LOCUS       NM_018009               1781 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens TAP binding protein like (TAPBPL), transcript variant
            1, mRNA.
ACCESSION   NM_018009
VERSION     NM_018009.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1781)
  AUTHORS   Satti,R., Morley,J.L. and Boyle,L.H.
  TITLE     Get into the groove! The influence of TAPBPR on cargo selection
  JOURNAL   Curr Opin Immunol 83, 102346 (2023)
   PUBMED   37295041
  REMARK    GeneRIF: Get into the groove! The influence of TAPBPR on cargo
            selection.
            Review article
REFERENCE   2  (bases 1 to 1781)
  AUTHORS   Sagert,L., Winter,C., Ruppert,I., Zehetmaier,M., Thomas,C. and
            Tampe,R.
  TITLE     The ER folding sensor UGGT1 acts on TAPBPR-chaperoned peptide-free
            MHC I
  JOURNAL   Elife 12, e85432 (2023)
   PUBMED   37345806
  REMARK    GeneRIF: The ER folding sensor UGGT1 acts on TAPBPR-chaperoned
            peptide-free MHC I.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1781)
  AUTHORS   van Hateren,A. and Elliott,T.
  TITLE     The role of MHC I protein dynamics in tapasin and TAPBPR-assisted
            immunopeptidome editing
  JOURNAL   Curr Opin Immunol 70, 138-143 (2021)
   PUBMED   34265495
  REMARK    GeneRIF: The role of MHC I protein dynamics in tapasin and
            TAPBPR-assisted immunopeptidome editing.
            Review article
REFERENCE   4  (bases 1 to 1781)
  AUTHORS   Hafstrand,I., Aflalo,A. and Boyle,L.H.
  TITLE     Why TAPBPR? Implications of an additional player in MHC class I
            peptide presentation
  JOURNAL   Curr Opin Immunol 70, 90-94 (2021)
   PUBMED   34052734
  REMARK    GeneRIF: Why TAPBPR? Implications of an additional player in MHC
            class I peptide presentation.
            Review article
REFERENCE   5  (bases 1 to 1781)
  AUTHORS   McShan,A.C., Devlin,C.A., Morozov,G.I., Overall,S.A., Moschidi,D.,
            Akella,N., Procko,E. and Sgourakis,N.G.
  TITLE     TAPBPR promotes antigen loading on MHC-I molecules using a peptide
            trap
  JOURNAL   Nat Commun 12 (1), 3174 (2021)
   PUBMED   34039964
  REMARK    GeneRIF: TAPBPR promotes antigen loading on MHC-I molecules using a
            peptide trap.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1781)
  AUTHORS   Hosgood,H.D. 3rd, Zhang,L., Shen,M., Berndt,S.I., Vermeulen,R.,
            Li,G., Yin,S., Yeager,M., Yuenger,J., Rothman,N., Chanock,S.,
            Smith,M. and Lan,Q.
  TITLE     Association between genetic variants in VEGF, ERCC3 and
            occupational benzene haematotoxicity
  JOURNAL   Occup Environ Med 66 (12), 848-853 (2009)
   PUBMED   19773279
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 1781)
  AUTHORS   Chapuis,J., Hot,D., Hansmannel,F., Kerdraon,O., Ferreira,S.,
            Hubans,C., Maurage,C.A., Huot,L., Bensemain,F., Laumet,G.,
            Ayral,A.M., Fievet,N., Hauw,J.J., DeKosky,S.T., Lemoine,Y.,
            Iwatsubo,T., Wavrant-Devrieze,F., Dartigues,J.F., Tzourio,C.,
            Buee,L., Pasquier,F., Berr,C., Mann,D., Lendon,C., Alperovitch,A.,
            Kamboh,M.I., Amouyel,P. and Lambert,J.C.
  TITLE     Transcriptomic and genetic studies identify IL-33 as a candidate
            gene for Alzheimer's disease
  JOURNAL   Mol Psychiatry 14 (11), 1004-1016 (2009)
   PUBMED   19204726
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 1781)
  AUTHORS   Lee,J.H., Cheng,R., Rogaeva,E., Meng,Y., Stern,Y., Santana,V.,
            Lantigua,R., Medrano,M., Jimenez-Velazquez,I.Z., Farrer,L.A., St
            George-Hyslop,P. and Mayeux,R.
