LOCUS       NM_005646               5206 bp    mRNA    linear   PRI 22-JAN-2025
DEFINITION  Homo sapiens tRNA guanosine 2 -O-methyltransferase TARBP1 (TARBP1),
            mRNA.
ACCESSION   NM_005646
VERSION     NM_005646.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5206)
  AUTHORS   Shi,X., Zhang,Y., Wang,Y., Wang,J., Gao,Y., Wang,R., Wang,L.,
            Xiong,M., Cao,Y., Ou,N., Liu,Q., Ma,H., Cai,J. and Chen,H.
  TITLE     The tRNA Gm18 methyltransferase TARBP1 promotes hepatocellular
            carcinoma progression via metabolic reprogramming of glutamine
  JOURNAL   Cell Death Differ 31 (9), 1219-1234 (2024)
   PUBMED   38867004
REFERENCE   2  (bases 1 to 5206)
  AUTHORS   Weiss,A.L., Meijer,M., Budeus,B., Pauper,M., Hakobjan,M.,
            Groothuismink,J., Shi,Y., Neveling,K., Buitelaar,J.K., Hoogman,M.,
            Franke,B. and Klein,M.
  TITLE     DNA methylation associated with persistent ADHD suggests TARBP1 as
            novel candidate
  JOURNAL   Neuropharmacology 184, 108370 (2021)
   PUBMED   33137342
  REMARK    GeneRIF: DNA methylation associated with persistent ADHD suggests
            TARBP1 as novel candidate.
REFERENCE   3  (bases 1 to 5206)
  AUTHORS   Freund,I., Buhl,D.K., Boutin,S., Kotter,A., Pichot,F., Marchand,V.,
            Vierbuchen,T., Heine,H., Motorin,Y., Helm,M., Dalpke,A.H. and
            Eigenbrod,T.
  TITLE     2'-O-methylation within prokaryotic and eukaryotic tRNA inhibits
            innate immune activation by endosomal Toll-like receptors but does
            not affect recognition of whole organisms
  JOURNAL   RNA 25 (7), 869-880 (2019)
   PUBMED   31019095
REFERENCE   4  (bases 1 to 5206)
  AUTHORS   Ye,J., Wang,J., Tan,L., Yang,S., Xu,L., Wu,X., Deng,H. and Tan,H.
  TITLE     Expression of protein TARBP1 in human hepatocellular carcinoma and
            its prognostic significance
  JOURNAL   Int J Clin Exp Pathol 8 (8), 9089-9096 (2015)
   PUBMED   26464651
  REMARK    GeneRIF: TARBP1 is up-regulated in hepatocellular carcinoma, and
            the expression of TARBP1 was associated with the pathological
            grading and clinical stage.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5206)
  AUTHORS   Beech,R.D., Leffert,J.J., Lin,A., Hong,K.A., Hansen,J., Umlauf,S.,
            Mane,S., Zhao,H. and Sinha,R.
  TITLE     Stress-related alcohol consumption in heavy drinkers correlates
            with expression of miR-10a, miR-21, and components of the
            TAR-RNA-binding protein-associated complex
  JOURNAL   Alcohol Clin Exp Res 38 (11), 2743-2753 (2014)
   PUBMED   25421511
  REMARK    GeneRIF: TARBP1 is positively regulated by MIR10A and MIR21 which
            are upregulated in heavy drinkers following psychological stress.
REFERENCE   6  (bases 1 to 5206)
  AUTHORS   Wu-Baer,F., Lane,W.S. and Gaynor,R.B.
  TITLE     Identification of a group of cellular cofactors that stimulate the
            binding of RNA polymerase II and TRP-185 to human immunodeficiency
            virus 1 TAR RNA
  JOURNAL   J Biol Chem 271 (8), 4201-4208 (1996)
   PUBMED   8626763
REFERENCE   7  (bases 1 to 5206)
  AUTHORS   Wu-Baer,F., Lane,W.S. and Gaynor,R.B.
