LOCUS       NM_007375               4185 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens TAR DNA binding protein (TARDBP), mRNA.
ACCESSION   NM_007375 NM_031214
VERSION     NM_007375.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4185)
  AUTHORS   Mai,Y., Jing,Z., Sun,P., Wang,Y., Dong,P. and Liu,J.
  TITLE     TARDBP drives T-cell acute lymphoblastic leukemia progression by
            binding MDM2 mRNA, involving beta-catenin pathway
  JOURNAL   FASEB J 38 (20), e70110 (2024)
   PUBMED   39417407
  REMARK    GeneRIF: TARDBP drives T-cell acute lymphoblastic leukemia
            progression by binding MDM2 mRNA, involving beta-catenin pathway.
REFERENCE   2  (bases 1 to 4185)
  AUTHORS   Lam,A.Y.W., Tsuboyama,K., Tadakuma,H. and Tomari,Y.
  TITLE     DNAJA2 and Hero11 mediate similar conformational extension and
            aggregation suppression of TDP-43
  JOURNAL   RNA 30 (11), 1422-1436 (2024)
   PUBMED   39117455
  REMARK    GeneRIF: DNAJA2 and Hero11 mediate similar conformational extension
            and aggregation suppression of TDP-43.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4185)
  AUTHORS   Yang,J., Li,Y., Li,H., Zhang,H., Guo,H., Zheng,X., Yu,X.F. and
            Wei,W.
  TITLE     HIV-1 Vpu induces neurotoxicity by promoting Caspase 3-dependent
            cleavage of TDP-43
  JOURNAL   EMBO Rep 25 (10), 4337-4357 (2024)
   PUBMED   39242776
  REMARK    GeneRIF: HIV-1 Vpu induces neurotoxicity by promoting Caspase
            3-dependent cleavage of TDP-43.
REFERENCE   4  (bases 1 to 4185)
  AUTHORS   Torres,P., Rico-Rios,S., Ceron-Codorniu,M., Santacreu-Vilaseca,M.,
            Seoane-Miraz,D., Jad,Y., Ayala,V., Marino,G., Beltran,M.,
            Miralles,M.P., Andres-Benito,P., Fernandez-Irigoyen,J.,
            Santamaria,E., Lopez-Otin,C., Soler,R.M., Povedano,M., Ferrer,I.,
            Pamplona,R., Wood,M.J.A., Varela,M.A. and Portero-Otin,M.
  TITLE     TDP-43 regulates LC3ylation in neural tissue through ATG4B cryptic
            splicing inhibition
  JOURNAL   Acta Neuropathol 148 (1), 45 (2024)
   PUBMED   39305312
  REMARK    GeneRIF: TDP-43 regulates LC3ylation in neural tissue through ATG4B
            cryptic splicing inhibition.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4185)
  AUTHORS   Buratti,E., Dork,T., Zuccato,E., Pagani,F., Romano,M. and
            Baralle,F.E.
  TITLE     Nuclear factor TDP-43 and SR proteins promote in vitro and in vivo
            CFTR exon 9 skipping
  JOURNAL   EMBO J 20 (7), 1774-1784 (2001)
   PUBMED   11285240
REFERENCE   6  (bases 1 to 4185)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
REFERENCE   7  (bases 1 to 4185)
  AUTHORS   Tokai,N., Fujimoto-Nishiyama,A., Toyoshima,Y., Yonemura,S.,
            Tsukita,S., Inoue,J. and Yamamota,T.
  TITLE     Kid, a novel kinesin-like DNA binding protein, is localized to
            chromosomes and the mitotic spindle
  JOURNAL   EMBO J 15 (3), 457-467 (1996)
   PUBMED   8599929
REFERENCE   8  (bases 1 to 4185)
  AUTHORS   Ou,S.H., Wu,F., Harrich,D., Garcia-Martinez,L.F. and Gaynor,R.B.
  TITLE     Cloning and characterization of a novel cellular protein, TDP-43,
            that binds to human immunodeficiency virus type 1 TAR DNA sequence
            motifs
  JOURNAL   J Virol 69 (6), 3584-3596 (1995)
   PUBMED   7745706
REFERENCE   9  (bases 1 to 4185)
  AUTHORS   Manohar,V., Crowley,L. and Sreedharan,J.
