LOCUS       NM_001135686             949 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens T cell-interacting, activating receptor on myeloid
            cells 1 (TARM1), transcript variant 1, mRNA.
ACCESSION   NM_001135686 XM_001127643 XM_001718727 XM_497642
VERSION     NM_001135686.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 949)
  AUTHORS   Radjabova,V., Mastroeni,P., Skjodt,K., Zaccone,P., de Bono,B.,
            Goodall,J.C., Chilvers,E.R., Juss,J.K., Jones,D.C., Trowsdale,J.
            and Barrow,A.D.
  TITLE     TARM1 Is a Novel Leukocyte Receptor Complex-Encoded ITAM Receptor
            That Costimulates Proinflammatory Cytokine Secretion by Macrophages
            and Neutrophils
  JOURNAL   J Immunol 195 (7), 3149-3159 (2015)
   PUBMED   26311901
  REMARK    GeneRIF: These results suggest that a putative T cell ligand can
            interact with TARM1 receptor, resulting in bidirectional signaling
            and raising the T cell activation threshold while costimulating the
            release of proinflammatory cytokines by macrophages and
            neutrophils.
REFERENCE   2  (bases 1 to 949)
  AUTHORS   Kohn,L., Bowne,S.J., S Sullivan,L., Daiger,S.P., Burstedt,M.S.,
            Kadzhaev,K., Sandgren,O. and Golovleva,I.
  TITLE     Breakpoint characterization of a novel approximately 59 kb genomic
            deletion on 19q13.42 in autosomal-dominant retinitis pigmentosa
            with incomplete penetrance
  JOURNAL   Eur J Hum Genet 17 (5), 651-655 (2009)
   PUBMED   19050727
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DQ479398.1, AC245052.3 and AC012314.8.
            
            On May 17, 2019 this sequence version replaced NM_001135686.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ479398.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2149004, SAMEA2154529
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000432826.2/ ENSP00000439454.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-356               DQ479398.1         1-356
            357-357             AC245052.3         3393-3393           c
            358-897             DQ479398.1         358-897
            898-949             AC012314.8         46648-46699         c
FEATURES             Location/Qualifiers
     source          1..949
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.42"
     gene            1..949
                     /gene="TARM1"
                     /gene_synonym="OLT-2"
                     /note="T cell-interacting, activating receptor on myeloid
                     cells 1"
                     /db_xref="GeneID:441864"
                     /db_xref="HGNC:HGNC:37250"
                     /db_xref="MIM:616802"
     exon            1..59
                     /gene="TARM1"
                     /gene_synonym="OLT-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..841
                     /gene="TARM1"
                     /gene_synonym="OLT-2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; OSCAR-like transcript-2 protein"
                     /codon_start=1
                     /product="T-cell-interacting, activating receptor on
                     myeloid cells protein 1 isoform 1 precursor"
                     /protein_id="NP_001129158.2"
                     /db_xref="CCDS:CCDS46173.1"
                     /db_xref="GeneID:441864"
                     /db_xref="HGNC:HGNC:37250"
                     /db_xref="MIM:616802"
                     /translation="MIPKLLSLLCFRLCVGQGDTRGDGSLPKPSLSAWPSSVVPANSN
                     VTLRCWTPARGVSFVLRKGGIILESPKPLDSTEGAAEFHLNNLKVRNAGEYTCEYYRK
                     ASPHILSQHSDVLLLLVTGHLSKPFLRTYQRGTVTAGGRVTLQCQKRDQLFVPIMFAL
                     LKAGTPSPIQLQSPAGKEIDFSLVDVTAGDAGNYSCMYYQTKSPFWASEPSDQLEILV
                     TVPPGTTSSNYSLGNFVRLGLAAVIVVIMGAFLVEAWYSRNVSPGESEAFKPE"
     exon            60..95
                     /gene="TARM1"
                     /gene_synonym="OLT-2"
                     /inference="alignment:Splign:2.1.0"
     exon            96..386
                     /gene="TARM1"
                     /gene_synonym="OLT-2"
                     /inference="alignment:Splign:2.1.0"
     exon            387..683
                     /gene="TARM1"
                     /gene_synonym="OLT-2"
                     /inference="alignment:Splign:2.1.0"
     exon            684..949
                     /gene="TARM1"
                     /gene_synonym="OLT-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actctgggag ggctaaggag ccatcatgat ccctaagctg ctttccctcc tctgtttcag
       61 actgtgcgtg ggccaaggag acacaagggg agatgggtca ctgcccaagc cgtccctcag
      121 tgcctggccc agctcggtgg tccctgccaa cagcaatgtg acgctgcgat gttggactcc
      181 tgccagaggt gtgagctttg ttctcaggaa gggaggaatt attctggagt ccccgaagcc
      241 ccttgattct acagagggcg cggccgaatt tcacctcaat aatctaaaag tcagaaatgc
      301 tggagagtac acctgtgaat actacagaaa agcatccccc cacatccttt cacagcacag
      361 tgacgtcctt ctactgttgg tgacaggaca tttatctaaa cctttcctcc gaacctacca
      421 aaggggtaca gtgaccgcag gtggaagggt gactctgcag tgccagaagc gagaccaatt
      481 gtttgtgcct atcatgttcg ctctactgaa ggcagggacg ccatcaccca tccagctgca
      541 gagtccagcg gggaaggaga tagacttctc tctggtggac gtgacagccg gcgatgctgg
      601 gaactacagc tgcatgtact accagacaaa gtctcccttc tgggcctcag aacccagtga
      661 tcagcttgag atattggtga cagttccccc aggtaccaca tcgagcaact actccctggg
      721 taacttcgta cgactgggtc tggctgccgt aattgtggtt atcatgggag ctttcctggt
      781 ggaggcctgg tacagccgga atgtgtctcc aggtgaatca gaggccttca aaccagagtg
      841 actccatctt gaaccggggc tgggtaaact gaggctgcaa cctgctggac tgcattccca
      901 gggggttgag gctttctaag tcacaggatg agacaggtca caacataca
//