  TITLE     The cellular factor TRP-185 regulates RNA polymerase II binding to
            HIV-1 TAR RNA
  JOURNAL   EMBO J 14 (23), 5995-6009 (1995)
   PUBMED   8846792
REFERENCE   8  (bases 1 to 5206)
  AUTHORS   Wu-Baer,F., Sigman,D. and Gaynor,R.B.
  TITLE     Specific binding of RNA polymerase II to the human immunodeficiency
            virus trans-activating region RNA is regulated by cellular
            cofactors and Tat
  JOURNAL   Proc Natl Acad Sci U S A 92 (16), 7153-7157 (1995)
   PUBMED   7638159
REFERENCE   9  (bases 1 to 5206)
  AUTHORS   Sheline,C.T., Milocco,L.H. and Jones,K.A.
  TITLE     Two distinct nuclear transcription factors recognize loop and bulge
            residues of the HIV-1 TAR RNA hairpin
  JOURNAL   Genes Dev 5 (12B), 2508-2520 (1991)
   PUBMED   1752441
REFERENCE   10 (bases 1 to 5206)
  AUTHORS   Wu,F., Garcia,J., Sigman,D. and Gaynor,R.
  TITLE     tat regulates binding of the human immunodeficiency virus
            trans-activating region RNA loop-binding protein TRP-185
  JOURNAL   Genes Dev 5 (11), 2128-2140 (1991)
   PUBMED   1936997
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL136124.10, U38847.1 and
            AL355472.19.
            
            On Nov 23, 2018 this sequence version replaced NM_005646.3.
            
            Summary: HIV-1, the causative agent of acquired immunodeficiency
            syndrome (AIDS), contains an RNA genome that produces a
            chromosomally integrated DNA during the replicative cycle.
            Activation of HIV-1 gene expression by the transactivator Tat is
            dependent on an RNA regulatory element (TAR) located downstream of
            the transcription initiation site. This element forms a stable
            stem-loop structure and can be bound by either the protein encoded
            by this gene or by RNA polymerase II. This protein may act to
            disengage RNA polymerase II from TAR during transcriptional
            elongation. Alternatively spliced transcripts of this gene may
            exist, but their full-length natures have not been determined.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U38847.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000040877.2/ ENSP00000040877.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-76                AL136124.10        60762-60837         c
            77-561              U38847.1           1-485
            562-562             AL136124.10        60276-60276         c
            563-3591            U38847.1           487-3515
            3592-3592           AL136124.10        2399-2399           c
            3593-3813           U38847.1           3517-3737
            3814-3814           AL355472.19        82785-82785         c
            3815-4332           U38847.1           3739-4256
            4333-4351           AL355472.19        66092-66110         c
            4352-5174           U38847.1           4276-5098
            5175-5206           AL355472.19        63599-63630         c
FEATURES             Location/Qualifiers
     source          1..5206
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q42.2"
     gene            1..5206
                     /gene="TARBP1"
                     /gene_synonym="TRM3; TRMT3; TRP-185; TRP185"
