L., Zhao,G., Ryba,N.J.
            and Zuker,C.S.
  TITLE     An amino-acid taste receptor
  JOURNAL   Nature 416 (6877), 199-202 (2002)
   PUBMED   11894099
  REMARK    GeneRIF: sequence differences in T1R receptors within and between
            species (human and mouse) can significantly influence the
            selectivity and specificity of taste responses
REFERENCE   9  (bases 1 to 2764)
  AUTHORS   Makalowska,I., Sood,R., Faruque,M.U., Hu,P., Robbins,C.M.,
            Eddings,E.M., Mestre,J.D., Baxevanis,A.D. and Carpten,J.D.
  TITLE     Identification of six novel genes by experimental validation of
            GeneMachine predicted genes
  JOURNAL   Gene 284 (1-2), 203-213 (2002)
   PUBMED   11891061
REFERENCE   10 (bases 1 to 2764)
  AUTHORS   Hoon,M.A., Adler,E., Lindemeier,J., Battey,J.F., Ryba,N.J. and
            Zuker,C.S.
  TITLE     Putative mammalian taste receptors: a class of taste-specific GPCRs
            with distinct topographic selectivity
  JOURNAL   Cell 96 (4), 541-551 (1999)
   PUBMED   10052456
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC136515.1, BC136516.1,
            AL591866.13 and AI742401.1.
            
            On Nov 23, 2018 this sequence version replaced NM_138697.3.
            
            Summary: The protein encoded by this gene is a G protein-coupled
            receptor and is a component of the heterodimeric amino acid taste
            receptor T1R1+3. The T1R1+3 receptor responds to L-amino acids but
            not to D-enantiomers or other compounds. Most amino acids that are
            perceived as sweet activate T1R1+3, and this activation is strictly
            dependent on an intact T1R1+3 heterodimer. Multiple transcript
            variants encoding different isoforms have been found for this gene.
            [provided by RefSeq, Jun 2010].
            
            Transcript Variant: This variant (2) represents the longer
            transcript and encodes the longer isoform (b).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC136515.1, AK315805.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148874
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000333172.11/ ENSP00000331867.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-87                BC136515.1         30-116
            88-1105             BC136516.1         116-1133
            1106-1106           AL591866.13        72361-72361
            1107-2731           BC136516.1         1135-2759
            2732-2754           AI742401.1         21-43               c
            2755-2757           AL591866.13        76936-76938
            2758-2764           AI742401.1         11-17               c
FEATURES             Location/Qualifiers
     source          1..2764
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.31"
     gene            1..2764
                     /gene="TAS1R1"
                     /gene_synonym="GM148; GPR70; T1R1; TR1"
                     /note="taste 1 receptor member 1"
                     /db_xref="GeneID:80835"
                     /db_xref="HGNC:HGNC:14448"
                     /db_xref="MIM:606225"
     exon            1..258
                     /gene="TAS1R1"
                     /gene_synonym="GM148; GPR70; T1R1; TR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..2593