  TITLE     TARDBP-Related Amyotrophic Lateral Sclerosis-Frontotemporal
            Dementia
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301761
REFERENCE   10 (bases 1 to 4185)
  AUTHORS   Siddique,N. and Siddique,T.
  TITLE     Amyotrophic Lateral Sclerosis Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301623
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CD703666.1, BC001487.2,
            AL050265.1, AL045296.1, BC059955.1, AF311304.1 and BM716882.1.
            
            On Nov 22, 2019 this sequence version replaced NM_007375.3.
            
            Summary: HIV-1, the causative agent of acquired immunodeficiency
            syndrome (AIDS), contains an RNA genome that produces a
            chromosomally integrated DNA during the replicative cycle.
            Activation of HIV-1 gene expression by the transactivator Tat is
            dependent on an RNA regulatory element (TAR) located downstream of
            the transcription initiation site. The protein encoded by this gene
            is a transcriptional repressor that binds to chromosomally
            integrated TAR DNA and represses HIV-1 transcription. In addition,
            this protein regulates alternate splicing of the CFTR gene. A
            similar pseudogene is present on chromosome 20. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC095435.1, AL050265.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000240185.8/ ENSP00000240185.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                CD703666.1         58-72
            16-882              BC001487.2         1-867
            883-1537            AL050265.1         869-1523
            1538-2736           BC001487.2         1523-2721
            2737-2967           AL045296.1         260-490
            2968-3446           BC059955.1         88-566
            3447-3641           AF311304.1         377-571
            3642-3735           AF311304.1         577-670
            3736-4185           BM716882.1         11-460
FEATURES             Location/Qualifiers
     source          1..4185
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.22"
     gene            1..4185
                     /gene="TARDBP"
                     /gene_synonym="ALS10; TDP-43"
                     /note="TAR DNA binding protein"
                     /db_xref="GeneID:23435"
                     /db_xref="HGNC:HGNC:11571"
                     /db_xref="MIM:605078"
     exon            1..90
                     /gene="TARDBP"
                     /gene_synonym="ALS10; TDP-43"
                     /inference="alignment:Splign:2.1.0"
     exon            91..340
                     /gene="TARDBP"
                     /gene_synonym="ALS10; TDP-43"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..1347
                     /gene="TARDBP"
                     /gene_synonym="ALS10; TDP-43"
                     /note="TAR DNA-binding protein-43"
                     /codon_start=1
                     /product="TAR DNA-binding protein 43"
                     /protein_id="NP_031401.1"
                     /db_xref="CCDS:CCDS122.1"
                     /db_xref="GeneID:23435"
                     /db_xref="HGNC:HGNC:11571"
                     /db_xref="MIM:605078"
                     /translation="MSEYIRVTEDENDEPIEIPSEDDGTVLLSTVTAQFPGACGLRYR
                     NPVSQCMRGVRLVEGILHAPDAGWGNLVYVVNYPKDNKRKMDETDASSAVKVKRAVQK
                     TSDLIVLGLPWKTTEQDLKEYFSTFGEVLMVQVKKDLKTGHSKGFGFVRFTEYETQVK
                     VMSQRHMIDGRWCDCKLPNSKQSQDEPLRSRKVFVGRCTEDMTEDELREFFSQYGDVM