                     /note="tRNA guanosine 2 -O-methyltransferase TARBP1"
                     /db_xref="GeneID:6894"
                     /db_xref="HGNC:HGNC:11568"
                     /db_xref="MIM:605052"
     exon            1..1007
                     /gene="TARBP1"
                     /gene_synonym="TRM3; TRMT3; TRP-185; TRP185"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..4942
                     /gene="TARBP1"
                     /gene_synonym="TRM3; TRMT3; TRP-185; TRP185"
                     /note="TAR (HIV) RNA-binding protein 1; TAR RNA loop
                     binding protein; TAR RNA-binding protein 1; TAR
                     RNA-binding protein of 185 kDa; TAR (HIV-1) RNA binding
                     protein 1; tRNA methyltransferase 3 homolog"
                     /codon_start=1
                     /product="probable methyltransferase TARBP1"
                     /protein_id="NP_005637.3"
                     /db_xref="CCDS:CCDS1601.1"
                     /db_xref="GeneID:6894"
                     /db_xref="HGNC:HGNC:11568"
                     /db_xref="MIM:605052"
                     /translation="MEWVLAEALLSQSRDPRALLGALCQGEASAERVETLRFLLQRLE
                     DEEARGSGGAGALPEAAREVAAGYLVPLLRSLRGRPAGGPDPSLQPRHRRRVLRAAGA
                     ALRSCVRLAGRPQLAAALAEEALRDLLAGWRAPGAEAAVEVLAAVGPCLRPREDGPLL
                     ERVAGTAVALALGGGGDGDEAGPAEDAAALVAGRLLPVLVQCGGAALRAVWGGLAAPG
                     ASLGSGRVEEKLLVLSALAEKLLPEPGGDRARGAREAGPDARRCWRFWRTVQAGLGQA
                     DALTRKRARYLLQRAVEVSAELGADCTCGPQEGNGPSLFWWSERKKDELLKFWENYIL
                     IMETLEGNQIHVIKPVLPKLNNLFEYAVSEENGCWLFHPSWHMCIYKRMFESENKILS
                     KEGVIHFLELYETKILPFSPEFSEFIIGPLMDALSESSLYSRSPGQPIGSCSPLGLKL
                     QKFLVTYISLLPEEIKSSFLLKFIRKMTSRHWCAVPILFLSKALANVPRHKALGIDGL
                     LALRDVIHCTMITHQILLRGAAQCYLLQTAMNLLDVEKVSLSDVSTFLMSLRQEESLG
                     RGTSLWTELCDWLRVNESYFKPSPTCSSIGLHKTSLNAYVKSIVQEYVKSSAWETGEN
                     CFMPDWFEAKLVSLMVLLAVDVEGMKTQYSGKQRTENVLRIFLDPLLDVLMKFSTNAY
                     MPLLKTDRCLQLLLKLLNTCRLKGSSAQDDEVSTVLQNFFMSTTESISEFILRRLTMN
                     ELNSVSDLDRCHLYLMVLTELINLHLKVGWKRGNPIWRVISLLKNASIQHLQEMDSGQ
                     EPTVGSQIQRVVSMAALAMVCEAIDQKPELQLDSLHAGPLESFLSSLQLNQTLQKPHA
                     EEQSSYAHPLECSSVLEESSSSQGWGKIVAQYIHDQWVCLSFLLKKYHTLIPTTGSEI
                     LEPFLPAVQMPIRTLQSALEALTVLSSDQVLPVFHCLKVLVPKLLTSSESLCIESFDM
                     AWKIISSLSNTQLIFWANLKAFVQFVFDNKVLTIAAKIKGQAYFKIKEIMYKIIEMSA
                     IKTGVFNTLISYCCQSWIVSASNVSQGSLSSAKNYSELILEACIFGTVFRRDQRLVQD
                     VQTFIENLGHDCAANIVMENTKREDHYVRICAVKFLCLLDGSNMSHKLFIEDLAIKLL
                     DKDELVSKSKKRYYVNSLQHRVKNRVWQTLLVLFPRLDQNFLNGIIDRIFQAGFTNNQ
                     ASIKYFIEWIIILILHKFPQFLPKFWDCFSYGEENLKTSICTFLAVLSHLDIITQNIP
                     EKKLILKQALIVVLQWCFNHNFSVRLYALVALKKLWTVCKVLSVEEFDALTPVIESSL
                     HQVESMHGAGNAKKNWQRIQEHFFFATFHPLKDYCLETIFYILPRLSGLIEDEWITID
                     KFTRFTDVPLAAGFQWYLSQTQLSKLKPGDWSQQDIGTNLVEADNQAEWTDVQKKIIP
                     WNSRVSDLDLELLFQDRAARLGKSISRLIVVASLIDKPTNLGGLCRTCEVFGASVLVV
                     GSLQCISDKQFQHLSVSAEQWLPLVEVKPPQLIDYLQQKKTEGYTIIGVEQTAKSLDL
