LOCUS       NM_152334               3481 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens threonyl-tRNA synthetase 3 (TARS3), mRNA.
ACCESSION   NM_152334
VERSION     NM_152334.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3481)
  AUTHORS   Liu,Y., Jiang,K., Zhi,T. and Xu,X.
  TITLE     miR-720 is a key regulator of glioma migration and invasion by
            controlling TARSL2 expression
  JOURNAL   Hum Cell 34 (5), 1504-1516 (2021)
   PUBMED   34024034
  REMARK    GeneRIF: miR-720 is a key regulator of glioma migration and
            invasion by controlling TARSL2 expression.
REFERENCE   2  (bases 1 to 3481)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3481)
  AUTHORS   Zhou,X.L., Chen,Y., Zeng,Q.Y., Ruan,Z.R., Fang,P. and Wang,E.D.
  TITLE     Newly acquired N-terminal extension targets threonyl-tRNA
            synthetase-like protein into the multiple tRNA synthetase complex
  JOURNAL   Nucleic Acids Res 47 (16), 8662-8674 (2019)
   PUBMED   31287872
  REMARK    GeneRIF: Newly acquired N-terminal extension targets threonyl-tRNA
            synthetase-like protein into the multiple tRNA synthetase complex.
REFERENCE   4  (bases 1 to 3481)
  AUTHORS   Chen,Y., Ruan,Z.R., Wang,Y., Huang,Q., Xue,M.Q., Zhou,X.L. and
            Wang,E.D.
  TITLE     A threonyl-tRNA synthetase-like protein has tRNA aminoacylation and
            editing activities
  JOURNAL   Nucleic Acids Res 46 (7), 3643-3656 (2018)
   PUBMED   29579307
REFERENCE   5  (bases 1 to 3481)
  AUTHORS   Kim,K., Park,S.J., Na,S., Kim,J.S., Choi,H., Kim,Y.K., Paek,E. and
            Lee,C.
  TITLE     Reinvestigation of aminoacyl-tRNA synthetase core complex by
            affinity purification-mass spectrometry reveals TARSL2 as a
            potential member of the complex
  JOURNAL   PLoS One 8 (12), e81734 (2013)
   PUBMED   24312579
  REMARK    GeneRIF: TARSL2 is potentially a new component of aminoacyl-tRNA
            synthetase core-complex
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC027559.17, AW161214.1, AK056653.1, AL833188.1, BU677165.1,
            BE856588.1 and AC090164.22.
            
            On Nov 23, 2018 this sequence version replaced NM_152334.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.115098.1,
                                           SRR1660807.41730.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000335968.8/ ENSP00000338093.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                AC027559.17        27784-27814
            32-41               AW161214.1         1-10
            42-372              AK056653.1         1-331
            373-2876            AL833188.1         8-2511
            2877-3137           AK056653.1         2552-2812
            3138-3301           BU677165.1         195-358             c
            3302-3325           BE856588.1         7-30                c
            3326-3481           AC090164.22        179812-179967       c
FEATURES             Location/Qualifiers
     source          1..3481
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q26.3"
     gene            1..3481
                     /gene="TARS3"
                     /gene_synonym="TARSL2; ThrRS-L"
                     /note="threonyl-tRNA synthetase 3"
                     /db_xref="GeneID:123283"
                     /db_xref="HGNC:HGNC:24728"
     exon            1..383
                     /gene="TARS3"
                     /gene_synonym="TARSL2; ThrRS-L"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..2495
                     /gene="TARS3"
                     /gene_synonym="TARSL2; ThrRS-L"
                     /EC_number="6.1.1.3"
