LOCUS       NM_001003799            1016 bp    mRNA    linear   PRI 11-JUN-2024
DEFINITION  Homo sapiens TCR gamma alternate reading frame protein (TARP),
            transcript variant 1, mRNA.
ACCESSION   NM_001003799
VERSION     NM_001003799.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1016)
  AUTHORS   Shi,Y., He,Z., Bei,L., Tao,H., Ding,B., Tao,S., Wang,C. and Yu,L.
  TITLE     High expression of TARP correlates with inferior FLT3 mutations in
            non-adolescents and young adults with acute myeloid leukaemia
  JOURNAL   Hematology 26 (1), 380-387 (2021)
   PUBMED   33971801
  REMARK    GeneRIF: High expression of TARP correlates with inferior FLT3
            mutations in non-adolescents and young adults with acute myeloid
            leukaemia.
REFERENCE   2  (bases 1 to 1016)
  AUTHORS   Depreter,B., Weening,K.E., Vandepoele,K., Essand,M., De
            Moerloose,B., Themeli,M., Cloos,J., Hanekamp,D., Moors,I.,
            D'hont,I., Denys,B., Uyttebroeck,A., Van Damme,A., Dedeken,L.,
            Snauwaert,S., Goetgeluk,G., De Munter,S., Kerre,T.,
            Vandekerckhove,B., Lammens,T. and Philippe,J.
  TITLE     TARP is an immunotherapeutic target in acute myeloid leukemia
            expressed in the leukemic stem cell compartment
  JOURNAL   Haematologica 105 (5), 1306-1316 (2020)
   PUBMED   31371409
REFERENCE   3  (bases 1 to 1016)
  AUTHORS   Yue,H., Cai,Y., Song,Y., Meng,L., Chen,X., Wang,M., Bian,Z. and
            Wang,R.
  TITLE     Elevated TARP promotes proliferation and metastasis of salivary
            adenoid cystic carcinoma
  JOURNAL   Oral Surg Oral Med Oral Pathol Oral Radiol 123 (4), 468-476 (2017)
   PUBMED   28153567
REFERENCE   4  (bases 1 to 1016)
  AUTHORS   Zhao,L.J., Li,X.P., Qi,W.J., Wang,J.L. and Wei,L.H.
  TITLE     Value of T cell receptor gamma alternate reading frame protein and
            keratin 5 in endometrial carcinoma
  JOURNAL   Chin Med J (Engl) 126 (22), 4260-4264 (2013)
   PUBMED   24238509
  REMARK    GeneRIF: The expression of TARP and KRT5 was correlated with the
            progress of endometrial cancer
REFERENCE   5  (bases 1 to 1016)
  AUTHORS   Maeda,H., Nagata,S., Wolfgang,C.D., Bratthauer,G.L., Bera,T.K. and
            Pastan,I.
  TITLE     The T cell receptor gamma chain alternate reading frame protein
            (TARP), a prostate-specific protein localized in mitochondria
  JOURNAL   J Biol Chem 279 (23), 24561-24568 (2004)
   PUBMED   15150260
REFERENCE   6  (bases 1 to 1016)
  AUTHORS   Wolfgang,C.D., Essand,M., Vincent,J.J., Lee,B. and Pastan,I.
  TITLE     TARP: a nuclear protein expressed in prostate and breast cancer
            cells derived from an alternate reading frame of the T cell
            receptor gamma chain locus
  JOURNAL   Proc Natl Acad Sci U S A 97 (17), 9437-9442 (2000)
   PUBMED   10931945
REFERENCE   7  (bases 1 to 1016)
  AUTHORS   Mami-Chouaib,F., Del Porto,P., Delorme,D. and Hercend,T.
  TITLE     Further evidence for a gamma/delta T cell receptor-mediated
            TCT.1/CD48 recognition
  JOURNAL   J Immunol 147 (9), 2864-2867 (1991)
   PUBMED   1655899
REFERENCE   8  (bases 1 to 1016)
  AUTHORS   Tighe,L., Forster,A., Clark,D.M., Boylston,A.W., Lavenir,I. and
            Rabbitts,T.H.
  TITLE     Unusual forms of T cell gamma mRNA in a human T cell leukemia cell
            line: implications for gamma gene expression
  JOURNAL   Eur J Immunol 17 (12), 1729-1736 (1987)
   PUBMED   2961573
REFERENCE   9  (bases 1 to 1016)
  AUTHORS   Krangel,M.S., Band,H., Hata,S., McLean,J. and Brenner,M.B.
  TITLE     Structurally divergent human T cell receptor gamma proteins encoded
            by distinct C gamma genes
  JOURNAL   Science 237 (4810), 64-67 (1987)
   PUBMED   2955517
REFERENCE   10 (bases 1 to 1016)
  AUTHORS   Yoshikai,Y., Toyonaga,B., Koga,Y., Kimura,N., Griesser,H. and
            Mak,T.W.