                     TQYCFPEKSLLLLGNEREGIPANLIQQLDVCVEIPQQGIIRSLNVHVSGALLIWEYTR
                     QQLLSHGDTKP"
     exon            1008..1105
                     /gene="TARBP1"
                     /gene_synonym="TRM3; TRMT3; TRP-185; TRP185"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1175
                     /gene="TARBP1"
                     /gene_synonym="TRM3; TRMT3; TRP-185; TRP185"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1324
                     /gene="TARBP1"
                     /gene_synonym="TRM3; TRMT3; TRP-185; TRP185"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1377
                     /gene="TARBP1"
                     /gene_synonym="TRM3; TRMT3; TRP-185; TRP185"
                     /inference="alignment:Splign:2.1.0"
     exon            1378..1475
                     /gene="TARBP1"
                     /gene_synonym="TRM3; TRMT3; TRP-185; TRP185"
                     /inference="alignment:Splign:2.1.0"
     exon            1476..1611
                     /gene="TARBP1"
                     /gene_synonym="TRM3; TRMT3; TRP-185; TRP185"
                     /inference="alignment:Splign:2.1.0"
     exon            1612..1708
                     /gene="TARBP1"
                     /gene_synonym="TRM3; TRMT3; TRP-185; TRP185"
                     /inference="alignment:Splign:2.1.0"
     exon            1709..1798
                     /gene="TARBP1"
                     /gene_synonym="TRM3; TRMT3; TRP-185; TRP185"
                     /inference="alignment:Splign:2.1.0"
     exon            1799..1937
                     /gene="TARBP1"
                     /gene_synonym="TRM3; TRMT3; TRP-185; TRP185"
                     /inference="alignment:Splign:2.1.0"
     exon            1938..2037
                     /gene="TARBP1"
                     /gene_synonym="TRM3; TRMT3; TRP-185; TRP185"
                     /inference="alignment:Splign:2.1.0"
     exon            2038..2210
                     /gene="TARBP1"
                     /gene_synonym="TRM3; TRMT3; TRP-185; TRP185"
                     /inference="alignment:Splign:2.1.0"
     exon            2211..2308
                     /gene="TARBP1"
                     /gene_synonym="TRM3; TRMT3; TRP-185; TRP185"
                     /inference="alignment:Splign:2.1.0"
     exon            2309..2470
                     /gene="TARBP1"
                     /gene_synonym="TRM3; TRMT3; TRP-185; TRP185"
                     /inference="alignment:Splign:2.1.0"
     exon            2471..2685
                     /gene="TARBP1"
                     /gene_synonym="TRM3; TRMT3; TRP-185; TRP185"
                     /inference="alignment:Splign:2.1.0"
     exon            2686..2947
                     /gene="TARBP1"
                     /gene_synonym="TRM3; TRMT3; TRP-185; TRP185"
                     /inference="alignment:Splign:2.1.0"
     exon            2948..3136
                     /gene="TARBP1"
                     /gene_synonym="TRM3; TRMT3; TRP-185; TRP185"
                     /inference="alignment:Splign:2.1.0"
     exon            3137..3327
                     /gene="TARBP1"
                     /gene_synonym="TRM3; TRMT3; TRP-185; TRP185"
                     /inference="alignment:Splign:2.1.0"
     exon            3328..3399