                     /gene="TAS1R1"
                     /gene_synonym="GM148; GPR70; T1R1; TR1"
                     /note="isoform b precursor is encoded by transcript
                     variant 2; seven transmembrane helix receptor; G-protein
                     coupled receptor 70; taste receptor, type 1, member 1"
                     /codon_start=1
                     /product="taste receptor type 1 member 1 isoform b
                     precursor"
                     /protein_id="NP_619642.2"
                     /db_xref="CCDS:CCDS81.1"
                     /db_xref="GeneID:80835"
                     /db_xref="HGNC:HGNC:14448"
                     /db_xref="MIM:606225"
                     /translation="MLLCTARLVGLQLLISCCWAFACHSTESSPDFTLPGDYLLAGLF
                     PLHSGCLQVRHRPEVTLCDRSCSFNEHGYHLFQAMRLGVEEINNSTALLPNITLGYQL
                     YDVCSDSANVYATLRVLSLPGQHHIELQGDLLHYSPTVLAVIGPDSTNRAATTAALLS
                     PFLVPMISYAASSETLSVKRQYPSFLRTIPNDKYQVETMVLLLQKFGWTWISLVGSSD
                     DYGQLGVQALENQATGQGICIAFKDIMPFSAQVGDERMQCLMRHLAQAGATVVVVFSS
                     RQLARVFFESVVLTNLTGKVWVASEAWALSRHITGVPGIQRIGMVLGVAIQKRAVPGL
                     KAFEEAYARADKKAPRPCHKGSWCSSNQLCRECQAFMAHTMPKLKAFSMSSAYNAYRA
                     VYAVAHGLHQLLGCASGACSRGRVYPWQLLEQIHKVHFLLHKDTVAFNDNRDPLSSYN
                     IIAWDWNGPKWTFTVLGSSTWSPVQLNINETKIQWHGKDNQVPKSVCSSDCLEGHQRV
                     VTGFHHCCFECVPCGAGTFLNKSDLYRCQPCGKEEWAPEGSQTCFPRTVVFLALREHT
                     SWVLLAANTLLLLLLLGTAGLFAWHLDTPVVRSAGGRLCFLMLGSLAAGSGSLYGFFG
                     EPTRPACLLRQALFALGFTIFLSCLTVRSFQLIIIFKFSTKVPTFYHAWVQNHGAGLF
                     VMISSAAQLLICLTWLVVWTPLPAREYQRFPHLVMLECTETNSLGFILAFLYNGLLSI
                     SAFACSYLGKDLPENYNEAKCVTFSLLFNFVSWIAFFTTASVYDGKYLPAANMMAGLS
                     SLSSGFGGYFLPKCYVILCRPDLNSTEHFQASIQDYTRRCGST"
     exon            259..565
                     /gene="TAS1R1"
                     /gene_synonym="GM148; GPR70; T1R1; TR1"
                     /inference="alignment:Splign:2.1.0"
     exon            566..1327
                     /gene="TAS1R1"
                     /gene_synonym="GM148; GPR70; T1R1; TR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1540
                     /gene="TAS1R1"
                     /gene_synonym="GM148; GPR70; T1R1; TR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1541..1661
                     /gene="TAS1R1"
                     /gene_synonym="GM148; GPR70; T1R1; TR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1662..2764
                     /gene="TAS1R1"
                     /gene_synonym="GM148; GPR70; T1R1; TR1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2746..2751
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TAS1R1"
                     /gene_synonym="GM148; GPR70; T1R1; TR1"
                     /note="hexamer: AATAAA"
     polyA_site      2764
                     /gene="TAS1R1"
                     /gene_synonym="GM148; GPR70; T1R1; TR1"
                     /note="major polyA site"
ORIGIN      
        1 ctatttaagc aactggcctc cttagaggcc actccttggc catgccaggc gcgggcatct
       61 ggccagcatg ctgctctgca cggctcgcct ggtcggcctg cagcttctca tttcctgctg
      121 ctgggccttt gcctgccata gcacggagtc ttctcctgac ttcaccctcc ccggagatta