  TITLE     Further examination of the candidate genes in chromosome 12p13
            locus for late-onset Alzheimer disease
  JOURNAL   Neurogenetics 9 (2), 127-138 (2008)
   PUBMED   18340469
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 1781)
  AUTHORS   Zhang,Z. and Henzel,W.J.
  TITLE     Signal peptide prediction based on analysis of experimentally
            verified cleavage sites
  JOURNAL   Protein Sci 13 (10), 2819-2824 (2004)
   PUBMED   15340161
REFERENCE   10 (bases 1 to 1781)
  AUTHORS   Teng,M.S., Stephens,R., Du Pasquier,L., Freeman,T., Lindquist,J.A.
            and Trowsdale,J.
  TITLE     A human TAPBP (TAPASIN)-related gene, TAPBP-R
  JOURNAL   Eur J Immunol 32 (4), 1059-1068 (2002)
   PUBMED   11920573
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB054664.1, CR997450.1, BC015017.2 and AI184901.1.
            
            On Nov 22, 2018 this sequence version replaced NM_018009.4.
            
            Summary: Tapasin, or TAPBP (MIM 601962), is a member of the
            variable-constant Ig superfamily that links major
            histocompatibility complex (MHC) class I molecules to the
            transporter associated with antigen processing (TAP; see MIM
            170260) in the endoplasmic reticulum (ER). The TAPBP gene is
            located near the MHC complex on chromosome 6p21.3. TAPBPL is a
            member of the Ig superfamily that is localized on chromosome
            12p13.3, a region somewhat paralogous to the MHC.[supplied by OMIM,
            Mar 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.273479.1,
                                           SRR3476690.1104705.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000266556.8/ ENSP00000266556.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-531               DB054664.1         32-562
            532-896             CR997450.1         445-809
            897-1760            BC015017.2         855-1718
            1761-1781           AI184901.1         15-35               c
FEATURES             Location/Qualifiers
     source          1..1781
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.31"
     gene            1..1781
                     /gene="TAPBPL"
                     /gene_synonym="TAPBP-R; TAPBPR"
                     /note="TAP binding protein like"
                     /db_xref="GeneID:55080"
                     /db_xref="HGNC:HGNC:30683"
                     /db_xref="MIM:607081"
     exon            1..271
                     /gene="TAPBPL"
                     /gene_synonym="TAPBP-R; TAPBPR"
                     /inference="alignment:Splign:2.1.0"
     CDS             208..1614
                     /gene="TAPBPL"
                     /gene_synonym="TAPBP-R; TAPBPR"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; TAP binding protein related; tapasin-related
                     protein; TAPASIN-R; tapasin-like; TAP-binding
                     protein-related protein"
                     /codon_start=1
                     /product="tapasin-related protein isoform 1 precursor"
                     /protein_id="NP_060479.3"
                     /db_xref="CCDS:CCDS8546.1"
                     /db_xref="GeneID:55080"
                     /db_xref="HGNC:HGNC:30683"
                     /db_xref="MIM:607081"
                     /translation="MGTQEGWCLLLCLALSGAAETKPHPAEGQWRAVDVVLDCFLAKD
                     GAHRGALASSEDRARASLVLKQVPVLDDGSLEDFTDFQGGTLAQDDPPIIFEASVDLV
                     QIPQAEALLHADCSGKEVTCEISRYFLQMTETTVKTAAWFMANMQVSGGGPSISLVMK
                     TPRVTKNEALWHPTLNLPLSPQGTVRTAVEFQVMTQTQSLSFLLGSSASLDCGFSMAP
                     GLDLISVEWRLQHKGRGQLVYSWTAGQGQAVRKGATLEPAQLGMARDASLTLPGLTIQ
                     DEGTYICQITTSLYRAQQIIQLNIQASPKVRLSLANEALLPTLICDIAGYYPLDVVVT