                     DVFIPKPFRAFAFVTFADDQIAQSLCGEDLIIKGISVHISNAEPKHNSNRQLERSGRF
                     GGNPGGFGNQGGFGNSRGGGAGLGNNQGSNMGGGMNFGAFSINPAMMAAAQAALQSSW
                     GMMGMLASQQNQSGPSGNNQNQGNMQREPNQAFGSGNNSYSGSNSGAAIGWGSASNAG
                     SGSGFNGGFGSSMDSKSSGWGM"
     exon            341..504
                     /gene="TARDBP"
                     /gene_synonym="ALS10; TDP-43"
                     /inference="alignment:Splign:2.1.0"
     exon            505..645
                     /gene="TARDBP"
                     /gene_synonym="ALS10; TDP-43"
                     /inference="alignment:Splign:2.1.0"
     exon            646..816
                     /gene="TARDBP"
                     /gene_synonym="ALS10; TDP-43"
                     /inference="alignment:Splign:2.1.0"
     exon            817..4185
                     /gene="TARDBP"
                     /gene_synonym="ALS10; TDP-43"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2717..2722
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TARDBP"
                     /gene_synonym="ALS10; TDP-43"
                     /note="hexamer: AATAAA"
     polyA_site      2736
                     /gene="TARDBP"
                     /gene_synonym="ALS10; TDP-43"
                     /note="major polyA site"
     regulatory      2856..2861
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TARDBP"
                     /gene_synonym="ALS10; TDP-43"
                     /note="hexamer: AATAAA"
     polyA_site      2876
                     /gene="TARDBP"
                     /gene_synonym="ALS10; TDP-43"
     regulatory      4161..4166
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TARDBP"
                     /gene_synonym="ALS10; TDP-43"
                     /note="hexamer: AATAAA"
     polyA_site      4185
                     /gene="TARDBP"
                     /gene_synonym="ALS10; TDP-43"
ORIGIN      
        1 attttgtggg agcgaagcgg tggctgggct gcgcttgggt ccgtcgctgc ttcggtgtcc
       61 ctgtcgggct tcccagcagc ggcctagcgg gaaaagtaaa agatgtctga atatattcgg
      121 gtaaccgaag atgagaacga tgagcccatt gaaataccat cggaagacga tgggacggtg
      181 ctgctctcca cggttacagc ccagtttcca ggggcgtgtg ggcttcgcta caggaatcca
      241 gtgtctcagt gtatgagagg tgtccggctg gtagaaggaa ttctgcatgc cccagatgct
      301 ggctggggaa atctggtgta tgttgtcaac tatccaaaag ataacaaaag aaaaatggat
      361 gagacagatg cttcatcagc agtgaaagtg aaaagagcag tccagaaaac atccgattta
      421 atagtgttgg gtctcccatg gaaaacaacc gaacaggacc tgaaagagta ttttagtacc
      481 tttggagaag ttcttatggt gcaggtcaag aaagatctta agactggtca ttcaaagggg
      541 tttggctttg ttcgttttac ggaatatgaa acacaagtga aagtaatgtc acagcgacat
      601 atgatagatg gacgatggtg tgactgcaaa cttcctaatt ctaagcaaag ccaagatgag
      661 cctttgagaa gcagaaaagt gtttgtgggg cgctgtacag aggacatgac tgaggatgag
      721 ctgcgggagt tcttctctca gtacggggat gtgatggatg tcttcatccc caagccattc
      781 agggcctttg cctttgttac atttgcagat gatcagattg cgcagtctct ttgtggagag
      841 gacttgatca ttaaaggaat cagcgttcat atatccaatg ccgaacctaa gcacaatagc
      901 aatagacagt tagaaagaag tggaagattt ggtggtaatc caggtggctt tgggaatcag
      961 ggtggatttg gtaatagcag agggggtgga gctggtttgg gaaacaatca aggtagtaat
     1021 atgggtggtg ggatgaactt tggtgcgttc agcattaatc cagccatgat ggctgccgcc
     1081 caggcagcac tacagagcag ttggggtatg atgggcatgt tagccagcca gcagaaccag
     1141 tcaggcccat cgggtaataa ccaaaaccaa ggcaacatgc agagggagcc aaaccaggcc
     1201 ttcggttctg gaaataactc ttatagtggc tctaattctg gtgcagcaat tggttgggga
     1261 tcagcatcca atgcagggtc gggcagtggt tttaatggag gctttggctc aagcatggat