                     /gene="TARBP1"
                     /gene_synonym="TRM3; TRMT3; TRP-185; TRP185"
                     /inference="alignment:Splign:2.1.0"
     exon            3400..3520
                     /gene="TARBP1"
                     /gene_synonym="TRM3; TRMT3; TRP-185; TRP185"
                     /inference="alignment:Splign:2.1.0"
     exon            3521..3631
                     /gene="TARBP1"
                     /gene_synonym="TRM3; TRMT3; TRP-185; TRP185"
                     /inference="alignment:Splign:2.1.0"
     exon            3632..3781
                     /gene="TARBP1"
                     /gene_synonym="TRM3; TRMT3; TRP-185; TRP185"
                     /inference="alignment:Splign:2.1.0"
     exon            3782..3868
                     /gene="TARBP1"
                     /gene_synonym="TRM3; TRMT3; TRP-185; TRP185"
                     /inference="alignment:Splign:2.1.0"
     exon            3869..4065
                     /gene="TARBP1"
                     /gene_synonym="TRM3; TRMT3; TRP-185; TRP185"
                     /inference="alignment:Splign:2.1.0"
     exon            4066..4147
                     /gene="TARBP1"
                     /gene_synonym="TRM3; TRMT3; TRP-185; TRP185"
                     /inference="alignment:Splign:2.1.0"
     exon            4148..4319
                     /gene="TARBP1"
                     /gene_synonym="TRM3; TRMT3; TRP-185; TRP185"
                     /inference="alignment:Splign:2.1.0"
     exon            4320..4511
                     /gene="TARBP1"
                     /gene_synonym="TRM3; TRMT3; TRP-185; TRP185"
                     /inference="alignment:Splign:2.1.0"
     exon            4512..4636
                     /gene="TARBP1"
                     /gene_synonym="TRM3; TRMT3; TRP-185; TRP185"
                     /inference="alignment:Splign:2.1.0"
     exon            4637..4773
                     /gene="TARBP1"
                     /gene_synonym="TRM3; TRMT3; TRP-185; TRP185"
                     /inference="alignment:Splign:2.1.0"
     exon            4774..5206
                     /gene="TARBP1"
                     /gene_synonym="TRM3; TRMT3; TRP-185; TRP185"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5117..5122
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TARBP1"
                     /gene_synonym="TRM3; TRMT3; TRP-185; TRP185"
                     /note="hexamer: AATAAA"
     polyA_site      5136
                     /gene="TARBP1"
                     /gene_synonym="TRM3; TRMT3; TRP-185; TRP185"
     regulatory      5152..5157
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TARBP1"
                     /gene_synonym="TRM3; TRMT3; TRP-185; TRP185"
                     /note="hexamer: AATAAA"
     regulatory      5178..5183
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TARBP1"
                     /gene_synonym="TRM3; TRMT3; TRP-185; TRP185"
                     /note="hexamer: AATAAA"
     polyA_site      5184
                     /gene="TARBP1"
                     /gene_synonym="TRM3; TRMT3; TRP-185; TRP185"
                     /note="major polyA site"
     polyA_site      5206
                     /gene="TARBP1"
                     /gene_synonym="TRM3; TRMT3; TRP-185; TRP185"
ORIGIN      