  TITLE     Repertoire of the human T cell gamma genes: high frequency of
            nonfunctional transcripts in thymus and mature T cells
  JOURNAL   Eur J Immunol 17 (1), 119-126 (1987)
   PUBMED   2949984
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF151103.1 and BF674593.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001003799.1.
            
            Summary: In some non-lymphoid tissues, the unrearranged T cell
            receptor gamma (TRG@) locus is expressed. The resulting transcript
            contains a subset of the TRG@ gene segments and is shorter than
            TRG@ transcripts expressed in lymphoid tissues. This RefSeq record
            represents the unrearranged TRG@ locus transcript; the complete
            TRG@ locus is represented by the genomic RefSeq NG_001336. The
            transcript represented by this RefSeq has two open reading frames
            (ORFs) that encode different proteins. The downstream ORF is in the
            same frame as TRG@ and its protein product is similar to TRG@
            proteins. The upstream ORF uses a different reading frame and
            encodes a novel protein. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) uses the upstream ORF. The
            resulting protein (isoform 1) localizes to the outer mitochondrial
            membrane.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF151103.1, BF679123.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2153427 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            MANE Ensembl match                 :: ENST00000698248.1/
                                                  ENSP00000513628.1
            NMD candidate                      :: PMID: 10931945, 15150260
            RefSeq Select criteria             :: based on manual assertion,
                                                  expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-378               AF151103.1         12-389
            379-399             BF674593.1         380-400
            400-1016            AF151103.1         411-1027
FEATURES             Location/Qualifiers
     source          1..1016
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p14.1"
     gene            1..1016
                     /gene="TARP"
                     /gene_synonym="CD3G"
                     /note="TCR gamma alternate reading frame protein"
                     /db_xref="GeneID:445347"
                     /db_xref="MIM:609642"
     exon            1..50
                     /gene="TARP"
                     /gene_synonym="CD3G"
                     /inference="alignment:Splign:2.1.0"
     exon            51..380
                     /gene="TARP"
                     /gene_synonym="CD3G"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..239
                     /gene="TARP"
                     /gene_synonym="CD3G"
                     /note="isoform 1 is encoded by transcript variant 1; TCR-
                     gamma V-IV; antigen, T-cell receptor"
                     /codon_start=1
                     /product="T-cell receptor gamma alternate reading frame
                     protein isoform 1"
                     /protein_id="NP_001003799.1"
                     /db_xref="CCDS:CCDS94087.1"
                     /db_xref="GeneID:445347"
                     /db_xref="MIM:609642"
                     /translation="MQMFPPSPLFFFLQLLKQSSRRLEHTFVFLRNFSLMLLRYIGKK
                     RRATRFWDPRRGTP"
     regulatory      332..337
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TARP"
                     /gene_synonym="CD3G"
                     /note="hexamer: AATAAA"
     polyA_site      356
                     /gene="TARP"
                     /gene_synonym="CD3G"
                     /note="major polyA site"
     exon            381..428
                     /gene="TARP"
                     /gene_synonym="CD3G"
                     /inference="alignment:Splign:2.1.0"
     exon            429..1016
                     /gene="TARP"
                     /gene_synonym="CD3G"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggcaaaaaa atcaaggtat ttggtcccgg aacaaagctt atcattacag ataaacaact
       61 tgatgcagat gtttccccca agcccactat ttttcttcct tcaattgctg aaacaaagct
      121 ccagaaggct ggaacatacc tttgtcttct tgagaaattt ttccctgatg ttattaagat
      181 acattggcaa gaaaagaaga gcaacacgat tctgggatcc caggagggga acaccatgaa
      241 gactaacgac acatacatga aatttagctg gttaacggtg ccagaaaagt cactggacaa
      301 agaacacaga tgtatcgtca gacatgagaa taataaaaac ggagttgatc aagaaattat
      361 ctttcctcca ataaagacag atgtcatcac aatggatccc aaagacaatt gttcaaaaga
      421 tgcaaatgat acactactgc tgcagctcac aaacacctct gcatattaca tgtacctcct
      481 cctgctcctc aagagtgtgg tctattttgc catcatcacc tgctgtctgc ttagaagaac
      541 ggctttctgc tgcaatggag agaaatcata acagacggtg gcacaaggag gccatctttt
      601 cctcatcggt tattgtccct agaagcgtct tctgaggatc tagttgggct ttctttctgg
      661 gtttgggcca tttcagttct catgtgtgta ctattctatc attattgtat aacggttttc
      721 aaaccagtgg gcacacagag aacctcactc tgtaataaca atgaggaata gccacggcga
      781 tctccagcac caatctctcc atgttttcca cagctcctcc agccaaccca aatagcgcct
      841 gctatagtgt agacatcctg cggcttctag ccttgtccct ctcttagtgt tctttaatca
      901 gataactgcc tggaagcctt tcattttaca cgccctgaag cagtcttctt tgctagttga
      961 attatgtggt gtgtttttcc gtaataagca aaataaattt aaaaaaatga aaagtt
//