                     /note="probable threonyl-tRNA synthetase 2, cytoplasmic;
                     thrRS; threonyl-tRNA synthetase-like protein 2;
                     threonyl-tRNA synthetase like 2; probable threonine--tRNA
                     ligase 2, cytoplasmic; threonyl-tRNA synthetase protein 3"
                     /codon_start=1
                     /product="threonine--tRNA ligase 2, cytoplasmic"
                     /protein_id="NP_689547.2"
                     /db_xref="CCDS:CCDS10394.1"
                     /db_xref="GeneID:123283"
                     /db_xref="HGNC:HGNC:24728"
                     /translation="MAAEALAAEAVASRLERQEEDIRWLWSEVERLRDEQLNAPYSCQ
                     AEGPCLTREVAQLRAENCDLRHRLCSLRLCLAEERSRQATLESAELEAAQEAGAQPPP
                     SQSQDKDMKKKKMKESEADSEVKHQPIFIKERLKLFEILKKDHQLLLAIYGKKGDTSN
                     IITVRVADGQTVQGEVWKTTPYQVAAEISQELAESTVIAKVNGELWDLDRPLEGDSSL
                     ELLTFDNEEAQAVYWHSSAHILGEAMELYYGGHLCYGPPIENGFYYDMFIEDRAVSST
                     ELSALENICKAIIKEKQPFERLEVSKEILLEMFKYNKFKCRILNEKVNTATTTVYRCG
                     PLIDLCKGPHVRHTGKIKTIKIFKNSSTYWEGNPEMETLQRIYGISFPDNKMMRDWEK
                     FQEEAKNRDHRKIGKEQELFFFHDLSPGSCFFLPRGAFIYNTLTDFIREEYHKRDFTE
                     VLSPNMYNSKLWEASGHWQHYSENMFTFEIEKDTFALKPMNCPGHCLMFAHRPRSWRE
                     MPIRFADFGVLHRNELSGTLSGLTRVRRFQQDDAHIFCTVEQIEEEIKGCLQFLQSVY
                     STFGFSFQLNLSTRPENFLGEIEMWNEAEKQLQNSLMDFGEPWKMNPGDGAFYGPKID
                     IKIKDAIGRYHQCATIQLDFQLPIRFNLTYVSKDGDDKKRPVIIHRAILGSVERMIAI
                     LSENYGGKWPFWLSPRQVMVIPVGPTCEKYALQVSSEFFEEGFMADVDLDHSCTLNKK
                     IRNAQLAQYNFILVVGEKEKIDNAVNVRTRDNKIHGEILVTSAIDKLKNLRKTRTLNA
                     EEAF"
     exon            384..455
                     /gene="TARS3"
                     /gene_synonym="TARSL2; ThrRS-L"
                     /inference="alignment:Splign:2.1.0"
     exon            456..652
                     /gene="TARS3"
                     /gene_synonym="TARSL2; ThrRS-L"
                     /inference="alignment:Splign:2.1.0"
     exon            653..776
                     /gene="TARS3"
                     /gene_synonym="TARSL2; ThrRS-L"
                     /inference="alignment:Splign:2.1.0"
     exon            777..898
                     /gene="TARS3"
                     /gene_synonym="TARSL2; ThrRS-L"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1016
                     /gene="TARS3"
                     /gene_synonym="TARSL2; ThrRS-L"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1081
                     /gene="TARS3"
                     /gene_synonym="TARSL2; ThrRS-L"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1160
                     /gene="TARS3"
                     /gene_synonym="TARSL2; ThrRS-L"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1307
                     /gene="TARS3"
                     /gene_synonym="TARSL2; ThrRS-L"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1406
                     /gene="TARS3"
                     /gene_synonym="TARSL2; ThrRS-L"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1573
                     /gene="TARS3"
                     /gene_synonym="TARSL2; ThrRS-L"
                     /inference="alignment:Splign:2.1.0"
     exon            1574..1736
                     /gene="TARS3"
                     /gene_synonym="TARSL2; ThrRS-L"
                     /inference="alignment:Splign:2.1.0"
     exon            1737..1874
                     /gene="TARS3"
                     /gene_synonym="TARSL2; ThrRS-L"
                     /inference="alignment:Splign:2.1.0"
     exon            1875..1952
