LOCUS       NM_134323               1510 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens TARBP2 subunit of RISC loading complex (TARBP2),
            transcript variant 1, mRNA.
ACCESSION   NM_134323
VERSION     NM_134323.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1510)
  AUTHORS   Shibata,K., Moriizumi,H., Onomoto,K., Kaneko,Y., Miyakawa,T.,
            Zenno,S., Tanokura,M., Yoneyama,M., Takahashi,T. and Ui-Tei,K.
  TITLE     Caspase-mediated processing of TRBP regulates apoptosis during
            viral infection
  JOURNAL   Nucleic Acids Res 52 (9), 5209-5225 (2024)
   PUBMED   38636948
  REMARK    GeneRIF: Caspase-mediated processing of TRBP regulates apoptosis
            during viral infection.
REFERENCE   2  (bases 1 to 1510)
  AUTHORS   Kim,D.K., Weller,B., Lin,C.W., Sheykhkarimli,D., Knapp,J.J.,
            Dugied,G., Zanzoni,A., Pons,C., Tofaute,M.J., Maseko,S.B.,
            Spirohn,K., Laval,F., Lambourne,L., Kishore,N., Rayhan,A.,
            Sauer,M., Young,V., Halder,H., la Rosa,N.M., Pogoutse,O.,
            Strobel,A., Schwehn,P., Li,R., Rothballer,S.T., Altmann,M.,
            Cassonnet,P., Cote,A.G., Vergara,L.E., Hazelwood,I., Liu,B.B.,
            Nguyen,M., Pandiarajan,R., Dohai,B., Coloma,P.A.R., Poirson,J.,
            Giuliana,P., Willems,L., Taipale,M., Jacob,Y., Hao,T., Hill,D.E.,
            Brun,C., Twizere,J.C., Krappmann,D., Heinig,M., Falter,C., Aloy,P.,
            Demeret,C., Vidal,M., Calderwood,M.A., Roth,F.P. and
            Falter-Braun,P.
  TITLE     A proteome-scale map of the SARS-CoV-2-human contactome
  JOURNAL   Nat Biotechnol 41 (1), 140-149 (2023)
   PUBMED   36217029
REFERENCE   3  (bases 1 to 1510)
  AUTHORS   Li,J.N., Chen,P.S., Chiu,C.F., Lyu,Y.J., Lo,C., Tsai,L.W. and
            Wang,M.Y.
  TITLE     TARBP2 Suppresses Ubiquitin-Proteasomal Degradation of HIF-1alpha
            in Breast Cancer
  JOURNAL   Int J Mol Sci 23 (1), 208 (2021)
   PUBMED   35008634
  REMARK    GeneRIF: TARBP2 Suppresses Ubiquitin-Proteasomal Degradation of
            HIF-1alpha in Breast Cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1510)
  AUTHORS   Zheng,X., Sun,Z., Yu,L., Shi,D., Zhu,M., Yao,H. and Li,L.
  TITLE     Interactome Analysis of the Nucleocapsid Protein of SARS-CoV-2
            Virus
  JOURNAL   Pathogens 10 (9), 1155 (2021)
   PUBMED   34578187
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1510)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 1510)
  AUTHORS   Gatignol,A., Duarte,M., Daviet,L., Chang,Y.N. and Jeang,K.T.
  TITLE     Sequential steps in Tat trans-activation of HIV-1 mediated through
            cellular DNA, RNA, and protein binding factors
  JOURNAL   Gene Expr 5 (4-5), 217-228 (1996)
   PUBMED   8723388
REFERENCE   7  (bases 1 to 1510)
  AUTHORS   Cosentino,G.P., Venkatesan,S., Serluca,F.C., Green,S.R.,
            Mathews,M.B. and Sonenberg,N.
  TITLE     Double-stranded-RNA-dependent protein kinase and TAR RNA-binding
            protein form homo- and heterodimers in vivo
  JOURNAL   Proc Natl Acad Sci U S A 92 (21), 9445-9449 (1995)
   PUBMED   7568151
REFERENCE   8  (bases 1 to 1510)
  AUTHORS   Kozak,C.A., Gatignol,A., Graham,K., Jeang,K.T. and McBride,O.W.
  TITLE     Genetic mapping in human and mouse of the locus encoding TRBP, a
            protein that binds the TAR region of the human immunodeficiency
            virus (HIV-1)
  JOURNAL   Genomics 25 (1), 66-72 (1995)
   PUBMED   7774957
REFERENCE   9  (bases 1 to 1510)
  AUTHORS   Gatignol,A., Buckler,C. and Jeang,K.T.
  TITLE     Relatedness of an RNA-binding motif in human immunodeficiency virus
            type 1 TAR RNA-binding protein TRBP to human P1/dsI kinase and
            Drosophila staufen
  JOURNAL   Mol Cell Biol 13 (4), 2193-2202 (1993)
   PUBMED   8455607
REFERENCE   10 (bases 1 to 1510)
  AUTHORS   Gatignol,A., Buckler-White,A., Berkhout,B. and Jeang,K.T.
  TITLE     Characterization of a human TAR RNA-binding protein that activates
            the HIV-1 LTR
  JOURNAL   Science 251 (5001), 1597-1600 (1991)
   PUBMED   2011739
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC002419.2 and BC005860.2.
            
            On May 17, 2019 this sequence version replaced NM_134323.1.
            
            Summary: HIV-1, the causative agent of acquired immunodeficiency
            syndrome (AIDS), contains an RNA genome that produces a
            chromosomally integrated DNA during the replicative cycle.