        1 cggtcctgtg cgcacgcatc gcacacgccg gcgccttcct ttgggagccc gggccggtgg
       61 cgcgggcgct cggcaaatgg agtgggtgct cgcggaagcg ctgctctcgc agagccggga
      121 cccccgggcc ctgcttgggg cgctgtgcca aggggaggca tccgcggagc gcgtggagac
      181 gctgcgcttc cttctgcagc ggctcgagga cgaggaggcg cgcggcagcg ggggcgcagg
      241 cgcgctcccg gaggcggcgc gcgaggtggc tgcagggtac ctcgtgccac tgctgcggag
      301 cctgcgcgga cgccccgcgg gcggcccgga ccccagtctg cagcctcgcc accgccggcg
      361 cgtgctgagg gcggcgggcg cggccctgcg ctcgtgcgtc cgcctggccg ggcgtccgca
      421 gctggcggcc gcgctggctg aggaggcgct gcgcgatctg ctcgccgggt ggcgcgcgcc
      481 tggcgccgag gctgccgtgg aagtgctagc agccgtcggg ccatgtttgc ggccccgcga
      541 ggacgggccg ctactggagc gcgtggcggg gaccgccgtc gccctggcgc tgggcggggg
      601 cggggacggg gatgaggccg ggcctgccga ggacgcggcg gcgctggtgg ccgggcgact
      661 gctgccagtg ctggtccaat gtggcggggc ggcgctgcgg gccgtgtggg gcgggctggc
      721 cgcgcctggg gcgtccctgg ggtccggccg cgtagaggag aagctgctgg tcctgagcgc
      781 cctggccgag aagctgttgc ccgagcccgg cggcgaccgc gcccgcggcg cgcgcgaggc
      841 gggcccggac gcccggcgct gctggcgctt ctggaggacg gtgcaggcgg ggctgggcca
      901 ggcggacgcc ctgacgcgca agcgagcgcg ctacctgctg cagagggcgg tggaggtgtc
      961 ggcggagctg ggggccgact gcacctgcgg gccccaggaa ggaaacggcc caagtctgtt
     1021 ttggtggtct gagaggaaaa aagatgagct tctaaagttt tgggaaaatt atattttaat
     1081 tatggagact ttagaaggaa atcagataca tgttataaag ccagttttac caaagctaaa
     1141 caatctgttt gaatatgcgg tgtcagagga aaatggatgt tggctctttc acccatcctg
     1201 gcatatgtgt atttataaaa gaatgtttga aagtgaaaac aaaatcctgt ccaaagaagg
     1261 tgttatccat tttttggagc tgtatgaaac aaagattctt ccattttcac cagaattttc
     1321 tgagtttatt attggaccat taatggatgc gctttcagag agctctctgt atagcaggtc
     1381 cccaggccag ccaataggaa gctgttctcc attgggactg aaattacaga agtttttagt
     1441 cacttatatt tctcttcttc cagaagaaat aaagagtagc ttcctattga agtttattcg
     1501 gaagatgaca agtaggcatt ggtgtgctgt tcccattttg tttctatcta aggctttggc
     1561 aaatgtccca agacataagg ccctgggtat agatgggctt cttgctctca gggatgttat
     1621 tcattgcact atgatcacac atcagattct cctgagaggg gcagcccaat gctaccttct
     1681 tcaaacagct atgaatttgc tagatgtgga gaaagtgtca ctttctgatg tctcaacttt
     1741 tctcatgtct ctgagacaag aggaatcctt aggacgagga acttcattgt ggacagagct
     1801 gtgtgactgg ctacgtgtta atgaaagcta ttttaagcca tcccctacgt gtagctccat
     1861 tggacttcac aagacatctt taaatgctta tgtaaagagc attgttcaag agtatgttaa
     1921 gtcatctgct tgggaaacag gagaaaactg ctttatgcct gattggtttg aagccaagct
     1981 tgtttctctg atggtcttgc tggctgtgga tgtggaagga atgaagactc agtatagcgg
     2041 aaagcagaga acagagaatg tattgcggat attcttagac cctcttctgg atgtgcttat
     2101 gaagtttagt accaatgcct acatgccctt gctgaagact gacagatgcc tccagctgct
     2161 gttgaagctg ttgaacacat gcaggttgaa aggttccagt gcccaagatg atgaggtgtc
     2221 tactgttctt cagaactttt tcatgtctac tacagagagc atttctgaat ttattctcag
     2281 aagacttact atgaatgagc taaatagtgt ttcagatctg gatcgttgcc atttatacct
     2341 gatggtgtta actgagctta taaatctgca tttgaaggtt gggtggaaaa ggggtaaccc
     2401 tatctggaga gttatttctc ttttgaaaaa tgcatccatt cagcatcttc aagagatgga
     2461 cagtggacag gagccaacag ttggaagtca gattcagaga gtagtgagca tggctgcctt
     2521 ggccatggtg tgtgaggcca tagaccagaa gcctgagctg cagctggact ctctccatgc
     2581 tgggcccctg gaaagcttcc tttcctctct tcagctcaat cagacgctgc agaagcccca