                     /gene="TARS3"
                     /gene_synonym="TARSL2; ThrRS-L"
                     /inference="alignment:Splign:2.1.0"
     exon            1953..2053
                     /gene="TARS3"
                     /gene_synonym="TARSL2; ThrRS-L"
                     /inference="alignment:Splign:2.1.0"
     exon            2054..2158
                     /gene="TARS3"
                     /gene_synonym="TARSL2; ThrRS-L"
                     /inference="alignment:Splign:2.1.0"
     exon            2159..2231
                     /gene="TARS3"
                     /gene_synonym="TARSL2; ThrRS-L"
                     /inference="alignment:Splign:2.1.0"
     exon            2232..2346
                     /gene="TARS3"
                     /gene_synonym="TARSL2; ThrRS-L"
                     /inference="alignment:Splign:2.1.0"
     exon            2347..3481
                     /gene="TARS3"
                     /gene_synonym="TARSL2; ThrRS-L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2825..2830
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TARS3"
                     /gene_synonym="TARSL2; ThrRS-L"
                     /note="hexamer: AATAAA"
     polyA_site      2852
                     /gene="TARS3"
                     /gene_synonym="TARSL2; ThrRS-L"
                     /note="major polyA site"
     regulatory      3116..3121
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TARS3"
                     /gene_synonym="TARSL2; ThrRS-L"
                     /note="hexamer: AATAAA"
     polyA_site      3138
                     /gene="TARS3"
                     /gene_synonym="TARSL2; ThrRS-L"
                     /note="major polyA site"
     regulatory      3313..3318
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TARS3"
                     /gene_synonym="TARSL2; ThrRS-L"
                     /note="hexamer: AATAGA"
     polyA_site      3334
                     /gene="TARS3"
                     /gene_synonym="TARSL2; ThrRS-L"
     regulatory      3376..3381
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TARS3"
                     /gene_synonym="TARSL2; ThrRS-L"
                     /note="hexamer: AAGAAA"
     regulatory      3385..3390
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TARS3"
                     /gene_synonym="TARSL2; ThrRS-L"
                     /note="hexamer: AAGAAA"
     polyA_site      3393
                     /gene="TARS3"
                     /gene_synonym="TARSL2; ThrRS-L"
     polyA_site      3408
                     /gene="TARS3"
                     /gene_synonym="TARSL2; ThrRS-L"
     regulatory      3460..3465
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TARS3"
                     /gene_synonym="TARSL2; ThrRS-L"
                     /note="hexamer: AACAAA"
     polyA_site      3481
                     /gene="TARS3"
                     /gene_synonym="TARSL2; ThrRS-L"
ORIGIN      
        1 gtcttctgcc gtgcgctgag tgtccgcgtc gccctcgccg cagtcgcggg caccccgctc
       61 ggcgtcggtg cctgagggag gccgcgatgg cggccgaggc cctggcggcg gaggccgtgg
      121 cgtcgcgcct ggagcggcag gaggaggaca tccgctggct gtggtcggag gtcgagcgcc
      181 tgagggacga gcagctgaac gcgccctaca gctgccaggc ggaggggccg tgcctcacgc
      241 gggaggtggc gcagctccgg gccgagaact gcgacctgcg ccaccgcctg tgcagcctgc
      301 ggctgtgcct cgccgaggag cggagccgcc aggccacgct ggagagcgcg gagctagagg
      361 cggcgcagga ggccggcgca cagcctcctc ctagtcaaag ccaagacaag gacatgaaaa
      421 agaagaaaat gaaggaaagc gaggctgaca gcgaggtgaa gcatcaacca attttcataa
      481 aagaaagatt gaagcttttt gaaatactga agaaagacca tcagctctta cttgccattt
      541 atggaaaaaa gggggataca agcaacatca tcacagtaag agtggctgat gggcaaacag