                     WTREELGGSPAQVSGASFSSLRQSVAGTYSISSSLTAEPGSAGATYTCQVTHISLEEP
                     LGASTQVVPPERRTALGVIFASSLFLLALMFLGLQRRQAPTGLGLLQAERWETTSCAD
                     TQSSHLHEDRTARVSQPS"
     exon            272..502
                     /gene="TAPBPL"
                     /gene_synonym="TAPBP-R; TAPBPR"
                     /inference="alignment:Splign:2.1.0"
     exon            503..772
                     /gene="TAPBPL"
                     /gene_synonym="TAPBP-R; TAPBPR"
                     /inference="alignment:Splign:2.1.0"
     exon            773..1111
                     /gene="TAPBPL"
                     /gene_synonym="TAPBP-R; TAPBPR"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1414
                     /gene="TAPBPL"
                     /gene_synonym="TAPBP-R; TAPBPR"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..1498
                     /gene="TAPBPL"
                     /gene_synonym="TAPBP-R; TAPBPR"
                     /inference="alignment:Splign:2.1.0"
     exon            1499..1781
                     /gene="TAPBPL"
                     /gene_synonym="TAPBP-R; TAPBPR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1740..1745
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TAPBPL"
                     /gene_synonym="TAPBP-R; TAPBPR"
                     /note="hexamer: AATACA"
     polyA_site      1781
                     /gene="TAPBPL"
                     /gene_synonym="TAPBP-R; TAPBPR"
                     /note="major polyA site"
ORIGIN      
        1 agacggcttc acacagggac gcgggctgcc atcttgctct aagtgaaagt gaaagaaaag
       61 tcggcagcag agggaacagg gaagaaacct aaaggctgca ggctgccagg tgtgcttgga
      121 gagccccctt cttccgccgg gcctcgcaag cagcgtagga ctgtggagaa gggcggtggg
      181 caaggaggga actcgagagc agcctccatg ggcacacagg agggctggtg cctgctgctc
      241 tgcctggctc tatctggagc agcagaaacc aagccccacc cagcagaggg gcagtggcgg
      301 gcagtggacg tggtcctaga ctgcttcctg gcgaaggacg gtgcgcaccg tggagctctc
      361 gccagcagtg aggacagggc aagggcctcc cttgtgctga agcaggtgcc agtgctggac
      421 gatggctccc tggaggactt caccgatttc caagggggca cactggccca agatgaccca
      481 cctattatct ttgaggcctc agtggacctg gtccagattc cccaggccga ggccttgctc
      541 catgctgact gcagtgggaa ggaggtgacc tgtgagatct cccgctactt tctccagatg
      601 acagagacca ctgttaagac agcagcttgg ttcatggcca acatgcaggt ctctggaggg
      661 ggacctagca tctccttggt gatgaagact cccagggtca ccaagaatga ggcgctctgg
      721 cacccgacgc tgaacttgcc actgagcccc caggggactg tgcgaactgc agtggagttc
      781 caggtgatga cacagaccca atccctgagc ttcctgctgg ggtcctcagc ctccttggac
      841 tgtggcttct ccatggcacc gggcttggac ctcatcagtg tggagtggcg actgcagcac
      901 aagggcaggg gtcagttggt gtacagctgg accgcagggc aggggcaggc tgtgcggaag
      961 ggcgctaccc tggagcctgc acaactgggc atggccaggg atgcctccct caccctgccc
     1021 ggcctcacta tacaggacga ggggacctac atttgccaga tcaccacctc tctgtaccga
     1081 gctcagcaga tcatccagct caacatccaa gcttccccta aagtacgact gagcttggca
     1141 aacgaagctc tgctgcccac cctcatctgc gacattgctg gctattaccc tctggatgtg
     1201 gtggtgacgt ggacccgaga ggagctgggt ggatccccag cccaagtctc tggtgcctcc
     1261 ttctccagcc tcaggcaaag cgtggcaggc acctacagca tctcctcctc tctcaccgca
     1321 gaacctggct ctgcaggtgc cacttacacc tgccaggtca cacacatctc tctggaggag
     1381 ccccttgggg ccagcaccca ggttgtccca ccagagcgga gaacagcctt gggagtcatc
     1441 tttgccagca gtctcttcct tcttgcactg atgttcctgg ggcttcagag acggcaagca
     1501 cctacaggac ttgggctgct tcaggctgaa cgctgggaga ccacttcctg tgctgacaca
     1561 cagagctccc atctccatga agaccgcaca gcgcgtgtaa gccagcccag ctgacctaaa
     1621 gcgacatgag actactagaa agaaacgaca cccttcccca agcccccaca gctactccaa
     1681 cccaaacaac aaccaagcca gtttaatggt aggaatttgt attttttgcc tttgttcaga
     1741 atacatgaca ttggtaaata tgccacatgc ctttggtgga a
//