            Activation of HIV-1 gene expression by the transactivator Tat is
            dependent on an RNA regulatory element (TAR) located downstream of
            the transcription initiation site. The protein encoded by this gene
            binds between the bulge and the loop of the HIV-1 TAR RNA
            regulatory element and activates HIV-1 gene expression in synergy
            with the viral Tat protein. Alternative splicing results in
            multiple transcript variants encoding different isoforms. This gene
            also has a pseudogene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) is the longer transcript and
            encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.321528.1, BC005860.2
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000266987.7/ ENSP00000266987.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-452               BC002419.2         363-814
            453-1510            BC005860.2         680-1737
FEATURES             Location/Qualifiers
     source          1..1510
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.13"
     gene            1..1510
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
                     /note="TARBP2 subunit of RISC loading complex"
                     /db_xref="GeneID:6895"
                     /db_xref="HGNC:HGNC:11569"
                     /db_xref="MIM:605053"
     exon            1..179
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             127..1227
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
                     /note="isoform a is encoded by transcript variant 1; TAR
                     (HIV) RNA-binding protein 2; trans-activation responsive
                     RNA-binding protein; TAR RNA binding protein 2;
                     RISC-loading complex subunit TARBP2; TAR (HIV) RNA-binding
                     protein TRBP1; TAR (HIV-1) RNA binding protein 2; TARBP2,
                     RISC loading complex RNA binding subunit"
                     /codon_start=1
                     /product="RISC-loading complex subunit TARBP2 isoform a"
                     /protein_id="NP_599150.1"
                     /db_xref="CCDS:CCDS8861.1"
                     /db_xref="GeneID:6895"
                     /db_xref="HGNC:HGNC:11569"
                     /db_xref="MIM:605053"
                     /translation="MSEEEQGSGTTTGCGLPSIEQMLAANPGKTPISLLQEYGTRIGK
                     TPVYDLLKAEGQAHQPNFTFRVTVGDTSCTGQGPSKKAAKHKAAEVALKHLKGGSMLE
                     PALEDSSSFSPLDSSLPEDIPVFTAAAAATPVPSVVLTRSPPMELQPPVSPQQSECNP
                     VGALQELVVQKGWRLPEYTVTQESGPAHRKEFTMTCRVERFIEIGSGTSKKLAKRNAA
                     AKMLLRVHTVPLDARDGNEVEPDDDHFSIGVGSRLDGLRNRGPGCTWDSLRNSVGEKI
                     LSLRSCSLGSLGALGPACCRVLSELSEEQAFHVSYLDIEELSLSGLCQCLVELSTQPA
                     TVCHGSATTREAARGEAARRALQYLKIMAGSK"
     exon            180..349
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            350..452
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            453..548
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            549..621
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            622..739
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            740..867
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            868..1069
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1510
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1482..1487
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
                     /note="hexamer: AATAAA"
     polyA_site      1510
                     /gene="TARBP2"
                     /gene_synonym="LOQS; TRBP; TRBP1; TRBP2"
                     /note="major polyA site"
ORIGIN      
        1 agcgtgcccc gcggcgggcc ctaccggccg cgactccggg cttggccccg gccctagctc
       61 gtcggctgtg tattggggcg cgtggaggct gcagtcacgg tggcgcccgc ggggacggag
      121 gagggaatga gtgaagagga gcaaggctcc ggcactacca cgggctgcgg gctgcctagt
      181 atagagcaaa tgctggccgc caacccaggc aagaccccga tcagccttct gcaggagtat
      241 gggaccagaa tagggaagac gcctgtgtac gaccttctca aagccgaggg ccaagcccac
      301 cagcctaatt tcaccttccg ggtcaccgtt ggcgacacca gctgcactgg tcagggcccc
      361 agcaagaagg cagccaagca caaggcagct gaggtggccc tcaaacacct caaagggggg
      421 agcatgctgg agccggccct ggaggacagc agttcttttt ctcccctaga ctcttcactg
      481 cctgaggaca ttccggtttt tactgctgca gcagctgcta ccccagttcc atctgtagtc
      541 ctaaccagga gcccccccat ggaactgcag ccccctgtct cccctcagca gtctgagtgc
      601 aaccccgttg gtgctctgca ggagctggtg gtgcagaaag gctggcggtt gccggagtac
      661 acagtgaccc aggagtctgg gccagcccac cgcaaagaat tcaccatgac ctgtcgagtg
      721 gagcgtttca ttgagattgg gagtggcact tccaaaaaat tggcaaagcg gaatgcggcg
      781 gccaaaatgc tgcttcgagt gcacacggtg cctctggatg cccgggatgg caatgaggtg
      841 gagcctgatg atgaccactt ctccattggt gtgggctccc gcctggatgg tcttcgaaac
      901 cggggcccag gttgcacctg ggattctcta cgaaattcag taggagagaa gatcctgtcc
      961 ctccgcagtt gctccctggg ctccctgggt gccctgggcc ctgcctgctg ccgtgtcctc
     1021 agtgagctct ctgaggagca ggcctttcac gtcagctacc tggatattga ggagctgagc
     1081 ctgagtggac tctgccagtg cctggtggaa ctgtccaccc agccggccac tgtgtgtcat
     1141 ggctctgcaa ccaccaggga ggcagcccgt ggtgaggctg cccgccgtgc cctgcagtac
     1201 ctcaagatca tggcaggcag caagtgaagc cccagctgga ctcatggatg tgcacccttt
     1261 gctccctgct ctttctgcct ctgggctcat gtatctgcgc agctctggta ccctctgtgg
     1321 gtgccatctc tacctctgac acagactgcc tgccttgaag ctgagaaggc acagggcaag
     1381 gagccaagga ccacagagcc tcagccagcc caggatccgt cctcatttta ttggtgatga
     1441 tgaatgggaa tgaaatcagg gggctgtcta ctagagcctg gaataaatat gctgctttgt
     1501 ggatttttaa
//