      601 tgcaagggga agtctggaaa acaacgcctt accaagtggc tgctgaaatt agtcaggaac
      661 tggctgaaag cacggtaata gccaaagtca atggtgaact gtgggacctg gaccgcccat
      721 tggaagggga ctcttctcta gagctgctta catttgataa tgaggaagct caagctgtgt
      781 actggcactc cagtgctcac attcttgggg aggccatgga gctttactat ggaggccacc
      841 tgtgctacgg tccgcccatt gaaaatggat tttattatga catgttcatt gaagacagag
      901 cagtgtccag cacagaattg tcagccctgg agaatatatg taaagccatc ataaaagaaa
      961 agcaaccttt tgaaagacta gaagtcagca aggaaatcct cctggaaatg tttaagtaca
     1021 ataaatttaa atgccgcatt ctgaatgaga aagttaacac tgcaactacc accgtgtaca
     1081 ggtgcggtcc attaattgac ctttgcaaag gtccacatgt aagacacact ggaaaaatta
     1141 aaaccatcaa aatttttaag aattcctcaa catattggga gggcaatccg gaaatggaaa
     1201 cattgcagag gatctatgga atatcctttc ctgataacaa gatgatgaga gactgggaaa
     1261 agttccaaga ggaagcaaag aaccgagatc acaggaagat cgggaaggaa caagaacttt
     1321 tctttttcca cgatttgagt cctggaagct gttttttcct tcccagagga gccttcattt
     1381 ataatacgct tacagatttc atacgagagg aatatcacaa acgggacttc acggaggtgc
     1441 tctctcccaa tatgtacaac agtaaactct gggaagcctc aggccactgg cagcattaca
     1501 gcgagaacat gtttaccttt gagattgaaa aggacacttt tgccctcaaa cccatgaatt
     1561 gtccagggca ctgtctaatg tttgcccatc gtccacgatc ttggagggaa atgcctatta
     1621 gatttgctga ttttggagtt ctgcatagaa atgaactgtc ggggactctc agcggcttga
     1681 ccagagtgag gcgcttccag caggacgatg ctcacatttt ttgcacagtg gagcagattg
     1741 aagaagaaat aaaggggtgt ttgcagtttt tgcaatctgt ttactcaaca tttggcttct
     1801 cctttcaatt aaacctgtca acaaggccgg aaaacttcct aggagagatt gagatgtgga
     1861 atgaggctga gaagcaactg cagaacagct tgatggactt tggagaaccg tggaaaatga
     1921 acccaggaga tggagcattt tatggcccta aaattgacat aaaaatcaag gatgctattg
     1981 gcagatacca tcaatgtgct acaattcagc tggacttcca actgcctatt agatttaatc
     2041 tcacatatgt tagtaaggat ggggatgata agaagagacc tgtgatcatt catcgagcca
     2101 ttttgggatc agtggaaaga atgatagcca ttctttcaga aaactatggc ggaaaatggc
     2161 ctttctggct atctcctcgt caggtgatgg tcatccctgt ggggccaact tgtgaaaaat
     2221 atgcacttca ggtatccagt gaattttttg aagaaggatt tatggctgac gttgacttgg
     2281 atcacagttg tacactaaat aagaaaatac gaaatgcaca gctggctcag tataatttta
     2341 ttttggtggt tggagaaaag gaaaagatag ataatgctgt aaacgtgcga acaagagaca
     2401 acaaaattca tggagagatt ttagtaactt ctgccattga taaactgaag aatctcagga
     2461 agacacggac actcaatgct gaggaggcct tttgaagtcc ttccctgata tttgcttctg
     2521 tgtaactttg ttttgaccct taaaaatgta tttttcttaa catgttagta cttctacgac
     2581 tttggagcca ctgatgggtc cactcatggc ctcagctgag aaaggagacg atgaacgtgt
     2641 agctgacatg cacgaagttt aatttactca tgtccacggg ggacgtttag agggcacgtg
     2701 ggaaattttc cagcaatcaa tgccttgaga aacttaaatg gggaaatatt attcatcgag
     2761 aaagtgaaac aaaacactag gaaatgatta tgaaatgtta gtgattttca aaagatgggc
     2821 ttcaaataaa agtctgcaga gtttttttta aataggaggg aaaatcttat tttctaatat
     2881 gtctcaggta tttttatgac ttctactaaa attcacactg aaactttatc ttctaaactg
     2941 gaatcattac ttaattttaa ctaaccaaca accacaaaag cagcagctac tgctaaatat
     3001 tggattactg acaaaggaat tcagttttgt ggaatctggt gtttgcacta taggttaaga
     3061 gttgccattt aaatgtttct tattcataat taggttttgt tccgctttag aaaaaaataa
     3121 attcccaaat gaattgcatc agtgtttcca gcgtttcagc tgtgggcttc taccaccact
     3181 aagccgctca cctagagttg ttactttttt gatgggatga cattccatgg atttatgtac
     3241 tgaaatggat ttcagatttt aaagagagga atgctctacg tgctcagaac tgaattaaaa
     3301 tggcattatg tcaatagaga attcagctac caaacaagaa gtattgttta ttttgcgata
     3361 tgctgtgaaa ttcaaaagaa atgtaagaaa taatctcttt tcaatatact gatcatttag
     3421 ttaacttcct gagggatgtg aacagtgaaa cagttggcaa acaaaacaat atatatcagg
     3481 c
//