      181 cctcctggca ggcctgttcc ctctccattc tggctgtctg caggtgaggc acagacccga
      241 ggtgaccctg tgtgacaggt cttgtagctt caatgagcat ggctaccacc tcttccaggc
      301 tatgcggctt ggggttgagg agataaacaa ctccacggcc ctgctgccca acatcaccct
      361 ggggtaccag ctgtatgatg tgtgttctga ctctgccaat gtgtatgcca cgctgagagt
      421 gctctccctg ccagggcaac accacataga gctccaagga gaccttctcc actattcccc
      481 tacggtgctg gcagtgattg ggcctgacag caccaaccgt gctgccacca cagccgccct
      541 gctgagccct ttcctggtgc ccatgattag ctatgcggcc agcagcgaga cgctcagcgt
      601 gaagcggcag tatccctctt tcctgcgcac catccccaat gacaagtacc aggtggagac
      661 catggtgctg ctgctgcaga agttcgggtg gacctggatc tctctggttg gcagcagtga
      721 cgactatggg cagctagggg tgcaggcact ggagaaccag gccactggtc aggggatctg
      781 cattgctttc aaggacatca tgcccttctc tgcccaggtg ggcgatgaga ggatgcagtg
      841 cctcatgcgc cacctggccc aggccggggc caccgtcgtg gttgtttttt ccagccggca
      901 gttggccagg gtgtttttcg agtccgtggt gctgaccaac ctgactggca aggtgtgggt
      961 cgcctcagaa gcctgggccc tctccaggca catcactggg gtgcccggga tccagcgcat
     1021 tgggatggtg ctgggcgtgg ccatccagaa gagggctgtc cctggcctga aggcgtttga
     1081 agaagcctat gcccgggcag acaagaaggc ccctaggcct tgccacaagg gctcctggtg
     1141 cagcagcaat cagctctgca gagaatgcca agctttcatg gcacacacga tgcccaagct
     1201 caaagccttc tccatgagtt ctgcctacaa cgcataccgg gctgtgtatg cggtggccca
     1261 tggcctccac cagctcctgg gctgtgcctc tggagcttgt tccaggggcc gagtctaccc
     1321 ctggcagctt ttggagcaga tccacaaggt gcatttcctt ctacacaagg acactgtggc
     1381 gtttaatgac aacagagatc ccctcagtag ctataacata attgcctggg actggaatgg
     1441 acccaagtgg accttcacgg tcctcggttc ctccacatgg tctccagttc agctaaacat
     1501 aaatgagacc aaaatccagt ggcacggaaa ggacaaccag gtgcctaagt ctgtgtgttc
     1561 cagcgactgt cttgaagggc accagcgagt ggttacgggt ttccatcact gctgctttga
     1621 gtgtgtgccc tgtggggctg ggaccttcct caacaagagt gacctctaca gatgccagcc
     1681 ttgtgggaaa gaagagtggg cacctgaggg aagccagacc tgcttcccgc gcactgtggt
     1741 gtttttggct ttgcgtgagc acacctcttg ggtgctgctg gcagctaaca cgctgctgct
     1801 gctgctgctg cttgggactg ctggcctgtt tgcctggcac ctagacaccc ctgtggtgag
     1861 gtcagcaggg ggccgcctgt gctttcttat gctgggctcc ctggcagcag gtagtggcag
     1921 cctctatggc ttctttgggg aacccacaag gcctgcgtgc ttgctacgcc aggccctctt
     1981 tgcccttggt ttcaccatct tcctgtcctg cctgacagtt cgctcattcc aactaatcat
     2041 catcttcaag ttttccacca aggtacctac attctaccac gcctgggtcc aaaaccacgg
     2101 tgctggcctg tttgtgatga tcagctcagc ggcccagctg cttatctgtc taacttggct
     2161 ggtggtgtgg accccactgc ctgctaggga ataccagcgc ttcccccatc tggtgatgct
     2221 tgagtgcaca gagaccaact ccctgggctt catactggcc ttcctctaca atggcctcct
     2281 ctccatcagt gcctttgcct gcagctacct gggtaaggac ttgccagaga actacaacga
     2341 ggccaaatgt gtcaccttca gcctgctctt caacttcgtg tcctggatcg ccttcttcac
     2401 cacggccagc gtctacgacg gcaagtacct gcctgcggcc aacatgatgg ctgggctgag
     2461 cagcctgagc agcggcttcg gtgggtattt tctgcctaag tgctacgtga tcctctgccg
     2521 cccagacctc aacagcacag agcacttcca ggcctccatt caggactaca cgaggcgctg
     2581 cggctccacc tgaccagtgg gtcagcaggc acggctggca gccttctctg ccctgagggt
     2641 cgaaggtcga gcaggccggg ggtgtccggg aggtctttgg gcatcgcggt ctggggttgg
     2701 gacgtgtaag cgcctgggag agcctagacc aggctccggg ctgccaataa agaagtgaaa
     2761 tgcg
//