     1321 tctaagtctt ctggctgggg aatgtagaca gtggggttgt ggttggttgg tatagaatgg
     1381 tgggaattca aatttttcta aactcatggt aagtatattg taaaatacat atgtactaag
     1441 aattttcaaa attggtttgt tcagtgtgga gtatattcag cagtattttt gacatttttc
     1501 tttagaaaaa ggaagagcta aaggaatttt ataagttttg ttacatgaaa ggttgaaata
     1561 ttgagtggtt gaaagtgaac tgctgtttgc ctgattggta aaccaacaca ctacaattga
     1621 tatcaaaagg tttctcctgt aatattttat ccctggactt gtcaagtgaa ttctttgcat
     1681 gttcaaaacg gaaaccattg attagaacta cattctttac cccttgtttt aatttgaacc
     1741 ccaccatatg gatttttttc cttaagaaaa tctcctttta ggagatcatg gtgtcacagt
     1801 gtttggttct tttgttttgt tttttaacac ttgtctcccc tcatacacaa aagtacaata
     1861 tgaagccttc atttaatctc tgcagttcat ctcatttcaa atgtttatgg aagaagcact
     1921 tcattgaaag tagtgctgta aatattctgc cataggaata ctgtctacat gctttctcat
     1981 tcaagaattc gtcatcacgc atcacaggcc gcgtctttga cggtgggtgt cccattttta
     2041 tccgctactc tttatttcat ggagtcgtat caacgctatg aacgcaaggc tgtgatatgg
     2101 aaccagaagg ctgtctgaac ttttgaaacc ttgtgtggga ttgatggtgg tgccgaggca
     2161 tgaaaggcta gtatgagcga gaaaaggaga gagcgcgtgc agagacttgg tggtgcataa
     2221 tggatatttt ttaacttggc gagatgtgtc tctcaatcct gtggctttgg tgagagagtg
     2281 tgcagagagc aatgatagca aataatgtac gaatgttttt tgcattcaaa ggacatccac
     2341 atctgttgga agacttttaa gtgagttttt gttcttagat aacccacatt agatgaatgt
     2401 gttaagtgaa atgatacttg tactccccct acccctttgt caactgctgt gaatgctgta
     2461 tggtgtgtgt tctcttctgt tactgatatg taagtgtggc aatgtgaact gaagctgatg
     2521 ggctgagaac atggactgag cttgtggtgt gctttgcagg aggacttgaa gcagagttca
     2581 ccagtgagct caggtgtctc aaagaagggt ggaagttcta atgtctgtta gctacccata
     2641 agaatgctgt ttgctgcagt tctgtgtcct gtgcttggat gctttttata agagttgtca
     2701 ttgttggaaa ttcttaaata aaactgattt aaataatatg tgtctttgtt ttgcagccct
     2761 gaatgcaaag aattcatagc agttaattcc ccttttttga cccttttgag atggaacttt
     2821 cataaagttt cttggcagta gtttattttg cttcaaataa acttatttga aaagttgtct
     2881 caagtcaaat ggattcatca cctgtcatgc attgacacct gatacccaga cttaattggt
     2941 atttgttctt gcattggcca aagtgaaaat tttttttttt cttttgaaat ctagttttga
     3001 ataagtctgg gtgaccgcac ctaaaatggt aagcagtacc ctccggcttt ttcttagtgc
     3061 ctctgtgcat ttgggtgatg ttctatttac atggcctgtg taaatctcca ttgggaagtc
     3121 atgccttcta aaaagattct tatttggggg agtgggcaaa atgttgatta ttttctaatg
     3181 ctttgtagca aagcatatca attgaaaagg gaatatcagc accttcctag tttgggattt
     3241 gaaaagtgga attaattgca gtagggataa agtagaagaa accacaaatt atcttgtgcc
     3301 tgaaatccat taagaggcct gatagcttta agaattaggg tgggttgtct gtctggaagt
     3361 gttaagtgga atgggctttg tcctccagga ggtgggggaa tgtggtaaca ttgaatacag
     3421 ttgaataaaa tcgcttacaa aactcacact ctcacaatgc attgttaagt atgtaaaagc
     3481 aataacattg attctctgtt gtactttttt gtaactaatt ctgtgagagt tgagctcatt
     3541 ttctagttgg aagaatgtga tatttgttgt gttggtagtt tacctaatgc ccttacctaa
     3601 ttagattatg ataaataggt ttgtcatttt gcaagttaca taaacattta tcaatgaagt
     3661 catcctttag acttgtaatc gccacattgt ttcattattc agtttcctct gtaaagggat
     3721 cttgagttgt tttaattttt tttttctgca tctgaatctg catgatttcc aaaccctgta
     3781 ccatctgaat tttgcatttt agcacttgca ctattactca gcagcagtaa catggtaaca
     3841 cttaaaatgg tactcgggga cctccaaaga ctaaactgac aagccttcaa ggagcccagg
     3901 ggtaagttaa cttgtcaacg gcatggttta atcccttctt tacacttgtg taaatttcag
     3961 ttactggtca tagaaggctt tcaatgttga gtggcctttt attaacatgt ttatggtact
     4021 gcatagatac gggtatttat tttaccctaa gaagattttg aagtttaaaa gtacttaaac
     4081 tatttggcaa agatttgttt ttaaaaatct atttggtcaa tctaaatgca ttcattctaa
     4141 aaaatttttt gaaccagata aataaaattt ttttttgaca ccaca
//