     2641 cgcagaggag cagagcagtt atgctcaccc cttggagtgc agcagtgttt tggaagaatc
     2701 gtcatcttcc caaggatggg gaaaaatagt tgcacaatat attcatgatc aatgggtgtg
     2761 cctctctttc ctgttgaaaa aatatcacac ccttatacca accacaggga gtgaaattct
     2821 ggaaccgttt ctacctgccg ttcagatgcc aataaggact ttgcagtctg cactagaagc
     2881 cctcacagtt ctttcttctg atcaagtttt accagtgttc cattgcttga aagtgttggt
     2941 tcccaagctt ctgacttcct ctgaatcact ctgcatagag tcttttgaca tggcgtggaa
     3001 aattatatct tctttaagca acactcagct gatattctgg gctaatttaa aagcttttgt
     3061 tcagtttgtt tttgataaca aagttcttac cattgctgcc aaaatcaagg gccaggcata
     3121 tttcaaaata aaagagatta tgtacaagat aattgaaatg tctgctataa agactggagt
     3181 cttcaataca ctgataagtt actgctgtca gtcttggata gtgtctgctt caaatgtgtc
     3241 ccaaggatct ttatcaagtg ctaaaaatta tagcgaactt atccttgagg cttgtatatt
     3301 tggaactgtg tttaggcgtg atcaaagact tgttcaggat gtacagacct tcatagaaaa
     3361 ccttggacat gactgtgcgg caaatattgt tatggaaaat actaagagag aagaccatta
     3421 tgtgagaatt tgtgctgtca aattcctgtg tttattagat ggctccaata tgtcccacaa
     3481 gttgtttatt gaggatcttg caatcaagct attagataaa gatgaattag tgtccaagtc
     3541 caaaaaacgc tactatgtga attctctaca gcacagagtg aaaaaccgag tgtggcagac
     3601 tctgctggta cttttcccta gacttgacca gaatttcttg aatggaatta ttgacaggat
     3661 tttccaggct ggtttcacca acaatcaagc atccataaaa tattttatag aatggattat
     3721 tatattgatt cttcataaat tccctcaatt tcttccaaag ttctgggatt gtttttctta
     3781 tggtgaagaa aatcttaaaa caagcatttg tacgttttta gcagttttat cacatttaga
     3841 cattattact caaaatattc cagaaaagaa actaattctg aagcaagccc ttatagttgt
     3901 gctgcagtgg tgtttcaatc acaattttag tgttcgactg tatgctttag ttgctcttaa
     3961 gaaactctgg actgtgtgta aagtgttaag tgttgaagaa tttgatgccc tgactcctgt
     4021 gattgaatcc agcctccatc aagtggaaag catgcacgga gcagggaatg ccaagaagaa
     4081 ttggcaacgc attcaggagc atttcttttt tgcaacattt cacccactca aggattattg
     4141 tctagagacc atattttaca tccttccacg cctttcaggc cttattgaag atgaatggat
     4201 caccattgat aaatttacca gattcactga tgttccttta gctgcgggat ttcagtggta
     4261 cctttctcaa actcaactta gtaaactaaa accaggtgac tggtctcagc aagacatagg
     4321 tactaatttg gtcgaagcag ataaccaagc ggagtggacc gacgttcaga agaagattat
     4381 cccgtggaac agtcgtgttt ccgacttaga cctggagctc ctgtttcagg atcgtgctgc
     4441 cagacttgga aagtcaatta gtagactcat cgttgtggcc tcgctcatcg acaaaccgac
     4501 caatttagga ggactgtgca ggacctgtga ggtatttggg gcttcagtgc tcgttgttgg
     4561 cagccttcag tgtatcagcg acaaacagtt tcagcacctc agtgtctctg cagaacagtg
     4621 gcttcctcta gtggaggtaa aaccacctca gctaattgat tatctgcagc agaagaaaac
     4681 agaaggttat accatcattg gagtggaaca aactgccaaa agtttagacc taacccaata
     4741 ttgctttcct gagaaatctc tgctcttgtt gggaaatgaa cgtgagggaa ttccagcaaa
     4801 tctgatccaa cagttggacg tttgtgtgga aattcctcaa cagggcatta tccgctccct
     4861 gaatgtccat gtgagtggag ccctgctgat ctgggagtac accaggcagc agctgctctc
     4921 gcacggagat accaagccat gatgtgcctt ccttagtgaa ctgctgctgc tgttcagact
     4981 tttttaaaaa aaactatttg gactaaagaa acagattctg aaatttattg tgataatttg
     5041 tatttctttt ttcttgcaat ttaatgccaa aagtttgcca tgtgccttaa acatattact
     5101 atatattttc ccctttaata aacacttttt gttaaattgt attcttcctt taataaaata
     5161 ttttaagcaa ttgtggaaat aaaacaatgg attttttaag agagaa
//
